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Passage Bio, Inc. (PASG)

USD4.91 +0.47 (+10.59%)
US NASDAQ Healthcare Biotechnology
Address One Commerce Square 19103
Philadelphia, PA, US
CEO William Chou
IPO 2020-02-28
CIK 1787297 ISIN US7027122099

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Description

Passage Bio, Inc. is a biopharmaceutical company dedicated to pioneering genetic therapies for conditions affecting the central nervous system. Their advanced pipeline includes PBGM01, designed to treat infantile GM1 gangliosidosis by utilizing a proprietary AAVhu68 capsid to deliver a functional GLB1 gene, which codes for the lysosomal acid beta-galactosidase enzyme, to both the brain and peripheral tissues. Another key program, PBFT02, employs an AAV1 capsid to introduce a functional granulin (GRN) gene, encoding progranulin (PGRN), to the brain as a treatment for FTD-GRN. Additionally, PBKR03 is under development for infantile Krabbe disease, leveraging a proprietary AAVhu68 capsid to deliver a functional GALC gene, responsible for producing the hydrolytic enzyme galactosylceramidase, to the brain and surrounding tissues. The company's portfolio also features PBML04 for metachromatic leukodystrophy, PBAL05 for amyotrophic lateral sclerosis, and PBCM06 for Charcot-Marie-Tooth Type 2A. Passage Bio maintains a significant research collaboration with the Trustees of the University of Pennsylvania's Gene Therapy Program, alongside a development services and clinical supply agreement with Catalent Maryland, Inc. Established in 2017, the company's headquarters are located in Philadelphia, Pennsylvania.

Market Cap & Enterprise Value
Merger & Acquisition History

No mergers or acquisitions recorded for this company.

Technical Outlook
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Signal Summary Loading…
Indicator 1D1W2W3W1M
Each column is computed on that timeframe's candles (1D = daily, 1W ≈ weekly, 1M ≈ monthly), not on the same last day. ▲ bullish · ▼ bearish · — neutral. The Net row counts signals per column; hover any cell (or the indicator name) to see the exact rule behind it.
Day Score & sub-scores
Statistical fingerprint & regime detail
Conditional historical analysis
Customize analysis (advanced)
Indicative levels generated algorithmically. Not financial advice.
Risk Profile
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Price Chart
Averages
Trend
Price
Levels
Draw
USD4.91 +0.47 (+10.59%)
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Volume Profile
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Liquidity & share structure
Average Volume
113.8K
Beta
1.41
Float Shares
2.89M
Free Float %
90.0%
Price Performance
1D5D1M3M6M YTD1Y3Y5Y10YMax
+9.74% +33.66% -48.94% -37.34% -35.29% -53.22% -6.44% -73.20% -98.25% -98.76% -98.76%
Rolling Volatility
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Drawdown
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Relative Strength
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Monthly Returns Heatmap
From To
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Annual Monthly Returns
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Daily Returns Distribution
vs.
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Revenue flow

Revenue by geography

Revenue by segment

From To

Revenue composition

From To

By product

By geography

Financial Statements

Income Statement

Balance Sheet

Cash Flow Statement

Key Metrics

Financial Ratios

Employees

Financial Growth (CAGR)

Market Data

Analyst Consensus (11 ratings, all time) Buy
Price Targets & DCF
Current price
4.91
Low 7.00 +42.6%
Consensus 10.00 +103.7%
Median 8.00 +62.9%
High 15.00 +205.5%
DCF (Unlevered) 6.70 +36.4%
DCF (Levered) 7.03 +43.1%

DCF figures are point estimates: small changes in growth or discount-rate assumptions move them materially. Read them as a reference, not a precise target.

Ratings Trend (MoM) 20% Bullish
Rating 2026-05 Change
Strong Buy 0 0
Buy 1 -5
Hold 4 0
Sell 0 0
Strong Sell 0 0
Price Target Summary
Period # Analysts Avg Target
Last Month 3
10.00
+103.7%
Last Quarter 3
10.00
+103.7%
Last Year 3
10.00
+103.7%
All Time 4
9.00
+83.3%
Quality scores
Altman Z-Score
-29.76
Distress
Piotroski F-Score
1 / 9
Weak
MOAT Score
3 / 10
No MOAT
Composite Rating
C
Overall Score
2 / 5
Medium
DCF Score
4 / 5
High
ROE Score
1 / 5
Low
ROA Score
1 / 5
Low
D/E Score
1 / 5
Low
P/E Score
1 / 5
Low
P/Book Score
3 / 5
Medium
Operational MOAT
✗ Below peers
  • Revenue growth Biotechnology: +1.6%
  • EPS growth Biotechnology: +29.7%
    +33.1% Q1'26: +52.4% (vs Q1'25)
  • FCF margin FCF growth · Biotechnology: +16.2%
  • EBIT margin Biotechnology: +0.0%
  • ROIC Biotechnology: -16.1%
    Q1'26: +0.0% (vs Q1'25)
  • Share dilution Biotechnology: -3.4%
    +5.1% Q1'26: +3.2% (vs Q1'25)
  • Debt / EBITDA Net debt/EBITDA · Biotechnology: 0.16×
    -0.57× Q1'26: -0.17× (vs Q1'25)
Valuation Multiples From To
Price Forecast (3Y) From To
Model
Adjust
P/E
Theoretical Return — If Invested Today

