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Ultragenyx Pharmaceutical Inc. (RARE)

USD33.22 -0.60 (-1.77%)
US NASDAQ Healthcare Biotechnology
Address 60 Leveroni Court 94949
Novato, CA, US
CEO Emil D. Kakkis
IPO 2014-01-31
CIK 1515673 ISIN US90400D1081

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Description

Ultragenyx Pharmaceutical Inc. is a biopharmaceutical firm dedicated to discovering, developing, and commercializing innovative treatments for rare and ultra-rare genetic conditions. Its operations span North America, Europe, and other international markets. The company's portfolio of marketed biologic products addresses several serious diseases. This includes Crysvita (burosumab), an antibody that targets fibroblast growth factor 23, used to treat X-linked hypophosphatemia and tumor-induced osteomalacia. Mepsevii offers enzyme replacement therapy for both pediatric and adult patients suffering from Mucopolysaccharidosis VII. Dojolvi is available for individuals with long-chain fatty acid oxidation disorders, while Evkeeza (evinacumab) provides a treatment option for homozygous familial hypercholesterolemia. Ultragenyx also boasts a robust pipeline of investigational therapies. Notable candidates include DTX401, an adeno-associated virus 8 (AAV8) gene therapy for glycogen storage disease type Ia, and DTX301, another AAV8 gene therapy aimed at ornithine transcarbamylase deficiency. Other promising developments feature UX143, a human monoclonal antibody for osteogenesis imperfecta; GTX-102, an antisense oligonucleotide designed for Angelman syndrome; UX701, targeting Wilson disease; and UX053, in development for glycogen storage disease type III. To advance its research and development efforts, Ultragenyx Pharmaceutical Inc. maintains strategic collaboration and licensing agreements with numerous partners, such as Kyowa Kirin Co., Ltd., Saint Louis University, REGENXBIO Inc., Bayer Healthcare LLC, GeneTx, Mereo, University of Pennsylvania, Arcturus Therapeutics Holdings Inc., Solid Biosciences Inc., and Daiichi Sankyo Co., Ltd. The company was founded in 2010 and operates from its headquarters in Novato, California.

News Sentiment (7d)
Market Cap & Enterprise Value
Merger & Acquisition History

No mergers or acquisitions recorded for this company.

Technical Outlook
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Signal Summary Loading…
Indicator 1D1W2W3W1M
Each column is computed on that timeframe's candles (1D = daily, 1W ≈ weekly, 1M ≈ monthly), not on the same last day. ▲ bullish · ▼ bearish · — neutral. The Net row counts signals per column; hover any cell (or the indicator name) to see the exact rule behind it.
Day Score & sub-scores
Statistical fingerprint & regime detail
Conditional historical analysis
Customize analysis (advanced)
Indicative levels generated algorithmically. Not financial advice.
Risk Profile
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Price Chart
Averages
Trend
Price
Levels
Draw
USD33.22 -0.60 (-1.77%)
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Volume Profile
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Liquidity & share structure
Average Volume
2M
Beta
0.38
Float Shares
92.93M
Free Float %
94.5%
Price Performance
1D5D1M3M6M YTD1Y3Y5Y10YMax
+2.05% +3.03% +13.58% +30.80% -18.42% +16.70% -24.18% -45.25% -74.85% -54.71% -36.47%
Rolling Volatility
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Drawdown
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Relative Strength
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Monthly Returns Heatmap
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Annual Monthly Returns
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Daily Returns Distribution
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Revenue flow

Revenue by geography

Revenue by segment

From To

Revenue composition

From To

By product

By geography

Financial Statements

Income Statement

Balance Sheet

Cash Flow Statement

Key Metrics

Financial Ratios

Employees

Financial Growth (CAGR)

Market Data

Analyst Consensus (33 ratings, all time) Buy
Price Targets & DCF
Current price
33.22
Low 26.00 -21.7%
Consensus 48.36 +45.6%
Median 45.00 +35.5%
High 67.00 +101.7%
Ratings Trend (MoM) 90% Bullish
Rating 2026-05 Change
Strong Buy 5 0
Buy 13 0
Hold 2 0
Sell 0 0
Strong Sell 0 0
Price Target Summary
Period # Analysts Avg Target
Last Month 2
55.00
+65.6%
Last Quarter 8
49.00
+47.5%
Last Year 17
50.47
+51.9%
All Time 42
86.71
+161.0%
Quality scores
Altman Z-Score
-4.63
Distress
Piotroski F-Score
2 / 9
Weak
MOAT Score
3 / 10
No MOAT
Composite Rating
C+
Overall Score
2 / 5
Medium
DCF Score
4 / 5
High
ROE Score
5 / 5
High
ROA Score
1 / 5
Low
D/E Score
1 / 5
Low
P/E Score
1 / 5
Low
P/Book Score
1 / 5
Low
Operational MOAT
✗ Below peers
  • Revenue growth Biotechnology: +1.6%
    +20.1% Q1'26: -2.4% (vs Q1'25)
  • EPS growth Biotechnology: +29.7%
    +7.3% Q1'26: -17.2% (vs Q1'25)
  • FCF margin FCF growth · Biotechnology: +16.2%
    -88.4% Q1'26: -145.6% (vs Q1'25)
  • EBIT margin Biotechnology: +0.0%
    -79.5% Q1'26: -124.3% (vs Q1'25)
  • ROIC Biotechnology: -16.1%
    -104.9% Q1'26: -121.1% (vs Q1'25)
  • Share dilution Biotechnology: -3.4%
    +8.9% Q1'26: +4.5% (vs Q1'25)
  • Debt / EBITDA Net debt/EBITDA · Biotechnology: 0.16×
    -2.55× Q1'26: -1.86× (vs Q1'25)
Valuation Multiples From To
DCF Interactive Model (UFCF)
Projection years:
Market assumptions
WACC components (optional)
Ke (Cost of Equity) = Rf + β (0.39) × ERP
WACC = 67% × Ke + 33% × Kd (4.9%) × (1−t)

Modifying these values recalculates WACC automatically.

Business assumptions
Current price: 33.22
Enterprise Value: Equity Value: Terminal Value: TV as % of EV:

Base values reflect the latest available data for this company and market conditions.

Consensus Estimates
Metric Dec 2016
actual
Dec 2017
actual
Dec 2018
actual
Dec 2019
actual
Dec 2020
actual
Dec 2021
actual
Dec 2022
actual
Dec 2023
actual
Dec 2024
actual
Dec 2025
actual
Dec 2026
14 Rev. Ana.
11 EPS Ana.
Dec 2027
14 Rev. Ana.
8 EPS Ana.
Dec 2028
13 Rev. Ana.
8 EPS Ana.
Dec 2029
12 Rev. Ana.
6 EPS Ana.
Dec 2030
6 Rev. Ana.
6 EPS Ana.
Revenue
133.0K
est: 250.6K (-46.9%)
2.61M
est: 611.5K (+327.2%)
51.50M
est: 49.01M (+5.1%)
103.71M
est: 100.42M (+3.3%)
271.03M
est: 250.02M (+8.4%)
351.41M
est: 351.78M (-0.1%)
363.33M
est: 361.74M (+0.4%)
434.25M
est: 481.30M (-9.8%)
560.23M
est: 547.60M (+2.3%)
673.00M
est: 664.69M (+1.3%)
741.94M
726.60M – 764.21M
+11.6% YoY
988.07M
741.23M – 1.47B
+33.2% YoY
1.23B
1.22B – 1.24B
+24.5% YoY
1.62B
1.36B – 2.21B
+32.0% YoY
2.13B
1.78B – 2.90B
+31.4% YoY
EBITDA
-244.58M
est: -234.22M (-4.4%)
-312.51M
est: -327.78M (+4.7%)
-177.56M
est: -69.36M (-156.0%)
-389.77M
est: -367.46M (-6.1%)
-139.81M
est: -101.61M (-37.6%)
-410.32M
est: -355.54M (-15.4%)
-640.49M
est: -375.95M (-70.4%)
-516.45M
est: -440.88M (-17.1%)
-469.00M
est: -501.61M (+6.5%)
-500.00M
est: -608.87M (+17.9%)
-679.63M
-700.03M – -665.58M
-11.6% YoY
-905.09M
-1.35B – -678.98M
-33.2% YoY
-1.13B
-1.14B – -1.11B
-24.5% YoY
-1.49B
-2.02B – -1.24B
-32.0% YoY
-1.95B
-2.66B – -1.63B
-31.4% YoY
EBIT
-248.01M
est: -238.75M (-3.9%)
-318.34M
est: -337.08M (+5.6%)
-197.10M
est: -777.41M (+74.6%)
-398.31M
est: -400.33M (+0.5%)
-152.07M
est: -515.06M (+70.5%)
-423.56M
est: -344.13M (-23.1%)
-658.71M
est: -399.22M (-65.0%)
-542.46M
est: -452.00M (-20.0%)
-504.55M
est: -514.25M (+1.9%)
-535.00M
est: -624.21M (+14.3%)
-696.76M
-717.68M – -682.36M
-11.6% YoY
-927.91M
-1.38B – -696.10M
-33.2% YoY
-1.16B
-1.17B – -1.14B
-24.5% YoY
-1.52B
-2.07B – -1.27B
-32.0% YoY
-2.00B
-2.73B – -1.68B
-31.4% YoY
Net Income
-245.87M
est: -236.72M (-3.9%)
-302.14M
est: -309.44M (+2.4%)
-197.61M
est: -115.30M (-71.4%)
-402.73M
est: -379.98M (-6.0%)
-186.57M
est: -176.32M (-5.8%)
-454.03M
est: -396.60M (-14.5%)
-707.42M
est: -413.87M (-70.9%)
-606.64M
est: -585.12M (-3.7%)
-569.18M
est: -612.92M (+7.1%)
-575.00M
est: -609.00M (+5.6%)
-498.15M
-532.30M – -195.34M
+18.2% YoY
-40.12M
-481.68M – 1.06B
+91.9% YoY
111.63M
-63.24M – 142.28M
+378.2% YoY
286.27M
225.24M – 420.30M
+156.4% YoY
530.25M
417.21M – 778.51M
+85.2% YoY
SGA
64.94M
est: 168.1K (+38,525.5%)
99.91M
est: 410.2K (+24,258.5%)
127.72M
est: 32.88M (+288.5%)
161.52M
est: 67.36M (+139.8%)
182.93M
est: 167.71M (+9.1%)
219.98M
est: 198.88M (+10.6%)
278.14M
est: 215.02M (+29.4%)
309.80M
est: 307.80M (+0.6%)
321.61M
est: 350.20M (-8.2%)
349.00M
est: 425.08M (-17.9%)
474.48M
464.68M – 488.73M
+11.6% YoY
631.89M
474.03M – 942.09M
+33.2% YoY
786.65M
777.30M – 796.00M
+24.5% YoY
1.04B
867.96M – 1.41B
+32.0% YoY
1.36B
1.14B – 1.86B
+31.4% YoY
EPS
-6.21
est: -6.14 (-1.1%)
-7.12
est: -7.28 (+2.2%)
-3.97
est: -4.17 (+4.9%)
-7.12
est: -6.94 (-2.6%)
-3.07
est: -3.79 (+19.1%)
-6.70
est: -6.25 (-7.1%)
-10.12
est: -9.92 (-2.0%)
-8.25
est: -7.23 (-14.1%)
-6.29
est: -6.19 (-1.6%)
-5.83
est: -5.60 (-4.1%)
-4.49
-5.40 – -1.98
+19.9% YoY
-0.65
-4.89 – 10.80
+85.5% YoY
0.59
-0.64 – 1.44
+190.2% YoY
2.90
2.28 – 4.26
+395.9% YoY
5.38
4.23 – 7.90
+85.2% YoY
Historical Ratings (3M)
Date Rating Overall DCF ROE ROA D/E P/E P/B
2026-05-12 C+ 2/5 4/5 5/5 1/5 1/5 1/5 1/5
2026-05-11 C+ 2/5 4/5 5/5 1/5 1/5 1/5 1/5
2026-05-08 C+ 2/5 4/5 5/5 1/5 1/5 1/5 1/5
2026-05-07 C+ 2/5 4/5 5/5 1/5 1/5 1/5 1/5
2026-05-06 C+ 2/5 4/5 5/5 1/5 1/5 1/5 1/5
2026-05-05 C+ 2/5 4/5 5/5 1/5 1/5 1/5 1/5
2026-05-04 C+ 2/5 4/5 5/5 1/5 1/5 1/5 1/5
2026-05-01 C+ 2/5 4/5 5/5 1/5 1/5 1/5 1/5
2026-04-30 C+ 2/5 4/5 5/5 1/5 1/5 1/5 1/5
2026-04-29 C+ 2/5 4/5 5/5 1/5 1/5 1/5 1/5
2026-04-28 C+ 2/5 4/5 5/5 1/5 1/5 1/5 1/5
2026-04-27 C+ 2/5 4/5 5/5 1/5 1/5 1/5 1/5
2026-04-24 C+ 2/5 4/5 5/5 1/5 1/5 1/5 1/5
2026-04-23 C+ 2/5 4/5 5/5 1/5 1/5 1/5 1/5
2026-04-22 C+ 2/5 4/5 5/5 1/5 1/5 1/5 1/5
2026-04-21 C+ 2/5 4/5 5/5 1/5 1/5 1/5 1/5
2026-04-20 C+ 2/5 4/5 5/5 1/5 1/5 1/5 1/5
2026-04-17 C+ 2/5 4/5 5/5 1/5 1/5 1/5 1/5
2026-04-16 C+ 2/5 4/5 5/5 1/5 1/5 1/5 1/5
2026-04-15 C+ 2/5 4/5 5/5 1/5 1/5 1/5 1/5

