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Spruce Biosciences, Inc. (SPRB)

USD45.44 -0.92 (-1.98%)
US NASDAQ Healthcare Biotechnology
Address 2001 Junipero Serra Boulevard 94014
Daly City, CA, US
CEO Javier Szwarcberg
IPO 2020-10-09
CIK 1683553 ISIN US85209E2081

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Description

Spruce Biosciences, Inc., founded in 2014 and situated in Daly City, California, operates as a biopharmaceutical enterprise. Its primary objective is to advance and bring to market innovative treatments, particularly for uncommon endocrine conditions. A central component of its therapeutic pipeline is tildacerfont, a non-steroidal drug candidate. This compound is currently undergoing Phase 2b clinical assessments in adult patients with congenital adrenal hyperplasia (CAH), with the aim of optimizing disease management and lessening dependence on steroid medications by examining reductions in glucocorticoid levels and their clinical consequences. Tildacerfont is also progressing through Phase 2 trials for pediatric classic CAH, as well as investigating its efficacy in women suffering from polycystic ovary syndrome (PCOS). Additionally, Spruce Biosciences maintains a collaborative licensing agreement with Eli Lilly and Company to jointly explore, formulate, and commercialize various pharmaceutical substances.

Market Cap & Enterprise Value
Merger & Acquisition History

No mergers or acquisitions recorded for this company.

Technical Outlook
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Signal Summary Loading…
Indicator 1D1W2W3W1M
Each column is computed on that timeframe's candles (1D = daily, 1W ≈ weekly, 1M ≈ monthly), not on the same last day. ▲ bullish · ▼ bearish · — neutral. The Net row counts signals per column; hover any cell (or the indicator name) to see the exact rule behind it.
Day Score & sub-scores
Statistical fingerprint & regime detail
Conditional historical analysis
Customize analysis (advanced)
Indicative levels generated algorithmically. Not financial advice.
Risk Profile
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Price Chart
Averages
Trend
Price
Levels
Draw
USD45.44 -0.92 (-1.98%)
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Volume Profile
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Liquidity & share structure
Average Volume
76.7K
Beta
3.20
Float Shares
908.8K
Free Float %
66.2%
Price Performance
1D5D1M3M6M YTD1Y3Y5Y10YMax
+0.47% -1.45% -12.16% -14.52% -49.66% -34.95% +1,044.75% -65.34% -94.83% -95.56% -95.56%
Rolling Volatility
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Drawdown
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Relative Strength
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Monthly Returns Heatmap
From To
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Annual Monthly Returns
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Daily Returns Distribution
vs.
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Revenue flow

Revenue by geography

Revenue by segment

From To

Revenue composition

From To

By product

By geography

Financial Statements

Income Statement

Balance Sheet

Cash Flow Statement

Key Metrics

Financial Ratios

Employees

Financial Growth (CAGR)

Market Data

Analyst Consensus (11 ratings, all time) Buy
Price Targets & DCF
Current price
45.44
Low 140.00 +208.1%
Consensus 211.50 +365.4%
Median 211.50 +365.4%
High 283.00 +522.8%
DCF (Unlevered) 61.81 +36.0%
DCF (Levered) 62.84 +38.3%

DCF figures are point estimates: small changes in growth or discount-rate assumptions move them materially. Read them as a reference, not a precise target.

Ratings Trend (MoM) 100% Bullish
Rating 2026-05 Change
Strong Buy 1 0
Buy 4 0
Hold 0 0
Sell 0 0
Strong Sell 0 0
Price Target Summary
Period # Analysts Avg Target
Last Month 1
140.00
+208.1%
Last Quarter 1
140.00
+208.1%
Last Year 5
219.20
+382.4%
All Time 5
219.20
+382.4%
Quality scores
Altman Z-Score
-4.62
Distress
Piotroski F-Score
3 / 9
Average
MOAT Score
1 / 10
No MOAT
Composite Rating
B-
Overall Score
2 / 5
Medium
DCF Score
4 / 5
High
ROE Score
1 / 5
Low
ROA Score
1 / 5
Low
D/E Score
3 / 5
Medium
P/E Score
1 / 5
Low
P/Book Score
4 / 5
High
Operational MOAT
✗ Below peers
  • Revenue growth Biotechnology: +1.6%
    -100.0%
  • EPS growth Biotechnology: +29.7%
    +47.5% Q1'26: +62.8% (vs Q1'25)
  • FCF margin FCF growth · Biotechnology: +16.2%
  • EBIT margin Biotechnology: +0.0%
  • ROIC Biotechnology: -16.1%
  • Share dilution Biotechnology: -3.4%
    +42.9% Q1'26: +140.2% (vs Q1'25)
  • Debt / EBITDA Net debt/EBITDA · Biotechnology: 0.16×
    -0.02× Q1'26: -0.03× (vs Q1'25)
Valuation Multiples From To
Price Forecast (3Y) From To
Model
Adjust
P/E
Theoretical Return — If Invested Today

* These projections are based on analyst consensus estimates and user-defined valuation multiples. This table is for informational purposes only and does not constitute a recommendation to buy or sell any security. Past performance is not indicative of future results.

DCF Interactive Model (UFCF)
Projection years:
Market assumptions
WACC components (optional)
Ke (Cost of Equity) = Rf + β (3.31) × ERP
WACC = 98% × Ke + 2% × Kd (12.2%) × (1−t)

Modifying these values recalculates WACC automatically.

Business assumptions
Intrinsic value (base): 61.81 Current price: 45.44
Enterprise Value: Equity Value: Terminal Value: TV as % of EV:

Base values reflect the latest available data for this company and market conditions.

