Panacea Life Sciences Holdings, Inc. (PLSH)
Greenwood Village, CO, US
Panacea Life Sciences Holdings, Inc. operates as an integrated research and production firm, specializing in cannabinoid and nutraceutical products across the entire supply chain, from sourcing to final sale. Its core mission is to develop and deliver natural, pharmaceutical-grade alternatives for both human and pet consumption. The company's diverse product range encompasses items such as softgels, edible gummies, liquid tinctures, sublingual tablets, and a variety of cosmetic and topical applications. In addition to these offerings, the company is involved in the personal protective equipment (PPE) market, importing and distributing hand sanitizers and masks. Panacea Life Sciences also provides white-label and contract manufacturing services to other cannabinoid companies, sells raw materials, and manages tolling arrangements. Established in 2008, the company is headquartered in Greenwood Village, Colorado.
No mergers or acquisitions recorded for this company.
| Indicator | 1D | 1W | 2W | 3W | 1M |
|---|
Day Score & sub-scores
Statistical fingerprint & regime detail
Conditional historical analysis
Customize analysis (advanced)
| 1D | 5D | 1M | 3M | 6M | YTD | 1Y | 3Y | 5Y | 10Y | Max |
|---|---|---|---|---|---|---|---|---|---|---|
| +5.49% | +1.69% | -25.56% | -33.26% | -50.00% | -40.00% | -40.00% | -93.48% | -95.71% | -95.71% | -95.71% |
Revenue flow
Revenue by geography
Revenue by segment
Revenue composition
By product
By geography
Income Statement
Balance Sheet
Cash Flow Statement
Key Metrics
Financial Ratios
Employees
Financial Growth (CAGR)
Market Data
DCF figures are point estimates: small changes in growth or discount-rate assumptions move them materially. Read them as a reference, not a precise target.
-
Revenue growth Drug Manufacturers - Specialty & Generic: +6.8%-77.8% Q1'26: -80.1% (vs Q1'25)
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EPS growth Drug Manufacturers - Specialty & Generic: +16.5%+77.9% ★ Q1'26: -29,850.0% (vs Q1'25)
-
FCF margin FCF growth · Drug Manufacturers - Specialty & Generic: +32.3%-612.9% Q1'26: -85.5% (vs Q1'25)
-
EBIT margin Drug Manufacturers - Specialty & Generic: +13.0%-192.6% Q1'26: -126.1% (vs Q1'25)
-
ROIC Drug Manufacturers - Specialty & Generic: +6.5%-31.6% Q1'26: -11.0% (vs Q1'25)
-
Share dilution Drug Manufacturers - Specialty & Generic: +0.0%+222.7% Q1'26: +195.3% (vs Q1'25)
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Debt / EBITDA Net debt/EBITDA · Drug Manufacturers - Specialty & Generic: -0.10×11.81× Q1'26: -1.02× (vs Q1'25)
* These projections are based on analyst consensus estimates and user-defined valuation multiples. This table is for informational purposes only and does not constitute a recommendation to buy or sell any security. Past performance is not indicative of future results.