Owner Earnings

Owner's Earnings (history) From To
Owner alignment
Owner's Earnings TTM
-445.84M
OE per share TTM
-4.47
Owner's Yield
-17.09%
Maintenance CapEx ratio
Maint CapEx / Avg PPE
52.5%

Ownership Overview

Ownership breakdown
At a glance
Institutional holders
40
Total invested
80.30M
Insider transactions (90d)
10
Beneficial owners (>5%)
26
Beneficial owners (>5%)
# Reporting person Amount owned % of class Sole voting Shared voting Sole dispositive Shared dispositive Type Citizenship Filing date SEC filing
1 Ultragenyx Pharmaceutical Inc. 7.83M 14.50% 7.83M 7.83M 11.00 CO 2020-11-06
2 Capital International Investors ** 6.59M 11.40% 6.31M 6.59M IA 2020-02-14
3 The Vanguard Group - 23-1945930 5.92M 8.69% 37.4K 5.83M 95.3K IA Pennsylvania For 2022-02-10
4 52-0556948 5.68M 8.10% 1.84M 5.68M IA Maryland 2022-08-10
5 Wellington Group Holdings LLP 5.20M 7.42% 4.80M HC Delaware 2023-02-06
6 Wellington Investment Advisors Holdings LLP 5.20M 7.42% 4.80M HC Delaware 2023-02-06
7 Wellington Management Group LLP 5.20M 7.42% 4.80M HC Massachusetts 2023-02-06
8 Wellington Management Company LLP 5.06M 7.22% 4.78M IA Delaware 2023-02-06
9 (1)Names of reporting persons. BlackRock, Inc. 4.34M 6.20% 4.10M 4.34M HC Delaware 2023-02-03
10 Federated Hermes, Inc. 4.28M 6.47% 4.28M 4.28M HC Citizenship or place of Organization 2021-02-12
11 J. Christopher Donahue 4.28M 6.47% 4.28M 4.28M IN Citizenship or place of Organization 2021-02-12
12 Rhodora J. Donahue 4.28M 6.47% 4.28M 4.28M IN Citizenship or place of Organization 2021-02-12
13 Thomas R. Donahue 4.28M 6.47% 4.28M 4.28M IN Citizenship or place of Organization 2021-02-12
14 Voting Shares Irrevocable Trust 4.28M 6.47% 4.28M 4.28M OO Citizenship or place of Organization 2021-02-12
15 Frank M. Sands 4.12M 5.00% 2.96M HC, IN United States 2024-02-13
16 Sands Capital Management, LLC 4.12M 5.00% 2.96M IA Delaware 2024-02-13
17 RTW Investments, LP 3.97M 5.70% 3.97M IA, PN Delaware 2023-02-14
18 Roderick Wong 3.97M 5.70% 3.97M HC, IN United States 2023-02-14
19 Abigail P. Johnson 3.81M 9.00% 3.81M IN Delaware 2017-07-10
20 FMR LLC 3.81M 9.00% 435.9K 3.81M HC Delaware 2017-07-10
21 (1) BlackRock, Inc. 3.41M 4.90% 3.24M 3.41M HC Delaware 2022-03-09
22 Capital World Investors ** 3.24M 5.60% 3.24M 3.24M IA 2020-02-14
23 New Perspective Fund 2.77M 6.50% IV Delaware 2018-02-14
24 Susan Jeffs 1.50M 8.40% 82.3K 1.5K 2.31M 82.2K IN Pennsylvania 2016-02-11
25 27-2546083 1.20M 4.60% 1.20M 1.20M CO 2021-10-26
26 95-1411037 13.00 8.30% 5.58M 5.63M IA Delaware 2022-02-11

Institutional Activity (13F)

