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Nuvalent, Inc. (NUVL)

USD123.96 +0.00 (+0.00%)
US NASDAQ Healthcare Biotechnology
Address One Broadway 2142
Cambridge, MA, US
CEO James R. Porter
IPO 2021-07-29
CIK 1861560 ISIN US6707031075

Explore sections of this company profile

Description

Nuvalent, Inc. is a clinical-stage biopharmaceutical firm dedicated to pioneering novel therapeutic solutions for individuals battling cancer. The company's pipeline features two prominent drug candidates. One of these is NVL-520, a highly selective ROS1 inhibitor capable of penetrating the brain. This compound is specifically designed to target ROS1 fusions that possess the normal ROS1 kinase domain, and crucially, it retains activity against mutations known to confer resistance to both approved and experimental ROS1 inhibitors. NVL-520 is currently undergoing Phase I clinical evaluation. Nuvalent's second key asset is NVL-655, an ALK-selective inhibitor that also exhibits brain-penetrant properties. This therapy seeks to address significant limitations of earlier generations of ALK inhibitors (first-, second-, and third-generation), including the development of treatment resistance, central nervous system-related adverse effects, and brain metastases. NVL-655 is presently being assessed in Phase I/II clinical trials. The company was established in 2017 and is based in Cambridge, Massachusetts.

Market Cap & Enterprise Value
Merger & Acquisition History

No mergers or acquisitions recorded for this company.

Technical Outlook
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Signal Summary Loading…
Indicator 1D1W2W3W1M
Each column is computed on that timeframe's candles (1D = daily, 1W ≈ weekly, 1M ≈ monthly), not on the same last day. ▲ bullish · ▼ bearish · — neutral. The Net row counts signals per column; hover any cell (or the indicator name) to see the exact rule behind it.
Day Score & sub-scores
Statistical fingerprint & regime detail
Conditional historical analysis
Customize analysis (advanced)
Indicative levels generated algorithmically. Not financial advice.
Risk Profile
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Price Chart
Averages
Trend
Price
Levels
Draw
USD123.96 +0.00 (+0.00%)
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Volume Profile
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Liquidity & share structure
Average Volume
2M
Beta
1.15
Float Shares
48.67M
Free Float %
66.2%
Price Performance
1D5D1M3M6M YTD1Y3Y5Y10YMax
-1.92% -1.51% -0.19% +1.19% +5.68% +1.94% +39.26% +160.25% +446.88% +446.88% +446.88%
Rolling Volatility
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Drawdown
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Relative Strength
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Monthly Returns Heatmap
From To
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Annual Monthly Returns
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Daily Returns Distribution
vs.
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Revenue flow

Revenue by geography

Revenue by segment

From To

Revenue composition

From To

By product

By geography

Financial Statements

Income Statement

Balance Sheet

Cash Flow Statement

Key Metrics

Financial Ratios

Employees

Financial Growth (CAGR)

Market Data

Analyst Consensus (14 ratings, all time) Buy
Price Targets & DCF
Current price
123.96
Low 140.00 +12.9%
Consensus 149.00 +20.2%
Median 150.50 +21.4%
High 155.00 +25.0%
DCF (Unlevered) 3.22 -97.4%
DCF (Levered) 3.60 -97.1%

DCF figures are point estimates: small changes in growth or discount-rate assumptions move them materially. Read them as a reference, not a precise target.

Ratings Trend (MoM) 100% Bullish
Rating 2026-05 Change
Strong Buy 4 0
Buy 15 0
Hold 0 0
Sell 0 0
Strong Sell 0 0
Price Target Summary
Period # Analysts Avg Target
Last Month
Last Quarter
Last Year 12
132.83
+7.2%
All Time 20
124.50
+0.4%
Quality scores
Altman Z-Score
28.13
Safe zone
Piotroski F-Score
2 / 9
Weak
MOAT Score
3 / 10
No MOAT
Composite Rating
D+
Overall Score
1 / 5
Low
DCF Score
2 / 5
Medium
ROE Score
1 / 5
Low
ROA Score
1 / 5
Low
D/E Score
1 / 5
Low
P/E Score
1 / 5
Low
P/Book Score
1 / 5
Low
Operational MOAT
✗ Below peers
  • Revenue growth Biotechnology: +1.6%
  • EPS growth Biotechnology: +29.7%
    -48.9% Q1'26: -17.8% (vs Q1'25)
  • FCF margin FCF growth · Biotechnology: +16.2%
  • EBIT margin Biotechnology: +0.0%
  • ROIC Biotechnology: -16.1%
    Q1'26: +422.3% (vs Q1'25)
  • Share dilution Biotechnology: -3.4%
    +9.5% Q1'26: +9.9% (vs Q1'25)
  • Debt / EBITDA Net debt/EBITDA · Biotechnology: 0.16×
    0.00× Q1'26: 0.00× (vs Q1'25)
Valuation Multiples From To
DCF Interactive Model (UFCF)
Projection years:
Market assumptions
WACC components (optional)
Ke (Cost of Equity) = Rf + β (1.15) × ERP
WACC = 100% × Ke + 0% × Kd (4.0%) × (1−t)

Modifying these values recalculates WACC automatically.

Business assumptions
Intrinsic value (base): 3.22 Current price: 123.96
Enterprise Value: Equity Value: Terminal Value: TV as % of EV:

Base values reflect the latest available data for this company and market conditions.

Consensus Estimates
Metric Dec 2024
actual
Dec 2025
actual
Dec 2026
12 Rev. Ana.
8 EPS Ana.
Dec 2027
13 Rev. Ana.
12 EPS Ana.
Dec 2028
13 Rev. Ana.
10 EPS Ana.
Dec 2029
12 Rev. Ana.
4 EPS Ana.
Dec 2030
6 Rev. Ana.
4 EPS Ana.
Revenue
est: 6.25M (-100.0%)
13.13M
571.0K – 31.62M
+110.1% YoY
191.87M
104.71M – 257.13M
+1,361.0% YoY
508.38M
503.75M – 513.00M
+165.0% YoY
908.51M
354.83M – 1.57B
+78.7% YoY
1.22B
475.76M – 2.11B
+34.1% YoY
EBITDA
-10.49M
— – —
— – —
— – —
— – —
— – —
EBIT
-280.37M
-424.79M
— – —
— – —
— – —
— – —
— – —
Net Income
-260.76M
est: -257.01M (-1.5%)
-425.38M
est: -416.53M (-2.1%)
-453.38M
-533.81M – -323.11M
-8.8% YoY
-362.25M
-483.78M – -162.84M
+20.1% YoY
-122.17M
-438.69M – 289.09M
+66.3% YoY
219.18M
45.53M – 427.82M
+279.4% YoY
391.56M
81.34M – 764.28M
+78.6% YoY
SGA
62.59M
107.34M
— – —
— – —
— – —
— – —
— – —
EPS
-3.93
est: -3.91 (-0.5%)
-5.85
est: -5.72 (-2.4%)
-5.63
-7.34 – -4.45
+1.5% YoY
-4.28
-6.66 – -2.24
+23.9% YoY
-1.35
-6.04 – 3.98
+68.4% YoY
3.02
0.63 – 5.89
+322.9% YoY
5.39
1.12 – 10.51
+78.6% YoY
Recent Grade Changes (3M)
Date Firm Previous New Grade Action
2026-04-21 HC Wainwright & Co. Buy Buy Maintain
Historical Ratings (3M)
Date Rating Overall DCF ROE ROA D/E P/E P/B
2026-05-07 D+ 1/5 2/5 1/5 1/5 1/5 1/5 1/5
2026-05-06 D+ 1/5 2/5 1/5 1/5 1/5 1/5 1/5
2026-05-05 D+ 1/5 2/5 1/5 1/5 1/5 1/5 1/5
2026-05-04 D+ 1/5 2/5 1/5 1/5 1/5 1/5 1/5
2026-05-01 D+ 1/5 2/5 1/5 1/5 1/5 1/5 1/5
2026-04-30 D+ 1/5 2/5 1/5 1/5 1/5 1/5 1/5
2026-04-29 D+ 1/5 2/5 1/5 1/5 1/5 1/5 1/5
2026-04-28 D+ 1/5 2/5 1/5 1/5 1/5 1/5 1/5
2026-04-27 D+ 1/5 2/5 1/5 1/5 1/5 1/5 1/5
2026-04-24 C- 1/5 3/5 1/5 1/5 1/5 1/5 1/5
2026-04-23 C- 1/5 3/5 1/5 1/5 1/5 1/5 1/5
2026-04-22 C- 1/5 3/5 1/5 1/5 1/5 1/5 1/5
2026-04-21 C- 1/5 3/5 1/5 1/5 1/5 1/5 1/5
2026-04-20 C- 1/5 3/5 1/5 1/5 1/5 1/5 1/5
2026-04-17 C- 1/5 3/5 1/5 1/5 1/5 1/5 1/5
2026-04-16 C- 1/5 3/5 1/5 1/5 1/5 1/5 1/5

Owner Earnings

Owner's Earnings (history)

Owner's Earnings history not available.