Consensus Estimates
Metric Dec 2023
actual
Dec 2024
actual
Dec 2025
actual
Dec 2026
3 Rev. Ana.
3 EPS Ana.
Dec 2027
4 Rev. Ana.
3 EPS Ana.
Dec 2028
2 Rev. Ana.
2 EPS Ana.
Dec 2029
1 Rev. Ana.
1 EPS Ana.
Dec 2030
1 Rev. Ana.
1 EPS Ana.
Revenue
10.09M
est: 10.13M (-0.4%)
4.91M
est: 5.09M (-3.6%)
est: 2.00M (-100.0%)
53.75M
12.09M – 124.43M
+2,587.6% YoY
76.56M
41.46M – 113.51M
+42.4% YoY
24.23M
5.45M – 56.09M
-68.4% YoY
52.35M
11.77M – 121.18M
+116.0% YoY
88.60M
19.92M – 205.10M
+69.3% YoY
EBITDA
-47.37M
est: 2.03M (-2,438.6%)
-52.68M
est: 1.02M (-5,271.7%)
-36.51M
est: 400.0K (-9,228.3%)
10.75M
2.42M – 24.89M
+2,587.6% YoY
15.31M
8.29M – 22.70M
+42.4% YoY
4.85M
1.09M – 11.22M
-68.4% YoY
10.47M
2.35M – 24.24M
+116.0% YoY
17.72M
3.98M – 41.02M
+69.3% YoY
EBIT
-47.44M
est: 2.03M (-2,442.1%)
-52.73M
est: 1.02M (-5,276.2%)
-36.51M
est: 400.0K (-9,228.3%)
10.75M
2.42M – 24.89M
+2,587.6% YoY
15.31M
8.29M – 22.70M
+42.4% YoY
4.85M
1.09M – 11.22M
-68.4% YoY
10.47M
2.35M – 24.24M
+116.0% YoY
17.72M
3.98M – 41.02M
+69.3% YoY
Net Income
-47.92M
est: -1.44M (-3,218.0%)
-53.04M
est: -55.45M (+4.4%)
-38.97M
est: -38.97M (+0.0%)
-24.95M
-26.27M – -23.63M
+36.0% YoY
-14.30M
-14.41M – -14.19M
+42.7% YoY
-7.62M
-11.03M – -4.21M
+46.7% YoY
-877.8K
-2.38M – 6.8K
+88.5% YoY
9.03M
-69.5K – 24.47M
+1,128.8% YoY
SGA
12.65M
est: 14.66M (-13.7%)
14.64M
est: 7.37M (+98.7%)
16.99M
est: 2.89M (+487.1%)
77.79M
17.49M – 180.07M
+2,587.6% YoY
110.79M
60.00M – 164.26M
+42.4% YoY
35.06M
7.88M – 81.17M
-68.4% YoY
75.75M
17.03M – 175.36M
+116.0% YoY
128.22M
28.83M – 296.81M
+69.3% YoY
EPS
-93.00
est: -1.15 (-8,017.7%)
-96.75
est: -70.05 (-38.1%)
-50.83
est: -21.24 (-139.3%)
-32.54
-34.26 – -30.82
-53.2% YoY
-18.65
-18.79 – -18.51
+42.7% YoY
-9.94
-14.39 – -5.49
+46.7% YoY
-1.15
-3.10 – 0.01
+88.5% YoY
11.78
-0.09 – 31.92
+1,128.8% YoY
Historical Ratings (3M)
Date Rating Overall DCF ROE ROA D/E P/E P/B
2026-05-11 B- 2/5 4/5 1/5 1/5 3/5 1/5 4/5
2026-05-08 B- 2/5 4/5 1/5 1/5 3/5 1/5 4/5
2026-05-07 B- 2/5 4/5 1/5 1/5 3/5 1/5 4/5
2026-05-06 B- 2/5 4/5 1/5 1/5 3/5 1/5 4/5
2026-05-05 B- 2/5 4/5 1/5 1/5 3/5 1/5 4/5
2026-05-04 B- 2/5 4/5 1/5 1/5 3/5 1/5 4/5
2026-05-01 B- 2/5 4/5 1/5 1/5 3/5 1/5 4/5
2026-04-30 B- 2/5 4/5 1/5 1/5 3/5 1/5 4/5
2026-04-29 B- 2/5 4/5 1/5 1/5 3/5 1/5 4/5
2026-04-28 B- 2/5 4/5 1/5 1/5 3/5 1/5 4/5
2026-04-27 B- 2/5 4/5 1/5 1/5 3/5 1/5 4/5
2026-04-24 C+ 2/5 4/5 1/5 1/5 2/5 1/5 4/5
2026-04-23 C+ 2/5 4/5 1/5 1/5 2/5 1/5 4/5
2026-04-22 C+ 2/5 4/5 1/5 1/5 2/5 1/5 4/5
2026-04-21 C+ 2/5 4/5 1/5 1/5 2/5 1/5 4/5
2026-04-20 C+ 2/5 4/5 1/5 1/5 2/5 1/5 4/5
2026-04-17 C+ 2/5 4/5 1/5 1/5 2/5 1/5 4/5
2026-04-16 C+ 2/5 4/5 1/5 1/5 2/5 1/5 4/5

Owner Earnings

Owner's Earnings (history) From To
Owner alignment
Owner's Earnings TTM
-35.79M
OE per share TTM
-58.79
Owner's Yield
-82.78%
Maintenance CapEx ratio
Maint CapEx / Avg PPE
50.2%