Institutional ownership trend From To
13F snapshot — 2026 Q1
Investors holding
40
-280 vs prev Q
New positions
11
Closed positions
264
Increased
25
Reduced
8
Put/Call ratio
0.00
Calls held
Puts held
Top institutional holders
# Investor Shares / Δ Mkt value / Δ Own% / Δ Weight% / Δ Avg px / Perf. Hold / Status
1 329.1K +329.1K (+100.0%) 7.57B +7.6B (+100.0%) 0.33% +0.334 pp 5.43% +5.426 pp USD23.00 +0.0% 1 qtrs NEW
2 MACQUARIE MANAGEMENT HOLDINGS, INC. 182.8K +182.8K (+100.0%) 4.21B +4.2B (+100.0%) 0.19% +0.185 pp 0.01% +0.006 pp USD23.00 +0.0% 1 qtrs NEW
3 VANGUARD GROUP INC 10.26M +131.1K (+1.3%) 236.07M -68.7M (-22.5%) 10.41% +0.118 pp 0.00% -0.001 pp USD60.30 -61.9% 48 qtrs
4 BLACKROCK, INC. 6.63M +206.3K (+3.2%) 152.53M -40.7M (-21.1%) 6.73% +0.200 pp 0.00% -0.001 pp USD52.25 -56.0% 6 qtrs
5 STATE STREET CORP 4.30M +610.6K (+16.5%) 98.97M -12.1M (-10.9%) 4.36% +0.614 pp 0.00% -0.001 pp USD45.73 -49.7% 48 qtrs
6 JPMORGAN CHASE & CO 3.97M -37.4K (-0.9%) 91.40M -29.3M (-24.3%) 3.98% -0.091 pp 0.01% -0.002 pp USD37.46 -38.6% 48 qtrs
7 SANDS CAPITAL MANAGEMENT, LLC 3.49M -284.1K (-7.5%) 80.17M -33.2M (-29.3%) 3.49% -0.335 pp 0.24% -0.069 pp USD45.19 -49.1% 11 qtrs
8 RTW INVESTMENTS, LP 3.00M -258.1K (-7.9%) 69.00M -29.0M (-29.6%) 3.04% -0.267 pp 0.69% -0.516 pp USD42.09 -45.4% 17 qtrs
9 BAKER BROS. ADVISORS LP 2.77M +— (+0.0%) 63.77M -19.6M (-23.5%) 2.81% -0.004 pp 0.37% -0.229 pp USD55.07 -58.2% 21 qtrs
10 FMR LLC 2.67M -4.6M (-63.4%) 61.32M -157.8M (-72.0%) 2.70% -4.693 pp 0.00% -0.008 pp USD33.46 -31.3% 48 qtrs
11 WELLINGTON MANAGEMENT GROUP LLP 2.46M +516.8K (+26.6%) 56.62M -1.9M (-3.2%) 2.50% +0.521 pp 0.01% 0.000 pp USD55.26 -58.4% 48 qtrs
12 CITADEL ADVISORS LLC 2.33M +2.0M (+602.9%) 53.50M +43.5M (+437.4%) 2.36% +2.023 pp 0.01% +0.007 pp USD24.22 -5.0% 48 qtrs
13 SUVRETTA CAPITAL MANAGEMENT, LLC 2.02M +— (+0.0%) 46.44M -14.3M (-23.5%) 2.05% -0.003 pp 0.95% -0.603 pp USD41.40 -44.4% 17 qtrs
14 FRONTIER CAPITAL MANAGEMENT CO LLC 1.97M +896.0K (+83.8%) 45.20M +13.0M (+40.5%) 1.99% +0.907 pp 0.48% +0.191 pp USD28.53 -19.4% 3 qtrs
15 BNP PARIBAS ASSET MANAGEMENT HOLDING S.A. 1.90M +354.4K (+22.9%) 43.69M -2.8M (-6.0%) 1.93% +0.357 pp 0.05% -0.070 pp USD37.46 -38.6% 9 qtrs
16 GEODE CAPITAL MANAGEMENT, LLC 1.84M +257.7K (+16.3%) 42.29M -5.3M (-11.1%) 1.86% +0.259 pp 0.00% 0.000 pp USD56.40 -59.2% 48 qtrs
17 MORGAN STANLEY 1.83M +916.1K (+100.7%) 42.00M +14.6M (+53.4%) 1.85% +0.928 pp 0.00% +0.001 pp USD35.52 -35.2% 48 qtrs
18 JACOBS LEVY EQUITY MANAGEMENT, INC 1.75M -418.5K (-19.3%) 40.23M -25.0M (-38.3%) 1.77% -0.428 pp 0.16% -0.104 pp USD30.96 -25.7% 3 qtrs
19 PRICE T ROWE ASSOCIATES INC /MD/ 1.55M -755.8K (-32.7%) 35.75M -33.7M (-48.6%) 1.58% -0.770 pp 0.00% -0.004 pp USD67.66 -66.0% 48 qtrs
20 ABRDN PLC 1.47M +496.3K (+51.0%) 33.81M +4.5M (+15.4%) 1.47% +0.484 pp 0.05% +0.006 pp USD31.45 -26.9% 9 qtrs
21 GW&K INVESTMENT MANAGEMENT, LLC 1.38M +225.2K (+19.6%) 31.63M -3.0M (-8.6%) 1.38% +0.210 pp 0.27% -0.033 pp USD34.02 -32.4% 12 qtrs
22 AQR CAPITAL MANAGEMENT LLC 1.36M +614.3K (+82.3%) 31.29M +8.8M (+39.4%) 1.38% +0.622 pp 0.02% +0.002 pp USD29.30 -21.5% 9 qtrs
23 ROCK SPRINGS CAPITAL MANAGEMENT LP 1.27M +20.9K (+1.7%) 29.15M -8.3M (-22.3%) 1.29% +0.019 pp 1.49% -0.696 pp USD58.30 -60.5% 48 qtrs
24 NORGES BANK 1.26M +1.3M (+100.0%) 29.00M +29.0M (+100.0%) 1.26% +1.264 pp 0.00% +0.003 pp USD23.00 +0.0% 1 qtrs NEW
25 BANK OF AMERICA CORP /DE/ 1.21M +558.9K (+85.3%) 27.92M +8.2M (+41.7%) 1.23% +0.566 pp 0.00% +0.001 pp USD36.16 -36.4% 48 qtrs
26 PICTET ASSET MANAGEMENT HOLDING SA 1.23M -226.9K (-15.6%) 26.56M -17.4M (-39.6%) 1.23% -0.247 pp 0.03% -0.017 pp USD38.91 -40.9% 10 qtrs
27 JANE STREET GROUP, LLC 1.02M +667.3K (+188.4%) 23.49M +12.8M (+120.5%) 1.04% +0.676 pp 0.00% +0.002 pp USD26.52 -13.3% 26 qtrs
28 BNP PARIBAS ARBITRAGE, SNC 903.1K +330.0K (+57.6%) 20.77M +3.5M (+20.5%) 0.92% +0.334 pp 0.01% +0.000 pp USD29.95 -23.2% 46 qtrs
29 MILLENNIUM MANAGEMENT LLC 880.6K +781.4K (+787.6%) 20.25M +17.3M (+578.7%) 0.89% +0.792 pp 0.01% +0.007 pp USD25.27 -9.0% 26 qtrs
30 RUSSELL INVESTMENTS GROUP, LTD. 840.8K +369.0 (+0.0%) 19.34M -5.9M (-23.5%) 0.85% -0.001 pp 0.02% -0.008 pp USD31.39 -26.7% 37 qtrs
31 NUVEEN, LLC 801.5K +119.3K (+17.5%) 18.43M -2.1M (-10.2%) 0.81% +0.120 pp 0.00% -0.001 pp USD32.89 -30.1% 4 qtrs
32 CANDRIAM S.C.A. 799.4K +44.7K (+5.9%) 18.39M -4.3M (-19.0%) 0.81% +0.044 pp 0.09% -0.027 pp USD42.78 -46.2% 21 qtrs
33 SCHONFELD STRATEGIC ADVISORS LLC 741.6K -403.0K (-35.2%) 17.06M -17.4M (-50.5%) 0.75% -0.410 pp 0.08% -0.120 pp USD36.49 -37.0% 9 qtrs
34 UBS GROUP AG 668.8K +121.8K (+22.3%) 15.38M -1.1M (-6.5%) 0.68% +0.123 pp 0.00% 0.000 pp USD36.22 -36.5% 45 qtrs
35 VOLORIDGE INVESTMENT MANAGEMENT, LLC 643.4K +160.8K (+33.3%) 14.80M +281.1K (+1.9%) 0.65% +0.162 pp 0.05% +0.003 pp USD28.31 -18.8% 2 qtrs
36 SUSQUEHANNA INTERNATIONAL GROUP, LLP 631.3K +322.9K (+104.7%) 14.52M +5.2M (+56.5%) 0.64% +0.327 pp 0.00% +0.001 pp USD31.43 -26.8% 47 qtrs
37 DEUTSCHE BANK AG\ 599.5K -946.6K (-61.2%) 13.79M -32.7M (-70.4%) 0.60% -0.969 pp 0.00% -0.011 pp USD49.47 -53.5% 48 qtrs
38 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 598.9K -1.2K (-0.2%) 13.78M -4.3M (-23.7%) 0.60% -0.009 pp 0.00% -0.001 pp USD66.62 -65.5% 48 qtrs
39 POLAR CAPITAL HOLDINGS PLC 556.6K -27.1K (-4.6%) 12.80M -4.8M (-27.1%) 0.56% -0.028 pp 0.05% -0.035 pp USD35.87 -35.9% 4 qtrs
40 NORTHERN TRUST CORP 526.7K +27.5K (+5.5%) 12.11M -2.9M (-19.3%) 0.53% +0.027 pp 0.00% 0.000 pp USD59.83 -61.6% 48 qtrs
41 BALYASNY ASSET MANAGEMENT L.P. 520.1K +520.1K (+100.0%) 11.96M +12.0M (+100.0%) 0.53% +0.527 pp 0.02% +0.015 pp USD23.00 +0.0% 5 qtrs
42 HRT FINANCIAL LP 501.7K +501.7K (+100.0%) 11.54M +11.5M (+100.0%) 0.51% +0.509 pp 0.04% +0.036 pp USD23.00 +0.0% 13 qtrs
43 TWO SIGMA ADVISERS, LP 481.6K -36.1K (-7.0%) 11.08M -4.5M (-28.9%) 0.49% -0.037 pp 0.02% -0.010 pp USD51.02 -54.9% 14 qtrs
44 JEFFERIES FINANCIAL GROUP INC. 477.1K +477.1K (+100.0%) 10.97M +11.0M (+100.0%) 0.48% +0.478 pp 0.06% +0.056 pp USD23.00 +0.0% 1 qtrs NEW