Owner alignment
Owner's Earnings TTM
OE per share TTM
Owner's Yield
Maintenance CapEx ratio
Maint CapEx / Avg PPE

Ownership Overview

Ownership breakdown
At a glance
Institutional holders
58
Total invested
197.45M
Insider transactions (90d)
4
Beneficial owners (>5%)
22
Beneficial owners (>5%)
# Reporting person Amount owned % of class Sole voting Shared voting Sole dispositive Shared dispositive Type Citizenship Filing date SEC filing
1 Deerfield Management Company, L.P. 25.47M 39.24% 25.47M PN Delaware 2022-11-14
2 James E. Flynn 25.47M 39.24% 25.47M IN Delaware 2022-11-14
3 Deerfield Healthcare Innovations Fund, L.P. 12.39M 18.96% 12.39M PN Delaware 2022-11-14
4 Deerfield Mgmt HIF, L.P. 12.39M 18.96% 12.39M PN Delaware 2022-11-14
5 Deerfield Mgmt IV, L.P. 12.39M 18.96% 12.39M PN Delaware 2022-11-14
6 Deerfield Private Design Fund IV, L.P. 12.39M 18.96% 12.39M PN Delaware 2022-11-14
7 Abigail P. Johnson 4.70M 11.42% 4.70M IN Delaware 2021-08-10
8 FMR LLC 4.70M 11.42% 983.5K 4.70M HC Delaware 2021-08-10
9 (1) BlackRock, Inc. 3.62M 5.60% 3.54M 3.62M HC Delaware 2024-11-08
10 The Vanguard Group - 23-1945930 3.34M 5.72% 75.3K IA Pennsylvania 2024-02-13
11 Joseph Edelman 2.92M 5.10% 2.92M 2.92M IN Delaware 2024-01-02
12 Perceptive Advisors LLC 2.92M 5.10% 2.92M 2.92M IA Delaware 2024-01-02
13 Perceptive Life Sciences Master Fund, Ltd. 2.92M 5.10% 2.92M 2.92M CO Delaware 2024-01-02
14 Fairmount Funds Management LLC 2.61M 5.13% 2.61M IA Delaware 2022-11-09
15 Peter Harwin 2.61M 5.13% 2.61M HC, IN Delaware 2022-11-09
16 Tomas Kiselak 2.61M 5.13% 2.61M HC, IN Delaware 2022-11-09
17 Fairmount Healthcare Fund II L.P. 2.52M 4.97% 2.52M PN Delaware 2022-11-09
18 Bain Capital Life Sciences Fund II, L.P. 2.40M 5.60% 2.40M 2.40M PN 2021-08-04
19 BCLS II Investco, LP 735.0K 1.70% 735.0K 735.0K PN 2021-08-04
20 Deerfield Mgmt, L.P. 650.0K 1.27% 650.0K PN Delaware 2022-11-14
21 Deerfield Partners, L.P. 650.0K 1.27% 650.0K PN Delaware 2022-11-14
22 BCIP Life Sciences Associates, LP 292.4K 0.70% 292.4K 292.4K PN 2021-08-04

Institutional Activity (13F)

