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TScan Therapeutics, Inc. (TCRX)

USD0.91 -0.02 (-1.81%)
US NASDAQ Healthcare Biotechnology
Address 830 Winter Street 2451
Waltham, MA, US
CEO Gavin MacBeath
Website tscan.com
IPO 2021-07-16
CIK 1783328 ISIN US89854M1018

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Description

TScan Therapeutics, Inc., a clinical-stage biotechnology company, develops T cell receptor-engineered T cell (TCR-T) therapies for the treatment of patients with cancer in the United States. The company’s lead product is TSC-101, for the treatment of patients with acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), and acute lymphoblastic leukemia (ALL) in patients undergoing allogeneic hematopoietic cell transplantation (HCT), which is in Phase I clinical trial, as well as eliminates residual disease and promotes donor chimerism. It also develops TSC-102-A01 and TSC-102-A03, which are allogeneic and donor-derived TCR-T therapy candidates targeting epitopes. In addition, the company develops TSC-200, TSC-201, TSC-202, TSC-203, and TSC-204 for the treatment of solid tumors. It has a research collaboration and license agreement with Amgen Inc. to identify antigens recognized by T cells in patients with Crohn’s disease. TScan Therapeutics, Inc. was incorporated in 2018 and is headquartered in Waltham, Massachusetts.

Market Cap & Enterprise Value
Merger & Acquisition History

No mergers or acquisitions recorded for this company.

Technical Outlook
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Signal Summary Loading…
Indicator 1D1W2W3W1M
Each column is computed on that timeframe's candles (1D = daily, 1W ≈ weekly, 1M ≈ monthly), not on the same last day. ▲ bullish · ▼ bearish · — neutral. The Net row counts signals per column; hover any cell (or the indicator name) to see the exact rule behind it.
Day Score & sub-scores
Statistical fingerprint & regime detail
Conditional historical analysis
Customize analysis (advanced)
Indicative levels generated algorithmically. Not financial advice.
Risk Profile
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Price Chart
Averages
Trend
Price
Levels
Draw
USD0.91 -0.02 (-1.81%)
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Volume Profile
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Liquidity & share structure
Average Volume
873.2K
Beta
1.03
Float Shares
47.79M
Free Float %
85.6%
Price Performance
1D5D1M3M6M YTD1Y3Y5Y10YMax
-6.35% -6.35% +12.38% +26.30% -0.84% +18.00% -13.87% -69.97% -88.76% -88.76% -88.76%
Rolling Volatility
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Drawdown
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Relative Strength
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Monthly Returns Heatmap
From To
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Annual Monthly Returns
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Daily Returns Distribution
vs.
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Revenue flow

Revenue by geography

Revenue by segment

From To

Revenue composition

From To

By product

By geography

Financial Statements

Income Statement

Balance Sheet

Cash Flow Statement

Key Metrics

Financial Ratios

Employees

Financial Growth (CAGR)

Market Data

Analyst Consensus (8 ratings, all time) Buy
Price Targets & DCF
Current price
0.91
Low 3.00 +228.5%
Consensus 7.50 +721.3%
Median 7.50 +721.3%
High 12.00 +1,214.1%
Ratings Trend (MoM) 83% Bullish
Rating 2026-05 Change
Strong Buy 1 0
Buy 4 0
Hold 1 0
Sell 0 0
Strong Sell 0 0
Price Target Summary
Period # Analysts Avg Target
Last Month
Last Quarter
Last Year
All Time 2
7.50
+721.3%
Quality scores
Altman Z-Score
-4.59
Distress
Piotroski F-Score
2 / 9
Weak
MOAT Score
1 / 10
No MOAT
Composite Rating
C
Overall Score
2 / 5
Medium
DCF Score
3 / 5
Medium
ROE Score
1 / 5
Low
ROA Score
1 / 5
Low
D/E Score
1 / 5
Low
P/E Score
1 / 5
Low
P/Book Score
4 / 5
High
Operational MOAT
✗ Below peers
  • Revenue growth Biotechnology: +1.6%
    +266.7% Q1'26: -54.8% (vs Q1'25)
  • EPS growth Biotechnology: +29.7%
    +12.3% Q1'26: +15.4% (vs Q1'25)
  • FCF margin FCF growth · Biotechnology: +16.2%
    -1,518.3% Q1'26: -2,479.5% (vs Q1'25)
  • EBIT margin Biotechnology: +0.0%
    -1,315.4% Q1'26: -2,967.3% (vs Q1'25)
  • ROIC Biotechnology: -16.1%
    -209.4% Q1'26: -405.4% (vs Q1'25)
  • Share dilution Biotechnology: -3.4%
    +16.0% Q1'26: +0.2% (vs Q1'25)
  • Debt / EBITDA Net debt/EBITDA · Biotechnology: 0.16×
    -0.71× Q1'26: -0.53× (vs Q1'25)
Valuation Multiples From To
Price Forecast (3Y) From To
Model
Adjust
P/E
Theoretical Return — If Invested Today

* These projections are based on analyst consensus estimates and user-defined valuation multiples. This table is for informational purposes only and does not constitute a recommendation to buy or sell any security. Past performance is not indicative of future results.

DCF Interactive Model (UFCF)
Projection years:
Market assumptions
WACC components (optional)
Ke (Cost of Equity) = Rf + β (1.06) × ERP
WACC = 63% × Ke + 37% × Kd (4.0%) × (1−t)

Modifying these values recalculates WACC automatically.

Business assumptions
Current price: 0.91
Enterprise Value: Equity Value: Terminal Value: TV as % of EV:

Base values reflect the latest available data for this company and market conditions.

