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Tango Therapeutics, Inc. (TNGX)

USD28.36 -2.70 (-8.69%)
US NASDAQ Healthcare Biotechnology
Address 100 Binney Street 2142
Boston, MA, US
CEO Malte Peters
IPO 2020-09-03
CIK 1819133 ISIN US87583X1090

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Description

Tango Therapeutics, Inc. is a biotechnology firm dedicated to the research and development of innovative cancer treatments. Their primary therapeutic candidate, TNG908, is a synthetic lethal small molecule designed to inhibit protein arginine methyltransferase 5 (PRMT5). This compound is currently being advanced as a potential therapy for cancers characterized by methylthioadenosine phosphorylase (MTAP) deletions. Additionally, their pipeline includes an Ubiquitin-specific protease 1 (USP1) inhibitor targeting BRCA1 or BRCA2-mutant cancers, and a program known as 'Target 3' which addresses STK11-mutant cancers. Tango Therapeutics maintains a strategic alliance with Gilead Sciences, Inc., focused on the identification, advancement, and commercialization of a diverse array of cancer therapies. Established in 2017, the company's operations are headquartered in Cambridge, Massachusetts.

Market Cap & Enterprise Value
Merger & Acquisition History
Target company Ticker Date Filing
BCTG Acquisition Corp. BCTG 2021-04-19 View
Technical Outlook
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Signal Summary Loading…
Indicator 1D1W2W3W1M
Each column is computed on that timeframe's candles (1D = daily, 1W ≈ weekly, 1M ≈ monthly), not on the same last day. ▲ bullish · ▼ bearish · — neutral. The Net row counts signals per column; hover any cell (or the indicator name) to see the exact rule behind it.
Day Score & sub-scores
Statistical fingerprint & regime detail
Conditional historical analysis
Customize analysis (advanced)
Indicative levels generated algorithmically. Not financial advice.
Risk Profile
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Price Chart
Averages
Trend
Price
Levels
Draw
USD28.36 -2.70 (-8.69%)
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Volume Profile
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Liquidity & share structure
Average Volume
4M
Beta
1.13
Float Shares
76.57M
Free Float %
65.9%
Price Performance
1D5D1M3M6M YTD1Y3Y5Y10YMax
+8.55% +7.59% +18.32% +97.75% +230.44% +187.92% +1,722.14% +576.66% +125.75% +149.36% +149.36%
Rolling Volatility
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Drawdown
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Relative Strength
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Monthly Returns Heatmap
From To
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Annual Monthly Returns
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Daily Returns Distribution
vs.
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Revenue flow

Revenue by geography

Revenue by segment

From To

Revenue composition

From To

By product

By geography

Financial Statements

Income Statement

Balance Sheet

Cash Flow Statement

Key Metrics

Financial Ratios

Employees

Financial Growth (CAGR)

Market Data

Analyst Consensus (10 ratings, all time) Buy
Price Targets & DCF
Current price
28.36
Low 14.00 -50.6%
Consensus 22.75 -19.8%
Median 18.50 -34.8%
High 40.00 +41.0%
Ratings Trend (MoM) 92% Bullish
Rating 2026-05 Change
Strong Buy 1 0
Buy 10 0
Hold 1 0
Sell 0 0
Strong Sell 0 0
Price Target Summary
Period # Analysts Avg Target
Last Month 1
40.00
+41.0%
Last Quarter 4
25.25
-11.0%
Last Year 7
20.29
-28.5%
All Time 10
18.60
-34.4%
Quality scores
Altman Z-Score
38.38
Safe zone
Piotroski F-Score
2 / 9
Weak
MOAT Score
2 / 10
No MOAT
Composite Rating
C-
Overall Score
1 / 5
Low
DCF Score
1 / 5
Low
ROE Score
1 / 5
Low
ROA Score
1 / 5
Low
D/E Score
3 / 5
Medium
P/E Score
1 / 5
Low
P/Book Score
1 / 5
Low
Operational MOAT
✗ Below peers
  • Revenue growth Biotechnology: +1.6%
    +48.3% Q1'26: -100.0% (vs Q1'25)
  • EPS growth Biotechnology: +29.7%
    +26.9% Q1'26: +11.1% (vs Q1'25)
  • FCF margin FCF growth · Biotechnology: +16.2%
    -284.1%
  • EBIT margin Biotechnology: +0.0%
    -178.4%
  • ROIC Biotechnology: -16.1%
    -304.0% Q1'26: +0.0% (vs Q1'25)
  • Share dilution Biotechnology: -3.4%
    +6.4% Q1'26: +30.2% (vs Q1'25)
  • Debt / EBITDA Net debt/EBITDA · Biotechnology: 0.16×
    -0.31× Q1'26: -0.17× (vs Q1'25)
Valuation Multiples From To
Price Forecast (3Y) From To
Model
Adjust
P/E
Theoretical Return — If Invested Today

* These projections are based on analyst consensus estimates and user-defined valuation multiples. This table is for informational purposes only and does not constitute a recommendation to buy or sell any security. Past performance is not indicative of future results.

DCF Interactive Model (UFCF)
Projection years:
Market assumptions
WACC components (optional)
Ke (Cost of Equity) = Rf + β (1.22) × ERP
WACC = 99% × Ke + 1% × Kd (4.1%) × (1−t)

Modifying these values recalculates WACC automatically.

Business assumptions
Current price: 28.36
Enterprise Value: Equity Value: Terminal Value: TV as % of EV:

Base values reflect the latest available data for this company and market conditions.