| Metric |
Dec 2019 actual |
Dec 2020 actual |
Dec 2025 actual |
Dec 2026 1 Rev. Ana. 1 EPS Ana. |
Dec 2027 1 Rev. Ana. 1 EPS Ana. |
Dec 2028 1 Rev. Ana. 1 EPS Ana. |
|---|---|---|---|---|---|---|
| Revenue |
345.7K
est: 1.90M (-81.8%)
|
9.02M
est: 7.60M (+18.7%)
|
910.5K
est: 910.5K (+0.0%)
|
956.0K
956.0K – 956.0K
+5.0% YoY
|
1.90M
1.90M – 1.90M
+98.7% YoY
|
7.60M
7.60M – 7.60M
+300.0% YoY
|
| EBITDA |
-8.65M
est: -981.9K (-780.7%)
|
-2.03M
est: -3.93M (+48.4%)
|
18.2K
est: -425.9K (+104.3%)
|
-447.2K
-447.2K – -447.2K
-5.0% YoY
|
-888.8K
-888.8K – -888.8K
-98.7% YoY
|
-3.56M
-3.56M – -3.56M
-300.0% YoY
|
| EBIT |
-9.54M
est: -1.18M (-707.2%)
|
-3.72M
est: -4.73M (+21.3%)
|
-1.75M
est: -673.4K (-160.4%)
|
-707.0K
-707.0K – -707.0K
-5.0% YoY
|
-1.41M
-1.41M – -1.41M
-98.7% YoY
|
-5.62M
-5.62M – -5.62M
-300.0% YoY
|
| Net Income |
-9.48M
est: -371.50M (+97.4%)
|
-6.99M
est: -165.11M (+95.8%)
|
-416.7K
est: -1.47B (+100.0%)
|
-1.33B
-1.33B – -1.33B
+9.1% YoY
|
-1.20B
-1.20B – -1.20B
+10.0% YoY
|
-532.89M
-532.89M – -532.89M
+55.6% YoY
|
| SGA |
8.95M
est: 1.39M (+545.0%)
|
2.81M
est: 5.55M (-49.4%)
|
533.8K
est: 715.1K (-25.4%)
|
750.8K
750.8K – 750.8K
+5.0% YoY
|
1.49M
1.49M – 1.49M
+98.7% YoY
|
5.97M
5.97M – 5.97M
+300.0% YoY
|
| EPS |
-7.83
est: -20.16 (+61.2%)
|
-0.41
est: -8.96 (+95.4%)
|
-0.01
est: -24.64 (+100.0%)
|
-22.40
-22.40 – -22.40
+9.1% YoY
|
-20.16
-20.16 – -20.16
+10.0% YoY
|
-8.96
-8.96 – -8.96
+55.6% YoY
|
| Date | Rating | Overall | DCF | ROE | ROA | D/E | P/E | P/B |
|---|---|---|---|---|---|---|---|---|
| 2026-05-11 | C+ | 2/5 | 1/5 | 1/5 | 1/5 | 3/5 | 1/5 | 5/5 |
| 2026-05-06 | C+ | 2/5 | 1/5 | 1/5 | 1/5 | 3/5 | 1/5 | 5/5 |
| 2026-05-04 | C+ | 2/5 | 1/5 | 1/5 | 1/5 | 3/5 | 1/5 | 5/5 |
| 2026-04-30 | C+ | 2/5 | 1/5 | 1/5 | 1/5 | 3/5 | 1/5 | 5/5 |
| 2026-04-28 | C | 2/5 | 1/5 | 1/5 | 1/5 | 2/5 | 1/5 | 5/5 |
| 2026-04-27 | C | 2/5 | 1/5 | 1/5 | 1/5 | 2/5 | 1/5 | 5/5 |
| 2026-04-24 | C | 2/5 | 1/5 | 1/5 | 1/5 | 2/5 | 1/5 | 5/5 |
| 2026-04-23 | C | 2/5 | 1/5 | 1/5 | 1/5 | 2/5 | 1/5 | 5/5 |
| 2026-04-22 | C | 2/5 | 1/5 | 1/5 | 1/5 | 2/5 | 1/5 | 5/5 |
| 2026-04-21 | C | 2/5 | 1/5 | 1/5 | 1/5 | 2/5 | 1/5 | 5/5 |
| 2026-04-20 | C | 2/5 | 1/5 | 1/5 | 1/5 | 2/5 | 1/5 | 5/5 |
| 2026-04-17 | C | 2/5 | 1/5 | 1/5 | 1/5 | 2/5 | 1/5 | 5/5 |
| 2026-04-16 | C | 2/5 | 1/5 | 1/5 | 1/5 | 2/5 | 1/5 | 5/5 |
Owner Earnings
Ownership Overview
Ownership breakdown not available.