Consensus Estimates
Metric Dec 2021
actual
Dec 2022
actual
Dec 2023
actual
Dec 2024
actual
Dec 2025
actual
Dec 2026
3 Rev. Ana.
4 EPS Ana.
Dec 2027
3 Rev. Ana.
4 EPS Ana.
Dec 2028
4 Rev. Ana.
3 EPS Ana.
Dec 2029
3 Rev. Ana.
1 EPS Ana.
Dec 2030
3 Rev. Ana.
1 EPS Ana.
Revenue
10.14M
est: 11.32M (-10.4%)
13.54M
est: 13.89M (-2.6%)
21.05M
est: 12.20M (+72.5%)
2.82M
est: 3.61M (-22.0%)
10.33M
est: 11.15M (-7.4%)
7.56M
1.09M – 12.10M
-32.2% YoY
7.81M
6.74M – 8.87M
+3.3% YoY
26.27M
19.23M – 32.54M
+236.5% YoY
49.07M
35.91M – 60.78M
+86.8% YoY
86.48M
63.29M – 107.12M
+76.2% YoY
EBITDA
-45.30M
est: -11.32M (-300.2%)
-59.91M
est: -13.89M (-331.2%)
-80.10M
est: -12.20M (-556.5%)
-119.74M
est: -3.61M (-3,218.2%)
-132.95M
est: -11.15M (-1,092.2%)
-7.56M
-12.10M – -1.09M
+32.2% YoY
-7.81M
-8.87M – -6.74M
-3.3% YoY
-26.27M
-32.54M – -19.23M
-236.5% YoY
-49.07M
-60.78M – -35.91M
-86.8% YoY
-86.48M
-107.12M – -63.29M
-76.2% YoY
EBIT
-48.63M
est: -11.32M (-329.6%)
-65.05M
est: -13.89M (-368.2%)
-85.46M
est: -12.20M (-600.5%)
-123.85M
est: -3.61M (-3,332.1%)
-135.81M
est: -11.15M (-1,117.9%)
-7.56M
-12.10M – -1.09M
+32.2% YoY
-7.81M
-8.87M – -6.74M
-3.3% YoY
-26.27M
-32.54M – -19.23M
-236.5% YoY
-49.07M
-60.78M – -35.91M
-86.8% YoY
-86.48M
-107.12M – -63.29M
-76.2% YoY
Net Income
-48.63M
est: -715.84M (+93.2%)
-66.22M
est: -322.61M (+79.5%)
-89.22M
est: -251.24M (+64.5%)
-127.50M
est: -164.51M (+22.5%)
-129.77M
est: -157.73M (+17.7%)
-115.07M
-210.73M – -104.76M
+27.0% YoY
-124.82M
-153.73M – -107.00M
-8.5% YoY
-127.31M
-136.33M – -93.89M
-2.0% YoY
-85.71M
-112.30M – -55.83M
+32.7% YoY
-52.38M
-68.62M – -34.12M
+38.9% YoY
SGA
13.83M
est: 47.06M (-70.6%)
20.35M
est: 57.76M (-64.8%)
25.49M
est: 43.12M (-40.9%)
29.56M
est: 12.75M (+131.7%)
31.99M
est: 39.42M (-18.8%)
26.71M
3.87M – 42.77M
-32.2% YoY
27.60M
23.82M – 31.34M
+3.3% YoY
92.86M
67.96M – 115.01M
+236.5% YoY
173.45M
126.94M – 214.84M
+86.8% YoY
305.68M
223.71M – 378.61M
+76.2% YoY
EPS
-2.03
est: -6.39 (+68.2%)
-2.74
est: -2.76 (+0.7%)
-1.36
est: -1.97 (+31.1%)
-1.14
est: -1.27 (+10.4%)
-1.00
est: -1.21 (+17.7%)
-1.02
-1.62 – -0.81
+16.0% YoY
-0.97
-1.18 – -0.82
+5.3% YoY
-0.86
-1.05 – -0.72
+11.5% YoY
-0.66
-0.86 – -0.43
+22.8% YoY
-0.40
-0.53 – -0.26
+38.9% YoY
Historical Ratings (3M)
Date Rating Overall DCF ROE ROA D/E P/E P/B
2026-05-06 C 2/5 3/5 1/5 1/5 1/5 1/5 4/5
2026-05-05 C 2/5 3/5 1/5 1/5 1/5 1/5 4/5
2026-05-04 C 2/5 3/5 1/5 1/5 1/5 1/5 4/5
2026-05-01 C 2/5 3/5 1/5 1/5 1/5 1/5 4/5
2026-04-30 C 2/5 3/5 1/5 1/5 1/5 1/5 4/5
2026-04-29 C 2/5 3/5 1/5 1/5 1/5 1/5 4/5
2026-04-28 C 2/5 3/5 1/5 1/5 1/5 1/5 4/5
2026-04-27 C 2/5 3/5 1/5 1/5 1/5 1/5 4/5
2026-04-24 C 2/5 3/5 1/5 1/5 1/5 1/5 4/5
2026-04-23 C 2/5 3/5 1/5 1/5 1/5 1/5 4/5
2026-04-22 C 2/5 3/5 1/5 1/5 1/5 1/5 4/5
2026-04-21 C 2/5 3/5 1/5 1/5 1/5 1/5 4/5
2026-04-20 C 2/5 3/5 1/5 1/5 1/5 1/5 4/5
2026-04-17 C+ 2/5 4/5 1/5 1/5 1/5 1/5 4/5
2026-04-16 C+ 2/5 4/5 1/5 1/5 1/5 1/5 4/5

Owner Earnings

Owner's Earnings (history) From To
Owner alignment
Owner's Earnings TTM
-109.24M
OE per share TTM
-0.84
Owner's Yield
-67.27%
Maintenance CapEx ratio
Maint CapEx / Avg PPE
421.0%

Ownership Overview

Ownership breakdown
At a glance
Institutional holders
59
Total invested
30.69M
Insider transactions (90d)
0
Beneficial owners (>5%)
25
Beneficial owners (>5%)
# Reporting person Amount owned % of class Sole voting Shared voting Sole dispositive Shared dispositive Type Citizenship Filing date SEC filing
1 Lynx1 Capital Management LP 5.22M 12.20% 5.22M PN Delaware 2023-06-02
2 Weston Nichols 5.22M 12.20% 5.22M IN Delaware 2023-06-02
3 EcoR1 Capital, LLC 5.00M 11.00% 5.00M 5.00M IA, OO Delaware 2023-06-05
4 Oleg Nodelman 5.00M 11.00% 5.00M 5.00M HC, IN Delaware 2023-06-05
5 EcoR1 Capital Fund Qualified, L.P. 4.64M 11.00% 4.64M 4.64M PN Delaware 2023-06-05
6 (1) BlackRock, Inc. 4.63M 9.50% 4.36M HC Delaware 2024-11-08
7 BVF Inc. 4.41M 9.99% 4.41M CO Delaware 2023-06-05
8 BVF Partners L.P. 4.41M 9.99% 4.41M IA, PN Delaware 2023-06-05
9 Mark N. Lampert 4.41M 9.99% 4.41M IN Delaware 2023-06-05
10 BVF GP Holdings LLC 4.23M 9.60% 4.23M OO Delaware 2023-06-05
11 Adage Capital Advisors, L.L.C. 4.00M 9.35% 4.00M OO Delaware 2023-06-12
12 Adage Capital Partners GP, L.L.C. 4.00M 9.35% 4.00M OO Delaware 2023-06-12
13 Adage Capital Partners, L.P. 4.00M 9.35% 4.00M PN Delaware 2023-06-12
14 Phillip Gross 4.00M 9.35% 4.00M IN Delaware 2023-06-12
15 Robert Atchinson 4.00M 9.35% 4.00M IN United States 2023-06-12
16 BVF I GP LLC 3.02M 6.80% 3.02M OO Delaware 2023-06-05
17 Biotechnology Value Fund, L.P. 3.02M 6.80% 3.02M PN Delaware 2023-06-05
18 Bihua Chen 2.50M 5.15% 2.50M 2.50M IN United States 2024-04-29
19 Cormorant Asset Management, LP 2.50M 5.15% 2.50M 2.50M PN Cayman Islands 2024-04-29
20 Cormorant Global Healthcare GP, LLC 2.50M 5.15% 2.50M 2.50M OO Delaware 2024-04-29
21 Cormorant Global Healthcare Master Fund, LP 2.50M 5.15% 2.50M 2.50M PN Cayman Islands 2024-04-29
22 BVF II GP LLC 1.21M 2.80% 1.21M OO Delaware 2023-06-05
23 Biotechnology Value Fund II, L.P. 1.21M 2.80% 1.21M PN Delaware 2023-06-05
24 BVF Partners OS Ltd. 140.6K 1.00% 140.6K CO Delaware 2023-06-05
25 Biotechnology Value Trading Fund OS LP 140.6K 1.00% 140.6K PN Delaware 2023-06-05