Institutional ownership trend From To
13F snapshot — 2026 Q1
Investors holding
58
-181 vs prev Q
New positions
8
Closed positions
186
Increased
29
Reduced
15
Put/Call ratio
0.00
Calls held
Puts held
Top institutional holders
# Investor Shares / Δ Mkt value / Δ Own% / Δ Weight% / Δ Avg px / Perf. Hold / Status
1 269.0K +269.0K (+100.0%) 27.06B +27.1B (+100.0%) 0.37% +0.373 pp 3.67% +3.668 pp USD100.59 +0.0% 1 qtrs NEW
2 DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) 17.25M -742.6K (-4.1%) 1.74B +179.2M (+11.5%) 23.91% -1.133 pp 22.16% -1.593 pp USD22.79 +341.4% 18 qtrs
3 FMR LLC 10.85M +839.6K (+8.4%) 1.09B +225.7M (+26.1%) 15.04% +1.106 pp 0.06% +0.011 pp USD42.74 +135.4% 18 qtrs
4 PARADIGM BIOCAPITAL ADVISORS LP 5.27M +— (+0.0%) 530.05M +74.4M (+16.3%) 7.30% -0.031 pp 13.53% +0.569 pp USD67.32 +49.4% 11 qtrs
5 VANGUARD GROUP INC 5.24M +639.3K (+13.9%) 527.52M +129.3M (+32.5%) 7.27% +0.860 pp 0.01% +0.002 pp USD58.92 +70.7% 18 qtrs
6 BLACKROCK, INC. 4.81M +719.5K (+17.6%) 483.36M +130.0M (+36.8%) 6.66% +0.974 pp 0.01% +0.002 pp USD99.20 +1.4% 6 qtrs
7 WELLINGTON MANAGEMENT GROUP LLP 2.46M +161.0K (+7.0%) 247.63M +48.7M (+24.5%) 3.41% +0.210 pp 0.04% +0.009 pp USD72.67 +38.4% 18 qtrs
8 JPMORGAN CHASE & CO 2.21M +531.2K (+31.7%) 221.83M +77.1M (+53.2%) 3.06% +0.727 pp 0.01% +0.005 pp USD83.71 +20.2% 18 qtrs
9 PRICE T ROWE ASSOCIATES INC /MD/ 2.15M +336.5K (+18.6%) 215.96M +59.4M (+37.9%) 2.98% +0.456 pp 0.02% +0.007 pp USD72.92 +37.9% 13 qtrs
10 RA CAPITAL MANAGEMENT, L.P. 1.88M +633.6K (+50.8%) 189.11M +81.3M (+75.4%) 2.61% +0.871 pp 1.94% +0.609 pp USD91.24 +10.2% 2 qtrs
11 STATE STREET CORP 1.86M +289.9K (+18.4%) 187.57M +51.4M (+37.7%) 2.58% +0.393 pp 0.01% +0.002 pp USD57.89 +73.8% 18 qtrs
12 PERCEPTIVE ADVISORS LLC 1.67M +102.8K (+6.6%) 167.49M +32.4M (+24.0%) 2.31% +0.133 pp 2.99% -0.916 pp USD50.35 +99.8% 18 qtrs
13 POLAR CAPITAL HOLDINGS PLC 1.54M +514.6K (+50.3%) 154.59M +66.2M (+74.9%) 2.13% +0.707 pp 0.60% +0.172 pp USD87.41 +15.1% 7 qtrs
14 JANUS HENDERSON GROUP PLC 1.50M -689.1K (-31.5%) 150.82M -38.5M (-20.3%) 2.08% -0.968 pp 0.07% -0.019 pp USD74.87 +34.4% 18 qtrs
15 T. ROWE PRICE INVESTMENT MANAGEMENT, INC. 1.32M +298.7K (+29.3%) 132.78M +44.5M (+50.3%) 1.83% +0.408 pp 0.08% +0.030 pp USD80.08 +25.6% 4 qtrs
16 GEODE CAPITAL MANAGEMENT, LLC 1.24M +144.2K (+13.2%) 124.58M +30.0M (+31.7%) 1.72% +0.194 pp 0.01% +0.002 pp USD58.46 +72.1% 18 qtrs
17 BELLEVUE GROUP AG 1.04M +1.0M (+100.0%) 104.36M +104.4M (+100.0%) 1.44% +1.438 pp 1.98% +1.978 pp USD100.59 +0.0% 1 qtrs NEW
18 BRAIDWELL LP 821.4K -191.6K (-18.9%) 82.63M -5.0M (-5.7%) 1.14% -0.271 pp 2.64% +0.043 pp USD73.96 +36.0% 5 qtrs
19 ALLIANCEBERNSTEIN L.P. 785.4K +735.5K (+1,471.9%) 79.01M +74.7M (+1,728.4%) 1.09% +1.019 pp 0.02% +0.024 pp USD98.08 +2.6% 14 qtrs
20 FAIRMOUNT FUNDS MANAGEMENT LLC 727.6K +— (+0.0%) 73.19M +10.3M (+16.3%) 1.01% -0.004 pp 5.57% -0.091 pp USD21.60 +365.7% 18 qtrs
21 ADAGE CAPITAL PARTNERS GP, L.L.C. 643.0K +68.5K (+11.9%) 64.68M +15.0M (+30.2%) 0.89% +0.092 pp 0.10% +0.019 pp USD86.18 +16.7% 6 qtrs
22 WOODLINE PARTNERS LP 610.5K -459.1K (-42.9%) 61.41M -31.1M (-33.6%) 0.85% -0.643 pp 0.24% -0.197 pp USD81.86 +22.9% 14 qtrs
23 GOLDMAN SACHS GROUP INC 594.5K +150.0K (+33.8%) 59.80M +21.4M (+55.6%) 0.82% +0.205 pp 0.01% +0.003 pp USD76.79 +31.0% 17 qtrs
24 NORGES BANK 574.2K +574.2K (+100.0%) 57.76M +57.8M (+100.0%) 0.80% +0.796 pp 0.01% +0.006 pp USD100.59 +0.0% 1 qtrs NEW
25 AMERIPRISE FINANCIAL INC 564.3K +37.2K (+7.1%) 56.76M +11.2M (+24.5%) 0.78% +0.049 pp 0.01% +0.002 pp USD81.90 +22.8% 6 qtrs
26 COMMODORE CAPITAL LP 550.0K -850.0K (-60.7%) 55.32M -65.7M (-54.3%) 0.76% -1.186 pp 3.68% -2.228 pp USD63.30 +58.9% 13 qtrs
27 DRIEHAUS CAPITAL MANAGEMENT LLC 483.5K +266.9K (+123.3%) 48.64M +29.9M (+159.7%) 0.67% +0.369 pp 0.33% +0.196 pp USD72.90 +38.0% 18 qtrs
28 HOOD RIVER CAPITAL MANAGEMENT LLC 475.4K +475.4K (+100.0%) 47.82M +47.8M (+100.0%) 0.66% +0.659 pp 0.52% +0.524 pp USD100.59 +0.0% 1 qtrs NEW
29 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 453.3K +48.8K (+12.1%) 45.60M +10.6M (+30.3%) 0.63% +0.065 pp 0.01% +0.002 pp USD66.69 +50.8% 18 qtrs
30 INVESCO LTD. 439.3K +405.5K (+1,201.4%) 44.19M +41.3M (+1,413.7%) 0.61% +0.562 pp 0.01% +0.006 pp USD100.28 +0.3% 14 qtrs
31 FRANKLIN RESOURCES INC 411.4K +251.2K (+156.9%) 41.38M +27.5M (+198.8%) 0.57% +0.347 pp 0.01% +0.007 pp USD81.68 +23.2% 11 qtrs
32 NORTHERN TRUST CORP 410.5K +29.0K (+7.6%) 41.29M +8.3M (+25.1%) 0.57% +0.038 pp 0.01% +0.001 pp USD55.29 +81.9% 18 qtrs
33 UBS GROUP AG 399.1K +185.9K (+87.2%) 40.14M +21.7M (+117.8%) 0.55% +0.257 pp 0.01% +0.004 pp USD87.43 +15.1% 13 qtrs
34 AMERICAN CENTURY COMPANIES INC 374.2K +11.3K (+3.1%) 37.64M +6.3M (+19.9%) 0.52% +0.014 pp 0.02% +0.003 pp USD76.66 +31.2% 5 qtrs
35 FIRST TURN MANAGEMENT, LLC 368.7K -26.1K (-6.6%) 37.09M +2.9M (+8.6%) 0.51% -0.038 pp 4.24% -0.888 pp USD82.40 +22.1% 9 qtrs
36 CANDRIAM S.C.A. 358.0K +28.3K (+8.6%) 36.01M +7.5M (+26.3%) 0.50% +0.037 pp 0.18% +0.030 pp USD56.70 +77.4% 13 qtrs
37 PICTET ASSET MANAGEMENT HOLDING SA 355.7K -28.9K (-7.5%) 35.78M +2.5M (+7.6%) 0.49% -0.042 pp 0.03% +0.003 pp USD77.16 +30.4% 9 qtrs
38 AFFINITY ASSET ADVISORS, LLC 322.6K -61.8K (-16.1%) 32.45M -790.7K (-2.4%) 0.45% -0.088 pp 1.85% -1.047 pp USD77.82 +29.3% 10 qtrs
39 SILVERARC CAPITAL MANAGEMENT, LLC 311.4K -60.9K (-16.3%) 31.33M -869.8K (-2.7%) 0.43% -0.087 pp 4.35% +0.009 pp USD79.05 +27.2% 14 qtrs
40 TRI LOCUM PARTNERS LP 307.4K +307.4K (+100.0%) 30.92M +30.9M (+100.0%) 0.43% +0.426 pp 4.01% +4.015 pp USD100.59 +0.0% 4 qtrs
41 ARROWMARK COLORADO HOLDINGS LLC 296.0K -66.6K (-18.4%) 29.78M -1.6M (-5.0%) 0.41% -0.094 pp 0.66% +0.073 pp USD69.73 +44.3% 13 qtrs
42 LORD, ABBETT & CO. LLC 281.2K +281.2K (+100.0%) 28.29M +28.3M (+100.0%) 0.39% +0.390 pp 0.09% +0.087 pp USD100.59 +0.0% 1 qtrs NEW
43 FRONTIER CAPITAL MANAGEMENT CO LLC 270.5K +270.5K (+100.0%) 27.21M +27.2M (+100.0%) 0.37% +0.375 pp 0.29% +0.289 pp USD100.59 +0.0% 1 qtrs NEW
44 MORGAN STANLEY 267.4K -7.7K (-2.8%) 26.90M +3.1M (+13.1%) 0.37% -0.012 pp 0.00% +0.000 pp USD71.32 +41.0% 18 qtrs
45 CITADEL ADVISORS LLC 195.2K +164.9K (+545.7%) 19.63M +17.0M (+651.0%) 0.27% +0.228 pp 0.00% +0.003 pp USD99.12 +1.5% 16 qtrs
46 BANK OF AMERICA CORP /DE/ 180.4K +19.2K (+11.9%) 18.14M +4.2M (+30.2%) 0.25% +0.026 pp 0.00% +0.000 pp USD71.35 +41.0% 18 qtrs
47 BNP PARIBAS ARBITRAGE, SNC 174.1K +36.1K (+26.2%) 17.51M +5.6M (+46.8%) 0.24% +0.049 pp 0.01% +0.002 pp USD80.39 +25.1% 5 qtrs
48 VOYA INVESTMENT MANAGEMENT LLC 172.5K +37.8K (+28.0%) 17.35M +5.7M (+48.9%) 0.24% +0.052 pp 0.02% +0.006 pp USD80.90 +24.3% 13 qtrs
49 ABRDN PLC 165.2K +88.5K (+115.4%) 16.62M +10.0M (+150.5%) 0.23% +0.122 pp 0.03% +0.015 pp USD88.55 +13.6% 7 qtrs