Ownership Overview

Ownership breakdown
At a glance
Institutional holders
5
Total invested
2.79M
Insider transactions (90d)
0
Beneficial owners (>5%)
36
Beneficial owners (>5%)
# Reporting person Amount owned % of class Sole voting Shared voting Sole dispositive Shared dispositive Type Citizenship Filing date SEC filing
1 5AM Opportunities II (GP), LLC 4.14M 9.97% 4.14M OO United States 2023-02-27
2 5AM Opportunities II, L.P. 4.14M 9.97% 4.14M PN United States 2023-02-27
3 Andrew J. Schwab 4.14M 9.97% 4.14M IN United States 2023-02-27
4 Dr. Kush Parmar 4.14M 9.97% 4.14M IN United States 2023-02-27
5 Bradley L. Radoff 2.83M 6.90% 2.83M IN USA 2024-03-28
6 Armistice Capital, LLC 2.23M 5.48% 2.23M IA, OO Delaware 2024-02-14
7 Steven Boyd 2.23M 5.48% 2.23M HC, IN Delaware 2024-02-14
8 Anne-Mari Paster 2.16M 9.30% 2.16M 2.16M IN 2021-02-12
9 Claudio Nessi 2.16M 9.30% 2.16M 2.16M IN 2021-02-12
10 Omega Fund VI GP Manager, Ltd. 2.16M 9.30% 2.16M 2.16M OO 2021-02-12
11 Omega Fund VI GP, L.P. 2.16M 9.30% 2.16M 2.16M PN 2021-02-12
12 Omega Fund VI, L.P. 2.16M 9.30% 2.16M 2.16M PN 2021-02-12
13 Otello Stampacchia 2.16M 9.30% 2.16M 2.16M IN 2021-02-12
14 Rock Springs Capital LLC 1.62M 6.92% 1.62M HC, OO Delaware 2022-02-15
15 Rock Springs Capital Management LP 1.62M 6.92% 1.62M IA Delaware 2022-02-15
16 Rock Springs Capital Master Fund LP 1.53M 6.50% 1.53M PN Cayman Islands 2022-02-15
17 Company, L.P. 1.42M 6.09% 1.42M PN Delaware 2021-05-17
18 Deerfield Mgmt, L.P. 1.42M 6.09% 1.42M PN Delaware 2021-05-17
19 Deerfield Partners, L.P. 1.42M 6.09% 1.42M PN Delaware 2021-05-17
20 James E. Flynn 1.42M 6.09% 1.42M IN Delaware 2021-05-17
21 Aisling Capital Partners V LLC 1.21M 5.18% 1.21M 1.21M OO 2021-02-12
22 Aisling Capital Partners V, LP 1.21M 5.18% 1.21M 1.21M PN 2021-02-12
23 Aisling Capital V, LP 1.21M 5.18% 1.21M 1.21M PN 2021-02-12
24 Andrew Schiff 1.21M 5.18% 1.21M 1.21M IN 2021-02-12
25 Steve Elms 1.21M 5.18% 1.21M 1.21M IN 2021-02-12
26 Abigail P. Johnson 1.19M 5.14% 205.5K 1.19M IN Delaware 2021-02-08
27 Citadel Advisors Holdings LP 10.00 7.30% 1.70M HC, PN Delaware 2021-02-16
28 Citadel GP LLC 10.00 7.30% 1.70M HC, OO Delaware 2021-02-16
29 Kenneth Griffin 10.00 7.30% 1.70M HC, IN Delaware 2021-02-16
30 2. 10.00 7.20% 1.70M IA, HC, OO 2022-02-14
31 CALC IV LP 10.00 0.00% HC, PN Delaware 2021-02-16
32 Citadel Securities GP LLC 10.00 0.00% HC, OO Delaware 2021-02-16
33 Citadel Securities LLC 10.00 0.00% BD, OO Delaware 2021-02-16
34 Gil Aharon 0.00% PN ONTARIO, CANADA 2024-10-23
35 Rosalind Master Fund L.P. 0.00% PN ONTARIO, CANADA 2024-10-23
36 Steven Salamon 0.00% IN ONTARIO, CANADA 2024-10-23

Institutional Activity (13F)