Consensus Estimates
Metric Dec 2021
actual
Dec 2022
actual
Dec 2023
actual
Dec 2024
actual
Dec 2025
actual
Dec 2026
7 Rev. Ana.
10 EPS Ana.
Dec 2027
7 Rev. Ana.
8 EPS Ana.
Dec 2028
9 Rev. Ana.
8 EPS Ana.
Dec 2029
4 Rev. Ana.
6 EPS Ana.
Dec 2030
4 Rev. Ana.
6 EPS Ana.
Revenue
37.04M
est: 37.91M (-2.3%)
24.86M
est: 24.78M (+0.3%)
36.53M
est: 42.51M (-14.1%)
42.07M
est: 46.01M (-8.6%)
62.38M
est: 62.81M (-0.7%)
6.06M
6.06M – 6.06M
-90.4% YoY
3.93M
3.93M – 3.93M
-35.2% YoY
49.03M
49.03M – 49.03M
+1,148.9% YoY
207.92M
207.92M – 207.92M
+324.1% YoY
568.17M
568.17M – 568.17M
+173.3% YoY
EBITDA
-57.29M
est: -37.91M (-51.1%)
-109.46M
est: -24.78M (-341.7%)
-111.76M
est: -42.51M (-162.9%)
-143.10M
est: -46.01M (-211.0%)
-109.01M
est: -62.81M (-73.5%)
-6.06M
-6.06M – -6.06M
+90.4% YoY
-3.93M
-3.93M – -3.93M
+35.2% YoY
-49.03M
-49.03M – -49.03M
-1,148.9% YoY
-207.92M
-207.92M – -207.92M
-324.1% YoY
-568.17M
-568.17M – -568.17M
-173.3% YoY
EBIT
-58.19M
est: -37.91M (-53.5%)
-111.07M
est: -24.78M (-348.2%)
-114.17M
est: -42.51M (-168.6%)
-145.60M
est: -46.01M (-216.5%)
-111.29M
est: -62.81M (-77.2%)
-6.06M
-6.06M – -6.06M
+90.4% YoY
-3.93M
-3.93M – -3.93M
+35.2% YoY
-49.03M
-49.03M – -49.03M
-1,148.9% YoY
-207.92M
-207.92M – -207.92M
-324.1% YoY
-568.17M
-568.17M – -568.17M
-173.3% YoY
Net Income
-58.24M
est: -113.16M (+48.5%)
-108.18M
est: -141.83M (+23.7%)
-101.74M
est: -129.15M (+21.2%)
-130.30M
est: -145.57M (+10.5%)
-101.59M
est: -101.59M (+0.0%)
-161.14M
-185.31M – -136.97M
-58.6% YoY
-181.12M
-223.67M – -138.57M
-12.4% YoY
-264.45M
-284.44M – -124.37M
-46.0% YoY
-142.50M
-142.50M – -142.50M
+46.1% YoY
87.32M
87.32M – 87.32M
+161.3% YoY
SGA
17.60M
est: 36.18M (-51.4%)
30.03M
est: 23.64M (+27.0%)
35.50M
est: 37.07M (-4.2%)
43.75M
est: 40.12M (+9.0%)
41.51M
est: 54.77M (-24.2%)
5.28M
5.28M – 5.28M
-90.4% YoY
3.42M
3.42M – 3.42M
-35.2% YoY
42.75M
42.75M – 42.75M
+1,148.9% YoY
181.30M
181.30M – 181.30M
+324.1% YoY
495.44M
495.44M – 495.44M
+173.3% YoY
EPS
-0.94
est: -1.04 (+9.3%)
-1.23
est: -1.26 (+2.1%)
-1.08
est: -1.11 (+2.9%)
-1.19
est: -1.20 (+0.9%)
-0.87
est: -0.87 (+0.2%)
-1.34
-1.60 – -1.18
-53.4% YoY
-1.60
-1.93 – -1.19
-19.7% YoY
-1.71
-2.45 – -1.07
-6.8% YoY
-1.23
-1.23 – -1.23
+28.3% YoY
0.75
0.75 – 0.75
+161.3% YoY
Recent Grade Changes (3M)
Date Firm Previous New Grade Action
2026-04-27 Stifel Buy Buy Maintain
Historical Ratings (3M)
Date Rating Overall DCF ROE ROA D/E P/E P/B
2026-05-13 C- 1/5 1/5 1/5 1/5 3/5 1/5 1/5
2026-05-12 C- 1/5 1/5 1/5 1/5 3/5 1/5 2/5
2026-05-11 C- 1/5 1/5 1/5 1/5 3/5 1/5 2/5
2026-05-08 C- 1/5 1/5 1/5 1/5 3/5 1/5 2/5
2026-05-07 C- 1/5 1/5 1/5 1/5 3/5 1/5 2/5
2026-05-06 C- 1/5 1/5 1/5 1/5 3/5 1/5 2/5
2026-05-05 C- 1/5 1/5 1/5 1/5 3/5 1/5 2/5
2026-05-04 C- 1/5 1/5 1/5 1/5 3/5 1/5 2/5
2026-05-01 C- 1/5 1/5 1/5 1/5 2/5 1/5 2/5
2026-04-30 C- 1/5 1/5 1/5 1/5 2/5 1/5 2/5
2026-04-29 C- 1/5 1/5 1/5 1/5 2/5 1/5 2/5
2026-04-28 C- 1/5 1/5 1/5 1/5 2/5 1/5 2/5
2026-04-27 C- 1/5 1/5 1/5 1/5 2/5 1/5 2/5
2026-04-24 C- 1/5 1/5 1/5 1/5 2/5 1/5 2/5
2026-04-23 C- 1/5 1/5 1/5 1/5 2/5 1/5 2/5
2026-04-22 C- 1/5 1/5 1/5 1/5 2/5 1/5 2/5
2026-04-21 C- 1/5 1/5 1/5 1/5 2/5 1/5 2/5
2026-04-20 C- 1/5 1/5 1/5 1/5 2/5 1/5 2/5
2026-04-17 C- 1/5 1/5 1/5 1/5 2/5 1/5 3/5
2026-04-16 C- 1/5 1/5 1/5 1/5 2/5 1/5 3/5
2026-04-15 C- 1/5 1/5 1/5 1/5 2/5 1/5 3/5

Owner Earnings

Owner's Earnings (history) From To
Owner alignment
Owner's Earnings TTM
-126.86M
OE per share TTM
-1.03
Owner's Yield
-4.28%
Maintenance CapEx ratio
Maint CapEx / Avg PPE
98.0%

Ownership Overview

Ownership breakdown
At a glance
Institutional holders
74
Total invested
430.07M
Insider transactions (90d)
3
Beneficial owners (>5%)
36
Beneficial owners (>5%)
# Reporting person Amount owned % of class Sole voting Shared voting Sole dispositive Shared dispositive Type Citizenship Filing date SEC filing
1 TRV GP IV, LLC 19.36M 22.10% 19.36M 19.36M OO 2021-08-19
2 Third Rock Ventures GP IV, L.P. 19.36M 22.10% 19.36M 19.36M PN 2021-08-19
3 Third Rock Ventures IV, L.P. 19.36M 22.10% 19.36M 19.36M PN 2021-08-19
4 Chen Yu 10.50M 9.80% 10.50M 10.50M IN Delaware 2024-11-20
5 TCG Crossover Fund II, L.P. 10.50M 9.80% 10.50M 10.50M PN Delaware 2024-11-20
6 TCG Crossover GP II, LLC 10.50M 9.80% 10.50M 10.50M OO Delaware 2024-11-20
7 EcoR1 Capital, LLC 7.83M 11.00% 7.83M 7.83M IA, OO Delaware 2023-09-21
8 Oleg Nodelman 7.83M 11.00% 7.83M 7.83M HC, IN Delaware 2023-09-21
9 EcoR1 Capital Fund Qualified, L.P. 7.37M 11.00% 7.37M 7.37M PN Delaware 2023-09-21
10 FMR LLC 7.18M 6.59% 1.07M 7.18M HC Delaware 2022-02-09
11 BCTG Holdings, LLC 6.99M 8.30% 6.99M 6.99M OO 2021-08-20
12 Boxer Asset Management Inc. 6.87M 8.10% 6.87M 6.87M CO 2021-08-20
13 Boxer Capital, LLC 6.87M 8.10% 6.87M 6.87M OO 2021-08-20
14 Joe Lewis 6.87M 8.10% 6.87M 6.87M IN 2021-08-20
15 Costas Constantinides 5.53M 5.40% 5.53M IN Luxembourg 2023-08-21
16 Ian Charoub 5.53M 5.40% 5.53M IN Luxembourg 2023-08-21
17 Nextech Crossover I GP S.à r.l. 5.53M 5.40% 5.53M 5.53M OO Luxembourg 2023-08-21
18 Nextech Crossover I SCSp 5.53M 5.40% 5.53M 5.53M PN Luxembourg 2023-08-21
19 Rocco Sgobbo 5.53M 5.40% 5.53M IN Luxembourg 2023-08-21
20 Casdin Capital, LLC 5.49M 6.30% 5.49M 5.49M IA Cayman Islands 2021-08-19
21 Casdin Partners GP, LLC 5.49M 6.30% 5.49M 5.49M OO Cayman Islands 2021-08-19
22 Casdin Partners Master Fund, L.P. 5.49M 6.30% 5.49M 5.49M PN Cayman Islands 2021-08-19
23 Eli Casdin 5.49M 6.30% 5.49M 5.49M HC, IN Cayman Islands 2021-08-19
24 Bihua Chen 4.90M 5.60% 4.90M 4.90M HC United States 2022-02-14
25 Cormorant Asset Management, LP 4.90M 5.60% 4.90M 4.90M IA Delaware 2022-02-14
26 Gilead Sciences, Inc. 4.85M 5.50% 4.85M 4.85M CO Delaware 2021-09-10
27 John S. Clark II 4.50M 5.10% 4.50M 4.50M IN Delaware 2022-07-11
28 Southpoint Capital Advisors LLC 4.50M 5.10% 4.50M 4.50M OO Delaware 2022-07-11
29 Southpoint Capital Advisors LP 4.50M 5.10% 4.50M 4.50M PN Delaware 2022-07-11
30 Southpoint GP, LLC 4.50M 5.10% 4.50M 4.50M OO Delaware 2022-07-11
31 Southpoint GP, LP 4.50M 5.10% 4.50M 4.50M PN Delaware 2022-07-11
32 Southpoint Master Fund, LP 4.50M 5.10% 4.50M 4.50M PN Delaware 2022-07-11
33 2 1.91M 8.90% 1.91M 1.91M PN Cayman Islands 2021-04-26
34 RA Capital Management, L.P. 1.25M 5.80% 1.25M 1.25M IA, PN United States of America 2021-02-16
35 Aaron I. Davis 101.5K 0.10% 101.5K 101.5K IN 2021-08-20
36 MVA Investors, LLC 101.5K 0.10% 101.5K 101.5K OO 2021-08-20

Institutional Activity (13F)