* These projections are based on analyst consensus estimates and user-defined valuation multiples. This table is for informational purposes only and does not constitute a recommendation to buy or sell any security. Past performance is not indicative of future results.

DCF Interactive Model (UFCF)
Projection years:
Market assumptions
WACC components (optional)
Ke (Cost of Equity) = Rf + β (1.38) × ERP
WACC = 37% × Ke + 63% × Kd (4.1%) × (1−t)

Modifying these values recalculates WACC automatically.

Business assumptions
Intrinsic value (base): 6.70 Current price: 4.91
Enterprise Value: Equity Value: Terminal Value: TV as % of EV:

Base values reflect the latest available data for this company and market conditions.

Consensus Estimates
Metric Dec 2024
actual
Dec 2025
actual
Dec 2026
5 Rev. Ana.
4 EPS Ana.
Dec 2027
4 Rev. Ana.
3 EPS Ana.
Dec 2028
3 Rev. Ana.
3 EPS Ana.
Dec 2029
2 Rev. Ana.
1 EPS Ana.
Dec 2030
1 Rev. Ana.
1 EPS Ana.
Revenue
est: 1.90M (-100.0%)
2.00M
2.00M – 2.00M
+5.3% YoY
45.01M
45.01M – 45.01M
+2,150.6% YoY
31.53M
31.53M – 31.53M
-30.0% YoY
15.03M
15.03M – 15.03M
-52.3% YoY
42.72M
42.72M – 42.72M
+184.2% YoY
EBITDA
-62.09M
-42.42M
— – —
— – —
— – —
— – —
— – —
EBIT
-65.17M
-43.15M
— – —
— – —
— – —
— – —
— – —
Net Income
-64.77M
est: -59.21M (-9.4%)
-45.52M
est: -28.50M (-59.7%)
-29.21M
-32.99M – -25.43M
-2.5% YoY
-24.87M
-29.70M – -20.04M
+14.9% YoY
-17.48M
-29.73M – -5.24M
+29.7% YoY
-22.43M
-22.43M – -22.43M
-28.3% YoY
-11.92M
-11.92M – -11.92M
+46.9% YoY
SGA
24.99M
19.88M
— – —
— – —
— – —
— – —
— – —
EPS
-21.44
est: -19.70 (-8.8%)
-14.35
est: -9.83 (-46.0%)
-9.21
-10.40 – -8.02
+6.3% YoY
-7.84
-9.36 – -6.32
+14.9% YoY
-6.63
-9.37 – -1.65
+15.4% YoY
-7.07
-7.07 – -7.07
-6.6% YoY
-3.76
-3.76 – -3.76
+46.9% YoY
Recent Grade Changes (3M)
Date Firm Previous New Grade Action
2026-04-21 Chardan Capital Buy Neutral Downgrade
Historical Ratings (3M)
Date Rating Overall DCF ROE ROA D/E P/E P/B
2026-05-11 C 2/5 4/5 1/5 1/5 1/5 1/5 3/5
2026-05-08 C 2/5 4/5 1/5 1/5 1/5 1/5 3/5
2026-05-07 C 2/5 4/5 1/5 1/5 1/5 1/5 3/5
2026-05-06 C 2/5 4/5 1/5 1/5 1/5 1/5 3/5
2026-05-05 C 2/5 4/5 1/5 1/5 1/5 1/5 3/5
2026-05-04 C 2/5 4/5 1/5 1/5 1/5 1/5 3/5
2026-05-01 C 2/5 4/5 1/5 1/5 1/5 1/5 3/5
2026-04-30 C 2/5 4/5 1/5 1/5 1/5 1/5 3/5
2026-04-29 C 2/5 4/5 1/5 1/5 1/5 1/5 3/5
2026-04-28 C 2/5 4/5 1/5 1/5 1/5 1/5 3/5
2026-04-27 C 2/5 4/5 1/5 1/5 1/5 1/5 3/5
2026-04-24 C 2/5 4/5 1/5 1/5 1/5 1/5 3/5
2026-04-23 C 2/5 4/5 1/5 1/5 1/5 1/5 3/5
2026-04-22 C 2/5 4/5 1/5 1/5 1/5 1/5 3/5
2026-04-21 C 2/5 3/5 1/5 1/5 1/5 1/5 3/5
2026-04-20 C 2/5 3/5 1/5 1/5 1/5 1/5 3/5
2026-04-17 C 2/5 3/5 1/5 1/5 1/5 1/5 3/5
2026-04-16 C 2/5 4/5 1/5 1/5 1/5 1/5 3/5