45 PALO ALTO INVESTORS LP 461.3K +91.8K (+24.8%) 10.61M -505.7K (-4.5%) 0.47% +0.093 pp 1.48% -0.580 pp USD29.34 -21.6% 3 qtrs
46 TWO SIGMA INVESTMENTS, LP 424.0K +97.9K (+30.0%) 9.75M -58.4K (-0.6%) 0.43% +0.099 pp 0.01% -0.001 pp USD41.95 -45.2% 23 qtrs
47 FRED ALGER MANAGEMENT, LLC 411.9K -36.9K (-8.2%) 9.47M -4.0M (-29.8%) 0.42% -0.038 pp 0.04% -0.015 pp USD52.19 -55.9% 45 qtrs
48 LEGAL & GENERAL GROUP PLC 411.3K +8.5K (+2.1%) 9.46M -2.7M (-21.9%) 0.41% +0.003 pp 0.00% -0.001 pp USD39.86 -42.3% 46 qtrs
49 CAPTION MANAGEMENT, LLC 404.7K +254.9K (+170.2%) 9.31M +4.8M (+106.6%) 0.41% +0.258 pp 0.06% +0.029 pp USD29.11 -21.0% 16 qtrs
50 MOORE CAPITAL MANAGEMENT, LP 403.3K +403.3K (+100.0%) 9.28M +9.3M (+100.0%) 0.41% +0.409 pp 0.13% +0.134 pp USD23.00 +0.0% 1 qtrs NEW
51 GOLDMAN SACHS GROUP INC 400.4K -76.6K (-16.1%) 9.21M -5.1M (-35.8%) 0.41% -0.078 pp 0.00% -0.001 pp USD48.23 -52.3% 48 qtrs
52 SQUAREPOINT OPS LLC 390.6K +256.8K (+192.0%) 8.98M +5.0M (+123.3%) 0.39% +0.256 pp 0.01% +0.006 pp USD25.90 -11.2% 16 qtrs
53 RENAISSANCE TECHNOLOGIES LLC 366.1K +344.2K (+1,571.7%) 8.42M +7.8M (+1,178.2%) 0.37% +0.349 pp 0.01% +0.012 pp USD24.58 -6.4% 6 qtrs
54 PRIVIUM FUND MANAGEMENT B.V. 357.5K +67.7K (+23.4%) 8.22M -494.8K (-5.7%) 0.36% +0.064 pp 1.51% -0.053 pp USD47.47 -51.5% 17 qtrs
55 SPHERA FUNDS MANAGEMENT LTD. 350.0K +350.0K (+100.0%) 8.05M +8.1M (+100.0%) 0.36% +0.355 pp 1.56% +1.556 pp USD23.00 +0.0% 4 qtrs
56 TEACHER RETIREMENT SYSTEM OF TEXAS 348.4K +327.5K (+1,570.9%) 8.01M +7.4M (+1,177.6%) 0.35% +0.328 pp 0.03% +0.025 pp USD25.18 -8.7% 22 qtrs
57 D. E. SHAW & CO., INC. 344.8K +107.1K (+45.1%) 7.93M +781.3K (+10.9%) 0.35% +0.108 pp 0.00% +0.000 pp USD34.91 -34.1% 7 qtrs
58 MANUFACTURERS LIFE INSURANCE COMPANY, THE 331.2K -13.8K (-4.0%) 7.61M -2.8M (-26.7%) 0.33% -0.018 pp 0.01% -0.002 pp USD45.23 -49.1% 16 qtrs
59 EVERSEPT PARTNERS, LP 317.2K +317.2K (+100.0%) 7.30M +7.3M (+100.0%) 0.32% +0.322 pp 0.37% +0.368 pp USD23.00 +0.0% 1 qtrs NEW
60 MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 310.1K -191.1K (-38.1%) 7.13M -7.9M (-52.7%) 0.31% -0.198 pp 0.00% -0.002 pp USD48.01 -52.1% 8 qtrs
61 FRANKLIN RESOURCES INC 309.1K -368.1K (-54.4%) 7.11M -13.3M (-65.1%) 0.31% -0.378 pp 0.00% -0.003 pp USD37.45 -38.6% 26 qtrs
62 GREAT POINT PARTNERS LLC 300.0K +300.0K (+100.0%) 6.90M +6.9M (+100.0%) 0.30% +0.304 pp 2.24% +2.237 pp USD23.00 +0.0% 1 qtrs NEW
63 BANK OF NEW YORK MELLON CORP 298.7K -26.1K (-8.0%) 6.87M -2.9M (-29.7%) 0.30% -0.031 pp 0.00% -0.001 pp USD56.63 -59.4% 48 qtrs
64 MOTLEY FOOL WEALTH MANAGEMENT, LLC 297.5K -58.1K (-16.3%) 6.84M -3.9M (-36.0%) 0.30% -0.063 pp 0.53% -0.195 pp USD45.64 -49.6% 20 qtrs
65 NEWTYN MANAGEMENT, LLC 295.9K +295.9K (+100.0%) 6.81M +6.8M (+100.0%) 0.30% +0.300 pp 0.72% +0.715 pp USD23.00 +0.0% 1 qtrs NEW
66 VERITION FUND MANAGEMENT LLC 282.4K +258.9K (+1,100.6%) 6.49M +5.8M (+818.0%) 0.28% +0.259 pp 0.03% +0.023 pp USD24.63 -6.6% 16 qtrs
67 ADAGE CAPITAL PARTNERS GP, L.L.C. 280.0K -150.0K (-34.9%) 6.44M -6.5M (-50.2%) 0.28% -0.153 pp 0.01% -0.011 pp USD41.62 -44.7% 21 qtrs
68 AMERIPRISE FINANCIAL INC 276.9K +138.2K (+99.7%) 6.37M +2.2M (+52.7%) 0.28% +0.140 pp 0.00% +0.001 pp USD29.81 -22.8% 48 qtrs
69 CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD. 263.9K +184.9K (+234.3%) 6.07M +3.7M (+155.6%) 0.26% +0.184 pp 0.02% +0.008 pp USD25.38 -9.4% 15 qtrs
70 ENSIGN PEAK ADVISORS, INC 250.6K +73.2K (+41.2%) 5.76M +426.3K (+8.0%) 0.25% +0.071 pp 0.01% +0.001 pp USD31.44 -26.8% 17 qtrs
71 IKARIAN CAPITAL, LLC 250.0K +250.0K (+100.0%) 5.75M +5.8M (+100.0%) 0.25% +0.254 pp 0.45% +0.449 pp USD23.00 +0.0% 4 qtrs
72 INVESCO LTD. 230.3K -564.6K (-71.0%) 5.30M -18.6M (-77.8%) 0.23% -0.574 pp 0.00% -0.003 pp USD46.43 -50.5% 38 qtrs
73 683 CAPITAL MANAGEMENT, LLC 222.4K +116.4K (+109.8%) 5.12M +1.9M (+60.4%) 0.23% +0.118 pp 0.22% +0.056 pp USD26.37 -12.8% 2 qtrs
74 ALGERT GLOBAL LLC 219.2K -102.4K (-31.8%) 5.04M -4.6M (-47.9%) 0.22% -0.104 pp 0.08% -0.083 pp USD34.38 -33.1% 12 qtrs
75 BLUE OWL CAPITAL HOLDINGS LP 212.6K -209.8K (-49.7%) 4.89M -7.8M (-61.5%) 0.22% -0.213 pp 0.37% -3.579 pp USD37.07 -38.0% 9 qtrs
76 EMERALD ADVISERS, LLC 212.4K -206.2K (-49.3%) 4.88M -7.7M (-61.2%) 0.21% -0.212 pp 0.15% -0.253 pp USD70.48 -67.4% 21 qtrs
77 UBS ASSET MANAGEMENT AMERICAS INC 204.1K -2.9K (-1.4%) 4.69M -1.5M (-24.6%) 0.20% -0.006 pp 0.00% 0.000 pp USD49.95 -54.0% 45 qtrs
78 BARCLAYS PLC 200.0K +— (+0.0%) 4.60M -1.4M (-23.5%) 0.20% 0.000 pp 0.00% 0.000 pp USD36.34 -36.7% 4 qtrs
79 ASSENAGON ASSET MANAGEMENT S.A. 199.7K -52.9K (-21.0%) 4.59M -3.0M (-39.6%) 0.20% -0.056 pp 0.01% -0.004 pp USD36.64 -37.2% 18 qtrs
80 FISHER ASSET MANAGEMENT, LLC 198.7K +30.6K (+18.2%) 4.57M -486.0K (-9.6%) 0.20% +0.028 pp 0.00% 0.000 pp USD39.13 -41.2% 5 qtrs
81 PDT PARTNERS, LLC 176.8K +20.1K (+12.8%) 4.07M -646.6K (-13.7%) 0.18% +0.020 pp 0.26% -0.033 pp USD38.15 -39.7% 11 qtrs
82 SCHRODER INVESTMENT MANAGEMENT GROUP 175.6K +25.1K (+16.6%) 4.00M -570.4K (-12.5%) 0.18% +0.025 pp 0.00% -0.001 pp USD39.55 -41.8% 9 qtrs
83 WOODLINE PARTNERS LP 171.8K -101.4K (-37.1%) 3.95M -4.3M (-51.9%) 0.17% -0.103 pp 0.02% -0.023 pp USD46.75 -50.8% 11 qtrs
84 SWISS NATIONAL BANK 171.1K +6.1K (+3.7%) 3.93M -1.0M (-20.7%) 0.17% +0.004 pp 0.00% -0.001 pp USD61.86 -62.8% 47 qtrs
85 TREXQUANT INVESTMENT LP 165.0K +9.6K (+6.2%) 3.80M -878.7K (-18.8%) 0.17% +0.010 pp 0.03% -0.014 pp USD45.76 -49.7% 16 qtrs
86 ROYAL BANK OF CANADA 163.2K -73.1K (-30.9%) 3.75M -3.4M (-47.2%) 0.17% -0.074 pp 0.00% -0.001 pp USD30.78 -25.3% 44 qtrs
87 CATALIO CAPITAL MANAGEMENT, LP 162.6K -128.7K (-44.2%) 3.74M -5.0M (-57.3%) 0.16% -0.131 pp 0.66% -0.959 pp USD34.68 -33.7% 3 qtrs
88 WCM INVESTMENT MANAGEMENT, LLC 163.3K -124.8K (-43.3%) 3.72M -5.0M (-57.5%) 0.16% -0.129 pp 0.01% -0.011 pp USD41.99 -45.2% 24 qtrs
89 RAFFERTY ASSET MANAGEMENT, LLC 157.1K +577.0 (+0.4%) 3.61M -1.1M (-23.3%) 0.16% +0.000 pp 0.01% -0.003 pp USD43.44 -47.1% 28 qtrs
90 SEI INVESTMENTS CO 153.7K -36.7K (-19.3%) 3.54M -2.2M (-38.3%) 0.15% -0.039 pp 0.00% -0.003 pp USD39.09 -41.2% 17 qtrs
Ownership breakdown by holder