Institutional ownership trend From To
13F snapshot — 2026 Q1
Investors holding
74
-97 vs prev Q
New positions
20
Closed positions
115
Increased
46
Reduced
19
Put/Call ratio
0.00
Calls held
Puts held
32.8K
Top institutional holders
# Investor Shares / Δ Mkt value / Δ Own% / Δ Weight% / Δ Avg px / Perf. Hold / Status
1 MASS GENERAL BRIGHAM, INC 354.2K +354.2K (+100.0%) 3.14B +3.1B (+100.0%) 0.32% +0.319 pp 0.39% +0.388 pp USD8.86 +0.0% 1 qtrs NEW
2 FARALLON CAPITAL MANAGEMENT LLC 13.06M +2.3M (+21.4%) 115.72M +25.4M (+28.1%) 11.77% +2.039 pp 0.55% +0.176 pp USD5.38 +64.7% 5 qtrs
3 TCG CROSSOVER MANAGEMENT, LLC 12.76M +4.2M (+49.5%) 113.07M +41.4M (+57.7%) 11.50% +3.779 pp 3.74% +0.215 pp USD5.00 +77.2% 5 qtrs
4 BOXER CAPITAL MANAGEMENT, LLC 10.88M +1.1M (+11.3%) 96.36M +14.3M (+17.4%) 9.80% +0.962 pp 21.09% -5.071 pp USD3.68 +140.8% 5 qtrs
5 ADAGE CAPITAL PARTNERS GP, L.L.C. 10.61M +8.1M (+322.5%) 93.99M +72.9M (+345.6%) 9.56% +7.288 pp 0.14% +0.109 pp USD7.97 +11.2% 3 qtrs
6 WOODLINE PARTNERS LP 10.07M +4.0M (+67.0%) 89.24M +38.6M (+76.2%) 9.08% +3.622 pp 0.35% +0.107 pp USD6.50 +36.3% 7 qtrs
7 BLACKROCK, INC. 8.54M +2.9M (+51.2%) 75.67M +28.2M (+59.5%) 7.70% +2.588 pp 0.00% +0.000 pp USD7.67 +15.5% 6 qtrs
8 SIREN, L.L.C. 8.17M +2.3M (+38.8%) 72.35M +22.9M (+46.4%) 7.36% +2.036 pp 2.16% +0.225 pp USD7.99 +10.9% 6 qtrs
9 TRV GP IV, LLC 7.87M -6.0M (-43.2%) 69.77M -46.7M (-40.1%) 7.10% -5.446 pp 27.35% -15.163 pp USD12.93 -31.5% 18 qtrs
10 NEXTECH INVEST, LTD. 7.27M +1.7M (+31.3%) 64.38M +17.9M (+38.5%) 6.55% +1.542 pp 6.22% -0.852 pp USD3.16 +180.4% 4 qtrs
11 VANGUARD GROUP INC 6.75M +1.7M (+33.6%) 59.81M +17.4M (+40.9%) 6.08% +1.514 pp 0.00% +0.000 pp USD8.73 +1.5% 18 qtrs
12 STATE STREET CORP 6.22M +2.9M (+84.8%) 55.10M +26.8M (+94.9%) 5.60% +2.560 pp 0.00% +0.001 pp USD8.30 +6.7% 18 qtrs
13 BALYASNY ASSET MANAGEMENT L.P. 5.28M +1.8M (+52.0%) 46.77M +17.6M (+60.3%) 4.76% +1.616 pp 0.06% +0.022 pp USD7.67 +15.5% 7 qtrs
14 GOLDMAN SACHS GROUP INC 4.94M +3.4M (+227.4%) 43.79M +31.1M (+245.4%) 4.45% +3.088 pp 0.01% +0.004 pp USD8.72 +1.6% 17 qtrs
15 LOGOS GLOBAL MANAGEMENT LP 4.20M +3.3M (+342.1%) 37.21M +29.2M (+366.3%) 3.78% +2.926 pp 2.25% +1.533 pp USD8.76 +1.1% 2 qtrs
16 BELLEVUE GROUP AG 3.93M +3.9M (+100.0%) 34.80M +34.8M (+100.0%) 3.54% +3.540 pp 0.66% +0.660 pp USD8.86 +0.0% 1 qtrs NEW
17 CALIGAN PARTNERS LP 3.73M +3.7M (+100.0%) 33.05M +33.0M (+100.0%) 3.36% +3.361 pp 2.72% +2.720 pp USD8.86 +0.0% 1 qtrs NEW
18 NANTAHALA CAPITAL MANAGEMENT, LLC 3.57M +1.8M (+97.4%) 31.65M +16.4M (+108.2%) 3.22% +1.582 pp 1.05% +0.519 pp USD6.03 +46.9% 5 qtrs
19 DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) 2.91M +2.9M (+100.0%) 25.76M +25.8M (+100.0%) 2.62% +2.620 pp 0.33% +0.329 pp USD8.86 +0.0% 1 qtrs NEW
20 FMR LLC 2.87M +2.9M (+44,524.2%) 25.41M +25.4M (+46,968.2%) 2.58% +2.578 pp 0.00% +0.001 pp USD8.86 +0.0% 18 qtrs
21 SUVRETTA CAPITAL MANAGEMENT, LLC 2.66M +2.7M (+100.0%) 23.59M +23.6M (+100.0%) 2.40% +2.399 pp 0.48% +0.483 pp USD8.86 +0.0% 1 qtrs NEW
22 JANUS HENDERSON GROUP PLC 2.64M +342.0K (+14.9%) 23.47M +4.2M (+21.5%) 2.38% +0.300 pp 0.01% +0.002 pp USD8.46 +4.7% 2 qtrs
23 GEODE CAPITAL MANAGEMENT, LLC 2.55M +670.9K (+35.6%) 22.63M +6.8M (+43.1%) 2.30% +0.598 pp 0.00% +0.000 pp USD8.20 +8.0% 18 qtrs
24 DEEP TRACK CAPITAL, LP 2.45M +1.0M (+68.7%) 21.75M +9.5M (+78.0%) 2.21% +0.896 pp 0.39% +0.047 pp USD8.59 +3.1% 2 qtrs
25 VIVO CAPITAL, LLC 2.15M +1.4M (+177.4%) 19.09M +12.6M (+192.6%) 1.94% +1.239 pp 1.23% +0.709 pp USD7.78 +13.9% 3 qtrs
26 POINT72 ASSET MANAGEMENT, L.P. 1.97M -945.4K (-32.4%) 17.49M -7.0M (-28.7%) 1.78% -0.862 pp 0.02% -0.022 pp USD8.40 +5.5% 2 qtrs
27 RTW INVESTMENTS, LP 1.49M +1.5M (+100.0%) 13.21M +13.2M (+100.0%) 1.34% +1.344 pp 0.13% +0.132 pp USD8.86 +0.0% 1 qtrs NEW
28 MORGAN STANLEY 1.42M +1.2M (+464.7%) 12.60M +10.5M (+495.6%) 1.28% +1.054 pp 0.00% +0.001 pp USD8.50 +4.2% 18 qtrs
29 FRANKLIN RESOURCES INC 1.40M +471.2K (+50.8%) 12.39M +4.6M (+59.1%) 1.26% +0.421 pp 0.00% +0.001 pp USD8.16 +8.6% 9 qtrs
30 D. E. SHAW & CO., INC. 1.03M +595.2K (+138.3%) 9.09M +5.5M (+151.3%) 0.92% +0.535 pp 0.01% +0.003 pp USD8.67 +2.2% 5 qtrs
31 AFFINITY ASSET ADVISORS, LLC 1.00M +1.0M (+100.0%) 8.86M +8.9M (+100.0%) 0.90% +0.901 pp 0.50% +0.505 pp USD8.86 +0.0% 1 qtrs NEW
32 UBS GROUP AG 990.5K +830.0K (+517.2%) 8.78M +7.4M (+551.0%) 0.89% +0.747 pp 0.00% +0.001 pp USD8.48 +4.5% 17 qtrs