Owner Earnings

Owner's Earnings (history)

Owner's Earnings history not available.

Owner alignment
Owner's Earnings TTM
OE per share TTM
Owner's Yield
Maintenance CapEx ratio
Maint CapEx / Avg PPE

Ownership Overview

Ownership breakdown
At a glance
Institutional holders
10
Total invested
6.67M
Insider transactions (90d)
0
Beneficial owners (>5%)
40
Beneficial owners (>5%)
# Reporting person Amount owned % of class Sole voting Shared voting Sole dispositive Shared dispositive Type Citizenship Filing date SEC filing
1 Ryan Wilder 6.10M 9.90% 6.10M HC, IN United States 2024-11-14
2 Vestal Point Capital, LP 6.10M 9.90% 6.10M IA, PN Delaware 2024-11-14
3 OrbiMed Advisors LLC 5.95M 13.50% 5.95M 10.00 IA Delaware 2020-03-09
4 OrbiMed Capital GP VII LLC 5.95M 13.50% 5.95M 10.00 OO Delaware 2020-03-09
5 FHMLS IX, L.L.C. 5.01M 10.90% 5.01M 5.01M OO 2020-03-09
6 FHMLS IX, L.P. 5.01M 10.90% 5.01M 5.01M PN 2020-03-09
7 Frazier Life Sciences IX, L.P. 5.01M 10.90% 5.01M 5.01M PN 2020-03-09
8 James N. Topper 5.01M 10.90% 5.01M 5.01M IN 2020-03-09
9 Patrick J. Heron 5.01M 10.90% 5.01M 5.01M IN 2020-03-09
10 Lynx1 Capital Management LP 4.85M 8.70% 4.85M PN Delaware 2024-03-29
11 Weston Nichols 4.85M 8.70% 4.85M IN Delaware 2024-03-29
12 Abigail P. Johnson 4.63M 10.20% 4.63M IN Delaware 2020-06-10
13 Versant Venture Capital VI, L.P. 4.03M 9.20% 4.03M 4.03M 11.00 PN 2020-03-13
14 Versant Ventures VI GP, L.P. 4.03M 9.20% 4.03M 11.00 PN 2020-03-13
15 Versant Ventures VI GP-GP, LLC 4.03M 9.20% 4.03M 11.00 OO 2020-03-13
16 David Kroin 2.85M 5.27% 2.85M HC, IN United States 2021-10-25
17 Deep Track Biotechnology Master Fund, Ltd. 2.85M 5.27% 2.85M CO United States 2021-10-25
18 Deep Track Capital, LP 2.85M 5.27% 2.85M IA, OO United States 2021-10-25
19 Yi Shi 2.83M 6.20% 2.83M 2.83M IN United States 2021-02-09
20 FMR LLC 2.67M 4.93% 2.67M HC United States of America 2021-12-10
21 10. 2.62M 5.90% 2.62M 2.62M OO State of Delaware 2020-03-12
22 AI Passage LLC 2.62M 4.80% 2.62M 2.62M OO 2022-02-14
23 Access Industries Holdings LLC 2.62M 4.80% 2.62M 2.62M OO 2022-02-14
24 Access Industries Management, LLC 2.62M 4.80% 2.62M 2.62M OO 2022-02-14
25 Len Blavatnik 2.62M 4.80% 2.62M 2.62M IN 2022-02-14
26 Page 2 of 10 Pages 2.50M 4.70% 2.50M 2.50M PN 2021-02-11
27 Page 3 of 10 Pages 2.50M 4.70% 2.50M 2.50M PN 2021-02-11
28 Page 4 of 10 Pages 2.50M 4.70% 2.50M 2.50M OO 2021-02-11
29 Page 5 of 10 Pages 2.50M 4.70% 2.50M 2.50M IN 2021-02-11
30 Page 6 of 10 Pages 2.50M 4.70% 2.50M IN 2021-02-11
31 LAV Prescience Limited (“LAVPRE”) 2.42M 5.30% 2.42M 2.42M 2.42M 2.42M OO British Virgin Islands 2021-02-09
32 Vivo Capital VIII, LLC 2.24M 4.90% 2.24M 2.24M OO Delaware 2020-03-06
33 (1) BlackRock, Inc. 1.37M 2.50% 1.28M 1.37M HC Delaware 2022-07-08
34 OrbiMed Capital LLC 1.02M 2.30% 1.02M 1.02M 10.00 IA Cayman Islands 2020-03-09
35 Versant Vantage I GP, L.P. 933.4K 2.10% 933.4K 11.00 PN 2020-03-13
36 Versant Vantage I GP-GP, LLC 933.4K 2.10% 933.4K 11.00 OO 2020-03-13
37 Versant Vantage I, L.P. 933.4K 2.10% 933.4K 933.4K 11.00 PN 2020-03-13
38 L.P. (“FUNDVSUBA”) 410.0K 0.90% 410.0K 410.0K 410.0K 410.0K PN United States 2021-02-09
39 Vivo Opportunity, LLC 213.5K 0.50% 213.5K 213.5K OO Delaware 2020-03-06
40 Vivo Capital IX, LLC. 47.6K 0.10% 47.6K 47.6K OO Delaware 2020-03-06

