Subscribe

Ono Pharmaceutical Co., Ltd. (4528.T)

JPY2,415.50 +15.00 (+0.62%)
JP JPX Healthcare Drug Manufacturers - General
Address 8-2, Kyutaromachi 1-chome 541-8564
Osaka, JP
CEO Gyo Sagara
IPO 2001-01-04
ISIN JP3197600004

Explore sections of this company profile

Also trades on Other OTC · OPHLF (USD) Other OTC · OPHLY (USD) Tokyo Stock Exchange · 4528.T (JPY)
Description

Ono Pharmaceutical Co., Ltd., along with its affiliated companies, is engaged in the global development, manufacturing, procurement, and sale of a diverse range of pharmaceutical products and diagnostic tools. Its diverse oncology portfolio includes OPDIVO intravenous infusions, KYPROLIS for injection, MEKTOVI, VELEXBRU, and ADLUMIZ tablets, along with BRAFTOVI capsules, all prescribed for various malignant tumors. It also provides EMEND capsules and PROEMEND intravenous injections to alleviate chemotherapy-induced nausea and vomiting, and DEMSER capsules for managing symptoms in pheochromocytoma patients. Beyond oncology, the company's offerings span multiple therapeutic areas. For metabolic disorders, it supplies GLACTIV and FORXIGA tablets for type 2 diabetes. Cardiovascular health is supported by ONOACT injections for tachyarrhythmia, CORALAN for chronic heart failure, and OPALMON tablets addressing peripheral circulatory disorders. Autoimmune conditions like rheumatoid arthritis are treated with ORENCIA injections. Neurological therapies include RIVASTACH patches for Alzheimer's disease and ONGENTYS tablets for Parkinson's disease. Other notable products are PARSABIV intravenous injections for dialysis patients, STAYBLA tablets for overactive bladder, ONON capsules and dry syrups for bronchial asthma and allergic rhinitis, and RECALBON tablets for osteoporosis, with JOYCLU intra-articular injection available to improve joint function. Moreover, the company is heavily invested in research and development, with a pipeline targeting a wide array of diseases. This includes various malignancies such as esophageal, urothelial, Hodgkin's lymphoma, ovarian, bladder, prostate, hepatocellular, pancreatic, biliary tract, gastric, thyroid, colorectal, melanoma, acute myeloid leukemia, non-small cell lung cancer, and virus-positive/negative solid tumors, as well as primary central nervous system lymphoma. Beyond cancer, its developmental efforts extend to myelodysplastic syndrome, polymyositis/dermatomyositis, tachyarrhythmia, pemphigus, generalized scleroderma, enthesopathy, diabetic polyneuropathy, neurodegenerative and autoimmune disorders, narcolepsy, and thrombosis. Established in 1717, the company maintains its corporate headquarters in Osaka, Japan.

Market Cap & Enterprise Value
Merger & Acquisition History

No mergers or acquisitions recorded for this company.

Technical Outlook
Loading outlook…
Loading forecast...
Signal Summary Loading…
Indicator 1D1W2W3W1M
Each column is computed on that timeframe's candles (1D = daily, 1W ≈ weekly, 1M ≈ monthly), not on the same last day. ▲ bullish · ▼ bearish · — neutral. The Net row counts signals per column; hover any cell (or the indicator name) to see the exact rule behind it.
Day Score & sub-scores
Statistical fingerprint & regime detail
Conditional historical analysis
Customize analysis (advanced)
Indicative levels generated algorithmically. Not financial advice.
Risk Profile
Loading risk profile…
Price Chart
Averages
Trend
Price
Levels
Draw
JPY2,415.50 +15.00 (+0.62%)
Loading historical data…
Volume Profile
Loading…
Liquidity & share structure
Average Volume
2M
Beta
0.14
Float Shares
332.90M
Free Float %
70.8%
Price Performance
1D5D1M3M6M YTD1Y3Y5Y10YMax
+3.03% +8.27% +2.49% +0.69% +27.45% +16.70% +65.09% -0.78% +3.67% -50.70% +225.77%
Rolling Volatility
Loading…
Drawdown
Loading…
Relative Strength
Loading…
Monthly Returns Heatmap
From To
Loading…
Annual Monthly Returns
Loading…
Daily Returns Distribution
vs.
Loading histogram data…

Revenue flow

Revenue by geography

Revenue by segment

From To

Revenue composition

From To

By product

By geography

Financial Statements

Income Statement

Balance Sheet

Cash Flow Statement

Key Metrics

Financial Ratios

Employees

Financial Growth (CAGR)

Market Data

Price Targets & DCF
Current price
2,415.50
DCF (Unlevered) 6,072.85 +151.4%
DCF (Levered) 5,106.06 +111.4%

DCF figures are point estimates: small changes in growth or discount-rate assumptions move them materially. Read them as a reference, not a precise target.