33 BOOTHBAY FUND MANAGEMENT, LLC 957.3K +957.3K (+100.0%) 8.48M +8.5M (+100.0%) 0.86% +0.863 pp 0.13% +0.127 pp USD8.86 +0.0% 1 qtrs NEW
34 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 841.0K +182.7K (+27.8%) 7.45M +1.9M (+34.7%) 0.76% +0.162 pp 0.00% +0.000 pp USD8.31 +6.6% 18 qtrs
35 NORTHERN TRUST CORP 803.2K +197.6K (+32.6%) 7.12M +2.0M (+39.9%) 0.72% +0.176 pp 0.00% +0.000 pp USD7.06 +25.5% 18 qtrs
36 CANDRIAM S.C.A. 708.8K +— (+0.0%) 6.28M +326.3K (+5.5%) 0.64% -0.003 pp 0.03% +0.000 pp USD5.12 +73.0% 3 qtrs
37 ARROWMARK COLORADO HOLDINGS LLC 708.4K +— (+0.0%) 6.28M +325.9K (+5.5%) 0.64% -0.003 pp 0.14% +0.028 pp USD9.90 -10.5% 9 qtrs
38 BESSEMER GROUP INC 708.4K +— (+0.0%) 6.28M +325.0K (+5.5%) 0.64% -0.003 pp 0.01% +0.001 pp USD4.53 +95.6% 15 qtrs
39 BAIN CAPITAL LIFE SCIENCES INVESTORS, LLC 653.5K -2.1M (-75.9%) 5.79M -17.0M (-74.6%) 0.59% -1.865 pp 0.44% -1.069 pp USD12.37 -28.4% 18 qtrs
40 MILLENNIUM MANAGEMENT LLC 593.0K -702.4K (-54.2%) 5.25M -5.6M (-51.7%) 0.53% -0.638 pp 0.00% -0.002 pp USD2.25 +293.8% 16 qtrs
41 SPHERA FUNDS MANAGEMENT LTD. 544.6K +544.6K (+100.0%) 4.82M +4.8M (+100.0%) 0.49% +0.491 pp 0.93% +0.933 pp USD8.86 +0.0% 1 qtrs NEW
42 PERCEPTIVE ADVISORS LLC 513.0K +513.0K (+100.0%) 4.55M +4.5M (+100.0%) 0.46% +0.462 pp 0.08% +0.081 pp USD8.86 +0.0% 1 qtrs NEW
43 DIMENSIONAL FUND ADVISORS LP 487.1K -185.7K (-27.6%) 4.32M -1.3M (-23.6%) 0.44% -0.170 pp 0.00% 0.000 pp USD6.61 +34.0% 10 qtrs
44 BANK OF AMERICA CORP /DE/ 478.1K +322.6K (+207.5%) 4.24M +2.9M (+224.4%) 0.43% +0.290 pp 0.00% +0.000 pp USD8.39 +5.6% 17 qtrs
45 T. ROWE PRICE INVESTMENT MANAGEMENT, INC. 446.2K -3.1M (-87.3%) 3.95M -25.7M (-86.7%) 0.40% -2.788 pp 0.00% -0.016 pp USD7.94 +11.6% 9 qtrs
46 ROCK SPRINGS CAPITAL MANAGEMENT LP 386.9K +386.9K (+100.0%) 3.43M +3.4M (+100.0%) 0.35% +0.349 pp 0.18% +0.176 pp USD8.86 +0.0% 1 qtrs NEW
47 BARCLAYS PLC 368.2K +241.9K (+191.6%) 3.26M +2.3M (+235.5%) 0.33% +0.218 pp 0.00% +0.001 pp USD8.13 +9.0% 16 qtrs
48 BANK OF NEW YORK MELLON CORP 343.8K +151.5K (+78.8%) 3.05M +1.4M (+88.5%) 0.31% +0.136 pp 0.00% +0.000 pp USD7.15 +23.9% 18 qtrs
49 MARSHALL WACE, LLP 329.2K -1.2M (-77.9%) 2.92M -9.6M (-76.7%) 0.30% -1.051 pp 0.00% -0.010 pp USD1.37 +546.7% 8 qtrs
50 QUBE RESEARCH & TECHNOLOGIES LTD 318.7K +318.7K (+100.0%) 2.82M +2.8M (+100.0%) 0.29% +0.287 pp 0.00% +0.003 pp USD8.86 +0.0% 1 qtrs NEW
51 NUVEEN, LLC 300.4K -627.6K (-67.6%) 2.66M -5.1M (-65.9%) 0.27% -0.569 pp 0.00% -0.001 pp USD6.02 +47.2% 4 qtrs
52 GREAT LAKES ADVISORS, LLC 294.3K -129.5K (-30.6%) 2.61M -952.8K (-26.8%) 0.27% -0.118 pp 0.02% -0.009 pp USD8.40 +5.5% 2 qtrs
53 ACUTA CAPITAL PARTNERS, LLC 282.7K +282.7K (+100.0%) 2.51M +2.5M (+100.0%) 0.25% +0.255 pp 1.70% +1.701 pp USD8.86 +0.0% 1 qtrs NEW
54 VOLORIDGE INVESTMENT MANAGEMENT, LLC 255.1K -129.1K (-33.6%) 2.26M -966.9K (-30.0%) 0.23% -0.118 pp 0.01% -0.003 pp USD8.40 +5.5% 2 qtrs
55 CONGRESS ASSET MANAGEMENT CO /MA 234.6K +6.5K (+2.9%) 2.08M +162.6K (+8.5%) 0.21% +0.005 pp 0.01% +0.002 pp USD8.52 +4.0% 7 qtrs
56 WELLINGTON MANAGEMENT GROUP LLP 233.9K -19.4K (-7.7%) 2.07M -55.6K (-2.6%) 0.21% -0.018 pp 0.00% +0.000 pp USD8.40 +5.5% 2 qtrs
57 RAFFERTY ASSET MANAGEMENT, LLC 226.6K +81.3K (+55.9%) 2.01M +787.0K (+64.5%) 0.20% +0.073 pp 0.01% +0.003 pp USD8.57 +3.4% 2 qtrs
58 INTEGRAL HEALTH ASSET MANAGEMENT, LLC 200.0K +200.0K (+100.0%) 1.77M +1.8M (+100.0%) 0.18% +0.180 pp 0.09% +0.088 pp USD8.86 +0.0% 1 qtrs NEW
59 TRV GP VI, LLC 194.2K +— (+0.0%) 1.72M +89.3K (+5.5%) 0.18% -0.001 pp 1.16% -0.330 pp USD3.09 +186.7% 5 qtrs
60 FISHER ASSET MANAGEMENT, LLC 187.7K -22.7K (-10.8%) 1.66M -104.0K (-5.9%) 0.17% -0.021 pp 0.00% 0.000 pp USD7.05 +25.7% 9 qtrs
61 INVESCO LTD. 177.6K -854.3K (-82.8%) 1.57M -7.1M (-81.8%) 0.16% -0.774 pp 0.00% -0.001 pp USD8.11 +9.2% 15 qtrs
62 SQUAREPOINT OPS LLC 173.9K +173.9K (+100.0%) 1.54M +1.5M (+100.0%) 0.16% +0.157 pp 0.00% +0.002 pp USD8.86 +0.0% 1 qtrs NEW
63 CITADEL ADVISORS LLC 151.9K +151.9K (+100.0%) 1.35M +1.3M (+100.0%) 0.14% +0.137 pp 0.00% +0.000 pp USD8.86 +0.0% 18 qtrs
64 TWO SIGMA INVESTMENTS, LP 144.4K +— (+0.0%) 1.28M +66.4K (+5.5%) 0.13% -0.001 pp 0.00% +0.000 pp USD8.25 +7.4% 12 qtrs
65 ADAR1 CAPITAL MANAGEMENT, LLC 140.0K +140.0K (+100.0%) 1.24M +1.2M (+100.0%) 0.13% +0.126 pp 0.09% +0.091 pp USD8.86 +0.0% 1 qtrs NEW