Institutional Activity (13F)

Institutional ownership trend From To
13F snapshot — 2026 Q1
Investors holding
10
-19 vs prev Q
New positions
4
Closed positions
23
Increased
5
Reduced
1
Put/Call ratio
0.00
Calls held
Puts held
Top institutional holders
# Investor Shares / Δ Mkt value / Δ Own% / Δ Weight% / Δ Avg px / Perf. Hold / Status
1 NANO CAP NEW MILLENNIUM GROWTH FUND L P 10.0K +10.0K (+100.0%) 118.00M +118.0M (+100.0%) 0.32% +0.316 pp 0.10% +0.101 pp USD11.80 +0.0% 1 qtrs NEW
2 LYNX1 CAPITAL MANAGEMENT LP 623.7K +— (+0.0%) 7.36M +2.4M (+46.9%) 19.68% +0.000 pp 1.49% +0.470 pp USD8.03 +46.9% 2 qtrs
3 VESTAL POINT CAPITAL, LP 305.0K +— (+0.0%) 3.60M +1.1M (+46.9%) 9.62% +0.000 pp 0.12% +0.012 pp USD8.03 +46.9% 2 qtrs
4 VANGUARD GROUP INC 126.6K +9.6K (+8.2%) 1.49M +557.0K (+59.4%) 4.00% +0.303 pp 0.00% +0.000 pp USD8.32 +41.8% 2 qtrs
5 EVERSEPT PARTNERS, LP 126.2K +126.2K (+100.0%) 1.49M +1.5M (+100.0%) 3.98% +3.983 pp 0.08% +0.075 pp USD11.80 +0.0% 1 qtrs NEW
6 RENAISSANCE TECHNOLOGIES LLC 109.1K +8.3K (+8.2%) 1.29M +477.9K (+59.1%) 3.44% +0.262 pp 0.00% +0.001 pp USD8.32 +41.8% 2 qtrs
7 ERSTE ASSET MANAGEMENT GMBH 85.3K -37.5K (-30.6%) 1.00M +4.6K (+0.5%) 2.69% -1.184 pp 0.01% -0.001 pp USD8.03 +46.9% 2 qtrs
8 YIHENG CAPITAL MANAGEMENT, L.P. 34.3K +34.3K (+100.0%) 404.8K +404.8K (+100.0%) 1.08% +1.082 pp 0.08% +0.082 pp USD11.80 +0.0% 1 qtrs NEW
9 GEODE CAPITAL MANAGEMENT, LLC 31.4K +4.1K (+15.1%) 370.6K +152.0K (+69.5%) 0.99% +0.130 pp 0.00% +0.000 pp USD8.52 +38.5% 2 qtrs
10 BLACKROCK, INC. 28.9K -846.0 (-2.8%) 341.1K +102.2K (+42.8%) 0.91% -0.027 pp 0.00% +0.000 pp USD8.03 +46.9% 2 qtrs
11 ACADIAN ASSET MANAGEMENT LLC 24.2K -1.4K (-5.4%) 284.0K +80.0K (+39.2%) 0.76% -0.043 pp 0.00% +0.000 pp USD8.03 +46.9% 2 qtrs
12 CITADEL ADVISORS LLC 17.7K -1.4K (-7.5%) 208.4K +55.5K (+36.3%) 0.56% -0.045 pp 0.00% +0.000 pp USD8.03 +46.9% 2 qtrs
13 NORTHERN TRUST CORP 14.2K +14.2K (+100.0%) 167.8K +167.8K (+100.0%) 0.45% +0.449 pp 0.00% +0.000 pp USD11.80 +0.0% 1 qtrs NEW
14 QUADRATURE CAPITAL LTD 12.6K +12.6K (+100.0%) 148.4K +148.4K (+100.0%) 0.40% +0.397 pp 0.00% +0.002 pp USD11.80 +0.0% 1 qtrs NEW
15 SQUAREPOINT OPS LLC 10.8K -12.7K (-54.0%) 127.4K -60.8K (-32.3%) 0.34% -0.401 pp 0.00% 0.000 pp USD8.03 +46.9% 2 qtrs
16 FIDUCIARY TRUST CO 10.8K +— (+0.0%) 126.9K +40.5K (+46.9%) 0.34% +0.000 pp 0.00% +0.001 pp USD8.03 +46.9% 2 qtrs