| # | Reporting person | Amount owned | % of class | Sole voting | Shared voting | Sole dispositive | Shared dispositive | Type | Citizenship | Filing date | SEC filing |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 22nd Century Group, Inc. | 91.02M | 15.20% | — | 91.02M | — | — | CO | Nevada | 2021-07-09 | ↗ |
| 2 | Ceed2Med, LLC | 67.09M | 57.36% | 67.09M | — | 67.09M | 10.00 | CO | 6. Citizenship or Place of Organization | 2019-01-22 | ↗ |
| 3 | Paradox Capital Partners, LLC | 13.73M | 9.99% | 13.00M | 726.9K | 13.00M | 726.9K | PN | — | 2021-02-08 | ↗ |
| 4 | Vladislav (Bobby) Yampolsky | 7.64M | 22.20% | 7.64M | — | 7.64M | 10.00 | OO | or Place of Organization | 2019-07-29 | ↗ |
| 5 | Real Estate Company, LLC | 7.30M | 47.00% | 7.30M | — | 7.30M | — | CO | Colorado | 2023-06-23 | ↗ |
| 6 | Buttorff | 1.54M | 9.90% | 1.54M | — | 1.54M | — | IN | Colorado | 2023-06-23 | ↗ |
| 7 | Harvey Kesner | 326.8K | 0.40% | 326.8K | — | 326.8K | 11.00 | IN | — | 2021-02-08 | ↗ |
| 8 | Harvey & Renee Kesner JTWROS | 250.0K | 0.31% | 250.0K | — | 250.0K | 11.00 | IN | — | 2021-02-08 | ↗ |
| 9 | Darwin Capital Investments, LLC | 150.0K | 0.18% | 150.0K | — | 150.0K | 11.00 | PN | — | 2021-02-08 | ↗ |
| 10 | Renee Kesner | 134.00 | 0.00% | 134.00 | — | 134.00 | 11.00 | IN | — | 2021-02-08 | ↗ |
Institutional Activity (13F)
Institutional history not available.
Top holders not available.
ETF Ownership
This company is not held by any ETF in our universe.
Insider Activity
| Date | Person | Role | Transaction | A/D | Security | Shares | Price | Value | Owned after | D/I | Filing |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 2023-09-18 | Buttorff Leslie | Director / Officer / 10% Owner | P-Purchase | A | Common Stock | 20,000 | 0.24 | 4.7K | 1,533,949 | — | ↗ |
| 2023-06-09 | Buttorff Leslie | Director / Officer / 10% Owner | P-Purchase | A | Common Stock | 3,000 | 0.43 | 1.3K | 1,513,949 | — | ↗ |
| 2023-06-02 | Buttorff Leslie | Director / Officer / 10% Owner | A-Award | A | Common Stock | 760,000 | 0.50 | 380.0K | 1,510,949 | — | ↗ |
| 2023-05-23 | Buttorff Leslie | Director / Officer / 10% Owner | P-Purchase | A | Common Stock | 500 | 0.50 | 249.00 | 751,449 | — | ↗ |
| 2023-05-19 | Buttorff Leslie | Director / Officer / 10% Owner | P-Purchase | A | Common Stock | 1,500 | 0.52 | 780.00 | 750,949 | — | ↗ |
| 2023-05-09 | Buttorff Leslie | Director / Officer / 10% Owner | P-Purchase | A | Common Stock | 2,300 | 0.38 | 867.10 | 741,949 | — | ↗ |
| 2023-05-08 | Buttorff Leslie | Director / Officer / 10% Owner | P-Purchase | A | Common Stock | 1,500 | 0.43 | 645.00 | 739,649 | — | ↗ |
| 2023-05-05 | Buttorff Leslie | Director / Officer / 10% Owner | P-Purchase | A | Common Stock | 11,500 | 0.49 | 5.6K | 738,149 | — | ↗ |