66 CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD. 129.5K +129.5K (+100.0%) 1.15M +1.1M (+100.0%) 0.12% +0.117 pp 0.00% +0.003 pp USD8.86 +0.0% 1 qtrs NEW
67 RHUMBLINE ADVISERS 129.1K +21.3K (+19.7%) 1.14M +238.0K (+26.3%) 0.12% +0.019 pp 0.00% +0.000 pp USD5.43 +63.2% 15 qtrs
68 VERITION FUND MANAGEMENT LLC 121.8K +97.0K (+392.0%) 1.08M +871.1K (+418.9%) 0.11% +0.087 pp 0.00% +0.003 pp USD8.77 +1.0% 2 qtrs
69 WELLS FARGO & COMPANY/MN 121.2K +66.2K (+120.3%) 1.07M +611.7K (+132.4%) 0.11% +0.059 pp 0.00% +0.000 pp USD7.19 +23.2% 12 qtrs
70 GSA CAPITAL PARTNERS LLP 118.6K +118.6K (+100.0%) 1.05M +1.1M (+100.0%) 0.11% +0.107 pp 0.09% +0.091 pp USD8.86 +0.0% 1 qtrs NEW
71 ALLIANCEBERNSTEIN L.P. 106.5K +4.2K (+4.1%) 943.5K +84.4K (+9.8%) 0.10% +0.003 pp 0.00% +0.000 pp USD6.51 +36.1% 13 qtrs
72 TREXQUANT INVESTMENT LP 105.3K -93.8K (-47.1%) 932.7K -739.6K (-44.2%) 0.09% -0.085 pp 0.01% -0.009 pp USD8.40 +5.5% 2 qtrs
73 SWISS NATIONAL BANK 87.8K +87.8K (+100.0%) 777.9K +777.9K (+100.0%) 0.08% +0.079 pp 0.00% +0.001 pp USD8.86 +0.0% 1 qtrs NEW
74 PROFUND ADVISORS LLC 83.8K +52.5K (+167.7%) 742.1K +479.3K (+182.4%) 0.08% +0.047 pp 0.02% +0.014 pp USD8.69 +2.0% 2 qtrs
75 AQR CAPITAL MANAGEMENT LLC 82.2K +3.1K (+3.9%) 728.6K +63.5K (+9.6%) 0.07% +0.003 pp 0.00% +0.000 pp USD1.67 +430.5% 9 qtrs
76 DEUTSCHE BANK AG\ 74.2K +15.1K (+25.5%) 657.4K +160.6K (+32.3%) 0.07% +0.013 pp 0.00% +0.000 pp USD5.39 +64.4% 15 qtrs
77 TUDOR INVESTMENT CORP ET AL 68.3K +14.7K (+27.4%) 604.7K +154.7K (+34.4%) 0.06% +0.013 pp 0.00% +0.000 pp USD8.50 +4.2% 9 qtrs
78 MIRAE ASSET GLOBAL ETFS HOLDINGS LTD. 62.6K +22.2K (+55.0%) 551.9K +212.3K (+62.5%) 0.06% +0.020 pp 0.00% +0.000 pp USD7.92 +11.9% 7 qtrs
79 METLIFE INVESTMENT MANAGEMENT, LLC 59.7K +12.0K (+25.1%) 528.9K +128.0K (+31.9%) 0.05% +0.011 pp 0.00% +0.001 pp USD5.87 +50.9% 15 qtrs
80 Y-INTERCEPT (HONG KONG) LTD 59.3K +22.4K (+60.5%) 525.7K +215.2K (+69.3%) 0.05% +0.020 pp 0.01% +0.004 pp USD8.57 +3.4% 2 qtrs
81 PRICE T ROWE ASSOCIATES INC /MD/ 58.4K +17.8K (+43.7%) 518.0K +175.0K (+51.0%) 0.05% +0.016 pp 0.00% +0.000 pp USD7.57 +17.0% 10 qtrs
82 LOS ANGELES CAPITAL MANAGEMENT LLC 64.2K +47.1K (+273.8%) 512.0K +367.7K (+254.7%) 0.06% +0.042 pp 0.00% +0.001 pp USD7.76 +14.2% 5 qtrs
83 JPMORGAN CHASE & CO 56.8K +22.9K (+67.6%) 503.6K +218.7K (+76.8%) 0.05% +0.021 pp 0.00% +0.000 pp USD7.37 +20.2% 18 qtrs
84 DEKABANK DEUTSCHE GIROZENTRALE 60.0K +— (+0.0%) 502.0K +5.0K (+1.0%) 0.05% 0.000 pp 0.00% +0.000 pp USD11.26 -21.3% 10 qtrs
85 SEI INVESTMENTS CO 53.9K +43.9K (+436.9%) 477.8K +393.4K (+466.2%) 0.05% +0.040 pp 0.00% +0.000 pp USD8.77 +1.0% 4 qtrs
86 GRAHAM CAPITAL MANAGEMENT, L.P. 51.3K +51.3K (+100.0%) 454.7K +454.7K (+100.0%) 0.05% +0.046 pp 0.01% +0.011 pp USD8.86 +0.0% 1 qtrs NEW
87 CANADA PENSION PLAN INVESTMENT BOARD 50.4K +50.4K (+100.0%) 446.5K +446.5K (+100.0%) 0.05% +0.045 pp 0.00% +0.000 pp USD8.86 +0.0% 1 qtrs NEW
88 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 48.2K +43.4K (+906.9%) 427.1K +386.9K (+962.0%) 0.04% +0.039 pp 0.00% +0.000 pp USD8.70 +1.8% 17 qtrs
89 VOYA INVESTMENT MANAGEMENT LLC 47.8K +34.3K (+255.1%) 423.6K +310.5K (+274.5%) 0.04% +0.031 pp 0.00% +0.000 pp USD7.79 +13.7% 15 qtrs
90 46.1K +46.1K (+100.0%) 408.7K +408.7K (+100.0%) 0.04% +0.042 pp 0.14% +0.142 pp USD8.86 +0.0% 1 qtrs NEW
91 CREATIVE PLANNING 41.9K +6.7K (+18.9%) 371.3K +75.2K (+25.4%) 0.04% +0.006 pp 0.00% +0.000 pp USD8.47 +4.6% 2 qtrs
92 UBS ASSET MANAGEMENT AMERICAS INC 41.5K +41.5K (+100.0%) 367.3K +367.3K (+100.0%) 0.04% +0.037 pp 0.00% +0.000 pp USD8.86 +0.0% 1 qtrs NEW
93 LEGAL & GENERAL GROUP PLC 39.4K +33.0K (+511.8%) 349.4K +295.2K (+545.3%) 0.04% +0.030 pp 0.00% +0.000 pp USD8.30 +6.7% 17 qtrs
94 INTECH INVESTMENT MANAGEMENT LLC 38.9K +10.8K (+38.3%) 345.0K +108.5K (+45.9%) 0.04% +0.010 pp 0.00% +0.001 pp USD6.57 +34.9% 6 qtrs
95 XTX TOPCO LTD 37.8K +37.8K (+100.0%) 335.2K +335.2K (+100.0%) 0.03% +0.034 pp 0.01% +0.009 pp USD8.86 +0.0% 8 qtrs
96 CITIGROUP INC 36.2K +18.1K (+100.2%) 321.1K +169.0K (+111.1%) 0.03% +0.016 pp 0.00% +0.000 pp USD7.88 +12.4% 18 qtrs
97 JANNEY MONTGOMERY SCOTT LLC 36.0K +— (+0.0%) 319.0K +17.0K (+5.6%) 0.03% 0.000 pp 0.00% +0.000 pp USD4.53 +95.6% 18 qtrs
98 SUSQUEHANNA INTERNATIONAL GROUP, LLP 35.2K -53.6K (-60.4%) 312.0K -434.2K (-58.2%) 0.03% -0.049 pp 0.00% +0.000 pp USD4.55 +94.7% 17 qtrs
Ownership breakdown by holder