17 MORGAN STANLEY 4.3K +3.9K (+1,164.8%) 50.4K +47.7K (+1,758.7%) 0.13% +0.124 pp 0.00% +0.000 pp USD11.50 +2.6% 2 qtrs
18 UBS GROUP AG 1.4K +1.4K (+8,382.4%) 17.0K +16.9K (+12,320.4%) 0.05% +0.045 pp 0.00% +0.000 pp USD11.76 +0.3% 2 qtrs
19 ROCKEFELLER CAPITAL MANAGEMENT L.P. 500.00 +500.0 (+100.0%) 5.9K +5.9K (+100.0%) 0.02% +0.016 pp 0.00% +0.000 pp USD11.80 +0.0% 1 qtrs NEW
20 SBI SECURITIES CO., LTD. 142.00 +— (+0.0%) 1.7K +536.0 (+47.0%) 0.00% +0.000 pp 0.00% +0.000 pp USD0.39 +2,925.6% 3 qtrs
21 BANK OF AMERICA CORP /DE/ 28.00 +— (+0.0%) 331.00 +106.0 (+47.1%) 0.00% +0.000 pp 0.00% +0.000 pp USD8.00 +47.5% 2 qtrs
22 ADVISOR GROUP HOLDINGS, INC. 20.00 +— (+0.0%) 236.00 +95.0 (+67.4%) 0.00% +0.000 pp 0.00% +0.000 pp USD8.00 +47.5% 2 qtrs
23 PARALLEL ADVISORS, LLC 16.00 +— (+0.0%) 189.00 +61.0 (+47.7%) 0.00% +0.000 pp 0.00% +0.000 pp USD8.00 +47.5% 2 qtrs
24 JPMORGAN CHASE & CO 15.00 +— (+0.0%) 177.00 +57.0 (+47.5%) 0.00% +0.000 pp 0.00% +0.000 pp USD8.00 +47.5% 2 qtrs
25 NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 2.00 +— (+0.0%) 163.00 +147.0 (+918.8%) 0.00% +0.000 pp 0.00% +0.000 pp USD8.00 +47.5% 2 qtrs
26 BNP PARIBAS ARBITRAGE, SNC 12.00 +— (+0.0%) 142.00 +46.0 (+47.9%) 0.00% +0.000 pp 0.00% +0.000 pp USD8.00 +47.5% 2 qtrs
27 LRI INVESTMENTS, LLC 12.00 +— (+0.0%) 142.00 +46.0 (+47.9%) 0.00% +0.000 pp 0.00% +0.000 pp USD0.33 +3,475.8% 3 qtrs
28 HARBOUR INVESTMENTS, INC. 3.00 +— (+0.0%) 35.00 +11.0 (+45.8%) 0.00% +0.000 pp 0.00% +0.000 pp USD8.00 +47.5% 2 qtrs
29 ORBIMED ADVISORS LLC -59.0K (-100.0%) -474.1K (-100.0%) 0.00% -1.863 pp 0.00% -0.011 pp USD 2 qtrs SOLD
30 CITIGROUP INC -77.0 (-100.0%) -617.0 (-100.0%) 0.00% -0.002 pp 0.00% +0.000 pp USD 2 qtrs SOLD
31 BRIDGEWAY CAPITAL MANAGEMENT, LLC -20.8K (-100.0%) -166.6K (-100.0%) 0.00% -0.657 pp 0.00% -0.004 pp USD 2 qtrs SOLD
32 MAI CAPITAL MANAGEMENT -200.0 (-100.0%) -1.6K (-100.0%) 0.00% -0.006 pp 0.00% +0.000 pp USD 2 qtrs SOLD
33 TANG CAPITAL MANAGEMENT LLC -75.0K (-100.0%) -602.3K (-100.0%) 0.00% -2.367 pp 0.00% -0.023 pp USD 2 qtrs SOLD
34 TOWER RESEARCH CAPITAL LLC (TRC) -289.0 (-100.0%) -2.3K (-100.0%) 0.00% -0.009 pp 0.00% 0.000 pp USD 2 qtrs SOLD
35 BARCLAYS PLC -13.2K (-100.0%) -9.2K (-100.0%) 0.00% -0.415 pp 0.00% +0.000 pp USD 16 qtrs SOLD
Ownership breakdown by holder