Institutional ownership trend From To
13F snapshot — 2026 Q1
Investors holding
5
-27 vs prev Q
New positions
1
Closed positions
28
Increased
1
Reduced
1
Put/Call ratio
0.00
Calls held
Puts held
Top institutional holders
# Investor Shares / Δ Mkt value / Δ Own% / Δ Weight% / Δ Avg px / Perf. Hold / Status
1 IKARIAN CAPITAL, LLC 121.4K +108.0K (+810.3%) 10.57M +10.5M (+8,759.5%) 21.55% +19.185 pp 0.83% +0.813 pp USD78.52 +10.9% 2 qtrs
2 70.0K +70.0K (+100.0%) 6.10M +6.1M (+100.0%) 12.43% +12.432 pp 2.58% +2.584 pp USD87.11 +0.0% 1 qtrs NEW
3 CITADEL ADVISORS LLC 70.0K +70.0K (+100.0%) 6.10M +6.1M (+100.0%) 12.43% +12.432 pp 0.00% +0.001 pp USD87.11 +0.0% 1 qtrs NEW
4 WELLINGTON MANAGEMENT GROUP LLP 58.9K +58.9K (+100.0%) 5.14M +5.1M (+100.0%) 10.47% +10.469 pp 0.00% +0.001 pp USD87.11 +0.0% 1 qtrs NEW
5 ADAR1 CAPITAL MANAGEMENT, LLC 58.0K +58.0K (+100.0%) 5.05M +5.1M (+100.0%) 10.30% +10.301 pp 0.37% +0.371 pp USD87.11 +0.0% 1 qtrs NEW
6 ALYESKA INVESTMENT GROUP, L.P. 51.7K +51.7K (+100.0%) 4.50M +4.5M (+100.0%) 9.18% +9.177 pp 0.01% +0.013 pp USD87.11 +0.0% 1 qtrs NEW
7 BOOTHBAY FUND MANAGEMENT, LLC 47.9K +47.9K (+100.0%) 4.18M +4.2M (+100.0%) 8.51% +8.513 pp 0.06% +0.062 pp USD87.11 +0.0% 1 qtrs NEW
8 BALYASNY ASSET MANAGEMENT L.P. 40.0K +40.0K (+100.0%) 3.48M +3.5M (+100.0%) 7.10% +7.104 pp 0.00% +0.004 pp USD87.11 +0.0% 1 qtrs NEW
9 CARLYLE GROUP INC. 38.6K -2.9M (-98.7%) 3.30M -21.5M (-86.7%) 6.86% -507.560 pp 0.02% -0.547 pp USD8.95 +873.3% 2 qtrs
10 EXODUSPOINT CAPITAL MANAGEMENT, LP 25.3K +25.3K (+100.0%) 2.20M +2.2M (+100.0%) 4.49% +4.488 pp 0.02% +0.017 pp USD87.11 +0.0% 1 qtrs NEW
11 SCHONFELD STRATEGIC ADVISORS LLC 24.8K +24.8K (+100.0%) 2.16M +2.2M (+100.0%) 4.40% +4.399 pp 0.01% +0.010 pp USD87.11 +0.0% 1 qtrs NEW
12 QUINN OPPORTUNITY PARTNERS LLC 22.8K +22.8K (+100.0%) 1.99M +2.0M (+100.0%) 4.05% +4.051 pp 0.08% +0.084 pp USD87.11 +0.0% 1 qtrs NEW
13 CALIGAN PARTNERS LP 20.5K +20.5K (+100.0%) 1.79M +1.8M (+100.0%) 3.64% +3.643 pp 0.15% +0.147 pp USD87.11 +0.0% 1 qtrs NEW
14 STONEPINE CAPITAL MANAGEMENT, LLC 19.7K +19.7K (+100.0%) 1.72M +1.7M (+100.0%) 3.51% +3.506 pp 1.26% +1.256 pp USD87.11 +0.0% 1 qtrs NEW
15 VANGUARD GROUP INC 17.9K +17.9K (+100.0%) 1.56M +1.6M (+100.0%) 3.17% +3.174 pp 0.00% +0.000 pp USD87.11 +0.0% 1 qtrs NEW
16 BLACKROCK, INC. 16.9K +16.9K (+100.0%) 1.48M +1.5M (+100.0%) 3.01% +3.008 pp 0.00% +0.000 pp USD87.11 +0.0% 1 qtrs NEW
17 GEODE CAPITAL MANAGEMENT, LLC 12.7K +12.7K (+100.0%) 1.11M +1.1M (+100.0%) 2.26% +2.261 pp 0.00% +0.000 pp USD87.11 +0.0% 1 qtrs NEW
18 SUPERSTRING CAPITAL MANAGEMENT LP 12.1K +12.1K (+100.0%) 1.06M +1.1M (+100.0%) 2.16% +2.156 pp 0.57% +0.566 pp USD87.11 +0.0% 1 qtrs NEW
19 STATE STREET CORP 6.4K +6.4K (+100.0%) 557.5K +557.5K (+100.0%) 1.14% +1.137 pp 0.00% +0.000 pp USD87.11 +0.0% 1 qtrs NEW
20 UBS GROUP AG 4.9K +4.8K (+3,613.6%) 427.0K +425.8K (+36,056.9%) 0.87% +0.847 pp 0.00% +0.000 pp USD85.01 +2.5% 2 qtrs
21 RESOLUTE CAPITAL ASSET PARTNERS LLC 4.0K +4.0K (+100.0%) 348.4K +348.4K (+100.0%) 0.71% +0.710 pp 0.17% +0.168 pp USD87.11 +0.0% 1 qtrs NEW
22 SKYVIEW INVESTMENT ADVISORS, LLC 3.0K +3.0K (+100.0%) 261.0K +261.0K (+100.0%) 0.53% +0.533 pp 0.03% +0.033 pp USD87.11 +0.0% 1 qtrs NEW
23 NORTHERN TRUST CORP 2.4K +2.4K (+100.0%) 211.0K +211.0K (+100.0%) 0.43% +0.430 pp 0.00% +0.000 pp USD87.11 +0.0% 1 qtrs NEW
24 BNP PARIBAS ARBITRAGE, SNC 2.0K +2.0K (+100.0%) 174.2K +174.2K (+100.0%) 0.36% +0.355 pp 0.00% +0.000 pp USD87.11 +0.0% 1 qtrs NEW
25 LION POINT CAPITAL, LP 1.0K +— (+0.0%) 87.1K +78.2K (+873.3%) 0.18% +0.000 pp 0.45% +0.400 pp USD8.95 +873.3% 2 qtrs
26 MORGAN STANLEY 388.00 +290.0 (+295.9%) 33.8K +32.9K (+3,749.5%) 0.07% +0.052 pp 0.00% +0.000 pp USD67.37 +29.3% 2 qtrs
27 SOUND INCOME STRATEGIES, LLC 200.00 +200.0 (+100.0%) 14.7K +14.7K (+100.0%) 0.04% +0.036 pp 0.00% +0.001 pp USD87.11 +0.0% 1 qtrs NEW
28 BANK OF AMERICA CORP /DE/ 93.00 +90.0 (+3,000.0%) 8.1K +8.1K (+29,903.7%) 0.02% +0.016 pp 0.00% +0.000 pp USD84.57 +3.0% 2 qtrs
29 JONES FINANCIAL COMPANIES LLLP 84.00 +84.0 (+100.0%) 7.3K +7.3K (+100.0%) 0.01% +0.015 pp 0.00% +0.000 pp USD87.11 +0.0% 1 qtrs NEW
30 ROYAL BANK OF CANADA 40.00 +40.0 (+100.0%) 3.0K +3.0K (+100.0%) 0.01% +0.007 pp 0.00% +0.000 pp USD87.10 +0.0% 1 qtrs NEW
31 CALDWELL SUTTER CAPITAL, INC. 13.00 +— (+0.0%) 1.1K +1.0K (+875.9%) 0.00% +0.000 pp 0.00% +0.000 pp USD8.92 +876.6% 2 qtrs
32 TOWER RESEARCH CAPITAL LLC (TRC) 1.00 +1.0 (+100.0%) 87.00 +87.0 (+100.0%) 0.00% +0.000 pp 0.00% +0.000 pp USD87.00 +0.1% 1 qtrs NEW
33 CABLE CAR CAPITAL LLC -26.7K (-100.0%) -238.7K (-100.0%) 0.00% -4.736 pp 0.00% -0.102 pp USD 2 qtrs SOLD
34 ADVISOR GROUP HOLDINGS, INC. -133.0 (-100.0%) -931.0 (-100.0%) 0.00% -0.024 pp 0.00% +0.000 pp USD 2 qtrs SOLD
Ownership breakdown by holder