Institutional Activity (13F)

Institutional ownership trend From To
13F snapshot — 2025 Q4
Investors holding
59
-13 vs prev Q
New positions
10
Closed positions
23
Increased
27
Reduced
18
Put/Call ratio
0.00
Calls held
Puts held
Top institutional holders
# Investor Shares / Δ Mkt value / Δ Own% / Δ Weight% / Δ Avg px / Perf. Hold / Status
1 LYNX1 CAPITAL MANAGEMENT LP 8.02M +161.8K (+2.1%) 8.02M -6.3M (-43.9%) 6.18% +0.120 pp 1.62% -1.287 pp USD2.15 -53.5% 11 qtrs
2 BVF INC/IL 5.23M +— (+0.0%) 5.23M -4.3M (-45.1%) 4.03% -0.003 pp 0.18% -0.210 pp USD2.03 -50.7% 11 qtrs
3 BAKER BROS. ADVISORS LP 2.78M +— (+0.0%) 2.78M -2.3M (-45.1%) 2.14% -0.002 pp 0.02% -0.020 pp USD5.80 -82.8% 18 qtrs
4 VANGUARD GROUP INC 2.48M +157.8K (+6.8%) 2.48M -1.7M (-41.3%) 1.91% +0.120 pp 0.00% +0.000 pp USD3.54 -71.8% 18 qtrs
5 BLACKROCK, INC. 1.85M -534.1K (-22.4%) 1.85M -2.5M (-57.4%) 1.42% -0.413 pp 0.00% +0.000 pp USD4.85 -79.4% 6 qtrs
6 ABRDN PLC 1.79M +430.4K (+31.8%) 1.79M -680.5K (-27.6%) 1.38% +0.331 pp 0.00% -0.001 pp USD2.77 -63.9% 9 qtrs
7 DEER MANAGEMENT CO. LLC 1.25M +— (+0.0%) 1.25M -1.0M (-45.1%) 0.96% -0.001 pp 0.12% -0.082 pp USD4.50 -77.8% 17 qtrs
8 RENAISSANCE TECHNOLOGIES LLC 1.14M +311.2K (+37.5%) 1.14M -369.4K (-24.5%) 0.88% +0.239 pp 0.00% 0.000 pp USD1.37 -27.0% 13 qtrs
9 TWO SIGMA INVESTMENTS, LP 651.2K +231.8K (+55.3%) 651.2K -112.1K (-14.7%) 0.50% +0.178 pp 0.00% 0.000 pp USD1.31 -23.7% 8 qtrs
10 DC FUNDS, LP 630.0K +— (+0.0%) 630.0K -516.6K (-45.1%) 0.49% 0.000 pp 43.36% +6.495 pp USD8.34 -88.0% 18 qtrs
11 GEODE CAPITAL MANAGEMENT, LLC 562.2K -5.5K (-1.0%) 562.4K -471.2K (-45.6%) 0.43% -0.005 pp 0.00% +0.000 pp USD4.78 -79.1% 18 qtrs
12 MILLENNIUM MANAGEMENT LLC 403.6K -62.5K (-13.4%) 403.6K -444.7K (-52.4%) 0.31% -0.048 pp 0.00% 0.000 pp USD1.42 -29.6% 9 qtrs
13 JANE STREET GROUP, LLC 388.3K +307.0K (+377.5%) 388.3K +240.3K (+162.4%) 0.30% +0.236 pp 0.00% +0.000 pp USD1.09 -8.3% 3 qtrs
14 TWO SIGMA ADVISERS, LP 353.9K +65.1K (+22.5%) 353.9K -171.7K (-32.7%) 0.27% +0.050 pp 0.00% 0.000 pp USD1.44 -30.6% 4 qtrs
15 MARSHALL WACE, LLP 339.2K +292.6K (+627.5%) 339.2K +254.4K (+299.7%) 0.26% +0.225 pp 0.00% +0.000 pp USD1.06 -5.7% 9 qtrs
16 GSA CAPITAL PARTNERS LLP 226.2K +226.2K (+100.0%) 226.0K +226.0K (+100.0%) 0.17% +0.174 pp 0.02% +0.020 pp USD1.00 +0.0% 1 qtrs NEW
17 MORGAN STANLEY 225.8K -621.7K (-73.4%) 225.8K -1.3M (-85.4%) 0.17% -0.479 pp 0.00% 0.000 pp USD2.33 -57.1% 18 qtrs
18 XTX TOPCO LTD 219.0K +201.4K (+1,142.5%) 219.0K +186.9K (+582.7%) 0.17% +0.155 pp 0.01% +0.004 pp USD1.07 -6.5% 2 qtrs
19 SUSQUEHANNA INTERNATIONAL GROUP, LLP 216.1K +136.4K (+171.0%) 216.1K +71.0K (+48.9%) 0.17% +0.105 pp 0.00% +0.000 pp USD1.32 -24.2% 10 qtrs
20 STATE STREET CORP 207.3K +10.0K (+5.1%) 207.3K -151.8K (-42.3%) 0.16% +0.008 pp 0.00% +0.000 pp USD5.38 -81.4% 18 qtrs
21 JACOBS LEVY EQUITY MANAGEMENT, INC 188.2K +188.2K (+100.0%) 188.2K +188.2K (+100.0%) 0.14% +0.145 pp 0.00% +0.001 pp USD1.00 +0.0% 1 qtrs NEW
22 CITADEL ADVISORS LLC 162.9K -227.9K (-58.3%) 162.9K -548.3K (-77.1%) 0.13% -0.176 pp 0.00% 0.000 pp USD1.83 -45.4% 8 qtrs
23 BROWN BROTHERS HARRIMAN & CO 143.1K +— (+0.0%) 143.1K -117.3K (-45.1%) 0.11% 0.000 pp 0.00% -0.001 pp USD5.48 -81.8% 7 qtrs
24 BRIDGEWAY CAPITAL MANAGEMENT, LLC 115.4K -25.0K (-17.8%) 115.4K -140.1K (-54.8%) 0.09% -0.019 pp 0.00% -0.003 pp USD2.54 -60.6% 17 qtrs