| 2023-04-26 | Buttorff Leslie | Director / Officer / 10% Owner | P-Purchase | A | Common Stock | 5,500 | 0.40 | 2.2K | 726,649 | — | ↗ |
| 2023-04-25 | Buttorff Leslie | Director / Officer / 10% Owner | P-Purchase | A | Common Stock | 3,500 | 0.38 | 1.3K | 721,149 | — | ↗ |
| 2023-04-05 | Buttorff Leslie | Director / Officer / 10% Owner | P-Purchase | A | Common Stock | 2,500 | 0.33 | 825.00 | 716,649 | — | ↗ |
| 2023-04-04 | Buttorff Leslie | Director / Officer / 10% Owner | P-Purchase | A | Common Stock | 3,200 | 0.35 | 1.1K | 714,149 | — | ↗ |
| 2023-04-03 | Buttorff Leslie | Director / Officer / 10% Owner | P-Purchase | A | Common Stock | 1,000 | 0.36 | 360.00 | 710,949 | — | ↗ |
| 2023-02-27 | Buttorff Leslie | Director / Officer / 10% Owner | P-Purchase | A | Common Stock | 1,000 | 0.19 | 190.00 | 709,949 | — | ↗ |
| 2023-02-26 | Buttorff Leslie | Director / Officer / 10% Owner | P-Purchase | A | Common Stock | 1,000 | 0.19 | 190.00 | 706,949 | — | ↗ |
| 2022-12-31 | Buttorff Leslie | Officer | — | I | Common Stock | 0 | 0.00 | — | 4,047,054 | — | ↗ |
| 2022-08-26 | Buttorff Leslie | Officer | P-Purchase | A | Common Stock | 11,500 | 0.14 | 1.6K | 657,449 | — | ↗ |
| 2022-08-11 | Wert Lawrence | Director | P-Purchase | A | Common Stock | 5,000 | 0.13 | 640.00 | 1,317,868 | — | ↗ |
| 2022-08-03 | Buttorff Leslie | Officer | P-Purchase | A | Common Stock | 2,600 | 0.10 | 260.00 | 639,349 | — | ↗ |
| 2022-07-08 | Buttorff Leslie | Officer | P-Purchase | A | Common Stock | 2,100 | 0.40 | 835.59 | 627,149 | — | ↗ |
| 2022-04-04 | Buttorff Leslie | Officer | P-Purchase | A | Common Stock | 1,404 | 0.60 | 842.40 | 618,399 | — | ↗ |
| 2021-12-31 | Buttorff Leslie | Director / Officer / 10% Owner | — | I | Series C Preferred Stock | 0 | 0.00 | — | 1,000,000 | — | ↗ |
| 2021-10-17 | Nerger Janice | Director | — | D | Common Stock | 0 | 0.00 | — | 1,987,828 | — | ↗ |
| 2021-06-30 | Wert Lawrence | Director | A-Award | A | Stock Options (Right to Buy) | 28,000,000 | 0.10 | 2.80M | 28,000,000 | — | ↗ |
| 2021-06-30 | Buttorff Leslie | Director / Officer / 10% Owner | A-Award | A | Series D Preferred Stock | 10,000 | 0.00 | — | 10,000 | — | ↗ |
| 2021-06-30 | Berman Nathan Joel | Officer | A-Award | A | Common Stock | 496,957 | 0.00 | — | 496,957 | — | ↗ |
| 2021-06-30 | 22nd Century Group, Inc. | 10% Owner | — | D | Common Stock | 0 | 0.00 | — | 91,016,026 | — | ↗ |
| 2021-05-04 | Kesner Harvey J | 10% Owner | — | I | Common Stock | 0 | 0.00 | — | 117,059 | — | ↗ |
| 2021-03-01 | Wert Lawrence | Director | A-Award | A | Common Stock | 3,500,000 | 0.00 | — | 8,620,297 | — | ↗ |
| 2021-01-22 | Alberttis Alvaro Daniel | Director / Officer | A-Award | A | Options to purchase common stock | 2,500,000 | 0.03 | 62.5K | 2,500,000 | — | ↗ |