ETF Ownership

Top ETFs holding this stock Held by 39 ETFs in our universe
# ETF Weight Est. AUM exposure TER
1 Invesco NASDAQ Future Gen 200 ETF QQQS 0.49% 107.2K 0.20%
2 iShares Micro-Cap ETF IWC 0.03% 456.7K 0.60%
3 iShares Russell 2000 Value ETF IWN 0.01% 878.1K 0.24%
4 Xtrackers Russell 2000 UCITS ETF 1C XRSU.L 0.00% 137.9K 0.30%
5 Invesco Russell 2000 UCITS ETF RTYS.L 0.00% 13.8K 0.25%
6 Global X - Russell 2000 ETF RSSL 0.00% 63.7K 0.08%
7 iShares Russell 2000 BuyWrite ETF IWMW 0.00% 2.4K 0.39%
8 iShares Russell 2000 ETF IWM 0.00% 3.51M 0.19%
9 iShares U.S. Small Cap Index ETF (CAD-Hedged) XSU.TO 0.00% 22.9K 0.36%
10 iShares Russell 2000 Growth ETF IWO 0.00% 327.8K 0.24%

Insider Activity

Insider Activity — Latest Quarter
Ratio by transactions
0.00
Bearish
Buys
1
Sells
0
Shares acquired
11.0K
Shares disposed
Cash buys
Cash sales
Net activity
+11,000
Insider buys vs sells (history) From To
Recent insider transactions From To
Date Person Role Transaction A/D Security Shares Price Value Owned after D/I Filing
2026-03-09 Hooks Corwin Dale Officer A-Award A Restricted Stock Units 11,000 0.00 11,000 D
2025-12-31 Szwarcberg Javier B. Director / Officer A-Award A Common Stock 4,690 4.53 21.2K 19,004 D
2025-12-15 Szwarcberg Javier B. Director / Officer M-Exempt D Restricted Stock Units 1,480 0.00 1,480 D
2025-12-15 Gharib Samir M. Officer M-Exempt A Common Stock 496 0.00 8,112 D
2025-12-11 Ways Douglas Kirk Director / Officer A-Award A Restricted Stock Units 5,000 0.00 5,000 D
2025-12-11 Walbert Keli 0 0.00 0
2025-12-11 Szwarcberg Javier B. Director / Officer D-Return D Employee Stock Option (right to buy) 10,000 344.25 3.44M 0 D
2025-12-11 SPIEGELMAN DANIEL K Director D-Return D Stock Option (Right to Buy) 458 564.00 258.3K 0 D
2025-12-11 SIMPSON CAMILLA V Director D-Return D Stock Option (Right to Buy) 400 169.50 67.8K 0 D
2025-12-11 Gharib Samir M. Officer D-Return D Stock Option (Right to Buy) 733 1,506.00 1.10M 0 D
2025-12-11 GREY MICHAEL G Director / Officer A-Award A Stock Option (Right to Buy) 1,499 104.13 156.1K 1,499 D
2025-12-11 Barretto-Ko Percival Director A-Award A Stock Option (Right to Buy) 800 104.13 83.3K 800 D
2025-12-10 Szwarcberg Javier B. Director / Officer M-Exempt A Common Stock 1,196 0.00 10,670 D
2025-12-10 Gharib Samir M. Officer M-Exempt A Common Stock 514 0.00 6,580 D
2025-10-20 Szwarcberg Javier B. Director / Officer M-Exempt A Common Stock 4,784 0.00 11,013 D
2025-10-20 Gharib Samir M. Officer F-InKind D Common Stock 661 148.16 97.9K 6,066 D
2025-10-06 Parkman Healthcare Partners LLC 10% Owner P-Purchase A Common Stock, $0.001 par value per share 256 17.91 4.6K 1,307 I
2025-07-23 Ways Kirk Director / Officer A-Award A Stock Option (Right to Buy) 30,000 0.12 3.7K 30,000 D
2025-07-22 SPIEGELMAN DANIEL K Director A-Award A Stock Option (Right to Buy) 30,000 0.12 3.5K 30,000 D
2025-07-22 SIMPSON CAMILLA V Director A-Award A Stock Option (Right to Buy) 30,000 0.12 3.5K 30,000 D
2025-07-22 Muralidhar Bali Director A-Award A Stock Option (Right to Buy) 30,000 0.12 3.5K 30,000 D
2025-07-22 GREY MICHAEL G Director / Officer A-Award A Stock Option (Right to Buy) 30,000 0.12 3.5K 30,000 D
2025-07-22 Barretto-Ko Percival Director A-Award A Stock Option (Right to Buy) 30,000 0.12 3.5K 30,000 D
2025-07-22 Aynechi Tiba Director A-Award A Stock Option (Right to Buy) 30,000 0.12 3.5K 30,000 D
2024-12-16 Szwarcberg Javier B. Director / Officer F-InKind D Common Stock 39,605 0.39 15.4K 467,191 D
2024-12-16 Gharib Samir M. Officer F-InKind D Common Stock 13,737 0.39 5.3K 326,591 D
2024-12-16 Charlton Ralph William III Officer M-Exempt A Common Stock 31,750 0.00 172,668 D
2024-12-10 Szwarcberg Javier B. Director / Officer F-InKind D Common Stock 128,020 0.54 68.7K 338,101 D
2024-12-10 Gharib Samir M. Officer M-Exempt A Common Stock 154,000 0.00 356,776 D
2024-12-10 Charlton Ralph William III Officer M-Exempt A Common Stock 106,400 0.00 161,773 D
2024-05-22 Ways Kirk Director A-Award A Stock Option (Right to Buy) 30,000 0.75 22.5K 30,000
2024-05-22 SPIEGELMAN DANIEL K Director A-Award A Stock Option (Right to Buy) 30,000 0.75 22.5K 30,000
2024-05-22 SIMPSON CAMILLA V Director A-Award A Stock Option (Right to Buy) 30,000 0.75 22.5K 30,000
2024-05-22 Muralidhar Bali Director A-Award A Stock Option (Right to Buy) 30,000 0.75 22.5K 30,000
2024-05-22 GREY MICHAEL G Director / Officer A-Award A Stock Option (Right to Buy) 30,000 0.75 22.5K 30,000