Ratings Trend (MoM) 8% Bullish
Rating 2026-05 Change
Strong Buy 0 0
Buy 1 0
Hold 8 0
Sell 2 0
Strong Sell 1 0
Quality scores
Altman Z-Score
4.93
Safe zone
Piotroski F-Score
7 / 9
Strong
MOAT Score
7 / 10
Strong MOAT
Composite Rating
A-
Overall Score
4 / 5
High
DCF Score
5 / 5
High
ROE Score
3 / 5
Medium
ROA Score
4 / 5
High
D/E Score
2 / 5
Medium
P/E Score
3 / 5
Medium
P/Book Score
4 / 5
High
Operational MOAT
✗ Below peers
  • Revenue growth Drug Manufacturers - General: +6.6%
    +5.9% Q1'26: +5.7% (vs Q1'25)
  • EPS growth Drug Manufacturers - General: +18.2%
    +39.5% Q1'26: +112.3% (vs Q1'25)
  • FCF margin FCF growth · Drug Manufacturers - General: +36.0%
    +25.3% Q1'26: +41.4% (vs Q1'25)
  • EBIT margin Drug Manufacturers - General: +19.4%
    +20.0% Q1'26: +10.5% (vs Q1'25)
  • ROIC Drug Manufacturers - General: +10.2%
    +10.5% Q1'26: +4.0% (vs Q1'25)
  • Share dilution Drug Manufacturers - General: +0.0%
    +0.0% Q1'26: +1.5% (vs Q1'25)
  • Debt / EBITDA Net debt/EBITDA · Drug Manufacturers - General: -0.29×
    0.86× Q1'26: 1.37× (vs Q1'25)
Valuation Multiples From To
Price Forecast (3Y) From To
Model
Adjust
P/E
Theoretical Return — If Invested Today

* These projections are based on analyst consensus estimates and user-defined valuation multiples. This table is for informational purposes only and does not constitute a recommendation to buy or sell any security. Past performance is not indicative of future results.

DCF Interactive Model (UFCF)
Projection years:
Market assumptions
WACC components (optional)
Ke (Cost of Equity) = Rf + β (0.11) × ERP
WACC = 91% × Ke + 9% × Kd (4.0%) × (1−t)

Modifying these values recalculates WACC automatically.

Business assumptions
Intrinsic value (base): 8,008.77 Current price: 2,415.50
Enterprise Value: Equity Value: Terminal Value: TV as % of EV:

Base values reflect the latest available data for this company and market conditions.