| 2020-02-18 | Du Chesne Derek | Officer | — | D | Options to purchase common stock | 1,000,000 | 0.50 | 500.0K | 0 | — | ↗ |
| 2020-02-01 | Puzder Ken | Director / Officer | A-Award | A | Common Stock | 250,000 | 0.00 | — | 500,000 | — | ↗ |
| 2020-02-01 | Johnson Andrew L. | Officer | A-Award | A | Common Stock | 250,000 | 0.00 | — | 1,106,250 | — | ↗ |
| 2020-01-16 | Alberttis Alvaro Daniel | Director | — | D | Common stock | 0 | 0.00 | — | 238,096 | — | ↗ |
| 2019-12-11 | Ceed2Med LLC | Director / 10% Owner | J-Other | D | Common Stock, Par Value $0.0001 per Share | 1,200,000 | 0.00 | — | 6,435,691 | — | ↗ |
| 2019-11-20 | Thompson Jeffrey M | Director | A-Award | A | Common Stock | 100,000 | 0.00 | — | 100,000 | — | ↗ |
| 2019-11-20 | Price John C | Director | A-Award | A | Common Stock | 100,000 | 0.00 | — | 100,000 | — | ↗ |
| 2019-11-20 | ESVAL KEVIN JAMES | Director | A-Award | A | Common Stock | 100,000 | 0.00 | — | 100,250 | — | ↗ |
| 2019-09-13 | Yampolsky Vladislav | Director / 10% Owner | A-Award | A | Common Stock | 1,000,000 | 0.00 | — | 1,000,000 | — | ↗ |
| 2019-09-13 | Aloi Emiliano Angel | Officer | A-Award | A | Common Stock | 1,000,000 | 0.00 | — | 1,000,000 | — | ↗ |
| 2019-06-24 | Yampolsky Vladislav | Director / 10% Owner | — | I | Common Stock | 0 | 0.00 | — | 7,635,690 | — | ↗ |
| 2019-06-24 | Schwartz Steven A | Director | — | D | Common Stock | 0 | 0.00 | — | 125,000 | — | ↗ |
| 2019-06-06 | Ceed2Med LLC | 10% Owner | D-Return | D | Common Stock | 750,000 | 0.30 | 225.0K | 7,635,690 | — | ↗ |
| 2019-03-12 | Johnson Andrew L. | Officer | — | D | Options to purchase common stock | 750,000 | 0.32 | 240.0K | 0 | — | ↗ |
| 2019-02-11 | Price John C | Director | — | D | Options to purchase common stock | 250,000 | 0.20 | 50.0K | 0 | — | ↗ |
| 2019-02-11 | GILBERT JONATHAN | Director / Officer | — | D | Options to purchase common stock | 1,000,000 | 0.01 | 10.0K | 0 | — | ↗ |
| 2019-01-15 | Johnson Andrew L. | Officer | — | D | Options to purchase common stock | 31,250 | 0.96 | 30.0K | 0 | — | ↗ |
| 2019-01-11 | Thompson Jeffrey M | Director | — | D | Options to purchase common stock | 2,000,000 | 0.03 | 50.0K | 0 | — | ↗ |
| 2019-01-11 | Puzder Ken | Director | — | D | Options to purchase common stock | 2,000,000 | 0.03 | 50.0K | 0 | — | ↗ |
| 2019-01-11 | ESVAL KEVIN JAMES | Director | — | I | Series B-2 Preferred Stock | 168,000 | 0.00 | — | 0 | — | ↗ |
| 2019-01-09 | Yampolsky Vladislav | Director / 10% Owner | — | D | Option (Right to Purchase) | 250,000 | 0.32 | 80.0K | 0 | — | ↗ |
| 2019-01-09 | Aloi Emiliano Angel | Officer | — | D | Options to purchase common stock | 250,000 | 0.32 | 80.0K | 0 | — | ↗ |
| 2019-01-08 | Ceed2Med LLC | — | — | — | — | 0 | 0.00 | — | 0 | — | ↗ |
| 2018-09-12 | Ryan Timothy John | Director / Officer / 10% Owner | D-Return | D | Series D Preferred Stock (the | 16 | 0.00 | — | 16 | — | ↗ |