50 RHENMAN & PARTNERS ASSET MANAGEMENT AB 163.4K +110.9K (+211.1%) 16.43M +11.9M (+261.9%) 0.23% +0.153 pp 1.54% +1.033 pp USD82.63 +21.7% 13 qtrs
51 BANK OF NEW YORK MELLON CORP 161.6K +16.2K (+11.1%) 16.26M +3.7M (+29.3%) 0.22% +0.022 pp 0.00% +0.001 pp USD58.43 +72.2% 18 qtrs
52 NICHOLAS INVESTMENT PARTNERS, LP 160.5K +36.3K (+29.2%) 16.14M +5.4M (+50.3%) 0.22% +0.050 pp 1.18% +0.355 pp USD73.36 +37.1% 10 qtrs
53 TD ASSET MANAGEMENT INC 153.4K +43.8K (+39.9%) 15.43M +5.9M (+62.8%) 0.21% +0.060 pp 0.01% +0.005 pp USD89.93 +11.9% 13 qtrs
54 RAYMOND JAMES FINANCIAL INC 152.0K +20.9K (+16.0%) 15.26M +3.9M (+34.6%) 0.21% +0.028 pp 0.00% +0.001 pp USD81.28 +23.8% 5 qtrs
55 BAKER BROS. ADVISORS LP 143.9K +— (+0.0%) 14.48M +2.0M (+16.3%) 0.20% -0.001 pp 0.08% -0.005 pp USD76.30 +31.8% 3 qtrs
56 BARCLAYS PLC 125.3K +57.2K (+84.0%) 12.61M +5.6M (+80.9%) 0.17% +0.079 pp 0.00% +0.001 pp USD88.91 +13.1% 16 qtrs
57 UBS ASSET MANAGEMENT AMERICAS INC 124.6K +59.1K (+90.4%) 12.53M +6.9M (+121.5%) 0.17% +0.082 pp 0.00% +0.001 pp USD85.50 +17.6% 13 qtrs
58 PARKMAN HEALTHCARE PARTNERS LLC 118.7K -1.5K (-1.2%) 11.94M +1.5M (+14.9%) 0.16% -0.003 pp 1.14% +0.053 pp USD71.96 +39.8% 9 qtrs
59 NUVEEN, LLC 107.6K +16.0K (+17.4%) 10.83M +2.9M (+36.6%) 0.15% +0.022 pp 0.00% +0.001 pp USD75.76 +32.8% 4 qtrs
60 FISHER ASSET MANAGEMENT, LLC 100.7K -5.7K (-5.4%) 10.13M +926.5K (+10.1%) 0.14% -0.009 pp 0.00% +0.000 pp USD70.92 +41.8% 4 qtrs
61 FRED ALGER MANAGEMENT, LLC 92.0K +3.5K (+4.0%) 9.26M +1.6M (+20.9%) 0.13% +0.004 pp 0.04% +0.007 pp USD74.26 +35.5% 15 qtrs
62 RUSSELL INVESTMENTS GROUP, LTD. 91.2K -1.3K (-1.4%) 9.17M +1.2M (+14.7%) 0.13% -0.002 pp 0.01% +0.001 pp USD72.78 +38.2% 7 qtrs
63 POINT72 ASSET MANAGEMENT, L.P. 88.4K +88.4K (+100.0%) 8.89M +8.9M (+100.0%) 0.12% +0.123 pp 0.01% +0.010 pp USD100.59 +0.0% 1 qtrs NEW
64 DEUTSCHE BANK AG\ 83.0K +11.3K (+15.8%) 8.35M +2.2M (+34.7%) 0.12% +0.015 pp 0.00% +0.001 pp USD79.71 +26.2% 18 qtrs
65 MILLENNIUM MANAGEMENT LLC 81.9K +81.9K (+100.0%) 8.23M +8.2M (+100.0%) 0.11% +0.114 pp 0.00% +0.004 pp USD100.59 +0.0% 1 qtrs NEW
66 SWISS NATIONAL BANK 78.9K +1.7K (+2.2%) 7.94M +1.3M (+18.9%) 0.11% +0.002 pp 0.00% +0.001 pp USD50.38 +99.7% 13 qtrs
67 MANUFACTURERS LIFE INSURANCE COMPANY, THE 78.3K +13.8K (+21.4%) 7.86M +2.3M (+41.1%) 0.11% +0.019 pp 0.01% +0.002 pp USD77.19 +30.3% 13 qtrs
68 HIGHVISTA STRATEGIES LLC 73.3K -20.0K (-21.4%) 7.37M -696.1K (-8.6%) 0.10% -0.028 pp 1.90% -0.079 pp USD71.04 +41.6% 12 qtrs
69 VERITION FUND MANAGEMENT LLC 72.0K +66.3K (+1,163.0%) 7.24M +6.8M (+1,369.0%) 0.10% +0.092 pp 0.03% +0.026 pp USD99.47 +1.1% 6 qtrs
70 BURKEHILL GLOBAL MANAGEMENT, LP 70.0K +70.0K (+100.0%) 7.04M +7.0M (+100.0%) 0.10% +0.097 pp 0.46% +0.464 pp USD100.59 +0.0% 1 qtrs NEW
71 RHUMBLINE ADVISERS 63.8K -1.4K (-2.1%) 6.42M +781.8K (+13.9%) 0.09% -0.002 pp 0.01% +0.001 pp USD46.64 +115.7% 16 qtrs
72 WELLS FARGO & COMPANY/MN 62.2K +31.3K (+101.3%) 6.25M +3.6M (+134.2%) 0.09% +0.043 pp 0.00% +0.001 pp USD85.20 +18.1% 18 qtrs
73 SQUAREPOINT OPS LLC 61.7K +54.3K (+731.6%) 6.21M +5.6M (+867.3%) 0.09% +0.075 pp 0.01% +0.006 pp USD98.89 +1.7% 13 qtrs
74 BNP PARIBAS ASSET MANAGEMENT HOLDING S.A. 61.1K +60.8K (+19,555.9%) 6.15M +6.1M (+22,674.1%) 0.08% +0.084 pp 0.01% +0.007 pp USD100.47 +0.1% 3 qtrs
75 IKARIAN CAPITAL, LLC 59.6K +59.6K (+100.0%) 5.99M +6.0M (+100.0%) 0.08% +0.083 pp 0.47% +0.468 pp USD100.59 +0.0% 1 qtrs NEW
76 ENSIGN PEAK ADVISORS, INC 54.2K -10.2K (-15.8%) 5.45M -115.3K (-2.1%) 0.08% -0.015 pp 0.01% +0.001 pp USD71.37 +40.9% 11 qtrs
77 UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH 46.7K +13.6K (+41.1%) 4.70M +1.8M (+64.2%) 0.06% +0.019 pp 0.01% +0.003 pp USD85.22 +18.0% 5 qtrs
78 VESTAL POINT CAPITAL, LP 46.0K -1.1M (-95.8%) 4.63M -90.5M (-95.1%) 0.06% -1.467 pp 0.16% -4.139 pp USD75.29 +33.6% 5 qtrs
79 RAFFERTY ASSET MANAGEMENT, LLC 45.9K -2.0K (-4.2%) 4.62M +472.2K (+11.4%) 0.06% -0.003 pp 0.02% +0.003 pp USD52.85 +90.3% 13 qtrs
80 CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD. 42.4K +18.6K (+78.1%) 4.26M +2.2M (+107.1%) 0.06% +0.026 pp 0.01% +0.005 pp USD92.67 +8.5% 2 qtrs
81 LEGAL & GENERAL GROUP PLC 41.7K -1.6K (-3.8%) 4.19M +446.6K (+11.9%) 0.06% -0.003 pp 0.00% +0.000 pp USD54.98 +83.0% 18 qtrs
82 GRANAHAN INVESTMENT MANAGEMENT, LLC 40.2K +40.2K (+100.0%) 4.04M +4.0M (+100.0%) 0.06% +0.056 pp 0.17% +0.173 pp USD100.59 +0.0% 1 qtrs NEW
83 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 38.3K +398.0 (+1.1%) 3.85M +574.6K (+17.5%) 0.05% +0.000 pp 0.00% +0.001 pp USD50.23 +100.3% 18 qtrs
84 NEOS INVESTMENT MANAGEMENT LLC 37.0K +4.0K (+12.1%) 3.72M +867.7K (+30.4%) 0.05% +0.005 pp 0.02% +0.000 pp USD76.64 +31.3% 8 qtrs
85 TEMA ETFS LLC 36.5K +3.5K (+10.5%) 3.67M +812.9K (+28.5%) 0.05% +0.005 pp 0.28% +0.048 pp USD76.46 +31.6% 5 qtrs
86 CITIGROUP INC 35.8K +671.0 (+1.9%) 3.60M +563.6K (+18.5%) 0.05% +0.001 pp 0.00% +0.000 pp USD69.61 +44.5% 18 qtrs
87 MIRAE ASSET GLOBAL ETFS HOLDINGS LTD. 32.5K +1.6K (+5.1%) 3.27M +599.3K (+22.4%) 0.05% +0.002 pp 0.00% +0.001 pp USD80.55 +24.9% 7 qtrs
88 NEW YORK STATE COMMON RETIREMENT FUND 32.5K +4.4K (+15.7%) 3.27M +838.3K (+34.5%) 0.05% +0.006 pp 0.00% +0.001 pp USD62.33 +61.4% 17 qtrs
89 CREATIVE PLANNING 29.9K +7.4K (+32.9%) 3.01M +1.1M (+54.6%) 0.04% +0.010 pp 0.00% +0.001 pp USD85.17 +18.1% 6 qtrs
90 JUMP FINANCIAL, LLC 28.0K +24.4K (+695.1%) 2.81M +2.5M (+824.8%) 0.04% +0.034 pp 0.03% +0.031 pp USD98.82 +1.8% 8 qtrs
91 METLIFE INVESTMENT MANAGEMENT, LLC 27.6K +2.5K (+10.1%) 2.78M +609.9K (+28.1%) 0.04% +0.003 pp 0.01% +0.003 pp USD54.72 +83.8% 18 qtrs
92 ALYESKA INVESTMENT GROUP, L.P. 25.5K -75.5K (-74.7%) 2.57M -6.2M (-70.6%) 0.04% -0.105 pp 0.01% -0.019 pp USD94.31 +6.7% 6 qtrs
93 AQR CAPITAL MANAGEMENT LLC 25.5K -2.1K (-7.8%) 2.57M +174.6K (+7.3%) 0.04% -0.003 pp 0.00% 0.000 pp USD73.35 +37.1% 11 qtrs
94 STATE OF WISCONSIN INVESTMENT BOARD 25.2K -3.4K (-11.8%) 2.53M +62.9K (+2.5%) 0.03% -0.005 pp 0.01% +0.000 pp USD54.61 +84.2% 13 qtrs
95 SEVEN GRAND MANAGERS, LLC 25.0K +25.0K (+100.0%) 2.51M +2.5M (+100.0%) 0.03% +0.035 pp 0.19% +0.192 pp USD100.59 +0.0% 1 qtrs NEW
96 MARSHALL WACE, LLP 23.9K +23.9K (+100.0%) 2.41M +2.4M (+100.0%) 0.03% +0.033 pp 0.00% +0.002 pp USD100.59 +0.0% 10 qtrs
97 SEI INVESTMENTS CO 23.2K +17.2K (+288.1%) 2.33M +1.8M (+351.2%) 0.03% +0.024 pp 0.00% +0.002 pp USD93.76 +7.3% 11 qtrs
98 FIRST TRUST ADVISORS LP 22.2K +22.2K (+100.0%) 2.23M +2.2M (+100.0%) 0.03% +0.031 pp 0.00% +0.002 pp USD100.59 +0.0% 9 qtrs
99 TANG CAPITAL MANAGEMENT LLC 21.9K -28.1K (-56.2%) 2.20M -2.1M (-49.1%) 0.03% -0.039 pp 0.11% -0.058 pp USD102.30 -1.7% 6 qtrs
100 LEGATO CAPITAL MANAGEMENT LLC 21.7K +9.1K (+71.8%) 2.19M +1.1M (+99.8%) 0.03% +0.013 pp 0.19% +0.069 pp USD83.68 +20.2% 10 qtrs
Ownership breakdown by holder