2024-05-22 Barretto-Ko Percival Director A-Award A Stock Option (Right to Buy) 30,000 0.75 22.5K 30,000
2024-05-22 Aynechi Tiba Director A-Award A Stock Option (Right to Buy) 30,000 0.75 22.5K 30,000
2024-03-21 Novo Holdings A/S 10% Owner S-Sale D COMMON STOCK 465,021 0.75 351.0K 2,550,000
2024-03-20 Novo Holdings A/S 10% Owner S-Sale D COMMON STOCK 359,979 0.73 264.1K 3,015,021
2024-03-19 Novo Holdings A/S 10% Owner S-Sale D COMMON STOCK 593,000 0.76 447.7K 3,375,000
2024-03-18 Novo Holdings A/S 10% Owner S-Sale D COMMON STOCK 842,020 0.77 647.0K 3,968,000
2024-03-14 Szwarcberg Javier B. Director / Officer A-Award A Restricted Stock Units 358,800 0.00 358,800
2024-03-14 Novo Holdings A/S 10% Owner S-Sale D COMMON STOCK 1,912,316 0.89 1.70M 4,810,020
2024-03-14 Gharib Samir M. Officer A-Award A Restricted Stock Units 154,000 0.00 154,000
2024-03-14 Charlton Ralph William III Officer A-Award A Restricted Stock Units 106,400 0.00 106,400
2023-12-29 Gharib Samir M. Officer A-Award A Common Stock 11,255 0.98 11.0K 202,776
2023-12-29 Charlton Ralph William III Officer A-Award A Common Stock 9,361 0.98 9.2K 55,373
2023-12-15 Szwarcberg Javier B. Director / Officer M-Exempt D Restricted Stock Units 111,000 0.00 333,000
2023-12-15 Gharib Samir M. Officer M-Exempt D Restricted Stock Units 37,250 0.00 111,750
2023-12-15 Charlton Ralph William III Officer F-InKind D Common Stock 10,980 1.66 18.2K 46,012
2023-12-14 Szwarcberg Javier B. Director / Officer A-Award A Restricted Stock Units 717,600 0.00 717,600
2023-12-14 Gharib Samir M. Officer A-Award A Restricted Stock Units 308,000 0.00 308,000
2023-12-14 Charlton Ralph William III Officer A-Award A Restricted Stock Units 212,800 0.00 212,800
2023-11-26 Szwarcberg Javier B. Director / Officer A-Award A Employee Stock Option (right to buy) 125,000 4.59 573.8K 125,000
2023-11-08 Gharib Samir M. Officer A-Award A Restricted Stock Units 75,000 0.00 75,000
2023-06-30 Szwarcberg Javier B. Director / Officer A-Award A Common Stock 20,000 0.98 19.6K 34,705
2023-06-30 Gharib Samir M. Officer M-Exempt D Restricted Stock Units 75,000 0.00 150,000
2023-06-30 Charlton Ralph William III Officer A-Award A Common Stock 12,378 0.98 12.1K 25,242
2023-05-25 Ways Kirk Director A-Award A Stock Option (Right to Buy) 30,000 2.26 67.8K 30,000
2023-05-25 SPIEGELMAN DANIEL K Director A-Award A Stock Option (Right to Buy) 30,000 2.26 67.8K 30,000
2023-05-25 SIMPSON CAMILLA V Director A-Award A Stock Option (Right to Buy) 30,000 2.26 67.8K 30,000
2023-05-25 O'Donnell Niall Director A-Award A Stock Option (Right to Buy) 30,000 2.26 67.8K 30,000
2023-05-25 Muralidhar Bali Director A-Award A Stock Option (Right to Buy) 30,000 2.26 67.8K 30,000
2023-05-25 GREY MICHAEL G Director / Officer A-Award A Stock Option (Right to Buy) 30,000 2.26 67.8K 30,000
2023-05-25 Barretto-Ko Percival Director D No securities beneficially owned 0 0.00 0
2023-05-25 Aynechi Tiba Director A-Award A Stock Option (Right to Buy) 30,000 2.26 67.8K 30,000
2023-02-16 O'Donnell Niall Director P-Purchase A Common Stock 630,400 3.17 2.00M 1,326,305
2023-02-16 Novo Holdings A/S 10% Owner P-Purchase A COMMON STOCK 2,208,000 3.17 7.00M 6,722,336
2023-01-03 Gharib Samir M. Officer M-Exempt A Common Stock 37,500 0.00 71,111
2022-12-30 Szwarcberg Javier B. Officer A-Award A Common Stock 14,705 0.93 13.7K 14,705
2022-12-30 Gharib Samir M. Officer A-Award A Common Stock 1 0.93 0.93 33,611
2022-12-30 Charlton Ralph William III Officer A-Award A Common Stock 12,864 0.93 12.0K 12,864
2022-12-05 Szwarcberg Javier B. Officer A-Award A Restricted Stock Units 444,000 0.00 444,000
2022-12-05 Gharib Samir M. Officer A-Award A Restricted Stock Units 149,000 0.00 149,000
2022-12-05 Charlton Ralph William III Officer A-Award A Restricted Stock Units 127,000 0.00 127,000
2022-06-30 Gharib Samir M. Officer A-Award A Common Stock 5,446 1.48 8.1K 46,578
2022-05-25 Ways Kirk Director A-Award A Stock Option (Right to Buy) 20,625 0.00 20,625
2022-05-25 SPIEGELMAN DANIEL K Director A-Award A Stock Option (Right to Buy) 22,500 1.32 29.7K 22,500
2022-05-25 SIMPSON CAMILLA V Director A-Award A Stock Option (Right to Buy) 22,500 0.00 22,500
2022-05-25 O'Donnell Niall Director A-Award A Stock Option (Right to Buy) 22,500 0.00 22,500
2022-05-25 Muralidhar Bali Director A-Award A Stock Option (Right to Buy) 22,500 1.32 29.7K 22,500
2022-05-25 GREY MICHAEL G Officer A-Award A Stock Option (Right to Buy) 22,500 0.00 22,500