ETF Ownership

Top ETFs holding this stock Held by 13 ETFs in our universe
# ETF Weight Est. AUM exposure TER
1 Vanguard Extended Market ETF VXF 0.00% 198.5K 0.05%
2 Dimensional - US Core Equity 1 ETF DCOR 0.00% 6.0K 0.14%
3 Vanguard U.S. Total Market Index ETF VUN.TO 0.00% 2.6K 0.17%
4 Vanguard U.S. Total Market Index ETF (CAD-hedged) VUS.TO 0.00% 195.31 0.17%
5 Vanguard U.S. Total Market Shares Index ETF VTS.AX 0.00% 963.00 0.03%
6 Vanguard Total Stock Market ETF VTI 0.00% 452.0K 0.03%
7 Vanguard All-Equity ETF Portfolio VEQT.TO 0.00% 990.02 0.22%
8 Dimensional - US Core Equity 2 ETF DFAC 0.00% 3.7K 0.17%
9 Vanguard Growth ETF Portfolio VGRO.TO 0.00% 539.45 0.22%
10 Vanguard Balanced ETF Portfolio VBAL.TO 0.00% 217.97 0.22%

Insider Activity

Insider Activity — Latest Quarter
Ratio by transactions
1.00
Neutral
Ratio by volume
3.00
Bullish
Buys
4
Sells
4
Shares acquired
88.6K
Shares disposed
21.1K
Cash buys
Cash sales
2.00
Net activity
+67,472
Insider buys vs sells (history) From To
Recent insider transactions From To
Date Person Role Transaction A/D Security Shares Price Value Owned after D/I Filing
2026-03-16 Chou William Director / Officer A-Award A Employee Stock Option (right to buy) 58,000 7.64 443.1K 58,000 D
2026-03-16 Borthwick Kathleen Officer A-Award A Employee Stock Option (right to buy) 15,610 7.64 119.3K 15,610 D
2026-01-08 Chou William Director / Officer M-Exempt A Common Stock 10,000 0.00 10,600 D
2026-01-08 Borthwick Kathleen Officer M-Exempt A Common Stock 5,000 0.00 7,464 D
2025-09-15 Lynx1 Capital Management LP 10% Owner P-Purchase A Common Stock 11,900 6.99 83.2K 623,704 I
2025-09-12 Lynx1 Capital Management LP 10% Owner P-Purchase A Common Stock 19,783 6.99 138.3K 611,804 I
2025-09-11 Lynx1 Capital Management LP 10% Owner P-Purchase A Common stock, $0.0001 par value per share (Common Stock) 325 6.96 2.3K 592,021 I
2025-07-24 Lynx1 Capital Management LP 10% Owner P-Purchase A Common Stock 66,423 5.71 379.5K 591,696 I
2025-07-23 Lynx1 Capital Management LP 10% Owner P-Purchase A Common Stock 49,302 5.74 283.0K 525,273 I
2025-07-22 Lynx1 Capital Management LP 10% Owner P-Purchase A Common stock, $0.0001 par value per share ("Common Stock") 13,123 5.44 71.3K 475,971 I
2025-06-26 ORBIMED ADVISORS LLC 10% Owner S-Sale D Common Stock 213,257 0.33 70.4K 6,066,343 I
2025-06-25 ORBIMED ADVISORS LLC 10% Owner S-Sale D Common Stock 138,800 0.33 45.8K 6,279,600 I
2025-06-24 ORBIMED ADVISORS LLC 10% Owner S-Sale D Common Stock 231,600 0.35 81.1K 6,418,400 I
2025-05-28 Sondhi Dolan Director A-Award A Director Stock Option (right to buy) 201,857 0.36 72.6K 201,857 D
2025-05-28 Porter Derrell Director A-Award A Director Stock Option (right to buy) 201,857 0.36 72.6K 201,857 D
2025-05-28 Kassberg Thomas Richard Director A-Award A Director Stock Option (right to buy) 143,789 0.36 51.7K 143,789 D
2025-05-28 Kapadia Sandip Director A-Award A Director Stock Option (right to buy) 201,857 0.36 72.6K 201,857 D
2025-05-28 Islam Saqib Director A-Award A Director Stock Option (right to buy) 201,857 0.36 72.6K 201,857 D