25 NORTHERN TRUST CORP 98.2K -350.0 (-0.4%) 98.2K -81.2K (-45.3%) 0.08% 0.000 pp 0.00% +0.000 pp USD4.44 -77.5% 13 qtrs
26 LETKO, BROSSEAU & ASSOCIATES INC 95.9K +— (+0.0%) 95.9K -78.6K (-45.1%) 0.07% 0.000 pp 0.00% -0.001 pp USD1.92 -47.9% 10 qtrs
27 NEWEDGE WEALTH, LLC 91.5K +— (+0.0%) 91.5K -12.3K (-11.9%) 0.07% 0.000 pp 0.00% -0.001 pp USD1.55 -35.5% 13 qtrs
28 GOLDMAN SACHS GROUP INC 86.9K -44.1K (-33.7%) 86.9K -151.5K (-63.5%) 0.07% -0.034 pp 0.00% +0.000 pp USD2.99 -66.6% 9 qtrs
29 DIMENSIONAL FUND ADVISORS LP 74.5K -12.8K (-14.7%) 74.5K -84.2K (-53.0%) 0.06% -0.010 pp 0.00% +0.000 pp USD4.01 -75.1% 7 qtrs
30 STIFEL FINANCIAL CORP 72.4K -25.0K (-25.7%) 72.4K -104.9K (-59.2%) 0.06% -0.019 pp 0.00% 0.000 pp USD2.65 -62.3% 11 qtrs
31 D. E. SHAW & CO., INC. 69.4K +69.4K (+100.0%) 69.4K +69.4K (+100.0%) 0.05% +0.054 pp 0.00% +0.000 pp USD1.00 +0.0% 1 qtrs NEW
32 UBS GROUP AG 55.2K +44.1K (+398.5%) 55.2K +35.0K (+173.9%) 0.04% +0.034 pp 0.00% +0.000 pp USD1.19 -16.0% 18 qtrs
33 TANG CAPITAL MANAGEMENT LLC 46.1K -553.9K (-92.3%) 46.1K -1.0M (-95.8%) 0.04% -0.427 pp 0.00% -0.040 pp USD1.71 -41.5% 5 qtrs
34 BANK OF AMERICA CORP /DE/ 38.7K -184.3K (-82.6%) 38.7K -367.2K (-90.5%) 0.03% -0.142 pp 0.00% +0.000 pp USD3.54 -71.8% 13 qtrs
35 DC INVESTMENTS MANAGEMENT, LLC 35.6K +— (+0.0%) 35.6K -29.2K (-45.1%) 0.03% +0.000 pp 0.02% -0.011 pp USD8.34 -88.0% 18 qtrs
36 JPMORGAN CHASE & CO 33.3K -204.4K (-86.0%) 33.3K -399.4K (-92.3%) 0.03% -0.158 pp 0.00% +0.000 pp USD2.10 -52.4% 9 qtrs
37 ACADIAN ASSET MANAGEMENT LLC 29.5K +29.5K (+100.0%) 28.0K +28.0K (+100.0%) 0.02% +0.023 pp 0.00% +0.000 pp USD1.00 +0.0% 1 qtrs NEW
38 BNP PARIBAS ARBITRAGE, SNC 26.4K -3.5K (-11.8%) 26.4K -28.0K (-51.5%) 0.02% -0.003 pp 0.00% +0.000 pp USD2.79 -64.2% 5 qtrs
39 HRT FINANCIAL LP 26.6K +26.6K (+100.0%) 26.0K +26.0K (+100.0%) 0.02% +0.021 pp 0.00% +0.000 pp USD1.00 +0.0% 3 qtrs
40 PANAGORA ASSET MANAGEMENT INC 25.3K +25.3K (+100.0%) 25.3K +25.3K (+100.0%) 0.02% +0.020 pp 0.00% +0.000 pp USD1.00 +0.0% 1 qtrs NEW
41 HSBC HOLDINGS PLC 24.6K +— (+0.0%) 24.8K -19.0K (-43.4%) 0.02% +0.000 pp 0.00% +0.000 pp USD1.38 -27.5% 4 qtrs
42 PRUDENTIAL FINANCIAL INC 24.4K +12.9K (+112.2%) 24.4K +3.5K (+16.6%) 0.02% +0.010 pp 0.00% +0.000 pp USD1.39 -28.1% 5 qtrs
43 BARCLAYS PLC 23.2K -34.9K (-60.1%) 23.2K -266.0K (-92.0%) 0.02% -0.027 pp 0.00% 0.000 pp USD2.94 -66.0% 7 qtrs
44 LPL FINANCIAL LLC 22.5K +1.0K (+4.7%) 22.5K -16.6K (-42.5%) 0.02% +0.001 pp 0.00% +0.000 pp USD1.78 -43.8% 2 qtrs
45 NEUBERGER BERMAN GROUP LLC 18.4K +— (+0.0%) 18.4K -15.1K (-45.1%) 0.01% +0.000 pp 0.00% +0.000 pp USD1.45 -31.0% 3 qtrs
46 R SQUARED LTD 16.0K -2.8K (-14.8%) 16.0K -18.2K (-53.2%) 0.01% -0.002 pp 0.01% -0.007 pp USD1.60 -37.5% 3 qtrs
47 TWO SIGMA SECURITIES, LLC 15.9K +15.9K (+100.0%) 15.9K +15.9K (+100.0%) 0.01% +0.012 pp 0.00% +0.002 pp USD1.00 +0.0% 1 qtrs NEW
48 VANGUARD PERSONALIZED INDEXING MANAGEMENT, LLC 14.7K -6.3K (-30.1%) 14.7K -23.5K (-61.6%) 0.01% -0.005 pp 0.00% 0.000 pp USD1.47 -32.0% 3 qtrs
49 POINT72 ASSET MANAGEMENT, L.P. 14.5K +14.5K (+100.0%) 14.5K +14.5K (+100.0%) 0.01% +0.011 pp 0.00% +0.000 pp USD1.00 +0.0% 1 qtrs NEW
50 ADVISOR GROUP HOLDINGS, INC. 12.2K +— (+0.0%) 12.2K -9.6K (-44.1%) 0.01% +0.000 pp 0.00% +0.000 pp USD5.16 -80.6% 7 qtrs
51 MIZUHO SECURITIES USA LLC 10.0K +10.0K (+100.0%) 10.1K +10.1K (+100.0%) 0.01% +0.008 pp 0.00% +0.000 pp USD1.00 +0.0% 1 qtrs NEW