Insider Activity

Insider Activity — Latest Quarter
Ratio by transactions
1.00
Neutral
Ratio by volume
0.63
Neutral
Buys
4
Sells
4
Shares acquired
83.0K
Shares disposed
130.9K
Cash buys
Cash sales
2.00
Net activity
-47,960
Insider buys vs sells (history) From To
Recent insider transactions From To
Date Person Role Transaction A/D Security Shares Price Value Owned after D/I Filing
2026-05-01 Gall Matthew Officer A-Award A Stock Option (Right to Buy) 240,000 20.98 5.04M 240,000 D
2026-05-01 Crystal Adam Officer M-Exempt D Stock Option (Right to Buy) 27,000 5.20 140.4K 368,040 D
2026-04-29 Lee Sung Director A-Award A Common Stock 12,300 0.00 22,300 D
2026-04-15 Newcomb Jessica Officer Stock Option (Right to Buy) 10,000 3.13 31.3K 0 D
2026-04-15 Gall Matthew 0 0.00 0
2026-04-15 Crystal Adam Officer S-Sale D Common Stock 38,460 25.00 961.5K 112,622 D
2026-04-01 Crystal Adam Officer M-Exempt D Stock Option (Right to Buy) 27,000 5.20 140.4K 433,500 D
2026-03-25 Crystal Adam Officer M-Exempt D Stock Option (Right to Buy) 12,000 5.20 62.4K 460,500 D
2026-03-05 Crystal Adam Officer S-Sale D Common Stock 20,251 15.00 303.8K 112,622 D
2026-02-25 Crystal Adam Officer S-Sale D Common Stock 54,345 12.77 694.2K 132,873 D
2026-02-03 Weber Barbara Director / Officer S-Sale D Common Stock 30,186 12.26 370.0K 1,629,587 D
2026-02-03 Crystal Adam Officer S-Sale D Common Stock 18,251 12.26 223.7K 187,419 D
2026-02-03 Beckman Daniella Officer S-Sale D Common Stock 10,204 12.26 125.1K 184,410 D
2026-02-02 Weber Barbara Director / Officer A-Award A Common Stock 37,522 0.00 1,659,773 D
2026-02-02 Crystal Adam Officer A-Award A Stock Option (Right to Buy) 284,760 11.94 3.40M 284,760 D
2026-02-02 Beckman Daniella Officer A-Award A Common Stock 44,330 0.00 194,614 D
2026-01-08 Peters Malte Director / Officer A-Award A Stock Option (Right to Buy) 1,650,000 11.06 18.25M 1,650,000 D
2026-01-02 Lee Sung Director A-Award A Common Stock 10,000 0.00 10,000 D
2025-11-03 Peters Malte Director A-Award A Stock Option (Right to Buy) 150,000 8.01 1.20M 150,000 D
2025-10-23 Third Rock Ventures IV, L.P. 10% Owner S-Sale D Common Stock 477,401 10.15 4.85M 13,386,574 D
2025-09-25 Third Rock Ventures IV, L.P. 10% Owner S-Sale D Common Stock 500,000 8.02 4.01M 13,863,975 D
2025-09-16 Third Rock Ventures IV, L.P. 10% Owner S-Sale D Common Stock 363,541 7.04 2.56M 14,363,975 D
2025-09-08 Third Rock Ventures IV, L.P. 10% Owner S-Sale D Common Stock 86,459 7.04 608.6K 14,727,516 D
2025-09-05 Third Rock Ventures IV, L.P. 10% Owner S-Sale D Common Stock 642,906 7.00 4.50M 14,813,975 D
2025-08-22 Third Rock Ventures IV, L.P. 10% Owner S-Sale D Common Stock 302,194 7.00 2.12M 15,456,881 D
2025-08-19 Third Rock Ventures IV, L.P. 10% Owner S-Sale D Common Stock 1,100,000 7.01 7.71M 15,759,075 D
2025-06-05 Rothenberg Mace Director A-Award A Stock Option (Right to Buy) 37,500 3.51 131.6K 37,500 D
2025-06-05 Peters Malte Director A-Award A Common Stock 6,250 0.00 17,500 D
2025-06-05 Ketchum John B Director A-Award A Common Stock 6,250 0.00 20,937 D
2025-06-05 Calhoun Lesley Ann Director A-Award A Common Stock 6,250 0.00 12,500 D
2025-06-05 Borisy Alexis Director A-Award A Common Stock 6,250 0.00 17,500 D
2025-02-05 Weber Barbara Director / Officer S-Sale D Common Stock 9,013 3.16 28.5K 1,622,251 D
2025-02-05 Crystal Adam Officer S-Sale D Common Stock 6,851 3.16 21.7K 158,210 D
2025-02-05 Beckman Daniella Officer S-Sale D Common Stock 3,948 3.16 12.5K 150,284 D
2025-02-05 Barry Douglas Officer S-Sale D Common Stock 2,556 3.16 8.1K 66,014 D
2025-02-04 Weber Barbara Director / Officer S-Sale D Common Stock 9,778 2.99 29.2K 1,631,264 D
2025-02-04 Crystal Adam Officer S-Sale D Common Stock 7,432 2.99 22.2K 165,061 D
2025-02-04 Beckman Daniella Officer S-Sale D Common Stock 4,284 2.99 12.8K 154,232 D
2025-02-04 Barry Douglas Officer S-Sale D Common Stock 2,774 2.99 8.3K 68,570 D
2025-02-03 Weber Barbara Director / Officer A-Award A Common Stock 105,875 0.00 1,641,042 D
2025-02-03 Crystal Adam Officer A-Award A Common Stock 53,015 0.00 172,493 D
2025-02-03 Beckman Daniella Officer A-Award A Stock Option (Right to Buy) 156,713 2.91 456.0K 156,713 D
2025-02-03 Barry Douglas Officer A-Award A Common Stock 27,363 0.00 71,344 D
2024-11-18 Rothenberg Mace Director P-Purchase A Common Stock 10,000 3.78 37.8K 31,250 D
2024-11-14 Rothenberg Mace Director P-Purchase A Common Stock 10,000 3.62 36.2K 21,250 D
2024-11-07 EcoR1 Capital, LLC 10% Owner S-Sale D Common Stock 62,318 3.29 205.1K 11,773,860 I
2024-11-06 EcoR1 Capital, LLC 10% Owner S-Sale D Common Stock 1,494,558 3.28 4.90M 11,836,178 I
2024-11-06 Boxer Capital Management, LLC Other S-Sale D Common Stock 3,080,000 3.14 9.67M 3,610,642 I
2024-10-25 Boxer Capital Management, LLC Other S-Sale D Common Stock 633,000 6.87 4.35M 6,690,642 D
2024-10-22 Boxer Capital Management, LLC Other S-Sale D Common Stock 250,000 6.78 1.70M 7,323,642 D
2024-10-21 Boxer Capital Management, LLC Other S-Sale D Common Stock 625,000 7.05 4.41M 7,573,642 D
2024-10-10 Boxer Capital Management, LLC Other Common Stock 0 0.00 8,198,642 I
2024-09-13 Third Rock Ventures IV, L.P. 10% Owner S-Sale D Common Stock 67,400 10.53 709.8K 16,859,075
2024-09-05 Third Rock Ventures IV, L.P. 10% Owner S-Sale D Common Stock 75,000 11.56 867.1K 16,926,475
2024-09-03 Davis Aaron I. Other J-Other A Stock Option (Right to Buy) 65,000 10.93 710.5K 65,000
2024-08-30 Third Rock Ventures IV, L.P. 10% Owner S-Sale D Common Stock 175,000 11.60 2.03M 17,001,475
2024-08-27 Third Rock Ventures IV, L.P. 10% Owner S-Sale D Common Stock 25,000 11.55 288.7K 17,176,475
2024-08-19 Third Rock Ventures IV, L.P. 10% Owner S-Sale D Common Stock 150,000 10.09 1.51M 17,201,475
2024-08-16 Third Rock Ventures IV, L.P. 10% Owner S-Sale D Common Stock 135,000 9.79 1.32M 17,351,475
2024-08-01 Third Rock Ventures IV, L.P. 10% Owner S-Sale D Common Stock 40,000 9.80 392.0K 17,486,475
2024-07-31 Third Rock Ventures IV, L.P. 10% Owner S-Sale D Common Stock 100,000 9.93 993.4K 17,526,475
2024-07-30 Third Rock Ventures IV, L.P. 10% Owner S-Sale D Common Stock 95,000 9.80 931.1K 17,626,475
2024-07-26 Third Rock Ventures IV, L.P. 10% Owner S-Sale D Common Stock 50,000 9.84 492.0K 17,721,475
2024-07-25 Third Rock Ventures IV, L.P. 10% Owner S-Sale D Common Stock 100,599 9.87 992.8K 17,771,475
2024-07-24 Third Rock Ventures IV, L.P. 10% Owner S-Sale D Common Stock 200,000 9.82 1.96M 17,872,074
2024-07-23 Third Rock Ventures IV, L.P. 10% Owner S-Sale D Common Stock 125,000 9.79 1.22M 18,072,074
2024-07-22 Third Rock Ventures IV, L.P. 10% Owner S-Sale D Common Stock 262,740 9.78 2.57M 18,197,074
2024-07-18 Third Rock Ventures IV, L.P. 10% Owner S-Sale D Common Stock 191,490 9.81 1.88M 18,459,814
2024-07-17 Third Rock Ventures IV, L.P. 10% Owner S-Sale D Common Stock 550,171 9.79 5.39M 18,651,304
2024-07-02 MVA Investors, LLC Other S-Sale D Common Stock 95,000 8.68 824.6K 108,793
2024-07-01 MVA Investors, LLC Other S-Sale D Common Stock 110,731 8.87 982.2K 203,793
2024-06-28 MVA Investors, LLC Other S-Sale D Common Stock 29,000 8.57 248.5K 314,524
2024-06-07 MVA Investors, LLC Other S-Sale D Common Stock 77,000 6.88 529.8K 343,524
2024-06-06 MVA Investors, LLC Other S-Sale D Common Stock 63,000 7.24 456.1K 420,524
2024-06-05 Rothenberg Mace Director A-Award A Stock Option (Right to Buy) 37,500 7.41 277.9K 37,500
2024-06-05 Peters Malte Director A-Award A Stock Option (Right to Buy) 37,500 7.41 277.9K 37,500
2024-06-05 Ketchum John B Director A-Award A Stock Option (Right to Buy) 28,125 7.41 208.4K 28,125