ETF Ownership

Top ETFs holding this stock Held by 105 ETFs in our universe
# ETF Weight Est. AUM exposure TER
1 ProShares - Merger ETF MRGR 2.34% 373.0K 0.75%
2 Global X - Guru Index ETF GURU 1.29% 816.6K 0.75%
3 Global X - S&P Biotech ETF CURE.AX 0.93% 333.0K 0.45%
4 State Street SPDR S&P Biotech ETF XBI 0.93% 100.29M 0.35%
5 Invesco Nasdaq Biotechnology ETF IBBQ 0.63% 470.1K 0.19%
6 Invesco NASDAQ Biotech UCITS ETF SBIO.L 0.63% 2.90M 0.40%
7 iShares Nasdaq US Biotechnology UCITS ETF BTEC.L 0.63% 6.86M 0.35%
8 iShares Nasdaq US Biotechnology UCITS ETF BTEE.L 0.63% 458.9K 0.35%
9 iShares Biotechnology ETF IBB 0.50% 46.66M 0.44%
10 iShares Russell 2000 Growth ETF IWO 0.41% 61.62M 0.24%

Insider Activity

Insider Activity — Latest Quarter
Ratio by transactions
0.35
Bearish
Ratio by volume
0.65
Neutral
Buys
11
Sells
31
Shares acquired
125.5K
Shares disposed
193.9K
Cash buys
Cash sales
22.00
Net activity
-68,453
Insider buys vs sells (history) From To
Recent insider transactions From To
Date Person Role Transaction A/D Security Shares Price Value Owned after D/I Filing
2026-05-04 Porter James Richard Director / Officer M-Exempt A Class A Common Stock 30,000 18.93 567.9K 354,879 D
2026-05-01 Balcom Alexandra Officer M-Exempt D Stock Option (Right to Buy) 7,159 1.08 7.7K 131,637 D
2026-04-30 Miller Deborah Ann Officer S-Sale D Class A Common Stock 4,418 99.13 438.0K 60,716 D
2026-04-29 Noci Darlene Officer M-Exempt D Stock Option (Right to Buy) 5,500 27.85 153.2K 92,329 D
2026-04-09 Pelish Henry E. Officer M-Exempt A Class A Common Stock 3,093 27.85 86.1K 68,697 D
2026-04-06 Porter James Richard Director / Officer S-Sale D Class A Common Stock 12,425 103.78 1.29M 331,100 D
2026-04-01 Lane Benjamin Officer A-Award A Class A Common Stock 9,500 0.00 50,368 D
2026-04-01 Balcom Alexandra Officer M-Exempt D Stock Option (Right to Buy) 11,430 1.08 12.3K 138,796 D
2026-03-30 Noci Darlene Officer M-Exempt D Stock Option (Right to Buy) 5,500 27.85 153.2K 97,829 D
2026-03-26 Miller Deborah Ann Officer S-Sale D Class A Common Stock 940 97.50 91.7K 64,194 D
2026-03-25 Balcom Alexandra Officer S-Sale D Class A Common Stock 13,700 100.16 1.37M 85,533 D
2026-03-24 Balcom Alexandra Officer M-Exempt D Stock Option (Right to Buy) 11,430 1.08 12.3K 150,226 D
2026-03-16 Lane Benjamin Officer Stock Option (Right to Buy) 731 18.93 13.8K 0 D
2026-03-13 Pelish Henry E. Officer S-Sale D Class A Common Stock 804 97.89 78.7K 69,904 D
2026-03-12 Pelish Henry E. Officer M-Exempt D Stock Option (Right to Buy) 8,456 18.93 160.1K 2,113 D
2026-03-06 Porter James Richard Director / Officer M-Exempt A Class A Common Stock 30,000 27.85 835.5K 354,879 D
2026-02-26 Noci Darlene Officer S-Sale D Class A Common Stock 200 104.25 20.9K 58,117 D
2026-02-26 Miller Deborah Ann Officer S-Sale D Class A Common Stock 200 103.96 20.8K 59,634 D
2026-01-29 Noci Darlene Officer S-Sale D Class A Common Stock 189 100.95 19.1K 63,428 D
2026-01-22 Miller Deborah Ann Officer M-Exempt D Stock Option (Right to Buy) 14,300 27.85 398.3K 75,154 D
2026-01-21 Miller Deborah Ann Officer M-Exempt D Stock Option (Right to Buy) 700 27.85 19.5K 89,454 D
2026-01-07 Turner Christopher Durant Officer A-Award A Class A Common Stock 17,500 0.00 72,630 D
2026-01-07 Porter James Richard Director / Officer A-Award A Class A Common Stock 46,250 0.00 324,879 D
2026-01-07 Pelish Henry E. Officer A-Award A Stock Option (Right to Buy) 17,500 106.82 1.87M 17,500 D
2026-01-07 Noci Darlene Officer A-Award A Class A Common Stock 17,500 0.00 58,117 D
2026-01-07 Miller Deborah Ann Officer A-Award A Stock Option (Right to Buy) 17,500 106.82 1.87M 17,500 D
2026-01-07 Balcom Alexandra Officer A-Award A Stock Option (Right to Buy) 17,500 106.82 1.87M 17,500 D
2026-01-06 Turner Christopher Durant Officer S-Sale D Class A Common Stock 225 98.40 22.1K 55,130 D
2026-01-06 Porter James Richard Director / Officer S-Sale D Class A Common Stock 675 98.40 66.4K 278,629 D
2026-01-06 Pelish Henry E. Officer S-Sale D Class A Common Stock 1,106 96.75 107.0K 67,446 D
2026-01-06 Noci Darlene Officer S-Sale D Class A Common Stock 225 98.40 22.1K 40,617 D
2026-01-06 Miller Deborah Ann Officer S-Sale D Class A Common Stock 183 98.40 18.0K 42,134 D
2026-01-06 Balcom Alexandra Officer S-Sale D Class A Common Stock 225 98.40 22.1K 81,733 D
2026-01-05 Turner Christopher Durant Officer S-Sale D Class A Common Stock 871 96.06 83.7K 61,676 D
2026-01-05 Porter James Richard Director / Officer S-Sale D Class A Common Stock 1,337 98.52 131.7K 288,172 D
2026-01-05 Pelish Henry E. Officer S-Sale D Class A Common Stock 513 96.06 49.3K 70,535 D
2026-01-05 Noci Darlene Officer S-Sale D Class A Common Stock 317 98.52 31.2K 43,798 D
2026-01-05 Miller Deborah Ann Officer S-Sale D Class A Common Stock 897 96.06 86.2K 48,189 D
2026-01-05 Balcom Alexandra Officer S-Sale D Class A Common Stock 317 98.52 31.2K 84,914 D
2026-01-02 Miller Deborah Ann Officer S-Sale D Class A Common Stock 4,005 100.03 400.6K 55,081 D
2025-12-30 Noci Darlene Officer M-Exempt D Stock Option (Right to Buy) 4,000 27.85 111.4K 114,329 D
2025-12-22 Pelish Henry E. Officer M-Exempt A Class A Common Stock 5,085 1.08 5.5K 71,048 D
2025-12-22 Balcom Alexandra Officer M-Exempt D Stock Option (Right to Buy) 34,500 1.08 37.3K 161,656 D
2025-12-19 Porter James Richard Director / Officer M-Exempt A Class A Common Stock 57,000 0.65 37.1K 306,062 D
2025-12-10 Squarer Ron Director A-Award A Stock Option (Right to Buy) 4,418 105.74 467.2K 4,418 D
2025-12-08 Balcom Alexandra Officer S-Sale D Class A Common Stock 6,984 110.31 770.4K 54,750 D
2025-11-28 Noci Darlene Officer M-Exempt D Stock Option (Right to Buy) 4,000 27.85 111.4K 118,329 D
2025-11-24 Shair Matthew Director S-Sale D Class A Common Stock 104 107.70 11.2K 203,218 I
2025-11-24 Flynn James E Director / 10% Owner S-Sale D Class A Common Stock 371,287 95.45 35.44M 8,299,225 I
2025-11-18 Balcom Alexandra Officer M-Exempt D Stock Option (Right to Buy) 729 72.35 52.7K 33,646 D
2025-11-17 Miller Deborah Ann Officer M-Exempt D Stock Option (Right to Buy) 24,200 6.89 166.7K 94,608 D
2025-11-17 Balcom Alexandra Officer M-Exempt D Stock Option (Right to Buy) 13,125 72.35 949.6K 34,375 D
2025-10-30 Noci Darlene Officer S-Sale D Class A Common Stock 218 104.58 22.8K 48,034 D
2025-10-30 Miller Deborah Ann Officer M-Exempt A Class A Common Stock 21,800 6.89 150.2K 70,886 D
2025-10-28 Shair Matthew Director S-Sale D Class A Common Stock 32,455 100.27 3.25M 1,383,044 D
2025-10-27 Shair Matthew Director S-Sale D Class A Common Stock 14,345 100.23 1.44M 1,415,499 D
2025-10-20 Miller Deborah Ann Officer M-Exempt A Class A Common Stock 5,000 6.89 34.5K 54,086 D
2025-10-16 Porter James Richard Director / Officer M-Exempt D Stock Option (Right to Buy) 27,000 18.93 511.1K 222,400 D