52 ARIES WEALTH MANAGEMENT 10.0K +— (+0.0%) 10.0K -8.2K (-45.1%) 0.01% +0.000 pp 0.00% -0.002 pp USD2.56 -60.9% 10 qtrs
53 WALDRON PRIVATE WEALTH LLC 10.0K +— (+0.0%) 10.0K -8.2K (-45.1%) 0.01% +0.000 pp 0.00% 0.000 pp USD2.10 -52.4% 12 qtrs
54 TOWER RESEARCH CAPITAL LLC (TRC) 6.8K -4.3K (-39.1%) 6.8K -13.5K (-66.6%) 0.01% -0.003 pp 0.00% 0.000 pp USD3.40 -70.6% 9 qtrs
55 FEDERATED HERMES, INC. 5.0K +2.8K (+128.7%) 5.0K +1.0K (+25.7%) 0.00% +0.002 pp 0.00% +0.000 pp USD1.17 -14.5% 4 qtrs
56 FMR LLC 500.00 -9.5K (-95.0%) 500.00 -17.7K (-97.3%) 0.00% -0.007 pp 0.00% +0.000 pp USD1.53 -34.6% 6 qtrs
57 SBI SECURITIES CO., LTD. 392.00 +180.0 (+84.9%) 392.00 +6.0 (+1.6%) 0.00% +0.000 pp 0.00% +0.000 pp USD1.46 -31.5% 5 qtrs
58 ROCKEFELLER CAPITAL MANAGEMENT L.P. 200.00 +— (+0.0%) 200.00 -164.0 (-45.1%) 0.00% +0.000 pp 0.00% +0.000 pp USD1.82 -45.1% 2 qtrs
59 NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 8.00 +8.0 (+100.0%) 8.00 +8.0 (+100.0%) 0.00% +0.000 pp 0.00% +0.000 pp USD1.00 +0.0% 1 qtrs NEW
60 CITIGROUP INC -1.1K (-100.0%) -2.0K (-100.0%) 0.00% -0.001 pp 0.00% +0.000 pp USD 9 qtrs SOLD
61 MARINER, LLC -16.0K (-100.0%) -29.2K (-100.0%) 0.00% -0.012 pp 0.00% +0.000 pp USD 4 qtrs SOLD
62 MILITIA CAPITAL PARTNERS, LP -102.1K (-100.0%) -185.8K (-100.0%) 0.00% -0.079 pp 0.00% -0.086 pp USD 3 qtrs SOLD
63 MIRAE ASSET GLOBAL INVESTMENTS CO., LTD. -2.0K (-100.0%) -3.7K (-100.0%) 0.00% -0.002 pp 0.00% +0.000 pp USD 5 qtrs SOLD
64 NISA INVESTMENT ADVISORS, LLC -593.0 (-100.0%) -1.1K (-100.0%) 0.00% -0.001 pp 0.00% +0.000 pp USD 6 qtrs SOLD
65 CATALYST FUNDS MANAGEMENT PTY LTD -30.8K (-100.0%) -56.0K (-100.0%) 0.00% -0.024 pp 0.00% -0.009 pp USD 3 qtrs SOLD
66 PROPEL BIO MANAGEMENT, LLC -1.9M (-100.0%) -3.5M (-100.0%) 0.00% -1.490 pp 0.00% -3.521 pp USD 9 qtrs SOLD
67 QUADRATURE CAPITAL LTD -56.7K (-100.0%) -103.4K (-100.0%) 0.00% -0.044 pp 0.00% -0.001 pp USD 3 qtrs SOLD
68 QUBE RESEARCH & TECHNOLOGIES LTD -27.7K (-100.0%) -50.4K (-100.0%) 0.00% -0.021 pp 0.00% 0.000 pp USD 10 qtrs SOLD
69 RIALTO WEALTH MANAGEMENT, LLC -381.0 (-100.0%) -694.0 (-100.0%) 0.00% 0.000 pp 0.00% 0.000 pp USD 3 qtrs SOLD
70 ROYAL BANK OF CANADA -806.0 (-100.0%) -1.0K (-100.0%) 0.00% -0.001 pp 0.00% +0.000 pp USD 7 qtrs SOLD
71 SIMPLIFY ASSET MANAGEMENT INC. -905.0K (-100.0%) -1.6M (-100.0%) 0.00% -0.698 pp 0.00% -0.030 pp USD 12 qtrs SOLD
72 GF FUND MANAGEMENT CO. LTD. -1.0K (-100.0%) -1.9K (-100.0%) 0.00% -0.001 pp 0.00% +0.000 pp USD 5 qtrs SOLD
73 CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD. -9.2K (-100.0%) -16.7K (-100.0%) 0.00% -0.007 pp 0.00% -0.001 pp USD 5 qtrs SOLD
74 TRUE WEALTH DESIGN, LLC -9.0 (-100.0%) -17.0 (-100.0%) 0.00% +0.000 pp 0.00% +0.000 pp USD 4 qtrs SOLD
75 ALPHABET INC. -1.1M (-100.0%) -2.0M (-100.0%) 0.00% -0.830 pp 0.00% -0.081 pp USD 18 qtrs SOLD
76 ALGERT GLOBAL LLC -28.0K (-100.0%) -51.0K (-100.0%) 0.00% -0.022 pp 0.00% -0.001 pp USD 3 qtrs SOLD
77 EVERSOURCE WEALTH ADVISORS, LLC -65.0 (-100.0%) -118.0 (-100.0%) 0.00% 0.000 pp 0.00% +0.000 pp USD 4 qtrs SOLD
78 VIRTU FINANCIAL LLC -60.5K (-100.0%) -110.0K (-100.0%) 0.00% -0.047 pp 0.00% -0.006 pp USD 4 qtrs SOLD
79 VOLEON CAPITAL MANAGEMENT LP -47.9K (-100.0%) -87.1K (-100.0%) 0.00% -0.037 pp 0.00% -0.002 pp USD 2 qtrs SOLD
Ownership breakdown by holder