2025-05-28 GOWEN MAXINE Director A-Award A Director Stock Option (right to buy) 201,857 0.36 72.6K 201,857 D
2025-05-28 Countouriotis Athena Director A-Award A Director Stock Option (right to buy) 201,857 0.36 72.6K 201,857 D
2025-04-24 ORBIMED ADVISORS LLC 10% Owner S-Sale D Common Stock 68,195 0.32 21.8K 6,650,000 I
2025-04-23 ORBIMED ADVISORS LLC 10% Owner S-Sale D Common Stock 89,328 0.34 30.4K 6,718,195 I
2025-04-22 ORBIMED ADVISORS LLC 10% Owner S-Sale D Common Stock 78,049 0.34 26.5K 6,807,523 I
2025-04-17 ORBIMED ADVISORS LLC 10% Owner S-Sale D Common Stock 77,090 0.33 25.4K 6,885,572 I
2025-04-16 ORBIMED ADVISORS LLC 10% Owner S-Sale D Common Stock 61,638 0.33 20.3K 6,962,662 I
2025-04-15 ORBIMED ADVISORS LLC 10% Owner S-Sale D Common Stock 10,326 0.38 3.9K 7,024,300 I
2025-03-15 Chou William Director / Officer A-Award A Employee Stock Option (right to buy) 779,533 0.39 301.7K 779,533 D
2025-03-15 Cale Edgar B. Officer A-Award A Employee Stock Option (right to buy) 278,386 0.39 107.7K 278,386 D
2025-03-15 Borthwick Kathleen Officer A-Award A Employee Stock Option (right to buy) 278,386 0.39 107.7K 278,386 D
2025-02-11 Borthwick Kathleen Officer S-Sale D Common Stock 3,183 0.53 1.7K 41,283 D
2025-02-10 Borthwick Kathleen Officer M-Exempt A Common Stock 8,000 0.00 44,466 D
2025-01-15 Chou William Director / Officer A-Award A Restricted Stock Unit 20,000 0.00 20,000 D
2025-01-15 Borthwick Kathleen Officer A-Award A Restricted Stock Unit 10,000 0.00 10,000 D
2025-01-14 ORBIMED ADVISORS LLC 10% Owner S-Sale D Common Stock 79,024 0.60 47.4K 7,034,626 I
2025-01-13 ORBIMED ADVISORS LLC 10% Owner S-Sale D Common Stock 17,986 0.64 11.5K 7,113,650 I
2025-01-10 ORBIMED ADVISORS LLC 10% Owner S-Sale D Common Stock 126,209 0.66 83.3K 7,131,636 I
2025-01-08 ORBIMED ADVISORS LLC 10% Owner S-Sale D Common Stock 75,007 0.68 51.0K 7,257,845 I
2025-01-07 ORBIMED ADVISORS LLC 10% Owner S-Sale D Common Stock 52,536 0.71 37.3K 7,332,852 I
2025-01-06 ORBIMED ADVISORS LLC 10% Owner S-Sale D Common Stock 19,481 0.77 15.0K 7,385,388 I
2024-12-27 Lynx1 Capital Management LP 10% Owner P-Purchase A Common stock, $0.0001 par value per share 373,645 0.65 241.0K 9,256,953 I
2024-12-20 ORBIMED ADVISORS LLC 10% Owner S-Sale D Common Stock 230,321 0.60 138.2K 7,404,869 I
2024-12-11 ORBIMED ADVISORS LLC 10% Owner S-Sale D Common Stock 80 0.80 64.00 7,635,190 I
2024-12-10 ORBIMED ADVISORS LLC 10% Owner S-Sale D Common Stock 8,015 0.80 6.4K 7,635,270 I
2024-12-09 ORBIMED ADVISORS LLC 10% Owner S-Sale D Common Stock 54,181 0.84 45.5K 7,643,285 I
2024-12-06 ORBIMED ADVISORS LLC 10% Owner S-Sale D Common Stock 20,903 0.82 17.1K 7,697,466 I
2024-12-04 ORBIMED ADVISORS LLC 10% Owner S-Sale D Common Stock 76,200 0.79 60.2K 7,718,369 I
2024-11-27 Lynx1 Capital Management LP 10% Owner P-Purchase A Common Stock 29,300 0.67 19.7K 8,883,308 I
2024-11-26 Lynx1 Capital Management LP 10% Owner P-Purchase A Common Stock 167,055 0.71 118.2K 8,854,008 I
2024-11-25 Lynx1 Capital Management LP 10% Owner P-Purchase A Common stock, $0.0001 par value per share ("Common Stock") 259,998 0.56 146.7K 8,686,953 I