2022-05-25 Chaya Moghrabi Dina Director A-Award A Stock Option (Right to Buy) 22,500 0.00 22,500
2022-05-25 Aynechi Tiba Director A-Award A Stock Option (Right to Buy) 22,500 0.00 22,500
2022-04-01 Charlton Ralph William III Officer A-Award A Employee Stock Option (right to buy) 250,000 0.00 250,000
2022-03-28 Charlton Ralph William III Officer D No securities beneficially owned 0 0.00 0
2022-01-03 Szwarcberg Javier B. Director / Officer A-Award A Employee Stock Option (right to buy) 750,000 4.59 3.44M 750,000
2022-01-03 Gharib Samir M. Officer A-Award A Employee Stock Option (right to buy) 70,000 4.59 321.3K 70,000
2022-01-01 Szwarcberg Javier B. Director / Officer D Employee Stock Option (right to buy) 250,000 4.59 1.15M 0
2021-12-31 Gharib Samir M. Officer 0 0.00 0
2021-12-16 Gharib Samir M. Officer A-Award A Employee Stock Option (right to buy) 145,000 2.48 359.6K 145,000
2021-12-16 GREY MICHAEL G Director / Officer A-Award A Employee Stock Option (right to buy) 50,000 2.48 124.0K 50,000
2021-12-16 Dias Subaweerage Officer A-Award A Restricted Stock Units 20,000 0.00 20,000
2021-06-30 KING RICHARD Director / Officer J-Other A Common Stock 2,230 9.53 21.2K 2,230
2021-06-30 Gharib Samir M. Officer J-Other A Common Stock 1,412 9.53 13.5K 1,412
2021-06-23 Ways Kirk Director A-Award A Stock Option (Right to Buy) 20,000 10.55 211.0K 20,000
2021-05-20 SPIEGELMAN DANIEL K Director A-Award A Stock Option (Right to Buy) 6,667 15.24 101.6K 6,667
2021-05-20 SIMPSON CAMILLA V Director A-Award A Stock Option (Right to Buy) 10,000 15.24 152.4K 10,000
2021-05-20 O'Donnell Niall Director A-Award A Stock Option (Right to Buy) 10,000 15.24 152.4K 10,000
2021-05-20 Muralidhar Bali Director A-Award A Stock Option (Right to Buy) 10,000 15.24 152.4K 10,000
2021-05-20 GREY MICHAEL G Officer A-Award A Stock Option (Right to Buy) 10,000 15.24 152.4K 10,000
2021-05-20 Chaya Moghrabi Dina Director A-Award A Stock Option (Right to Buy) 10,000 15.24 152.4K 10,000
2021-05-19 Novo Holdings A/S 10% Owner S-Sale D COMMON STOCK 475,000 13.90 6.60M 4,514,336
2021-04-30 SIMPSON CAMILLA V Director M-Exempt A Common Stock 14,045 0.85 11.9K 14,045
2021-01-28 KING RICHARD Director / Officer A-Award A Stock Option (Right to Buy) 155,000 20.08 3.11M 155,000
2021-01-28 Gharib Samir M. Officer A-Award A Stock Option (Right to Buy) 55,000 20.08 1.10M 55,000
2021-01-28 Dias Subaweerage Officer A-Award A Stock Option (Right to Buy) 27,500 20.08 552.2K 27,500
2020-10-14 RiverVest Venture Fund III, L.P. 10% Owner C-Conversion A Common Stock 828,109 0.00 1,898,281
2020-10-14 Omega Fund VI, L.P. C-Conversion D Series B Preferred Stock 12,500,000 0.00 0
2020-10-14 O'Donnell Niall Director C-Conversion D Series B Preferred Stock 2,916,664 0.00 0
2020-10-14 Novo Holdings A/S 10% Owner C-Conversion A COMMON STOCK 4,739,336 0.00 4,739,336
2020-10-14 Muralidhar Bali Director C-Conversion D Series B Preferred Stock 10,416,666 0.00 0
2020-10-14 HealthCap VIII, L.P. C-Conversion A Common Stock 1,783,621 0.00 1,783,621
2020-10-14 HANSSON JONAS Director C-Conversion D Series B Preferred Stock 11,666,666 0.00 0
2020-10-14 Chaya Moghrabi Dina Director P-Purchase A Common Stock 250,000 15.00 3.75M 2,161,022
2020-10-08 SPIEGELMAN DANIEL K Director D Stock Option (Right to Buy) 34,398 7.52 258.7K 0
2020-10-08 SIMPSON CAMILLA V Director D Stock Option (Right to Buy) 27,212 3.07 83.5K 0
2020-10-08 RiverVest Venture Fund III, L.P. 10% Owner I Series A Preferred Stock 1,070,172 0.00 0
2020-10-08 O'Donnell Niall Director I Series B Preferred Stock 445,905 0.00 0
2020-10-08 Novo Holdings A/S 10% Owner D SERIES B CONVERTIBLE PREFERRED STOCK 1,528,818 0.00 0
2020-10-08 Muralidhar Bali Director I Series B Preferred Stock 1,592,518 0.00 0
2020-10-08 KING RICHARD Director / Officer D Stock Option (Right to Buy) 310,197 3.07 952.3K 0
2020-10-08 HealthCap VIII, L.P. 10% Owner D Series B Preferred Stock 1,783,621 0.00 0
2020-10-08 HANSSON JONAS Director I Series B Preferred Stock 1,783,621 0.00 0
2020-10-08 Gharib Samir M. Officer D Stock Option (Right to Buy) 118,483 1.64 194.3K 0
2020-10-08 GREY MICHAEL G Director / Officer D Stock Option (Right to Buy) 94,174 1.64 154.4K 0
2020-10-08 Dias Subaweerage Officer D Stock Option (Right to Buy) 209,035 7.52 1.57M 0
2020-10-08 Chaya Moghrabi Dina Director I Series B Preferred Stock 1,911,022 0.00 0
2020-10-08 Aynechi Tiba Director 0 0.00 0