ETF Ownership

Top ETFs holding this stock Held by 12 ETFs in our universe
# ETF Weight Est. AUM exposure TER
1 iShares Micro-Cap ETF IWC 0.01% 182.6K 0.60%
2 Vanguard Extended Market ETF VXF 0.00% 607.6K 0.05%
3 Vanguard U.S. Total Market Shares Index ETF VTS.AX 0.00% 3.4K 0.03%
4 Vanguard U.S. Total Market Index ETF VUN.TO 0.00% 9.4K 0.17%
5 Vanguard U.S. Total Market Index ETF (CAD-hedged) VUS.TO 0.00% 696.49 0.17%
6 Vanguard Total Stock Market ETF VTI 0.00% 1.61M 0.03%
7 Vanguard All-Equity ETF Portfolio VEQT.TO 0.00% 3.5K 0.22%
8 Vanguard Growth ETF Portfolio VGRO.TO 0.00% 1.9K 0.22%
9 Vanguard Balanced ETF Portfolio VBAL.TO 0.00% 776.68 0.22%
10 Vanguard Conservative ETF Portfolio VCNS.TO 0.00% 85.60 0.22%

Insider Activity

Insider Activity — Latest Quarter
Ratio by transactions
0.00
Bearish
Buys
5
Sells
0
Shares acquired
2.39M
Shares disposed
Cash buys
Cash sales
Net activity
+2,385,000
Insider buys vs sells (history) From To
Recent insider transactions From To
Date Person Role Transaction A/D Security Shares Price Value Owned after D/I Filing
2026-01-20 ZDRAVESKI ZORAN Officer A-Award A Stock Option (Right to Buy) 350,000 1.12 392.0K 350,000 D
2026-01-20 MacBeath Gavin Director / Officer A-Award A Stock Option (Right to Buy) 1,165,000 1.12 1.30M 1,165,000 D
2026-01-20 Louis Chrystal Officer A-Award A Stock Option (Right to Buy) 420,000 1.12 470.4K 420,000 D
2026-01-20 Dworak Leiden Officer A-Award A Stock Option (Right to Buy) 100,000 1.12 112.0K 100,000 D
2026-01-20 Amello Jason Officer A-Award A Stock Option (Right to Buy) 350,000 1.12 392.0K 350,000 D
2025-12-23 Lynx1 Capital Management LP 10% Owner P-Purchase A Common Stock 6,232 0.90 5.6K 8,019,148 I
2025-12-22 Lynx1 Capital Management LP 10% Owner P-Purchase A Common Stock 75,500 0.90 68.0K 8,012,916 I
2025-12-19 Lynx1 Capital Management LP 10% Owner P-Purchase A Common stock, $0.0001 par value per share ("Common Stock") 80,069 0.90 72.0K 7,937,416 I
2025-08-14 Dworak Leiden Officer Stock Option (Right to Buy) 46,875 6.00 281.3K 0 D
2025-06-30 Woods Keith Director A-Award A Stock Option (Right to Buy) 67,000 1.45 97.2K 67,000 D
2025-06-30 Nicholson Garry A Director A-Award A Stock Option (Right to Buy) 67,000 1.45 97.2K 67,000 D
2025-06-30 Klencke Barbara Director A-Award A Stock Option (Right to Buy) 67,000 1.45 97.2K 67,000 D
2025-06-30 Gruia Gabriela Director A-Award A Stock Option (Right to Buy) 67,000 1.45 97.2K 67,000 D
2025-06-30 Dorton Katina Director A-Award A Stock Option (Right to Buy) 67,000 1.45 97.2K 67,000 D
2025-06-30 BAKER BROS. ADVISORS LP Director A-Award A Non- Qualified Stock Option (right to buy) 67,000 1.45 97.2K 67,000 I
2025-05-20 Lynx1 Capital Management LP 10% Owner P-Purchase A Common Stock 1,200,000 1.20 1.44M 7,946,141 I
2025-05-19 Lynx1 Capital Management LP 10% Owner P-Purchase A Common stock, $0.0001 par value per share ("Common Stock") 1,388,794 1.20 1.67M 6,746,141 I
2025-01-03 ZDRAVESKI ZORAN Officer A-Award A Stock Option (Right to Buy) 250,000 3.07 766.3K 250,000 D
2025-01-03 MacBeath Gavin Director / Officer A-Award A Stock Option (Right to Buy) 800,000 3.07 2.45M 800,000 D
2025-01-03 Louis Chrystal Officer A-Award A Stock Option (Right to Buy) 400,000 3.07 1.23M 400,000 D
2025-01-03 Amello Jason Officer A-Award A Stock Option (Right to Buy) 270,000 3.07 827.6K 270,000 D
2024-12-26 Lynx1 Capital Management LP 10% Owner P-Purchase A Pre-funded Warrant (right to buy) 7,500,000 0.00 750.00 7,500,000 I
2024-12-13 Lynx1 Capital Management LP 10% Owner P-Purchase A Common Stock 100,000 2.90 290.1K 5,357,347 I
2024-12-12 Lynx1 Capital Management LP 10% Owner P-Purchase A Common stock, $0.0001 par value per share ("Common Stock") 31,800 3.01 95.6K 5,257,347 I
2024-11-15 Lynx1 Capital Management LP 10% Owner P-Purchase A Common stock, $0.0001 par value per share 947 4.34 4.1K 5,225,547 I
2024-09-23 Klencke Barbara Director P-Purchase A Voting Common Stock 5,000 5.29 26.5K 45,000 D
2024-08-26 Klencke Barbara Director P-Purchase A Voting Common Stock 5,000 5.53 27.7K 40,000
2024-08-23 ZDRAVESKI ZORAN Officer M-Exempt D Stock Option (Right to Buy) 25,000 3.27 81.8K 25,000
2024-08-23 Klencke Barbara Director P-Purchase A Voting Common Stock 5,000 5.69 28.5K 35,000
2024-06-12 Woods Keith Director A-Award A Stock Option (Right to Buy) 47,500 8.88 421.8K 47,500
2024-06-12 Nicholson Garry A 0 0.00 0
2024-06-12 Klencke Barbara Director A-Award A Stock Option (Right to Buy) 47,500 8.88 421.8K 47,500
2024-06-12 Gruia Gabriela Director A-Award A Stock Option (Right to Buy) 47,500 8.88 421.8K 47,500
2024-06-12 Dorton Katina Director A-Award A Stock Option (Right to Buy) 47,500 8.88 421.8K 47,500
2024-06-12 BAKER BROS. ADVISORS LP Director A-Award A Non- Qualified Stock Option (right to buy) 47,500 8.88 421.8K 47,500
2024-05-01 Louis Chrystal Officer A-Award A Stock Option (Right to Buy) 380,000 8.62 3.28M 380,000
2024-04-22 Louis Chrystal 0 0.00 0
2024-04-19 Lynx1 Capital Management LP 10% Owner P-Purchase A Pre-funded Warrant (right to buy) 5,000,000 0.00 500.00 5,000,000
2024-04-19 BAKER BROS. ADVISORS LP Director P-Purchase A Warrants to purchase Common Stock 8,851,451 0.00 885.15 43,158,741
2024-02-01 Amello Jason Officer A-Award A Stock Option (Right to Buy) 750,000 5.15 3.86M 750,000
2024-01-29 Amello Jason 0 0.00 0
2024-01-12 ZDRAVESKI ZORAN Officer A-Award A Stock Option (Right to Buy) 52,500 6.00 315.0K 52,500 D
2024-01-12 MacBeath Gavin Director / Officer A-Award A Stock Option (Right to Buy) 160,000 6.00 960.0K 160,000 D
2024-01-12 Dworak Leiden Other A-Award A Stock Option (Right to Buy) 46,875 6.00 281.3K 46,875 D
2023-12-19 BARBERICH TIMOTHY J Director P-Purchase A Voting Common Stock 317 4.97 1.6K 67,027
2023-12-18 BARBERICH TIMOTHY J Director P-Purchase A Voting Common Stock 28,830 4.89 140.9K 66,710
2023-12-14 Klencke Barbara Director P-Purchase A Voting Common Stock 5,000 5.08 25.4K 30,000
2023-12-06 Woods Keith Director A-Award A Stock Option (Right to Buy) 17,500 6.74 118.0K 17,500
2023-07-21 Dworak Leiden Officer A-Award A Stock Option (Right to Buy) 25,000 2.23 55.8K 25,000
2023-06-13 ZDRAVESKI ZORAN Officer A-Award A Stock Option (Right to Buy) 430,000 2.49 1.07M 430,000