| 2018-09-04 | Young Philip J | Director / Officer | A-Award | A | Stock Options (Right to Buy) | 225,000 | 0.09 | 20.0K | 225,000 | — | ↗ |
| 2018-09-04 | Wendt Kelley A | Officer | A-Award | A | Stock Options (Right to Buy) | 225,000 | 0.09 | 20.0K | 225,000 | — | ↗ |
| 2018-09-04 | Ryan Timothy John | Director / Officer / 10% Owner | A-Award | A | Stock Options (Right to Buy) | 225,000 | 0.09 | 20.0K | 225,000 | — | ↗ |
| 2018-09-04 | Erickson James R. | Officer | A-Award | A | Stock Options (Right to Buy) | 1,000,000 | 0.09 | 89.0K | 1,000,000 | — | ↗ |
| 2018-07-05 | Ryan Timothy John | Director / Officer | A-Award | A | Series D Preferred Stock (the "Series D") | 16 | 0.00 | — | 27 | — | ↗ |
| 2018-03-28 | Young Philip J | Officer | A-Award | A | Series D Preferred Stock (the "Series D") | 11 | 0.00 | — | 11 | — | ↗ |
| 2018-03-28 | Wendt Kelley A | Officer | A-Award | A | Series D Preferred Stock (the "Series D") | 12 | 0.00 | — | 12 | — | ↗ |
| 2018-03-28 | Ryan Timothy John | Director / Officer | A-Award | A | Series D Preferred Stock (the "Series D") | 11 | 0.00 | — | 11 | — | ↗ |
| 2018-03-28 | Erickson James R. | Officer | A-Award | A | Series D Preferred Stock (the "Series D") | 6 | 0.00 | — | 6 | — | ↗ |
| 2017-08-18 | Young Philip J | Director / Officer | — | D | Common Stock | 0 | 0.00 | — | 8,520,000 | — | ↗ |
| 2017-08-18 | Wendt Kelley A | Officer | — | D | Series B-1 Preferred Stock | 600,000 | 0.00 | — | 0 | — | ↗ |
| 2017-08-18 | Ryan Timothy John | Director / Officer | — | I | Common Stock | 0 | 0.00 | — | 300,000 | — | ↗ |
| 2017-08-18 | Erickson James R. | Officer | — | D | Common Stock | 0 | 0.00 | — | 1,600,000 | — | ↗ |
| 2017-08-18 | Dimitrov Krassen | Director | — | I | Common Stock | 0 | 0.00 | — | 3,600,000 | — | ↗ |
Executive team
Executive compensation
Executive compensation not available.
No CEO compensation history available.
Proxy statements
No proxy statements available for this company yet.
Recent SEC filings
Executive team
| Name | Title | Compensation | Gender |
|---|---|---|---|
| Leslie A. Buttorff | Chairman, Chief Executive Officer & Chief Financial Officer | — | female |
| Nathan Joel Berman | Secretary & Principal Accounting Officer | — | male |
No Senate trading activity found for this company.
No House trading activity found for this company.
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Community Opinion for PLSH
Short-term intention
Target Price Distribution
These are community opinions and do not constitute buy or sell advice to act on. The results shown are based on aggregated opinions and are not an investment recommendation, nor do they intend to influence any investment decision.

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