Insider Activity

Insider Activity — Latest Quarter
Ratio by transactions
5.33
Bullish
Ratio by volume
3.00
Bullish
Buys
16
Sells
3
Shares acquired
790.1K
Shares disposed
9.7K
Cash buys
Cash sales
3.00
Net activity
+780,383
Insider buys vs sells (history) From To
Recent insider transactions From To
Date Person Role Transaction A/D Security Shares Price Value Owned after D/I Filing
2026-05-05 Crombez Eric Officer S-Sale D Common Stock 344 24.96 8.6K 111,189 D
2026-05-01 Horn Howard Officer S-Sale D Common Stock 4,683 24.90 116.6K 110,342 D
2026-04-22 Huizenga Theodore Alan Officer A-Award A Common Stock 20,241 0.00 68,911 D
2026-04-16 Pinion John Richard Officer A-Award A Stock Option (Right to Buy) 79,936 24.52 1.96M 79,936 D
2026-04-16 Parschauer Karah Herdman Officer A-Award A Common Stock 28,895 0.00 95,715 D
2026-04-16 KAKKIS EMIL D Director / Officer A-Award A Stock Option (Right to Buy) 132,693 24.52 3.25M 132,693 D
2026-04-16 Huang Dennis Karl Officer A-Award A Stock Option (Right to Buy) 79,936 24.52 1.96M 79,936 D
2026-04-16 Horn Howard Officer A-Award A Stock Option (Right to Buy) 59,952 24.52 1.47M 59,952 D
2026-04-16 Harris Erik Officer A-Award A Stock Option (Right to Buy) 49,960 24.52 1.23M 49,960 D
2026-04-16 Crombez Eric Officer A-Award A Common Stock 34,674 0.00 110,975 D
2026-04-01 Horn Howard Officer S-Sale D Common Stock 4,683 20.97 98.2K 80,351 D
2026-03-10 Parschauer Karah Herdman Officer S-Sale D Common Stock 3,508 22.67 79.5K 66,820 D
2026-03-06 Parschauer Karah Herdman Officer S-Sale D Common Stock 6,018 21.40 128.8K 70,328 D
2026-03-03 Horn Howard Officer S-Sale D Common Stock 1,635 22.40 36.6K 85,034 D
2026-03-02 Pinion John Richard Officer S-Sale D Common Stock 10,029 22.80 228.7K 110,026 D
2026-03-02 Parschauer Karah Herdman Officer S-Sale D Common Stock 8,135 22.80 185.5K 76,346 D
2026-03-02 KAKKIS EMIL D Director / Officer S-Sale D Common Stock 54,404 22.80 1.24M 658,994 D
2026-03-02 Huizenga Theodore Alan Officer S-Sale D Common Stock 1,632 22.80 37.2K 48,670 D
2026-03-02 Huang Dennis Karl Officer F-InKind D Common Stock 999 23.39 23.4K 124,729 D
2026-03-02 Horn Howard Officer S-Sale D Common Stock 5,290 22.80 120.6K 89,788 D
2026-03-02 Harris Erik Officer S-Sale D Common Stock 10,539 22.80 240.3K 89,515 D
2026-03-02 Crombez Eric Officer S-Sale D Common Stock 7,029 22.80 160.3K 76,301 D
2026-03-01 Pinion John Richard Officer A-Award A Common Stock 11,137 0.00 119,565 D
2026-03-01 Parschauer Karah Herdman Officer A-Award A Common Stock 11,137 0.00 84,408 D
2026-03-01 KAKKIS EMIL D Director / Officer A-Award A Common Stock 71,177 0.00 712,908 D
2026-03-01 Huang Dennis Karl Officer A-Award A Common Stock 11,137 0.00 125,728 D
2026-03-01 Horn Howard Officer A-Award A Common Stock 6,143 0.00 95,078 D
2026-03-01 Harris Erik Officer A-Award A Common Stock 11,643 0.00 99,498 D
2026-03-01 Crombez Eric Officer A-Award A Common Stock 11,643 0.00 83,173 D
2026-02-02 Horn Howard Officer S-Sale D Common Stock 3,061 23.56 72.1K 88,935 D
2026-01-02 Horn Howard Officer S-Sale D Common Stock 3,150 22.84 71.9K 91,996 D
2025-12-29 Huizenga Theodore Alan Officer S-Sale D Common Stock 85 34.38 2.9K 50,450 D
2025-12-10 Horn Howard Officer S-Sale D Common Stock 3,081 36.38 112.1K 95,146 D
2025-10-13 Horn Howard Officer S-Sale D Common Stock 7,942 31.51 250.3K 98,227 D
2025-09-18 Huizenga Theodore Alan Officer S-Sale D Common Stock 64 29.17 1.9K 50,242 D
2025-09-12 Parschauer Karah Herdman Officer S-Sale D Common Stock 2,450 31.17 76.4K 73,271 D
2025-09-05 Huizenga Theodore Alan Officer S-Sale D Common Stock 84 31.39 2.6K 50,306 D
2025-06-20 Sanders Corazon (Corsee) D. Director S-Sale D Common Stock 2,405 37.39 89.9K 15,344 D
2025-05-15 WELCH DANIEL G Director A-Award A Stock Option (Right to Buy) 10,787 34.84 375.8K 10,787 D
2025-05-15 Sanders Corazon (Corsee) D. Director A-Award A Common Stock 5,740 0.00 17,749 D
2025-05-15 SULIMAN SHEHNAAZ Director A-Award A Stock Option (Right to Buy) 10,787 34.84 375.8K 10,787 D
2025-05-15 Ray Amrit Director A-Award A Common Stock 5,740 0.00 23,365 D
2025-05-15 NARACHI MICHAEL Director A-Award A Stock Option (Right to Buy) 10,787 34.84 375.8K 10,787 D
2025-05-15 Fust Matthew K Director A-Award A Stock Option (Right to Buy) 10,787 34.84 375.8K 10,787 D
2025-05-15 Dunsire Deborah Director A-Award A Stock Option (Right to Buy) 10,787 34.84 375.8K 10,787 D
2025-05-05 Crombez Eric Officer S-Sale D Common Stock 520 39.24 20.4K 71,530 D
2025-04-21 Crombez Eric Officer S-Sale D Common Stock 242 35.11 8.5K 71,680 D
2025-03-06 Horn Howard Officer S-Sale D Common Stock 1,785 40.40 72.1K 106,169 D
2025-03-03 Pinion John Richard Officer S-Sale D Common Stock 14,439 42.10 607.9K 107,766 D
2025-03-03 Parschauer Karah Herdman Officer S-Sale D Common Stock 12,846 42.10 540.8K 75,287 D
2025-03-03 Kassberg Thomas Richard Officer S-Sale D Common Stock 6,028 42.10 253.8K 265,238 D
2025-03-03 KAKKIS EMIL D Director / Officer S-Sale D Common Stock 73,434 42.10 3.09M 641,731 D
2025-03-03 Huizenga Theodore Alan Officer F-InKind D Common Stock 141 42.92 6.1K 50,124 D
2025-03-03 Huang Dennis Karl Officer F-InKind D Common Stock 1,348 42.92 57.9K 114,591 D
2025-03-03 Harris Erik Officer S-Sale D Common Stock 15,103 42.10 635.8K 87,855 D
2025-03-03 Crombez Eric Officer S-Sale D Common Stock 8,945 42.10 376.6K 71,922 D
2025-03-01 Pinion John Richard Officer A-Award A Common Stock 18,443 0.00 122,205 D
2025-03-01 Parschauer Karah Herdman Officer A-Award A Stock Option (Right to Buy) 26,074 42.92 1.12M 26,074 D
2025-03-01 Kassberg Thomas Richard Officer A-Award A Common Stock 18,443 0.00 271,266 D
2025-03-01 KAKKIS EMIL D Director / Officer A-Award A Stock Option (Right to Buy) 78,448 42.92 3.37M 78,448 D
2025-03-01 Huizenga Theodore Alan Officer A-Award A Common Stock 9,392 0.00 51,232 D
2025-03-01 Huang Dennis Karl Officer A-Award A Stock Option (Right to Buy) 26,074 42.92 1.12M 26,074 D
2025-03-01 Horn Howard Officer A-Award A Stock Option (Right to Buy) 28,160 42.92 1.21M 28,160 D
2025-03-01 Harris Erik Officer A-Award A Stock Option (Right to Buy) 30,246 42.92 1.30M 30,246 D
2025-03-01 Crombez Eric Officer A-Award A Common Stock 16,813 0.00 65,244 D
2025-02-28 KAKKIS EMIL D Director / Officer S-Sale D Common Stock 25,000 42.48 1.06M 2,158,985 I
2025-02-27 Parschauer Karah Herdman Officer S-Sale D Common Stock 2,230 42.93 95.7K 55,751 D
2024-12-30 KAKKIS EMIL D Director / Officer S-Sale D Common Stock 11,727 42.23 495.2K 2,183,985 I
2024-12-10 KAKKIS EMIL D Director / Officer S-Sale D Common Stock 8,273 50.00 413.7K 2,195,712 I
2024-12-10 Huizenga Theodore Alan Officer G-Gift D Common Stock 648 0.00 41,840 D
2024-12-09 KAKKIS EMIL D Director / Officer G-Gift D Common Stock 20,000 0.00 2,203,985 I
2024-10-10 Horn Howard Officer S-Sale D Common Stock 7,465 52.76 393.9K 92,301 D
2024-09-16 Huizenga Theodore Alan Officer A-Award A Common Stock 700 0.00 42,251
2024-09-03 KAKKIS EMIL D Director / Officer S-Sale D Common Stock 20,000 55.85 1.12M 2,223,985
2024-09-03 Huizenga Theodore Alan Officer S-Sale D Common Stock 91 56.19 5.1K 41,551
2024-08-06 KAKKIS EMIL D Director / Officer S-Sale D Common Stock 20,000 50.17 1.00M 2,243,985
2024-07-02 Sanders Corazon (Corsee) D. Director S-Sale D Common Stock 584 40.98 23.9K 12,009
2024-06-18 WELCH DANIEL G Director A-Award A Common Stock 5,345 0.00 26,950
2024-06-18 Sanders Corazon (Corsee) D. Director A-Award A Stock Option (Right to Buy) 9,900 37.42 370.5K 9,900
2024-06-18 SULIMAN SHEHNAAZ Director A-Award A Stock Option (Right to Buy) 9,900 37.42 370.5K 9,900
2024-06-18 Ray Amrit Director A-Award A Stock Option (Right to Buy) 9,900 37.42 370.5K 9,900
2024-06-18 NARACHI MICHAEL Director A-Award A Stock Option (Right to Buy) 9,900 37.42 370.5K 9,900
2024-06-18 Fust Matthew K Director A-Award A Stock Option (Right to Buy) 9,900 37.42 370.5K 9,900
2024-06-18 Dunsire Deborah Director A-Award A Common Stock 5,345 0.00 25,075
2024-06-12 Parschauer Karah Herdman Officer S-Sale D Common Stock 9,806 45.00 441.3K 57,981
2024-06-10 Sanders Corazon (Corsee) D. Director S-Sale D Common Stock 1,737 41.10 71.4K 7,248
2024-05-02 Crombez Eric Officer S-Sale D Common Stock 354 43.66 15.5K 48,431
2024-04-18 Crombez Eric Officer S-Sale D Common Stock 142 44.10 6.3K 48,785
2024-04-16 Huizenga Theodore Alan Officer F-InKind D Common Stock 14 42.31 592.34 41,366
2024-03-11 Kassberg Thomas Richard Officer S-Sale D Common Stock 11,509 49.93 574.6K 252,823
2024-03-07 Fust Matthew K Director S-Sale D Common Stock 2,550 50.89 129.8K 24,505
2024-03-01 Pinion John Richard Officer S-Sale D Common Stock 4,173 53.76 224.3K 89,268
2024-03-01 Parschauer Karah Herdman Officer A-Award A Common Stock 957 0.00 70,739
2024-03-01 Kassberg Thomas Richard Officer F-InKind D Common Stock 274 53.69 14.7K 265,343
2024-03-01 KAKKIS EMIL D Director / Officer A-Award A Stock Option (Right to Buy) 70,094 53.69 3.76M 70,094
2024-03-01 Huizenga Theodore Alan Officer A-Award A Common Stock 13,950 0.00 41,842