2025-10-16 Miller Deborah Ann Officer S-Sale D Class A Common Stock 4,900 92.50 453.3K 49,086 D
2025-10-15 Pelish Henry E. Officer S-Sale D Class A Common Stock 14,205 90.04 1.28M 65,963 D
2025-10-15 Miller Deborah Ann Officer S-Sale D Class A Common Stock 15,624 89.98 1.41M 49,086 D
2025-10-15 Balcom Alexandra Officer M-Exempt D Stock Option (Right to Buy) 1,683 18.93 31.9K 28,979 D
2025-10-14 Pelish Henry E. Officer M-Exempt D Stock Option (Right to Buy) 825 29.33 24.2K 14,025 D
2025-10-14 Balcom Alexandra Officer M-Exempt D Stock Option (Right to Buy) 20,000 18.93 378.6K 30,662 D
2025-10-13 Pelish Henry E. Officer M-Exempt D Stock Option (Right to Buy) 4,168 27.85 116.1K 21,528 D
2025-10-13 Balcom Alexandra Officer M-Exempt D Stock Option (Right to Buy) 13,125 18.93 248.5K 50,662 D
2025-10-01 Balcom Alexandra Officer M-Exempt D Stock Option (Right to Buy) 3,213 18.93 60.8K 63,787 D
2025-09-30 Balcom Alexandra Officer M-Exempt A Class A Common Stock 20,000 6.89 137.8K 81,734 D
2025-09-29 Noci Darlene Officer M-Exempt A Class A Common Stock 4,000 27.85 111.4K 52,034 D
2025-09-29 Balcom Alexandra Officer M-Exempt A Class A Common Stock 7,588 6.89 52.3K 69,322 D
2025-09-15 Porter James Richard Director / Officer M-Exempt A Class A Common Stock 27,000 18.93 511.1K 276,062 D
2025-09-10 Pelish Henry E. Officer S-Sale D Class A Common Stock 3,725 78.83 293.6K 65,963 D
2025-08-29 Pelish Henry E. Officer M-Exempt A Class A Common Stock 3,000 1.08 3.2K 65,963 D
2025-08-25 Noci Darlene Officer S-Sale D Class A Common Stock 1,348 73.96 99.7K 50,686 D
2025-08-15 Porter James Richard Director / Officer M-Exempt D Stock Option (Right to Buy) 27,000 18.93 511.1K 276,400 D
2025-08-07 Pelish Henry E. Officer S-Sale D Class A Common Stock 5,500 74.85 411.7K 60,956 D
2025-07-30 Noci Darlene Officer M-Exempt D Stock Option (Right to Buy) 4,000 27.85 111.4K 134,329 D
2025-07-16 Balcom Alexandra Officer M-Exempt A Class A Common Stock 14,700 18.93 278.3K 76,434 D
2025-07-15 Porter James Richard Director / Officer M-Exempt D Stock Option (Right to Buy) 27,000 18.93 511.1K 303,400 D
2025-07-15 Balcom Alexandra Officer M-Exempt A Class A Common Stock 5,300 18.93 100.3K 67,034 D
2025-07-10 Pelish Henry E. Officer M-Exempt A Class A Common Stock 182 18.93 3.4K 61,138 D
2025-07-09 Pelish Henry E. Officer S-Sale D Class A Common Stock 1,945 81.08 157.7K 61,156 D
2025-06-27 Pelish Henry E. Officer M-Exempt D Stock Option (Right to Buy) 1,823 29.33 53.5K 25,299 D
2025-06-27 Balcom Alexandra Officer S-Sale D Class A Common Stock 20,000 80.02 1.60M 61,734 D
2025-06-26 Noci Darlene Officer M-Exempt A Class A Common Stock 4,000 27.85 111.4K 52,034 D
2025-06-25 Pelish Henry E. Officer M-Exempt D Stock Option (Right to Buy) 3,677 27.85 102.4K 28,675 D
2025-06-18 Wheeler Cameron Director A-Award A Stock Option (Right to Buy) 4,147 75.53 313.2K 4,147 D
2025-06-18 Srivastava Sapna Director A-Award A Stock Option (Right to Buy) 4,147 75.53 313.2K 4,147 D
2025-06-18 Shair Matthew Director A-Award A Class A Common Stock 2,647 0.00 1,429,844 D
2025-06-18 Protopapas Anna Director A-Award A Stock Option (Right to Buy) 4,147 75.53 313.2K 4,147 D
2025-06-18 Pearlberg Joseph Director A-Award A Stock Option (Right to Buy) 4,147 75.53 313.2K 4,147 D
2025-06-18 Oliger Christy J. 0 0.00 0
2025-06-18 Meyers Michael L. Director A-Award A Stock Option (Right to Buy) 4,147 75.53 313.2K 4,147 D
2025-06-18 Flynn James E Director / 10% Owner A-Award A Class A Common Stock 2,647 0.00 2,647 I
2025-06-18 Bogle Grant C. Director A-Award A Stock Option (Right to Buy) 4,147 75.53 313.2K 4,147 D
2025-06-16 Porter James Richard Director / Officer S-Sale D Class A Common Stock 11,601 77.26 896.3K 249,262 D
2025-06-06 Pelish Henry E. Officer M-Exempt A Class A Common Stock 100 29.33 2.9K 63,301 D
2025-05-29 Noci Darlene Officer M-Exempt D Stock Option (Right to Buy) 1,871 27.85 52.1K 142,329 D
2025-05-15 Porter James Richard Director / Officer S-Sale D Class A Common Stock 11,489 69.99 804.1K 249,397 D
2025-04-29 Noci Darlene Officer M-Exempt A Class A Common Stock 4,000 14.40 57.6K 52,034 D
2025-04-15 Porter James Richard Director / Officer S-Sale D Class A Common Stock 11,060 69.05 763.7K 254,015 D
2025-03-27 Noci Darlene Officer M-Exempt A Class A Common Stock 1,773 14.40 25.5K 52,034 D
2025-03-17 Porter James Richard Director / Officer M-Exempt D Stock Option (Right to Buy) 27,000 27.85 752.0K 258,780 D
2025-03-07 Noci Darlene Officer M-Exempt A Class A Common Stock 4,000 1.08 4.3K 52,034 D
2025-03-06 Noci Darlene Officer M-Exempt A Class A Common Stock 8,015 6.89 55.2K 78,034 D
2025-02-24 Shair Matthew Director S-Sale D Class A Common Stock 1,382 78.49 108.5K 216,824 I
2025-02-18 Porter James Richard Director / Officer M-Exempt A Class A Common Stock 27,000 27.85 752.0K 276,062 D
2025-01-31 Pelish Henry E. Officer M-Exempt A Class A Common Stock 3,120 0.87 2.7K 63,101 D
2025-01-27 Shair Matthew Director S-Sale D Class A Common Stock 1,040 82.24 85.5K 219,482 I
2025-01-15 Porter James Richard Director / Officer S-Sale D Class A Common Stock 5,493 76.65 421.0K 254,904 D
2025-01-06 Turner Christopher Durant Officer S-Sale D Class A Common Stock 1,152 78.28 90.2K 65,411 D
2025-01-06 Porter James Richard Director / Officer A-Award A Class A Common Stock 56,250 0.00 266,363 D
2025-01-06 Pelish Henry E. Officer A-Award A Class A Common Stock 18,750 0.00 62,464 D
2025-01-06 Noci Darlene Officer S-Sale D Class A Common Stock 1,152 78.28 90.2K 50,898 D
2025-01-06 Miller Deborah Ann Officer A-Award A Stock Option (Right to Buy) 37,500 78.09 2.93M 37,500 D
2025-01-06 Balcom Alexandra Officer S-Sale D Class A Common Stock 2,173 80.54 175.0K 61,734 D
2024-12-23 Shair Matthew Director S-Sale D Class A Common Stock 1,409 83.62 117.8K 221,113 I
2024-12-19 Porter James Richard Director / Officer M-Exempt D Stock Option (Right to Buy) 22,000 0.65 14.3K 565,942 D
2024-12-17 Balcom Alexandra Officer M-Exempt A Class A Common Stock 8,972 6.89 61.8K 47,000 D
2024-12-16 Porter James Richard Director / Officer S-Sale D Class A Common Stock 18,969 86.46 1.64M 196,144 D
2024-12-16 Pelish Henry E. Officer M-Exempt D Stock Option (Right to Buy) 5,914 0.65 3.8K 0 D
2024-12-11 Hack Andrew A. F. Director S-Sale D Class A Common Stock 1,250,000 88.00 110.00M 1,447,267 I
2024-12-05 Bogle Grant C. Director A-Award A Stock Option (Right to Buy) 4,851 93.73 454.7K 4,851 D
2024-11-29 Balcom Alexandra Officer M-Exempt D Stock Option (Right to Buy) 10,000 27.85 278.5K 84,200 D
2024-11-25 Shair Matthew Director S-Sale D Class A Common Stock 992 96.69 95.9K 222,552 I
2024-11-15 Porter James Richard Director / Officer M-Exempt D Stock Option (Right to Buy) 27,000 27.85 752.0K 366,780 D
2024-11-01 Noci Darlene Officer S-Sale D Class A Common Stock 2,513 88.79 223.1K 33,800 D