2023-06-13 Silver Brian M. Officer A-Award A Stock Option (Right to Buy) 632,500 2.49 1.57M 632,500
2023-06-13 MacBeath Gavin Director / Officer A-Award A Stock Option (Right to Buy) 1,121,300 2.49 2.79M 1,121,300
2023-06-13 Klencke Barbara Director A-Award A Stock Option (Right to Buy) 36,524 2.66 97.2K 36,524
2023-06-13 Gruia Gabriela Director A-Award A Stock Option (Right to Buy) 35,000 2.66 93.1K 35,000
2023-06-13 Dorton Katina Director A-Award A Stock Option (Right to Buy) 35,000 2.66 93.1K 35,000
2023-06-13 Barton Debora Officer A-Award A Stock Option (Right to Buy) 430,000 2.49 1.07M 430,000
2023-06-13 BARBERICH TIMOTHY J Director A-Award A Stock Option (Right to Buy) 35,000 2.66 93.1K 35,000
2023-06-13 BAKER BROS. ADVISORS LP Director A-Award A Non- Qualified Stock Option (right to buy) 35,000 2.66 93.1K 35,000
2023-06-02 BARBERICH TIMOTHY J Director P-Purchase A Voting Common Stock 37,880 2.63 99.6K 37,880
2023-06-01 BAKER BROS. ADVISORS LP Director A-Award A Warrants to purchase Common Stock 34,307,290 0.00 3.4K 34,307,290
2023-05-31 Lynx1 Capital Management LP 10% Owner S-Sale D Common stock, $0.0001 par value per share Common Stock 10,000 2.51 25.1K 5,240,000
2023-05-26 EcoR1 Capital, LLC 10% Owner I Voting Common Stock 0 0.00 5,000,000
2023-04-06 Klencke Barbara Director A-Award A Stock Option (Right to Buy) 9,146 2.20 20.1K 9,146
2023-02-02 ZDRAVESKI ZORAN Officer A-Award A Stock Option (Right to Buy) 35,000 1.81 63.4K 35,000
2023-02-02 SOUTHWELL DAVID P Director / Officer A-Award A Stock Option (Right to Buy) 100,000 1.81 181.0K 100,000
2023-02-02 MacBeath Gavin Officer A-Award A Stock Option (Right to Buy) 40,000 1.81 72.4K 40,000
2023-02-02 Barton Debora Officer A-Award A Stock Option (Right to Buy) 50,000 1.81 90.5K 50,000
2022-12-28 Silver Brian M. Officer P-Purchase A Voting Common Stock 3,158 1.56 4.9K 32,885
2022-12-27 Silver Brian M. Officer P-Purchase A Voting Common Stock 2,842 1.50 4.3K 29,727
2022-07-25 ZDRAVESKI ZORAN Officer A-Award A Stock Option (Right to Buy) 50,000 0.00 50,000
2022-07-25 Silver Brian M. Officer A-Award A Stock Option (Right to Buy) 220,000 0.00 220,000
2022-07-25 SOUTHWELL DAVID P Officer A-Award A Stock Option (Right to Buy) 100,000 0.00 100,000
2022-07-25 MacBeath Gavin Officer A-Award A Stock Option (Right to Buy) 100,000 0.00 100,000
2022-07-25 Desmarais William Officer A-Award A Stock Option (Right to Buy) 30,000 0.00 30,000
2022-07-05 Barton Debora Officer A-Award A Stock Option (right to buy) 150,000 0.00 150,000
2022-06-01 Harel Ittai Director A-Award A Stock Option (Right to Buy) 9,146 0.00 9,146
2022-06-01 Gruia Gabriela Director A-Award A Stock Option (Right to Buy) 9,146 0.00 9,146
2022-06-01 Dorton Katina Director A-Award A Stock Option (Right to Buy) 9,146 0.00 9,146
2022-06-01 Baker Brothers Life Sciences LP Director A-Award A Non- Qualified Stock Option (right to buy) 9,146 0.00 9,146
2022-06-01 BARBERICH TIMOTHY J Director A-Award A Stock Option (Right to Buy) 9,146 0.00 9,146
2022-06-01 BAKER BROS. ADVISORS LP Director / 10% Owner A-Award A Non- Qualified Stock Option (right to buy) 9,146 3.17 29.0K 9,146
2022-05-18 SOUTHWELL DAVID P Director / Officer P-Purchase A Voting Common Stock 10,000 3.55 35.5K 171,569
2022-05-11 BAKER BROS. ADVISORS LP Director / 10% Owner P-Purchase A Common Stock 22,983 1.99 45.6K 2,528,583
2022-05-10 Baker Brothers Life Sciences LP Director P-Purchase A Common Stock 22,983 1.99 45.6K 2,528,583
2022-05-10 BAKER BROS. ADVISORS LP Director / 10% Owner P-Purchase A Common Stock 758,094 1.95 1.48M 2,505,600
2022-03-24 Silver Brian M. Officer P-Purchase A Voting Common Stock 15,000 3.40 51.0K 26,885
2022-01-18 ZDRAVESKI ZORAN Officer A-Award A Stock Option (Right to Buy) 85,000 4.85 412.3K 85,000
2022-01-18 Silver Brian M. Officer A-Award A Stock Option (Right to Buy) 115,000 4.85 557.8K 115,000
2022-01-18 SOUTHWELL DAVID P Director / Officer A-Award A Stock Option (Right to Buy) 275,000 4.85 1.33M 275,000
2022-01-18 MacBeath Gavin Officer A-Award A Stock Option (Right to Buy) 140,000 4.85 679.0K 140,000
2022-01-18 Desmarais William Officer A-Award A Stock Option (Right to Buy) 50,000 4.85 242.5K 50,000
2021-12-23 SOUTHWELL DAVID P Director / Officer M-Exempt A Voting Common Stock 48,670 1.97 95.9K 146,569
2021-09-23 ZDRAVESKI ZORAN Officer P-Purchase A Voting Common Stock 4,716 7.48 35.3K 4,716
2021-09-21 Silver Brian M. Officer P-Purchase A Voting Common Stock 5,000 6.32 31.6K 11,885
2021-09-21 MacBeath Gavin Officer P-Purchase A Voting Common Stock 57 6.19 352.72 49,767
2021-09-20 MacBeath Gavin Officer P-Purchase A Voting Common Stock 4,943 6.22 30.7K 49,710
2021-09-09 Silver Brian M. Officer P-Purchase A Voting Common Stock 5,885 8.48 49.9K 6,885
2021-09-08 SOUTHWELL DAVID P Director / Officer P-Purchase A Voting Common Stock 11,000 8.73 96.1K 97,899
2021-09-07 ZDRAVESKI ZORAN Officer A-Award A Stock Option (right to buy) 150,000 8.99 1.35M 150,000
2021-08-27 Desmarais William Officer P-Purchase A Voting Common Stock 2,500 9.08 22.7K 2,500
2021-07-20 Westphal Christoph H 10% Owner C-Conversion D Series C Preferred Stock 171,063 0.00 0
2021-07-20 Silver Brian M. Officer P-Purchase A Voting Common Stock 1,000 15.00 15.0K 1,000
2021-07-20 BARBERICH TIMOTHY J Director C-Conversion D Series B Preferred Stock 33,259 0.00 0
2021-07-20 BAKER BROS. ADVISORS LP Director P-Purchase A Common Stock 104,698 15.00 1.57M 104,698
2021-07-15 Westphal Christoph H Director / 10% Owner I Series C Preferred Stock 171,063 0.00 0
2021-07-15 Silver Brian M. Officer D Stock Option (right to buy) 48,780 5.82 283.9K 0
2021-07-15 SOUTHWELL DAVID P Director / Officer D Employee Stock Option (right to buy) 200,822 2.46 494.0K 0
2021-07-15 MacBeath Gavin Officer D Voting Common Stock 0 0.00 44,767
2021-07-15 Harel Ittai Director 0 0.00 0
2021-07-15 Gruia Gabriela Director 0 0.00 0
2021-07-15 Dorton Katina Director D Stock Option (right to buy) 48,780 11.56 563.9K 0
2021-07-15 Desmarais William Officer D Employee Stock Option (right to buy) 119,688 13.94 1.67M 0
2021-07-15 Biggar Stephen R Director 0 0.00 0
2021-07-15 BARBERICH TIMOTHY J Director D Series B Preferred Stock 33,259 0.00 0
2021-07-15 BAKER BROS. ADVISORS LP Director / 10% Owner I Series C Convertible Preferred Stock 3,960,811 0.00 0