2024-03-01 Huang Dennis Karl Officer A-Award A Common Stock 957 0.00 83,472
2024-03-01 Horn Howard Officer A-Award A Common Stock 19,400 0.00 99,766
2024-03-01 Harris Erik Officer A-Award A Common Stock 957 0.00 71,638
2024-03-01 Crombez Eric Officer A-Award A Stock Option (Right to Buy) 34,200 53.69 1.84M 34,200
2024-02-07 KAKKIS EMIL D Director / Officer S-Sale D Common Stock 30,000 45.00 1.35M 539,770
2024-01-02 Huizenga Theodore Alan Officer M-Exempt A Common Stock 3,000 21.00 63.0K 27,892
2023-12-29 KAKKIS EMIL D Director / Officer S-Sale D Common Stock 30,000 47.87 1.44M 569,770
2023-12-20 Huizenga Theodore Alan Officer A-Award A Common Stock 1,000 0.00 24,614
2023-10-23 Kassberg Thomas Richard Officer S-Sale D Common Stock 39,878 32.78 1.31M 246,860
2023-10-19 KAKKIS EMIL D Director / Officer M-Exempt A Common Stock 47,853 6.86 328.3K 647,029
2023-10-09 Horn Howard Officer A-Award A Stock Option (Right to Buy) 140,469 35.68 5.01M 140,469
2023-09-27 Huizenga Theodore Alan Officer A-Award A Stock Option (Right to Buy) 2,351 67.37 158.4K 2,351
2023-09-27 Crombez Eric Officer A-Award A Stock Option (Right to Buy) 2,351 67.37 158.4K 2,351
2023-09-07 Huizenga Theodore Alan Officer S-Sale D Common Stock 2,000 41.00 82.0K 23,777
2023-09-05 Harris Erik Officer S-Sale D Common Stock 6,000 37.96 227.8K 51,281
2023-09-01 Huizenga Theodore Alan Officer S-Sale D Common Stock 883 37.04 32.7K 23,864
2023-06-30 Sanders Corazon (Corsee) D. Director S-Sale D Common Stock 585 46.76 27.4K 8,985
2023-06-19 Harris Erik Officer S-Sale D Common Stock 305 48.20 14.7K 57,281
2023-06-08 Sanders Corazon (Corsee) D. Director S-Sale D Common Stock 1,485 51.65 76.7K 9,570
2023-06-07 WELCH DANIEL G Director A-Award A Stock Option (Right to Buy) 7,110 51.82 368.4K 7,110
2023-06-07 Sanders Corazon (Corsee) D. Director A-Award A Stock Option (Right to Buy) 7,110 51.82 368.4K 7,110
2023-06-07 SULIMAN SHEHNAAZ Director A-Award A Common Stock 3,860 0.00 14,855
2023-06-07 Ray Amrit Director A-Award A Stock Option (Right to Buy) 7,110 51.82 368.4K 7,110
2023-06-07 NARACHI MICHAEL Director A-Award A Common Stock 7,110 51.82 368.4K 7,110
2023-06-07 Fust Matthew K Director A-Award A Stock Option (Right to Buy) 7,110 51.82 368.4K 7,110
2023-06-07 Dunsire Deborah Director A-Award A Stock Option (Right to Buy) 7,110 51.82 368.4K 7,110
2023-05-18 Pinion John Richard Officer S-Sale D Common Stock 2,012 50.00 100.6K 74,744
2023-05-09 Huizenga Theodore Alan Officer M-Exempt A Common Stock 3,000 21.00 63.0K 30,747
2023-05-04 Parschauer Karah Herdman Officer S-Sale D Common Stock 4,378 45.00 197.0K 51,982
2023-05-01 Crombez Eric Officer D Stock Option (Right to Buy) 8,000 67.55 540.4K 0
2023-04-16 Huizenga Theodore Alan Officer F-InKind D Common Stock 14 38.20 534.80 27,701
2023-03-01 Pinion John Richard Officer A-Award A 3/1/2023 39,400 45.65 1.80M 39,400
2023-03-01 Parschauer Karah Herdman Officer A-Award A Common Stock 2,663 0.00 37,101
2023-03-01 Kassberg Thomas Richard Officer A-Award A Stock Option (Right to Buy) 39,400 45.65 1.80M 39,400
2023-03-01 KAKKIS EMIL D Director / Officer A-Award A Common Stock 8,716 0.00 569,406
2023-03-01 Huizenga Theodore Alan Officer A-Award A Stock Option (Right to Buy) 10,120 45.65 462.0K 10,120
2023-03-01 Huang Dennis Karl Officer A-Award A Stock Option (Right to Buy) 39,400 45.65 1.80M 39,400
2023-03-01 Harris Erik Officer A-Award A Common Stock 2,663 0.00 38,823
2023-03-01 Bedrosian Camille L Officer S-Sale D Common Stock 3,881 45.25 175.6K 46,720
2023-02-28 Huizenga Theodore Alan Officer S-Sale D Common Stock 639 43.40 27.7K 15,558
2022-12-30 KAKKIS EMIL D Officer S-Sale D Common Stock 19,582 45.57 892.4K 541,108
2022-12-21 Huizenga Theodore Alan Officer S-Sale D Common Stock 2,031 43.96 89.3K 16,197
2022-10-14 Dier Mardi Officer S-Sale D Common Stock 1,629 40.16 65.4K 66,695
2022-10-12 Dier Mardi Officer S-Sale D Common Stock 3,484 38.22 133.2K 68,324
2022-09-01 Huizenga Theodore Alan Officer A-Award A Common Stock 1,000 0.00 18,094
2022-06-24 WELCH DANIEL G Director A-Award A Stock Option (Right to Buy) 6,245 60.57 378.3K 6,245
2022-06-24 Sanders Corazon (Corsee) D. Director A-Award A Common Stock 3,300 0.00 7,195
2022-06-24 SULIMAN SHEHNAAZ Director A-Award A Common Stock 3,300 0.00 10,995
2022-06-24 Ray Amrit Director A-Award A Common Stock 3,300 0.00 8,420
2022-06-24 NARACHI MICHAEL Director A-Award A Stock Option (Right to Buy) 6,245 60.57 378.3K 6,245
2022-06-24 Fust Matthew K Director A-Award A Stock Option (Right to Buy) 6,245 60.57 378.3K 6,245
2022-06-24 Ekman Lars Director A-Award A Stock Option (Right to Buy) 6,245 60.57 378.3K 6,245
2022-06-24 Dunsire Deborah Director A-Award A Common Stock 3,300 0.00 15,870
2022-06-19 Harris Erik Officer S-Sale D Common Stock 295 54.78 16.2K 36,160
2022-04-19 Ray Amrit Director 0 0.00 0
2022-04-16 Huizenga Theodore Alan Officer S-Sale D Common Stock 132 84.55 11.2K 16,914
2022-03-11 Kassberg Thomas Richard Officer S-Sale D Common Stock 10,281 67.01 688.9K 227,559
2022-03-07 Parschauer Karah Herdman Officer S-Sale D Common Stock 5,140 62.95 323.6K 34,438
2022-03-04 Fust Matthew K Director M-Exempt A Common Stock 7,500 40.37 302.8K 23,195
2022-03-01 Pinion John Richard Officer A-Award A Common Stock 14,000 0.00 59,266
2022-03-01 Parschauer Karah Herdman Officer A-Award A Common Stock 14,000 0.00 39,578
2022-03-01 Kassberg Thomas Richard Officer A-Award A Common Stock 14,000 0.00 227,840
2022-03-01 KAKKIS EMIL D Director / Officer A-Award A Common Stock 52,041 0.00 634,226
2022-03-01 Huizenga Theodore Alan Officer A-Award A Common Stock 3,710 0.00 17,046
2022-03-01 Huang Dennis Karl Officer A-Award A Stock Option (Right to Buy) 24,900 0.00 24,900
2022-03-01 Harris Erik Officer S-Sale D Common Stock 2,713 66.62 180.7K 22,317
2022-03-01 Dier Mardi Officer A-Award A Stock Option (Right to Buy) 24,900 0.00 24,900
2022-03-01 Bedrosian Camille L Officer A-Award A Common Stock 14,000 0.00 47,938
2022-01-30 Bedrosian Camille L Officer S-Sale D Common Stock 1,657 66.30 109.9K 36,759
2021-12-31 Kassberg Thomas Richard Officer 0 0.00 0
2021-12-31 KAKKIS EMIL D Director / Officer D Common Stock 0 0.00 594,347
2021-10-14 Pinion John Richard Officer S-Sale D Common Stock 358 81.14 29.0K 49,764
2021-10-14 Parschauer Karah Herdman Officer S-Sale D Common Stock 310 81.14 25.2K 28,358
2021-10-14 Kassberg Thomas Richard Officer S-Sale D Common Stock 286 81.14 23.2K 216,266
2021-10-14 KAKKIS EMIL D Director / Officer F-InKind D Common Stock 853 81.00 69.1K 594,347
2021-10-14 Huizenga Theodore Alan Officer S-Sale D Common Stock 140 81.14 11.4K 14,072
2021-10-14 Huang Dennis Karl Officer S-Sale D Common Stock 358 81.14 29.0K 40,148
2021-10-14 Harris Erik Officer S-Sale D Common Stock 303 81.14 24.6K 25,030
2021-10-14 Dier Mardi Officer S-Sale D Common Stock 3,261 81.16 264.7K 38,762
2021-10-14 Bedrosian Camille L Officer S-Sale D Common Stock 359 81.14 29.1K 38,416
2021-10-12 Dier Mardi Officer S-Sale D Common Stock 3,477 82.79 287.9K 42,023
2021-09-30 Kassberg Thomas Richard Officer M-Exempt A Common Stock 109,734 0.31 34.0K 216,552
2021-09-13 Huizenga Theodore Alan Officer G-Gift D Common Stock 819 0.00 14,212
2021-09-08 Parschauer Karah Herdman Officer M-Exempt D Stock Option (Right to Buy) 7,336 54.50 399.8K 17,664
2021-09-02 Bedrosian Camille L Officer M-Exempt D Stock Option (Right to Buy) 2,500 55.00 137.5K 53,000
2021-09-01 Bedrosian Camille L Officer M-Exempt D Stock Option (Right to Buy) 2,500 55.00 137.5K 55,500
2021-07-06 Harris Erik Officer S-Sale D Common Stock 375 91.53 34.3K 25,333
2021-06-29 Sanders Corazon (Corsee) D. Director A-Award A Common Stock 3,895 0.00 3,895
2021-06-24 WELCH DANIEL G Director A-Award A Common Stock 2,145 0.00 14,445
2021-06-24 SULIMAN SHEHNAAZ Director A-Award A Common Stock 2,145 0.00 7,695
2021-06-24 NARACHI MICHAEL Director A-Award A Common Stock 2,145 0.00 14,445
2021-06-24 Fust Matthew K Director A-Award A Common Stock 2,145 0.00 15,695
2021-06-24 Ekman Lars Director A-Award A Common Stock 2,145 0.00 14,445
2021-06-24 Dunsire Deborah Director A-Award A Common stock 2,145 0.00 12,570
2021-06-24 Aliski William Director A-Award A Common Stock 2,145 0.00 66,849
2021-06-21 Harris Erik Officer S-Sale D Common Stock 572 94.96 54.3K 25,708
2021-06-19 Harris Erik Officer S-Sale D Common Stock 437 94.63 41.4K 26,280
2021-06-10 Parschauer Karah Herdman Officer S-Sale D Common Stock 1,329 100.00 132.9K 28,668
2021-05-07 Harris Erik Officer S-Sale D Common Stock 393 113.67 44.7K 26,717
2021-05-06 Pinion John Richard Officer S-Sale D Common Stock 363 113.69 41.3K 50,122
2021-05-06 Parschauer Karah Herdman Officer S-Sale D Common Stock 313 113.67 35.6K 29,997
2021-05-06 Kassberg Thomas Richard Officer S-Sale D Common Stock 363 113.69 41.3K 106,818
2021-05-06 KAKKIS EMIL D Director / Officer F-InKind D Common Stock 852 115.71 98.6K 595,200
2021-05-06 Huizenga Theodore Alan Officer S-Sale D Common Stock 142 113.67 16.1K 15,031