2024-10-31 Balcom Alexandra Officer M-Exempt D Stock Option (Right to Buy) 10,000 27.85 278.5K 94,200 D
2024-10-28 Shair Matthew Director S-Sale D Class A Common Stock 746 92.27 68.8K 224,595 I
2024-10-22 Flynn James E Director / 10% Owner S-Sale D Class A Common Stock 1,000,000 97.75 97.75M 8,670,512 I
2024-10-15 Porter James Richard Director / Officer M-Exempt D Stock Option (Right to Buy) 27,000 27.85 752.0K 393,780 D
2024-10-01 Noci Darlene Officer M-Exempt D Stock Option (Right to Buy) 5,000 18.93 94.7K 35,800 D
2024-09-30 Balcom Alexandra Officer M-Exempt D Stock Option (Right to Buy) 10,000 27.85 278.5K 104,200 D
2024-09-23 Shair Matthew Director S-Sale D Class A Common Stock 1,121 102.29 114.7K 227,045 I
2024-09-16 Pelish Henry E. Officer S-Sale D Class A Common Stock 100 102.80 10.3K 33,300
2024-09-16 Miller Deborah Ann Officer S-Sale D Class A Common Stock 300 102.00 30.6K 33,300
2024-09-09 Miller Deborah Ann Officer M-Exempt D Stock Option (Right to Buy) 3,000 6.89 20.7K 173,608
2024-09-03 Noci Darlene Officer S-Sale D Class A Common Stock 1,978 83.95 166.1K 36,322
2024-08-30 Balcom Alexandra Officer M-Exempt D Stock Option (Right to Buy) 10,000 27.85 278.5K 114,200
2024-08-26 Shair Matthew Director S-Sale D Class A Common Stock 797 83.81 66.8K 229,725
2024-08-23 Pelish Henry E. Officer S-Sale D Class A Common Stock 10,500 85.08 893.3K 66,095
2024-08-23 Miller Deborah Ann Officer M-Exempt A Class A Common Stock 5,000 18.93 94.7K 38,300
2024-08-23 Conley Emily Director S-Sale D Class A Common Stock 3,334 85.02 283.5K 2,507
2024-08-08 Miller Deborah Ann Officer S-Sale D Class A Common Stock 624 67.17 41.9K 35,564
2024-08-01 Noci Darlene Officer M-Exempt D Stock Option (Right to Buy) 5,000 18.93 94.7K 45,800
2024-07-31 Balcom Alexandra Officer S-Sale D Class A Common Stock 597 78.05 46.6K 41,807
2024-07-29 Shair Matthew Director S-Sale D Class A Common Stock 1,200 78.93 94.7K 231,322
2024-07-15 Conley Emily Director S-Sale D Class A Common Stock 700 79.43 55.6K 6,807
2024-07-12 Miller Deborah Ann Officer M-Exempt D Stock Option (Right to Buy) 6,000 27.85 167.1K 96,154
2024-07-09 Pelish Henry E. Officer D Stock Option (Right to Buy) 8,085 1.08 8.7K 0
2024-07-08 Miller Deborah Ann Officer M-Exempt D Stock Option (Right to Buy) 3,000 6.89 20.7K 179,608
2024-07-01 Noci Darlene Officer M-Exempt D Stock Option (Right to Buy) 5,000 18.93 94.7K 50,800
2024-06-28 Balcom Alexandra Officer S-Sale D Class A Common Stock 7,565 75.15 568.5K 35,735
2024-06-24 Shair Matthew Director S-Sale D Class A Common Stock 634 79.47 50.4K 233,888
2024-06-14 Conley Emily Director M-Exempt D Stock Option (Right to Buy) 5,000 13.79 69.0K 31,667
2024-06-12 Wheeler Cameron Director A-Award A Class A Common Stock 2,499 0.00 2,499
2024-06-12 Srivastava Sapna Director A-Award A Stock Option (Right to Buy) 3,789 80.03 303.2K 3,789
2024-06-12 Shair Matthew Director A-Award A Class A Common Stock 2,499 0.00 1,427,197
2024-06-12 Protopapas Anna Director A-Award A Stock Option (Right to Buy) 3,789 80.03 303.2K 3,789
2024-06-12 Pearlberg Joseph Director A-Award A Class A Common Stock 2,499 0.00 2,499
2024-06-12 Meyers Michael L. Director A-Award A Class A Common Stock 2,499 0.00 2,499
2024-06-12 Hack Andrew A. F. Director A-Award A Class A Common Stock 2,499 0.00 2,499
2024-06-12 Gilliland Dwight Gary Director A-Award A Stock Option (Right to Buy) 3,789 80.03 303.2K 3,789
2024-06-12 Flynn James E Director / 10% Owner A-Award A Class A Common Stock 2,499 0.00 2,499
2024-06-12 Conley Emily Director A-Award A Class A Common Stock 2,499 0.00 2,507
2024-06-06 Miller Deborah Ann Officer S-Sale D Class A Common Stock 526 76.88 40.4K 39,638
2024-05-28 Shair Matthew Director S-Sale D Class A Common Stock 1,256 66.87 84.0K 235,266
2024-05-15 Conley Emily Director S-Sale D Class A Common Stock 5,000 69.09 345.5K 8
2024-05-13 Shair Matthew Director S-Sale D Class A Common Stock 19,909 65.42 1.30M 1,442,289
2024-05-06 Shair Matthew Director S-Sale D Class A Common Stock 29,600 69.27 2.05M 1,470,098
2024-05-02 Miller Deborah Ann Officer S-Sale D Class A Common Stock 138 73.13 10.1K 33,300
2024-04-29 Shair Matthew Director S-Sale D Class A Common Stock 15,693 67.01 1.05M 1,521,505
2024-04-22 Shair Matthew Director S-Sale D Class A Common Stock 14,650 64.52 945.2K 1,537,198
2024-04-15 Shair Matthew Director S-Sale D Class A Common Stock 11,900 66.17 787.4K 1,574,698
2024-04-15 Conley Emily Director S-Sale D Class A Common Stock 6 66.66 399.96 8
2024-04-08 Shair Matthew Director S-Sale D Class A Common Stock 11,022 67.89 748.3K 1,638,676
2024-04-04 Miller Deborah Ann Officer S-Sale D Class A Common Stock 731 71.54 52.3K 35,569
2024-04-01 Shair Matthew Director S-Sale D Class A Common Stock 27,806 76.82 2.14M 1,659,392
2024-03-28 Miller Deborah Ann Officer M-Exempt A Class A Common Stock 13,000 18.93 246.1K 46,300
2024-03-27 Hack Andrew A. F. Director S-Sale D Class A Common Stock 88,205 76.88 6.78M 3,489,062
2024-03-25 Shair Matthew Director S-Sale D Class A Common Stock 35,545 76.74 2.73M 1,689,153
2024-03-22 Noci Darlene Officer M-Exempt D Stock Option (Right to Buy) 10,000 1.08 10.8K 36,201
2024-03-15 Conley Emily Director S-Sale D Class A Common Stock 1,000 84.44 84.4K 8
2024-01-05 Turner Christopher Durant Officer A-Award A Class A Common Stock 33,300 0.00 47,813
2024-01-05 Porter James Richard Director / Officer A-Award A Stock Option (Right to Buy) 161,100 72.35 11.66M 161,100
2024-01-05 Noci Darlene Officer A-Award A Class A Common Stock 33,300 0.00 33,300
2024-01-05 Miller Deborah Ann Officer A-Award A Class A Common Stock 33,300 0.00 33,300
2024-01-05 Balcom Alexandra Officer A-Award A Class A Common Stock 33,300 0.00 33,300
2023-12-28 Shair Matthew Director S-Sale D Class A Common Stock 35,056 75.20 2.64M 1,738,190
2023-12-27 Shair Matthew Director S-Sale D Class A Common Stock 1,000 75.17 75.2K 1,773,246
2023-12-26 Shair Matthew Director S-Sale D Class A Common Stock 937 74.22 69.5K 1,842,911
2023-12-19 Miller Deborah Ann Officer M-Exempt D Stock Option (Right to Buy) 5,000 18.93 94.7K 102,000
2023-12-18 Protopapas Anna Director S-Sale D Class A Common Stock 5,000 75.67 378.4K 0
2023-12-18 Noci Darlene Officer M-Exempt D Stock Option (Right to Buy) 22,601 1.08 24.4K 46,201
2023-12-18 Miller Deborah Ann Officer S-Sale D Class A Common Stock 33,046 75.82 2.51M 0
2023-12-18 Balcom Alexandra Officer S-Sale D Class A Common Stock 30,000 75.82 2.27M 0
2023-11-28 Shair Matthew Director S-Sale D Class A Common Stock 6,352 61.68 391.8K 1,846,646
2023-11-01 Noci Darlene Officer S-Sale D Class A Common Stock 976 53.11 51.8K 0
2023-10-24 Shair Matthew Director S-Sale D Class A Common Stock 81,531 50.63 4.13M 1,863,167
2023-10-04 Turner Christopher Durant Officer S-Sale D Class A Common Stock 1,465 57.70 84.5K 14,513