2024-06-05 Calhoun Lesley Ann Director A-Award A Stock Option (Right to Buy) 37,500 7.41 277.9K 37,500
2024-06-05 Borisy Alexis Director A-Award A Common Stock 6,250 0.00 11,250
2024-05-03 MVA Investors, LLC Other S-Sale D Common Stock 60,000 7.61 456.6K 483,524
2024-05-02 MVA Investors, LLC Other S-Sale D Common Stock 75,000 7.56 567.0K 543,524
2024-05-01 MVA Investors, LLC Other S-Sale D Common Stock 75,000 7.43 557.3K 618,524
2024-02-20 Third Rock Ventures IV, L.P. 10% Owner S-Sale D Common Stock 162,500 12.00 1.95M 19,201,475
2024-02-07 Weber Barbara Director / Officer S-Sale D Common Stock 4,457 12.62 56.2K 1,535,167
2024-02-07 Crystal Adam Officer S-Sale D Common Stock 4,083 12.62 51.5K 119,478
2024-02-07 Beckman Daniella Officer S-Sale D Common Stock 1,817 12.62 22.9K 132,397
2024-02-07 Barry Douglas Officer S-Sale D Common Stock 1,354 12.62 17.1K 43,981
2024-02-06 Weber Barbara Director / Officer S-Sale D Common Stock 4,681 12.56 58.8K 1,539,624
2024-02-06 Crystal Adam Officer S-Sale D Common Stock 4,288 12.56 53.9K 123,561
2024-02-06 Beckman Daniella Officer S-Sale D Common Stock 1,908 12.56 24.0K 134,214
2024-02-06 Barry Douglas Officer S-Sale D Common Stock 1,422 12.56 17.9K 45,335
2024-02-01 Weber Barbara Director / Officer A-Award A Stock Option (Right to Buy) 523,012 12.28 6.42M 523,012
2024-02-01 Crystal Adam Officer A-Award A Common Stock 46,599 0.00 46,599
2024-02-01 Beckman Daniella Officer A-Award A Common Stock 39,413 0.00 39,413
2024-02-01 Barry Douglas Officer A-Award A Common Stock 22,859 0.00 22,859
2023-11-06 Pothula Kanishka 0 0.00 0
2023-11-01 Crystal Adam Officer S-Sale D Common Stock 7,507 8.39 63.0K 81,250
2023-10-16 Boxer Capital, LLC Other P-Purchase A Common Stock 500,000 6.84 3.42M 8,198,642 D
2023-10-13 EcoR1 Capital, LLC 10% Owner I Common Stock 0 0.00 13,330,736
2023-10-13 Boxer Capital, LLC Other P-Purchase A Common Stock 750,000 7.07 5.30M 7,698,642 D
2023-10-09 Boxer Capital, LLC S-Sale D Common Stock 175,000 9.97 1.74M 6,948,642
2023-08-29 Ketchum John B 0 0.00 0
2023-08-11 Third Rock Ventures VI, L.P. Director D Common Stock 0 0.00 194,174
2023-08-11 Boxer Capital, LLC P-Purchase A Prefunded Warrant 2,340,579 0.00 2,340,597
2023-06-06 Rothenberg Mace Director A-Award A Common Stock 5,000 0.00 5,000
2023-06-06 Peters Malte Director A-Award A Common Stock 5,000 0.00 5,000
2023-06-06 Huber Reid M Director A-Award A Common Stock 5,000 0.00 5,000
2023-06-06 Davis Aaron I. Director A-Award A Common Stock 5,000 0.00 5,000
2023-06-06 Calhoun Lesley Ann Director A-Award A Common Stock 5,000 0.00 5,000
2023-06-06 Borisy Alexis Director A-Award A Common Stock 5,000 0.00 5,000
2023-03-01 Weber Barbara Director / Officer A-Award A Stock Option (Right to Buy) 537,273 5.20 2.79M 537,273
2023-03-01 Huang Alan Officer A-Award A Stock Option (Right to Buy) 190,181 5.20 988.9K 190,181
2023-03-01 Crystal Adam Officer A-Award A Common Stock 81,250 0.00 81,250
2023-03-01 Beckman Daniella Officer A-Award A Common Stock 32,842 0.00 96,709
2023-03-01 Barry Douglas Officer A-Award A Common Stock 23,898 0.00 23,898
2023-02-27 Crystal Adam Officer 0 0.00 0
2022-12-01 Weitzman Aaron Officer A-Award A Stock Option (Right to Buy) 350,000 0.00 350,000
2022-10-13 Davis Aaron I. Director P-Purchase A Common Stock 70,000 4.65 325.2K 7,123,642
2022-10-13 Boxer Capital, LLC 10% Owner P-Purchase A Common Stock 70,000 4.65 325.2K 7,123,642
2022-10-12 Davis Aaron I. Director P-Purchase A Common Stock 50,000 4.43 221.6K 268,524
2022-10-12 Boxer Capital, LLC 10% Owner P-Purchase A Common Stock 50,000 4.43 221.6K 268,524
2022-10-11 Davis Aaron I. Director P-Purchase A Common Stock 117,000 4.25 497.7K 218,524
2022-10-11 Boxer Capital, LLC 10% Owner P-Purchase A Common Stock 117,000 4.25 497.7K 218,524
2022-10-06 LEWIS JOSEPH Director P-Purchase A Common Stock 70,394 4.06 286.1K 7,053,642
2022-10-06 Boxer Capital, LLC 10% Owner P-Purchase A Common Stock 70,394 4.06 286.1K 7,053,642
2022-10-05 LEWIS JOSEPH Director P-Purchase A Common Stock 40,500 3.84 155.4K 6,983,248
2022-10-05 Boxer Capital, LLC 10% Owner P-Purchase A Common Stock 40,500 3.84 155.4K 6,983,248
2022-10-04 LEWIS JOSEPH Director P-Purchase A Common Stock 25,606 3.67 94.0K 6,897,248
2022-10-04 Boxer Capital, LLC 10% Owner P-Purchase A Common Stock 25,606 3.67 94.0K 6,897,248
2022-06-08 Rothenberg Mace Director A-Award A Stock Option (Right to Buy) 40,000 0.00 40,000
2022-06-08 Peters Malte Director A-Award A Stock Option (Right to Buy) 40,000 0.00 40,000
2022-06-08 Huber Reid M Director A-Award A Stock Option (Right to Buy) 40,000 0.00 40,000
2022-06-08 Davis Aaron I. Director A-Award A Stock Option (Right to Buy) 40,000 5.90 236.0K 40,000
2022-06-08 Calhoun Lesley Ann Director A-Award A Stock Option (Right to Buy) 40,000 5.90 236.0K 40,000
2022-06-08 Borisy Alexis Director A-Award A Stock Option (Right to Buy) 40,000 5.90 236.0K 40,000
2022-02-01 Weber Barbara Director / Officer A-Award A Stock Option (Right to Buy) 625,000 9.22 5.76M 625,000
2022-02-01 Huang Alan Officer A-Award A Stock Option (Right to Buy) 200,000 9.22 1.84M 200,000
2022-02-01 Beckman Daniella Officer A-Award A Stock Option (Right to Buy) 150,000 9.22 1.38M 150,000
2022-02-01 Barry Douglas Officer A-Award A Stock Option (Right to Buy) 69,500 9.22 640.8K 69,500
2021-11-01 Rudoltz Marc Officer A-Award A Stock Option (Right to Buy) 350,000 12.91 4.52M 350,000
2021-10-18 Rudoltz Marc Officer 0 0.00 0
2021-10-14 Barry Douglas Officer D Stock Option (Right to Buy) 246,296 9.56 2.35M 0
2021-08-12 Weber Barbara Director / Officer A-Award A Stock Option (Right to Buy) 961,403 9.56 9.19M 961,403
2021-08-12 Huang Alan Officer A-Award A Stock Option (Right to Buy) 169,859 9.56 1.62M 169,859
2021-08-12 Beckman Daniella Officer A-Award A Stock Option (Right to Buy) 380,485 9.56 3.64M 380,485
2021-08-10 Weber Barbara Director / Officer D Stock Option (Right to Buy) 219,164 1.65 361.2K 0
2021-08-10 Third Rock Ventures IV, L.P. 10% Owner D Common Stock 0 0.00 19,363,975
2021-08-10 Rothenberg Mace Director D Stock Option (Right to Buy) 84,929 7.57 642.5K 0
2021-08-10 Peters Malte Director D Stock Option (Right to Buy) 118,901 1.38 164.4K 0
2021-08-10 Huber Reid M Director 0 0.00 0
2021-08-10 Huang Alan Officer D Stock Option (Right to Buy) 67,944 3.50 238.0K 0
2021-08-10 Calhoun Lesley Ann Director D Stock Option (Right to Buy) 84,929 7.57 642.5K 0
2021-08-10 Braslyn Ltd. 10% Owner D Common Stock 0 0.00 26,961
2021-08-10 Boxer Capital, LLC 10% Owner D Common Stock 0 0.00 101,524
2021-08-10 Borisy Alexis Director D Stock Option (Right to Buy) 131,471 1.53 201.3K 0
2021-08-10 Beckman Daniella Officer D Stock Option (Right to Buy) 165,443 1.53 253.3K 0
2021-08-10 BCTG Holdings, LLC 10% Owner D Common Stock 0 0.00 6,988,450
2020-11-20 BCTG Holdings, LLC 10% Owner S-Sale D Common Stock 2,500 0.01 15.00 4,490,950
2020-10-06 Avery James B Director 0 0.00 0
2020-09-08 BCTG Holdings, LLC 10% Owner P-Purchase A Common Stock 533,500 10.00 5.34M 4,493,450
2020-09-02 Nuechterlein Carole Director 0 0.00 0
2020-09-02 Heyman Richard A. Director D Common Stock 0 0.00 40,600
2020-09-02 Fuglesang Christopher Director / Officer 0 0.00 0
2020-09-02 Ellis Andrew Ruel Officer 0 0.00 0
2020-09-02 Davis Aaron I. Director / Officer 0 0.00 0
2020-09-02 Christensen Jamie Director D Common Stock 0 0.00 40,600
2020-09-02 Beauchamp Michael Officer 0 0.00 0
2020-09-02 BCTG Holdings, LLC 10% Owner D Common Stock 0 0.00 3,959,950
2020-09-02 BAUM CHARLES M Director D Common Stock 0 0.00 40,600