Executive team

Top executives
EBIT / Employee
-413.4K
Shares Outstanding
98.32M

Executive compensation

Executive compensation (annual)
# Year Executive Salary Bonus Stock award Option award Incentive Other Total % Stock-
based
Filing
1 2025 Emil D. Kakkis, M.D., Ph.D. President and Chief Executive Officer 861.1K 8.36M 1.85M 299.7K 32.5K 11.41M 89.54%
2 2025 Erik Harris Chief Commercial Officer and Executive Vice President 619.7K 2.41M 712.3K 291.6K 14.0K 4.05M 77.13%
3 2025 Eric Crombez, M.D. Chief Medical Officer and Executive Vice President 630.2K 2.41M 712.3K 238.1K 14.0K 4.00M 77.95%
4 2025 Howard Horn Chief Financial Officer, Corporate Strategy and Executive Vice President 604.4K 2.24M 663.1K 227.6K 14.0K 3.75M 77.44%
5 2025 Karah Parschauer Chief Legal Officer and Corporate Affairs, Executive Vice President 585.3K 2.08M 614.0K 220.5K 14.0K 3.51M 76.64%
6 2024 Emil D. Kakkis, M.D., Ph.D. President and Chief Executive Officer 856.0K 9.37M 2.72M 757.8K 13.8K 13.72M 88.14%
7 2024 Eric Crombez, M.D. Chief Medical Officer and Executive Vice President 591.8K 2.27M 1.04M 382.0K 13.8K 4.30M 77.02%
8 2024 Howard Horn Chief Financial Officer, Corporate Strategy and Executive Vice President 590.0K 2.27M 1.08M 344.0K 13.8K 4.30M 77.94%
9 2024 Erik Harris Chief Commercial Officer and Executive Vice President 604.2K 2.27M 1.04M 367.2K 13.8K 4.30M 77.06%
10 2024 John R. Pinion II Chief Quality Officer and Executive Vice President, Translational Sciences 570.4K 2.08M 1.12M 339.8K 13.8K 4.13M 77.63%
11 2023 Emil D. Kakkis, M.D., Ph.D. President and Chief Executive Officer 823.7K 9.46M 2.16M 622.7K 13.2K 13.08M 88.84%
12 2023 Howard Horn Chief Financial Officer, Corporate Strategy and Executive Vice President 124.8K 60.0K 2.87M 2.89M 5.94M 96.89%
13 2023 Erik Harris Chief Commercial Officer and Executive Vice President 586.0K 2.17M 1.02M 279.6K 13.2K 4.07M 78.40%
14 2023 John R. Pinion II Chief Quality Officer and Executive Vice President, Translational Sciences 552.1K 2.17M 1.02M 294.8K 13.2K 4.05M 78.76%
15 2023 John R. Pinion II, Chief Quality Officer and Executive Vice President, Translational Sciences 552.1K 2.17M 1.02M 294.8K 13.2K 4.05M 78.76%
16 2023 Karah Parschauer Chief Legal Officer & Corporate Affairs and Executive Vice President 535.2K 2.17M 1.02M 298.4K 13.2K 4.04M 79.02%
17 2022 Emil D. Kakkis, M.D., Ph.D. President and Chief Executive Officer 796.2K 7.46M 3.31M 558.0K 12.2K 12.14M 88.75%
18 2022 Mardi Dier Former Chief Financial Officer and Executive Vice President 607.3K 2.93M 892.6K 8.5K 4.44M 86.12%
19 2022 Camille L. Bedrosian, M.D. Chief Medical Officer and Executive Vice President 596.0K 2.01M 892.6K 246.8K 12.2K 3.76M 77.23%
20 2022 Erik Harris Chief Commercial Officer and Executive Vice President 566.3K 2.01M 892.6K 269.7K 12.2K 3.75M 77.37%
21 2022 John R. Pinion II Chief Quality Officer and Executive Vice President, Translational Sciences 533.3K 2.01M 892.6K 260.7K 12.2K 3.71M 78.25%
22 2022 John R. Pinion II, Chief Quality Officer and Executive Vice President, Translational Sciences 533.3K 2.01M 892.6K 260.7K 12.2K 3.71M 78.25%
23 2021 Emil D. Kakkis, M.D., Ph.D. President and Chief Executive Officer 768.8K 5.41M 2.84M 499.1K 8.7K 9.52M 86.59%
24 2021 Camille L. Bedrosian, M.D. Chief Medical Officer and Executive Vice President 567.1K 1.65M 866.4K 249.3K 8.7K 3.34M 75.33%
25 2021 Mardi Dier Former Chief Financial Officer and Executive Vice President 561.5K 1.65M 866.4K 247.5K 3.2K 3.33M 75.62%
26 2021 Mardi Dier Chief Financial Officer and Executive Vice President 561.5K 1.65M 866.4K 247.5K 3.2K 3.33M 75.62%
27 2021 Erik Harris Chief Commercial Officer and Executive Vice President 543.8K 1.65M 866.4K 245.0K 8.7K 3.32M 75.96%
28 2021 John R. Pinion II, Chief Quality Officer and Executive Vice President, Translational Sciences 509.9K 1.65M 866.4K 224.9K 8.7K 3.26M 77.21%
29 2020 Mardi Dier Chief Financial Officer and Executive Vice President 116.3K 100.0K 3.82M 2.08M 6.12M 96.47%
30 2020 Mardi Dier Former Chief Financial Officer and Executive Vice President 116.3K 100.0K 3.82M 2.08M 6.12M 96.47%
31 2020 Emil D. Kakkis, M.D., Ph.D. President and Chief Executive Officer 759.2K 1.91M 1.80M 668.9K 6.6K 5.14M 72.11%
32 2020 Erik Harris Chief Commercial Officer and Executive Vice President 501.2K 723.4K 707.0K 292.6K 2.22M 64.31%
33 2020 Camille L. Bedrosian, M.D. Chief Medical Officer and Executive Vice President 546.7K 695.4K 674.9K 297.7K 2.21M 61.87%
34 2020 John R. Pinion II Chief Quality Officer and Executive Vice President, Translational Sciences 480.1K 723.4K 707.0K 267.1K 2.18M 65.69%
35 2020 John R. Pinion II, Chief Quality Officer and Executive Vice President, Translational Sciences 480.1K 723.4K 707.0K 267.1K 2.18M 65.69%
36 2020 Shalini Sharp Former Chief Financial Officer and Executive Vice President 499.6K 293.6K 793.2K 0.00%
37 2019 Emil D. Kakkis, M.D., Ph.D. President and Chief Executive Officer 714.0K 2.70M 2.65M 479.8K 6.6K 6.55M 81.68%
38 2019 John R. Pinion II Chief Quality Officer and Executive Vice President, Translational Sciences 447.7K 1.76M 923.6K 205.5K 3.33M 80.40%
39 2019 John R. Pinion II, Chief Quality Officer and Executive Vice President, Translational Sciences 447.7K 1.76M 923.6K 205.5K 3.33M 80.40%
40 2019 Shalini Sharp, Chief Financial Officer and Executive Vice President 484.5K 945.7K 923.8K 218.2K 33.3K 2.61M 71.75%
41 2019 Shalini Sharp Former Chief Financial Officer and Executive Vice President 484.5K 945.7K 923.8K 218.2K 2.57M 72.68%
42 2019 Camille L. Bedrosian, M.D. Chief Medical Officer and Executive Vice President 511.2K 878.2K 863.5K 230.1K 2.7K 2.49M 70.07%
43 2019 Thomas Kassberg Chief Business Officer and Executive Vice President 474.0K 878.2K 863.5K 206.9K 33.9K 2.46M 70.90%
44 2019 Erik Harris Chief Commercial Officer and Executive Vice President 418.1K 691.7K 962.1K 201.5K 2.27M 72.75%
45 2018 Wladimir Hogenhuis, M.D. Chief Operating Officer and Executive Vice President 110.9K 200.0K 1.16M 3.50M 67.0K 215.8K 5.26M 88.71%
46 2018 Camille L. Bedrosian, M.D. Chief Medical Officer and Executive Vice President 442.3K 210.0K 990.0K 2.91M 189.3K 97.6K 4.84M 80.58%
47 2018 Emil D. Kakkis, M.D., Ph.D. President and Chief Executive Officer 680.0K 944.4K 2.75M 428.4K 6.6K 4.81M 76.83%
48 2018 Shalini Sharp, Chief Financial Officer and Executive Vice President 470.4K 339.0K 1.02M 198.7K 32.8K 2.06M 65.94%
49 2018 Karah Parschauer General Counsel and Executive Vice President 386.3K 363.2K 1.08M 175.9K 32.8K 2.04M 70.78%
50 2018 Shalini Sharp Former Chief Financial Officer and Executive Vice President 470.4K 339.0K 1.02M 198.7K 2.03M 67.00%
51 2018 Thomas Kassberg Chief Business Officer and Executive Vice President 441.3K 242.2K 786.7K 189.6K 32.9K 1.69M 60.78%
52 2018 John R. Pinion II, Chief Quality Officer and Executive Vice President, Translational Sciences 430.3K 217.9K 728.4K 188.0K 36.3K 1.60M 59.11%
53 2018 John R. Pinion II Chief Quality Officer and Executive Vice President, Translational Sciences 430.3K 217.9K 728.4K 188.0K 1.56M 60.48%
54 2018 Erik Harris Chief Commercial Officer and Executive Vice President 356.2K 7.5K 31.5K 113.6K 132.3K 641.1K 22.64%
55 2017 Emil D. Kakkis, M.D., Ph.D. President and Chief Executive Officer 638.1K 1.32M 4.30M 393.0K 39.2K 6.68M 83.99%
56 2017 Jayson Dallas, M.D. Chief Commercial Officer and Executive Vice President 447.5K 50.0K 468.4K 1.65M 180.4K 36.3K 2.83M 74.80%
57 2017 Shalini Sharp, Chief Financial Officer and Executive Vice President 455.8K 424.0K 1.54M 188.3K 32.7K 2.64M 74.39%
58 2017 Thomas Kassberg Chief Business Officer and Executive Vice President 418.4K 335.2K 1.38M 168.6K 32.7K 2.33M 73.42%
59 2017 Thomas Kassberg Chief Business Officers and Executive Vice President 418.4K 335.2K 1.38M 168.6K 32.7K 2.33M 73.42%
60 2017 John R. Pinion II, Chief Quality Officer and Executive Vice President, Translational Sciences 412.6K 308.6K 991.2K 170.5K 36.5K 1.92M 67.72%
61 2017 John R. Pinion II Chief Quality 412.6K 308.6K 991.2K 170.5K 36.5K 1.92M 67.72%
62 2017 Karah Parschauer General Counsel and Executive Vice President 357.3K 246.4K 660.8K 150.1K 19.7K 1.43M 63.25%
63 2016 Emil D. Kakkis, M.D., Ph.D. President and Chief Executive Officer 567.2K 755.1K 2.72M 340.3K 38.4K 4.42M 78.62%
64 2016 Karah Parschauer General Counsel and Executive Vice President 175.0K 50.0K 408.8K 1.97M 76.5K 19.5K 2.70M 88.12%
65 2016 Jayson Dallas, M.D. Chief Commercial Officer and Executive Vice President 433.0K 50.0K 239.9K 1.32M 181.9K 32.4K 2.26M 69.18%
66 2016 John R. Pinion II Chief Quality 399.2K 211.7K 1.22M 167.7K 34.6K 2.04M 70.45%
67 2016 John R. Pinion II Chief Quality Operations Officer and Executive Vice President Analytical Sciences and Research 399.2K 211.7K 1.22M 167.7K 34.6K 2.04M 70.45%
68 2016 Shalini Sharp, Chief Financial Officer and Executive Vice President 441.0K 282.3K 1.03M 185.2K 32.2K 1.97M 66.52%
69 2016 Thomas Kassberg Chief Business Officers and Executive Vice President 405.6K 282.3K 1.03M 166.3K 35.6K 1.92M 68.29%
70 2015 John R. Pinion II Chief Quality Operations Officer and Executive Vice President Analytical Sciences and Research 171.4K 936.5K 6.73M 79.9K 10.7K 7.93M 96.70%
71 2015 John R. Pinion II Chief Quality Operations Officer and Senior Vice President Analytical Sciences and Research 171.4K 936.5K 6.73M 79.9K 10.7K 7.93M 96.70%
72 2015 John R. Pinion II Chief Quality 171.4K 936.5K 6.73M 79.9K 10.7K 7.93M 96.70%
73 2015 Jayson Dallas, M.D. Chief Commercial Officer and Senior Vice President 164.3K 100.0K 1.16M 6.27M 74.7K 40.6K 7.81M 95.14%
74 2015 Jayson Dallas, M.D. Chief Commercial Officer and Executive Vice President 164.3K 100.0K 1.16M 6.27M 74.7K 40.6K 7.81M 95.14%
75 2015 Emil D. Kakkis, M.D., Ph.D. President and Chief Executive Officer 535.0K 967.7K 3.58M 280.9K 38.4K 5.40M 84.18%
76 2015 Dennis Huang Chief Technical Operations Officer and Senior Vice President 215.1K 469.7K 3.44M 95.8K 20.4K 4.24M 92.19%
77 2015 Shalini Sharp, Chief Financial Officer and Senior Vice President 420.0K 373.5K 1.38M 182.7K 28.1K 2.38M 73.52%
78 2015 Shalini Sharp, Chief Financial Officer and Executive Vice President 420.0K 373.5K 1.38M 182.7K 28.1K 2.38M 73.52%
79 2015 Thomas Kassberg Chief Business Officers and Executive Vice President 390.0K 373.5K 1.38M 165.8K 31.0K 2.34M 74.91%
80 2014 Sunil Agarwal, M.D. Senior Vice President and Chief Medical Officer 150.2K 100.0K 1.40M 5.39M 164.6K 7.5K 7.21M 94.14%
81 2014 Emil D. Kakkis, M.D., Ph.D. President and Chief Executive Officer 496.9K 175.0K 27.2K 699.0K 0.00%
82 2014 Emil D. Kakkis, M.D., Ph.D. President and Chief Executive Officer 496.9K 175.0K 27.2K 699.0K 0.00%
83 2014 Shalini Sharp, Chief Financial Officer and Senior Vice President 350.0K 30.0K 117.6K 14.5K 512.1K 0.00%
84 2014 Shalini Sharp, Chief Financial Officer and Executive Vice President 350.0K 30.0K 117.6K 14.5K 512.1K 0.00%
85 2014 Thomas Kassberg Senior Vice President 362.9K 112.2K 16.9K 491.9K 0.00%
86 2013 Emil D. Kakkis, M.D., Ph.D. President and Chief Executive Officer 306.0K 218.9K 140.9K 19.7K 685.5K 31.93%
87 2013 Emil D. Kakkis, M.D., Ph.D. President and Chief Executive Officer 306.0K 218.9K 140.9K 19.7K 685.5K 31.93%
88 2013 Shalini Sharp, Chief Financial Officer and Senior Vice President 278.4K 30.0K 182.4K 110.2K 24.2K 625.2K 29.17%
89 2013 Shalini Sharp Chief Financial Officer and Senior Vice President 278.4K 30.0K 182.4K 110.2K 24.2K 625.2K 29.17%
90 2013 Thomas Kassberg Senior Vice President 289.4K 182.4K 114.3K 20.4K 606.5K 30.07%
91 2013 Thomas Kassberg Chief Business Officer 289.4K 182.4K 114.3K 20.4K 606.5K 30.07%
92 2013 Sunil Agarwal, M.D. Senior Vice President and Chief Medical Officer
93 2012 Emil D. Kakkis, M.D., Ph.D. President and Chief Executive Officer 300.2K 92.1K 9.1K 401.4K 0.00%
94 2012 Thomas Kassberg Chief Business Officer 272.0K 81.8K 15.6K 369.5K 0.00%
95 2012 Shalini Sharp Chief Financial Officer and Senior Vice President 148.7K 90.0K 51.6K 13.2K 303.5K 29.67%
CEO compensation breakdown