Executive team

Top executives
EBIT / Employee
-9.5K
Shares Outstanding
55.82M

Executive compensation

Executive compensation (annual)
# Year Executive Salary Bonus Stock award Option award Incentive Other Total % Stock-
based
Filing
1 2025 Gavin MacBeath, Ph.D. Chief Executive Officer and Director 665.0K 1.98M 139.7K 14.0K 2.80M 70.78%
2 2025 Chrystal Louis, M.D., M.P.H. Chief Medical Officer 530.0K 991.4K 74.2K 14.0K 1.61M 61.59%
3 2025 Jason A. Amello Chief Financial Officer and Treasurer 520.0K 669.2K 72.8K 14.0K 1.28M 52.44%
4 2024 Jason A. Amello Chief Financial Officer and Treasurer 463.5K 60.0K 2.97M 230.0K 13.8K 3.73M 79.45%
5 2024 Chrystal Louis, M.D., M.P.H. Chief Medical Officer 343.1K 45.0K 2.48M 162.0K 3.03M 81.85%
6 2024 Gavin MacBeath, Ph.D. Chief Executive Officer and Director 620.0K 734.9K 392.0K 13.7K 1.76M 41.74%
7 2023 Gavin MacBeath, Ph.D. Chief Executive Officer and Director 545.1K 2.34M 296.0K 12.4K 3.20M 73.29%
8 2023 Debora Barton, M.D. Former Chief Medical Officer 472.5K 944.9K 217.0K 75.6K 1.71M 55.25%
9 2023 Brian Silver, J.D. Former Chief Financial Officer and Treasurer 283.1K 1.29M 10.2K 1.58M 81.48%
10 2023 Zoran Zdraveski, J.D., Ph.D. Chief Legal and Strategy Officer and Secretary 441.0K 924.6K 203.0K 13.2K 1.58M 58.45%
11 2023 David Southwell Former President, Chief Executive Officer and Director 153.5K 135.3K 1.00M 1.29M 10.46%
12 2022 David Southwell Former President, Chief Executive Officer and Director 622.2K 1.17M 342.2K 8.9K 2.14M 54.57%
13 2022 Brian Silver, J.D. Former Chief Financial Officer and Treasurer 480.0K 910.9K 192.0K 18.2K 1.60M 56.89%
14 2022 Brian Silver, J.D. Chief Financial Officer and Treasurer 480.0K 910.9K 192.0K 18.2K 1.60M 56.89%
15 2022 Gavin MacBeath, Ph.D. Chief Executive Officer and Director 450.0K 711.6K 188.0K 12.2K 1.36M 52.25%
16 2022 Gavin MacBeath, Ph.D. Acting Chief Executive Officer, Chief Scientific and Operating Officer 450.0K 711.6K 188.0K 12.2K 1.36M 52.25%
17 2021 Brian Silver, J.D. Chief Financial Officer and Treasurer 305.0K 2.74M 122.0K 17.0K 3.18M 86.05%
18 2021 David Southwell Former President, Chief Executive Officer and Director 564.5K 1.92M 310.4K 8.9K 2.81M 68.52%
19 2021 David Southwell President, Chief Executive Officer and Director 550.0K 1.92M 302.5K 8.9K 2.79M 69.07%
20 2021 Gavin MacBeath, Ph.D. Chief Scientific Officer 400.0K 618.0K 160.0K 11.8K 1.19M 51.94%
21 2021 Gavin MacBeath, Ph.D. Acting Chief Executive Officer, Chief Scientific and Operating Officer 400.0K 618.0K 160.0K 11.8K 1.19M 51.94%
22 2020 David Southwell President, Chief Executive Officer and Director 466.7K 275.4K 8.2K 750.2K 0.00%
23 2020 Gavin MacBeath, Ph.D. Chief Scientific Officer 350.2K 171.6K 11.2K 533.0K 0.00%
CEO compensation breakdown

Proxy statements

Proxy statements (DEF 14A)
Filing date Form type Filing
2026-04-17 DEF 14A
2026-04-07 PRE 14A
2025-05-14 DEFA14A
2025-05-14 DEF 14A
2024-04-30 DEFA14A
2024-04-30 DEF 14A

Recent SEC filings

Recent SEC filings
Filing date Form type Filing
2026-05-06 8-K
2026-05-06 10-Q
2026-04-17 DEF 14A
2026-04-17 ARS
2026-04-07 PRE 14A
2026-04-02 8-K
2026-03-04 S-8
2026-03-04 8-K
2026-03-04 10-K
2026-01-22 4

Executive team

NameTitleCompensationGender
Gavin MacBeath Chief Executive Officer & Director 818.7K
Zoran Zdraveski Chief Legal & Strategy Officer and Company Secretary 657.2K
Chrystal U. Louis Chief Medical Officer 618.2K
Jason A. Amello CFO, Treasurer, Principal Financial Officer & Principal Accounting Officer 606.8K male
Ray Lockard Chief Manufacturing & Quality Officer male
Shrikanta Chattopadhyay Senior Vice President & Head of Translational Medicine
Stephen Camiolo Senior Vice President of Market Access male
Stephen J. Elledge Co-Founder & Chairman of Scientific Advisory Board
Tomasz Kula Co-Founder & Member of Advisory Board male
Leiden Dworak VP of Finance & Principal Accounting Officer male
Cagan Gurer Senior Vice President of Discovery male
Jim Murray Chief Development Operations Officer male
ESG Rating
B
BIOTECHNOLOGY
2026
E (Environmental)
53.8 / 56.3
Company / Sector avg.
S (Social)
57.1 / 62.4
Company / Sector avg.
G (Governance)
57.2 / 60.9
Company / Sector avg.
ESG Total
56.0 / 59.9
Company / Sector avg.
ESG Score History BIOTECHNOLOGY
Benchmark vs Sector
Senate Trading Activity

No Senate trading activity found for this company.

House Trading Activity

No House trading activity found for this company.

Market share among peers
Peer comparison — filtered group (TTM)
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Dividend history

Earnings history

Earnings reports

Stock splits