Consensus Estimates
Metric Mar 2015
actual
Mar 2016
actual
Mar 2017
actual
Mar 2018
actual
Mar 2019
actual
Mar 2020
actual
Mar 2021
actual
Mar 2022
actual
Mar 2023
actual
Mar 2024
actual
Mar 2025
actual
Mar 2026
11 Rev. Ana.
10 EPS Ana.
Mar 2027
10 Rev. Ana.
9 EPS Ana.
Mar 2028
10 Rev. Ana.
9 EPS Ana.
Mar 2029
7 Rev. Ana.
6 EPS Ana.
Mar 2030
3 Rev. Ana.
2 EPS Ana.
Revenue
135.78B
est: 134.72B (+0.8%)
160.28B
est: 160.16B (+0.1%)
244.80B
est: 247.83B (-1.2%)
261.84B
est: 263.47B (-0.6%)
288.63B
est: 287.20B (+0.5%)
292.42B
est: 296.60B (-1.4%)
309.28B
est: 312.83B (-1.1%)
361.36B
est: 362.99B (-0.5%)
447.19B
est: 447.56B (-0.1%)
502.67B
est: 500.33B (+0.5%)
486.87B
est: 494.77B (-1.6%)
506.24B
488.11B – 514.60B
+2.3% YoY
460.03B
451.30B – 485.34B
-9.1% YoY
447.34B
427.03B – 514.84B
-2.8% YoY
461.17B
455.87B – 466.48B
+3.1% YoY
470.05B
454.94B – 518.33B
+1.9% YoY
EBITDA
21.46B
est: 43.92B (-51.1%)
36.55B
est: 52.21B (-30.0%)
67.54B
est: 80.79B (-16.4%)
68.78B
est: 85.89B (-19.9%)
75.39B
est: 93.63B (-19.5%)
93.39B
est: 96.69B (-3.4%)
107.92B
est: 101.98B (+5.8%)
132.64B
est: 118.34B (+12.1%)
169.75B
est: 145.91B (+16.3%)
181.70B
est: 156.81B (+15.9%)
90.28B
est: 155.07B (-41.8%)
158.66B
152.98B – 161.28B
+2.3% YoY
144.18B
141.44B – 152.11B
-9.1% YoY
140.20B
133.84B – 161.36B
-2.8% YoY
144.54B
142.87B – 146.20B
+3.1% YoY
147.32B
142.58B – 162.45B
+1.9% YoY
EBIT
15.36B
est: 37.71B (-59.3%)
30.01B
est: 44.83B (-33.0%)
59.72B
est: 69.37B (-13.9%)
59.57B
est: 73.74B (-19.2%)
64.76B
est: 80.39B (-19.4%)
79.18B
est: 83.02B (-4.6%)
92.10B
est: 87.56B (+5.2%)
114.91B
est: 101.60B (+13.1%)
152.30B
est: 125.27B (+21.6%)
163.56B
est: 131.54B (+24.3%)
63.38B
est: 130.07B (-51.3%)
133.09B
128.32B – 135.29B
+2.3% YoY
120.94B
118.64B – 127.59B
-9.1% YoY
117.60B
112.26B – 135.35B
-2.8% YoY
121.24B
119.85B – 122.64B
+3.1% YoY
123.57B
119.60B – 136.27B
+1.9% YoY
Net Income
12.98B
est: 11.34B (+14.4%)
24.98B
est: 19.91B (+25.4%)
55.79B
est: 50.95B (+9.5%)
50.28B
est: 42.22B (+19.1%)
51.54B
est: 48.46B (+6.4%)
59.70B
est: 54.48B (+9.6%)
75.43B
est: 70.78B (+6.6%)
80.52B
est: 81.43B (-1.1%)
112.72B
est: 113.68B (-0.8%)
127.98B
est: 120.95B (+5.8%)
50.05B
est: 65.13B (-23.2%)
69.77B
65.37B – 78.05B
+7.1% YoY
67.75B
60.79B – 72.42B
-2.9% YoY
58.87B
51.12B – 63.42B
-13.1% YoY
63.66B
53.53B – 69.49B
+8.1% YoY
63.23B
60.59B – 71.68B
-0.7% YoY
SGA
40.82B
est: 28.53B (+43.1%)
42.63B
est: 33.92B (+25.7%)
60.66B
est: 52.49B (+15.6%)
66.35B
est: 55.80B (+18.9%)
68.00B
est: 60.83B (+11.8%)
65.20B
est: 62.82B (+3.8%)
66.62B
est: 66.26B (+0.5%)
74.12B
est: 76.88B (-3.6%)
86.64B
est: 94.80B (-8.6%)
97.39B
est: 108.42B (-10.2%)
122.22B
est: 107.21B (+14.0%)
109.70B
105.77B – 111.51B
+2.3% YoY
99.68B
97.79B – 105.17B
-9.1% YoY
96.93B
92.53B – 111.56B
-2.8% YoY
99.93B
98.78B – 101.08B
+3.1% YoY
101.85B
98.58B – 112.32B
+1.9% YoY
EPS
24.48
est: 24.14 (+1.4%)
47.13
est: 42.39 (+11.2%)
105.27
est: 108.45 (-2.9%)
97.00
est: 89.88 (+7.9%)
100.25
est: 103.15 (-2.8%)
118.47
est: 115.96 (+2.2%)
151.11
est: 150.67 (+0.3%)
162.19
est: 173.34 (-6.4%)
230.85
est: 241.98 (-4.6%)
266.61
est: 254.46 (+4.8%)
106.55
est: 132.50 (-19.6%)
151.52
139.09 – 166.07
+14.4% YoY
146.84
129.35 – 154.10
-3.1% YoY
123.47
108.78 – 134.95
-15.9% YoY
134.68
113.91 – 147.85
+9.1% YoY
134.55
128.93 – 152.52
-0.1% YoY
Historical Ratings (3M)
Date Rating Overall DCF ROE ROA D/E P/E P/B
2026-05-08 A- 4/5 5/5 3/5 4/5 2/5 3/5 4/5
2026-05-07 A- 4/5 5/5 3/5 4/5 2/5 3/5 4/5
2026-05-01 A- 4/5 5/5 3/5 4/5 2/5 3/5 4/5
2026-04-30 A- 4/5 5/5 3/5 4/5 2/5 3/5 4/5
2026-04-28 A 4/5 5/5 3/5 5/5 2/5 3/5 4/5
2026-04-27 A 4/5 5/5 3/5 5/5 2/5 3/5 4/5
2026-04-24 A 4/5 5/5 3/5 5/5 2/5 3/5 4/5
2026-04-23 A 4/5 5/5 3/5 5/5 2/5 3/5 4/5
2026-04-22 A 4/5 5/5 3/5 5/5 2/5 3/5 4/5
2026-04-21 A 4/5 5/5 3/5 5/5 2/5 3/5 4/5
2026-04-20 A 4/5 5/5 3/5 5/5 2/5 3/5 4/5
2026-04-17 A 4/5 5/5 3/5 5/5 2/5 3/5 4/5
2026-04-16 A 4/5 5/5 3/5 5/5 2/5 3/5 4/5
2026-04-15 A 4/5 5/5 3/5 5/5 2/5 3/5 4/5
2026-04-14 A 4/5 5/5 3/5 5/5 2/5 3/5 4/5