Proxy statements

Proxy statements (DEF 14A)
Filing date Form type Filing
2026-04-30 DEFA14A
2026-03-27 DEFA14A
2026-03-27 DEF 14A
2025-03-28 DEFA14A
2025-03-28 DEF 14A

Recent SEC filings

Recent SEC filings
Filing date Form type Filing
2026-05-06 4
2026-05-06 10-Q
2026-05-05 8-K
2026-05-04 4
2026-04-30 DEFA14A
2026-04-29 SC 13G
2026-04-24 4
2026-04-20 4
2026-04-20 4
2026-04-20 4

Executive team

NameTitleCompensationGender
Emil D. Kakkis Founder, President, Chief Executive Officer & Director 1M
Erik Harris Executive Vice President & Chief Commercial Officer 925.3K male
John Richard Pinion Chief Quality Operations Officer & Executive Vice President of Translational Sciences 923.9K male
Eric Crombez Chief Medical Officer & Executive Vice President 882.4K
Howard Horn Executive Vice President of Corporate Strategy & Chief Financial Officer 846.0K male
Karah Herdman Parschauer Chief Legal Officer & Executive Vice President of Corporate Affairs 819.9K female
Eric Olson Chief Business Officer & Executive Vice President 714.8K male
Dennis Karl Huang Chief Technical Operations Officer and Executive Vice President of Gene Therapy Operations 331.3K male
Vimal Srivastava Senior Vice President of Business Development & Alliance Management male
Alison Skrinar Vice President of Clinical Outcomes Research and Evaluation
Arjun Natesan Vice President of Translational Research
Ernie W. Meyer Chief Human Resources Officer & Executive Vice President male
ESG Rating
B
BIOTECHNOLOGY
2025
E (Environmental)
54.9 / 56.3
Company / Sector avg.
S (Social)
63.1 / 62.4
Company / Sector avg.
G (Governance)
62.8 / 60.9
Company / Sector avg.
ESG Total
60.3 / 59.9
Company / Sector avg.
ESG Score History BIOTECHNOLOGY
Benchmark vs Sector
Political Trading Activity (25M)
Senate Trading Activity

No Senate trading activity found for this company.

House Trading Activity
Transaction Date Disclosed Representative District Owner Type Amount Link
2026-02-18 2026-03-10 Gilbert Cisneros CA31 Purchase $1,001 - $15,000
2025-08-08 2025-09-12 Gilbert Cisneros CA31 Purchase $1,001 - $15,000
2025-07-15 2025-08-15 Gilbert Cisneros CA31 Purchase $1,001 - $15,000
2022-01-21 2022-02-08 Ro Khanna CA17 Spouse Sale $1,001 - $15,000
2022-01-11 2022-02-08 Ro Khanna CA17 Sale $1,001 - $15,000
2021-08-30 2021-09-08 Kurt Schrader OR05 Purchase $1,001 - $15,000
Market share among peers
Peer comparison — filtered group (TTM)
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Dividend history

Earnings history

Earnings reports

Stock splits