Executive team

Top executives
EBIT / Employee
-718.0K
Shares Outstanding
116.17M

Executive compensation

Executive compensation (annual)
# Year Executive Salary Bonus Stock award Option award Incentive Other Total % Stock-
based
Filing
1 2025 Barbara Weber, M.D. Executive Chairman 698.0K 308.1K 1.28M 524.3K 18.4K 2.82M 56.07%
2 2025 Adam Crystal, M.D., Ph.D. President of Research and Development 588.6K 154.3K 638.6K 321.5K 18.1K 1.72M 46.07%
3 2025 Daniella Beckman Former Chief Financial Officer 502.9K 76.0K 314.6K 244.1K 18.2K 1.16M 33.80%
4 2024 Barbara Weber, M.D. President, Chief Executive Officer and Director 660.0K 1.07M 4.35M 447.5K 18.0K 6.54M 82.79%
5 2024 Barbara Weber, M.D. Executive Chairman 660.0K 1.07M 4.35M 447.5K 18.0K 6.54M 82.79%
6 2024 Adam Crystal, M.D., Ph.D. President of Research and Development 569.3K 572.2K 2.32M 297.1K 15.8K 3.78M 76.65%
7 2024 Daniella Beckman Former Chief Financial Officer 486.3K 484.0K 1.96M 213.5K 17.8K 3.17M 77.34%
8 2024 Daniella Beckman Chief Financial Officer 486.3K 484.0K 1.96M 213.5K 17.8K 3.17M 77.34%
9 2024 Douglas Barry Chief Legal Officer 451.2K 280.7K 1.14M 204.8K 18.2K 2.09M 67.81%
10 2023 Barbara Weber, M.D. President, Chief Executive Officer and Director 626.0K 465.6K 1.89M 396.6K 17.2K 3.39M 69.34%
11 2023 Barbara Weber, M.D. Executive Chairman 626.0K 465.6K 1.89M 396.6K 17.2K 3.39M 69.34%
12 2023 Adam Crystal, M.D., Ph.D. President of Research and Development 454.8K 275.0K 422.5K 1.71M 242.8K 4.6K 3.11M 68.58%
13 2023 Alan Huang, Ph.D. Former Chief Scientific Officer 350.6K 197.8K 807.0K 330.0K 85.4K 1.77M 56.74%
14 2023 Daniella Beckman Chief Financial Officer 441.8K 170.8K 691.6K 210.0K 8.6K 1.52M 56.63%
15 2023 Daniella Beckman Former Chief Financial Officer 441.8K 170.8K 691.6K 210.0K 8.6K 1.52M 56.63%
16 2022 Barbara Weber, M.D. President, Chief Executive Officer and Director 575.0K 3.74M 363.7K 2.5K 4.68M 79.90%
17 2022 Alan Huang, Ph.D. Former Chief Scientific Officer 425.4K 1.20M 193.6K 3.0K 1.82M 65.81%
18 2022 Alan Huang, Ph.D. Chief Scientific Officer 425.4K 1.20M 193.6K 3.0K 1.82M 65.81%
19 2022 Daniella Beckman Chief Financial Officer 425.1K 897.8K 191.6K 2.4K 1.52M 59.18%
20 2021 Barbara Weber, M.D. President, Chief Executive Officer and Director 513.7K 10.72M 277.9K 4.6K 11.52M 93.09%
21 2021 Daniella Beckman Chief Financial Officer 377.9K 2.63M 164.6K 3.3K 3.18M 82.82%
22 2021 Alan Huang, Ph.D. Chief Scientific Officer 394.8K 1.65M 168.3K 3.4K 2.22M 74.43%
23 2020 Barbara Weber, M.D. President, Chief Executive Officer and Director 491.6K 227.6K 226.2K 12.8K 958.2K 23.75%
24 2020 Daniella Beckman Chief Financial Officer 323.4K 368.3K 131.8K 10.8K 834.4K 44.14%
25 2020 Alan Huang, Ph.D. Chief Scientific Officer 373.8K 70.6K 135.8K 9.4K 589.5K 11.97%
CEO compensation breakdown

Proxy statements

Proxy statements (DEF 14A)
Filing date Form type Filing
2026-04-17 DEFA14A
2026-04-17 DEF 14A
2025-04-22 DEFA14A
2025-04-21 DEF 14A
2025-04-11 PRE 14A

Recent SEC filings

Recent SEC filings
Filing date Form type Filing
2026-05-13 SC 13G/A
2026-05-13 8-K
2026-05-13 10-Q
2026-05-11 SC 13G/A
2026-05-08 8-K
2026-05-06 SC 13G
2026-05-05 4
2026-05-05 4
2026-05-04 SC 13G/A
2026-05-01 4

Executive team

NameTitleCompensationGender
Barbara L. Weber Founder & Executive Chair 1M
Adam S. Crystal President of Research & Development 928.2K
Matthew Gall Chief Financial Officer 717.6K male
Daniella Beckman Chief Financial Officer 717.6K female
Malte Peters President, Chief Executive Officer & Director 148.3K
Julie Carretero Chief Human Resources Officer female
Julie Fogarty Vice President of Legal & Corporate Secretary female
Michael Palmieri Chief Technical Operations Officer
Philippe Serrano Chief Regulatory Officer
William G. Kaelin Jr. Founder & Member of Scientific Advisory Board
Alan Ashworth Founder & Member of Scientific Advisory Board
Antoni Ribas Founder & Member of Scientific Advisory Board
ESG Rating
B
BIOTECHNOLOGY
Rank: 142 out of 662
2026
E (Environmental)
56.6 / 56.3
Company / Sector avg.
S (Social)
70.1 / 62.4
Company / Sector avg.
G (Governance)
73.1 / 60.9
Company / Sector avg.
ESG Total
66.6 / 59.9
Company / Sector avg.
ESG Score History BIOTECHNOLOGY
Benchmark vs Sector
Senate Trading Activity

No Senate trading activity found for this company.

House Trading Activity

No House trading activity found for this company.

Market share among peers
Peer comparison — filtered group (TTM)
Your opinion

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Dividend history

Earnings history

Earnings reports

Stock splits