Executive team

Top executives
Shares Outstanding
73.54M

Executive compensation

Executive compensation (annual)
# Year Executive Salary Bonus Stock award Option award Incentive Other Total % Stock-
based
Filing
1 2025 James R. Porter, Ph.D. President and Chief Executive Officer 652.1K 4.39M 5.86M 469.5K 21.5K 11.39M 89.97%
2 2025 Christopher D. Turner, M.D. Chief Medical Officer 520.1K 1.46M 1.95M 280.9K 21.5K 4.24M 80.60%
3 2025 Alexandra Balcom, MBA, CPA Chief Financial Officer and Treasurer 475.5K 1.46M 1.95M 256.8K 21.5K 4.17M 81.93%
4 2025 Darlene Noci, ALM Chief Development Officer 467.4K 1.46M 1.95M 252.4K 21.5K 4.16M 82.17%
5 2025 Deborah Miller, Ph.D., J.D. Chief Legal Officer and Secretary 467.0K 1.46M 1.95M 252.2K 21.5K 4.16M 82.18%
6 2024 James R. Porter, Ph.D. President and Chief Executive Officer 627.0K 8.16M 8.04M 431.1K 21.1K 17.28M 93.76%
7 2024 Christopher D. Turner, M.D. Chief Medical Officer 500.1K 2.41M 2.37M 250.1K 21.1K 5.55M 86.11%
8 2024 Christopher Turner, M.D. Chief Medical Officer 500.1K 2.41M 2.37M 250.1K 21.1K 5.55M 86.11%
9 2024 Alexandra Balcom, MBA, CPA Chief Financial Officer and Treasurer 457.2K 2.41M 2.37M 228.6K 21.1K 5.49M 87.12%
10 2024 Deborah Miller, Ph.D., J.D. Chief Legal Officer and Secretary 440.5K 2.41M 2.37M 220.3K 21.1K 5.46M 87.52%
11 2024 Darlene Noci, ALM Chief Development Officer 432.7K 2.41M 2.37M 216.4K 21.1K 5.45M 87.70%
12 2023 James R. Porter, Ph.D. President and Chief Executive Officer 602.8K 8.32M 431.0K 20.2K 9.38M 88.76%
13 2023 Christopher Turner, M.D. Chief Medical Officer 480.8K 2.85M 250.0K 20.2K 3.60M 79.16%
14 2023 Christopher D. Turner, M.D. Chief Medical Officer 480.8K 2.85M 250.0K 20.2K 3.60M 79.16%
15 2023 Alexandra Balcom, MBA, CPA Chief Financial Officer and Treasurer 440.3K 2.85M 229.0K 20.2K 3.54M 80.53%
16 2023 Alexandra Balcom, MBA, CPA Chief Financial Officer 440.3K 2.85M 229.0K 20.2K 3.54M 80.53%
17 2022 James Porter, Ph.D. President and Chief Executive Officer 579.6K 4.22M 398.5K 19.9K 5.21M 80.86%
18 2022 James R. Porter, Ph.D. President and Chief Executive Officer 579.6K 4.22M 398.5K 19.9K 5.21M 80.86%
19 2022 Christopher Turner, M.D. Chief Medical Officer 462.3K 1.37M 231.2K 20.8K 2.08M 65.66%
20 2022 Alexandra Balcom, MBA, CPA Chief Financial Officer and Treasurer 423.4K 1.37M 211.7K 19.1K 2.02M 67.61%
21 2022 Alexandra Balcom, MBA, CPA Chief Financial Officer 423.4K 1.37M 211.7K 19.1K 2.02M 67.61%
22 2021 James Porter, Ph.D. President and Chief Executive Officer 424.4K 4.07M 354.2K 42.00 4.85M 83.93%
23 2021 Christopher Turner, M.D. Chief Medical Officer 314.9K 1.61M 161.6K 62.00 2.09M 77.20%
24 2021 Deborah Miller, Ph.D., J.D. Chief Legal Officer 210.4K 1.10M 184.0K 1.49M 73.57%
25 2020 James Porter, Ph.D. President and Chief Executive Officer 334.6K 306.9K 117.3K 758.7K 40.44%
CEO compensation breakdown

Proxy statements

Proxy statements (DEF 14A)
Filing date Form type Filing
2026-04-28 DEFA14A
2026-04-28 DEF 14A

Recent SEC filings

Recent SEC filings
Filing date Form type Filing
2026-05-07 8-K
2026-05-07 10-Q
2026-05-06 SC 13G/A
2026-05-06 4
2026-05-05 4
2026-05-01 4
2026-05-01 4
2026-04-28 DEFA14A
2026-04-28 DEF 14A
2026-04-28 ARS

Executive team

NameTitleCompensationGender
James R. Porter Chief Executive Officer, President & Director 1M
Christopher D. Turner Chief Medical Officer 822.5K
Darlene Noci Chief Development Officer 741.3K female
Deborah Ann Miller Chief Legal Officer & Secretary 740.7K female
Alex Balcom Chief Financial Officer & Treasurer 706.9K female
Chelcie Lister Senior Director of Investor Relations & Corporate Communications
Henry Pelish Chief Scientific Officer male
Benjamin Lane Chief Technical Operations Officer
John Soglia Senior Vice President of Translational Development male
Joshua Horan Senior Vice President of Chemistry male
Matthew Metivier Senior Vice President of Human Resources male
ESG Rating
B
BIOTECHNOLOGY
2026
E (Environmental)
62.3 / 56.3
Company / Sector avg.
S (Social)
62.8 / 62.4
Company / Sector avg.
G (Governance)
62.9 / 60.9
Company / Sector avg.
ESG Total
62.7 / 59.9
Company / Sector avg.
ESG Score History BIOTECHNOLOGY
Benchmark vs Sector
Senate Trading Activity

No Senate trading activity found for this company.

House Trading Activity

No House trading activity found for this company.

Market share among peers
Peer comparison — filtered group (TTM)
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Dividend history

Earnings history

Earnings reports

Stock splits