Owner Earnings

Owner's Earnings (history) From To
Owner alignment
Owner's Earnings TTM
138.34B
OE per share TTM
292.45
Owner's Yield
11.87%
Maintenance CapEx ratio
73.93%
Maint CapEx / Avg PPE
26.1%

Ownership Overview

Ownership breakdown

Ownership breakdown not available.

At a glance
Institutional holders
Total invested
Insider transactions (90d)
0
Beneficial owners (>5%)
0
Beneficial owners (>5%)

No beneficial ownership filings recorded.

Institutional Activity (13F)

Institutional ownership trend

Institutional history not available.

Top institutional holders

Top holders not available.

Insider Activity

Insider Activity — Latest Quarter

No insider activity available.

Insider buys vs sells (history)

Insider history not available.

Recent insider transactions

No recent insider transactions.

Executive team

Top executives
EBIT / Employee
26.82M
Shares Outstanding
469.91M

Executive compensation

Executive compensation (annual)

Executive compensation not available.

CEO compensation breakdown

No CEO compensation history available.

Proxy statements

Proxy statements (DEF 14A)

No proxy statements available for this company yet.

Recent SEC filings

Recent SEC filings

No SEC filings available for this company yet.

Executive team

NameTitleCompensationGender
Gyo Sagara Chief Executive Officer & Chairman of the Board 142M male
Toichi Takino President, Chief Operating Officer & Representative Director 102M male
Toshihiro Tsujinaka EVice President, Executive Director of Corporate Strategy & Planning, HR Division and Representative Director 78M male
Masayuki Tanigawa Corporate Officer & Head of Business Strategy, License
Akira Takada Corporate Executive Officer & Executive Director of CMC & Production
Shinji Takai Corporate Officer & Head of Medical Affairs
Takehiro Yamada Corporate Officer & Head of Risk and Compliance Management Department
Satoshi Takahagi Senior Director of EHS Promotion & Corporate Officer
Hiromu Habashita Corporate Officer, Senior Vice President, Discovery & Research
Masaki Ito Corporate Executive Officer and Div. Director of Corporate Strategy, Planning & Bus. Management Div. male
ESG Score History

No data available for this company.

Senate Trading Activity

No Senate trading activity found for this company.

House Trading Activity

No House trading activity found for this company.

Market share among peers
Peer comparison — filtered group (TTM)
Your opinion

Share your view on this stock and instantly see how the community has voted over the last 6 months.

These are community opinions and do not constitute buy or sell advice to act on. The results shown are based on aggregated opinions and are not an investment recommendation, nor do they intend to influence any investment decision.

Dividend yield history

Dividend history

Earnings history

Earnings reports

Stock splits