Executive team

Top executives
Shares Outstanding
1.37M

Executive compensation

Executive compensation (annual)
# Year Executive Salary Bonus Stock award Option award Incentive Other Total % Stock-
based
Filing
1 2025 Javier Szwarcberg, M.D., MPH Chief Executive Officer 610.0K 503.3K 1.75M 41.8K 5.0K 2.91M 61.58%
2 2025 Samir Gharib President and Chief Financial Officer 465.1K 313.9K 671.9K 17.3K 5.0K 1.47M 46.78%
3 2025 Kirk Ways, M.D., Ph.D. Interim Chief Medical Officer 442.1K 5.5K 596.8K 1.04M 42.85%
4 2024 Javier Szwarcberg, M.D., MPH Chief Executive Officer 610.0K 335.5K 581.7K 5.0K 1.53M 37.96%
5 2024 Ralph William Charlton III, M.D., M.A.S. Former Chief Medical Officer 457.6K 183.0K 172.5K 348.2K 1.16M 14.85%
6 2024 Samir Gharib President and Chief Financial Officer 465.1K 209.9K 249.7K 5.0K 929.7K 26.85%
7 2023 Javier Szwarcberg, M.D., MPH Chief Executive Officer 580.0K 47.9K 1.21M 319.0K 5.0K 2.16M 55.88%
8 2023 Samir Gharib President and Chief Financial Officer 447.2K 30.2K 517.4K 201.2K 5.0K 1.20M 43.08%
9 2023 Ralph William Charlton III, M.D., M.A.S. Chief Medical Officer 440.0K 26.4K 357.5K 176.0K 5.0K 1.00M 35.58%
10 2023 Ralph William Charlton III, M.D., M.A.S. Former Chief Medical Officer 440.0K 26.4K 357.5K 176.0K 5.0K 1.00M 35.58%
11 2022 Javier Szwarcberg, M.D., MPH Chief Executive Officer 540.0K 519.5K 3.27M 153.9K 5.0K 4.49M 84.44%
12 2022 Samir Gharib President and Chief Financial Officer 425.8K 174.3K 259.9K 110.3K 5.0K 975.4K 44.52%
13 2022 Ralph William Charlton III, M.D., M.A.S. Chief Medical Officer 305.6K 148.6K 433.5K 69.7K 5.0K 962.4K 60.49%
14 2022 Michael Grey Executive Chairman and Former Interim Chief Executive Officer 70.0K 29.7K 99.7K 29.79%
15 2021 Richard King Former Chief Executive Officer 437.5K 4.11M 559.7K 5.11M 80.47%
16 2021 Samir Gharib President and Chief Financial Officer 380.0K 558.0K 1.16M 100.0K 2.19M 78.13%
17 2021 Rosh Dias, M.D., M.R.C.P. Former Chief Medical Officer 430.0K 49.6K 583.0K 43.0K 1.11M 57.22%
18 2021 Michael Grey Executive Chairman and Former Interim Chief Executive Officer 65.0K 667.3K 732.3K 91.12%
19 2020 Richard King Former Chief Executive Officer 409.6K 1.63M 430.0K 2.47M 65.98%
20 2020 Richard King Chief Executive Officer 409.6K 1.63M 430.0K 2.47M 65.98%
21 2020 Rosh Dias, M.D., M.R.C.P. Chief Medical Officer 159.8K 1.38M 52.5K 91.6K 1.68M 81.92%
22 2020 Rosh Dias, M.D., M.R.C.P. Former Chief Medical Officer 159.8K 1.38M 52.5K 91.6K 1.68M 81.92%
23 2020 Samir Gharib President and Chief Financial Officer 227.4K 452.2K 113.9K 793.4K 56.99%
24 2020 Samir Gharib Chief Financial Officer 227.4K 452.2K 113.9K 793.4K 56.99%
25 2020 Michael Grey Executive Chairman and Former Interim Chief Executive Officer 608.0K 14.9K 622.9K 97.62%
26 2019 Richard King Chief Executive Officer 270.5K 229.3K 50.0K 549.8K 41.71%
CEO compensation breakdown

Proxy statements

Proxy statements (DEF 14A)
Filing date Form type Filing
2026-04-09 DEFA14A
2026-04-09 DEF 14A
2025-06-12 DEFA14A
2025-06-06 DEFA14A
2025-06-06 DEFA14A
2025-04-28 DEFA14A
2025-04-28 DEF 14A
2025-04-18 PRE 14A

Recent SEC filings

Recent SEC filings
Filing date Form type Filing
2026-05-07 SC 13G/A
2026-04-28 SC 13G
2026-04-22 8-K
2026-04-21 424B5
2026-04-20 424B5
2026-04-09 DEFA14A
2026-04-09 DEF 14A
2026-04-09 ARS
2026-03-20 8-K
2026-03-09 S-8

Executive team

NameTitleCompensationGender
Javier Szwarcberg Chief Executive Officer & Director 1M
Samir Gharib President & Chief Financial Officer 784.0K male
Kirk Ways Chief Medical Officer & Director 596.8K
Michael G. Grey Executive Chairman 70.0K male
Corwin Dale Hooks Chief Commercial Officer male
Daven Mody Senior Vice President of Regulatory & Quality
Bruno Gagnon BPHARM Senior Vice President of Clinical Development Operations male
ESG Rating
B
BIOTECHNOLOGY
Rank: 529 out of 710
2025
E (Environmental)
59.4 / 56.3
Company / Sector avg.
S (Social)
62.5 / 62.4
Company / Sector avg.
G (Governance)
57.9 / 60.9
Company / Sector avg.
ESG Total
59.9 / 59.9
Company / Sector avg.
ESG Score History BIOTECHNOLOGY
Benchmark vs Sector
Senate Trading Activity

No Senate trading activity found for this company.

House Trading Activity

No House trading activity found for this company.

Market share among peers
Peer comparison — filtered group (TTM)
Your opinion

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Dividend history

Earnings history

Earnings reports

Stock splits