2024-09-30 Kassberg Thomas Richard Director A-Award A Employee Stock Option (right to buy) 174,139 0.70 121.9K 174,139 D
2024-09-30 Cale Edgar B. Officer A-Award A Employee Stock Option (right to buy) 50,000 0.70 35.0K 50,000 D
2024-09-19 ORBIMED ADVISORS LLC 10% Owner S-Sale D Common Stock 39,300 0.71 27.9K 7,794,569 I
2024-09-18 ORBIMED ADVISORS LLC 10% Owner S-Sale D Common Stock 25,631 0.73 18.7K 7,833,869
2024-09-17 ORBIMED ADVISORS LLC 10% Owner S-Sale D Common Stock 111,400 0.73 81.3K 7,859,500
2024-09-16 ORBIMED ADVISORS LLC 10% Owner S-Sale D Common Stock 63,100 0.74 46.7K 7,970,900
2024-09-10 Kassberg Thomas Richard 0 0.00 0
2024-08-07 Lynx1 Capital Management LP 10% Owner I Common stock, $0.0001 par value per share 0 0.00 8,426,955
2024-05-21 Sondhi Dolan Director A-Award A Director Stock Option (right to buy) 39,092 1.28 50.0K 39,092
2024-05-21 Porter Derrell Director A-Award A Director Stock Option (right to buy) 47,693 1.28 61.0K 47,693
2024-05-21 Kapadia Sandip Director A-Award A Director Stock Option (right to buy) 47,693 1.28 61.0K 47,693
2024-05-21 Islam Saqib Director A-Award A Director Stock Option (right to buy) 47,693 1.28 61.0K 47,693
2024-05-21 GOWEN MAXINE Director A-Award A Director Stock Option (right to buy) 47,693 1.28 61.0K 47,693
2024-05-21 Countouriotis Athena Director A-Award A Director Stock Option (right to buy) 47,693 1.28 61.0K 47,693
2024-03-15 Forman Mark S Officer A-Award A Employee Stock Option (right to buy) 203,000 1.50 304.5K 203,000
2024-03-15 Chou William Director / Officer A-Award A Employee Stock Option (right to buy) 575,000 1.50 862.5K 575,000
2024-03-15 Cale Edgar B. Officer A-Award A Employee Stock Option (right to buy) 203,000 1.50 304.5K 203,000
2024-03-15 Borthwick Kathleen Officer A-Award A Employee Stock Option (right to buy) 227,000 1.50 340.5K 227,000
2024-02-13 Forman Mark S Officer S-Sale D Common Stock 1,638 0.97 1.6K 48,631
2024-02-13 Borthwick Kathleen Officer S-Sale D Common Stock 1,470 0.97 1.4K 28,466
2024-02-10 Forman Mark S Officer M-Exempt A Common Stock 5,000 0.00 50,269
2024-02-10 Borthwick Kathleen Officer M-Exempt D Restricted Stock Unit 4,000 0.00 8,000
2024-01-02 Forman Mark S Officer S-Sale D Common Stock 15,813 0.91 14.4K 45,269
2024-01-02 Cale Edgar B. Officer S-Sale D Common Stock 15,813 0.91 14.4K 45,995
2024-01-02 Borthwick Kathleen Officer S-Sale D Common Stock 10,672 0.91 9.7K 25,936
2023-12-31 Forman Mark S Officer M-Exempt D Restricted Stock Unit 50,000 0.00 0
2023-12-31 Cale Edgar B. Officer M-Exempt A Common Stock 50,000 0.00 61,808
2023-12-31 Borthwick Kathleen Officer M-Exempt A Common Stock 30,000 0.00 36,608
2023-07-28 Sondhi Dolan Director 0 0.00 0
2023-07-28 King Simona Officer S-Sale D Common Stock 11,453 0.88 10.1K 23,994
2023-07-28 Borthwick Kathleen Officer D Employee Stock Option (right to buy) 56,000 6.75 378.0K 0
2023-07-27 Sondhi Dolan Director A-Award A Director Stock Option (right to buy) 48,000 0.85 40.7K 48,000
2023-06-28 ORBIMED ADVISORS LLC 10% Owner P-Purchase A Common Stock 575,195 0.84 483.2K 8,034,000
2023-06-27 ORBIMED ADVISORS LLC 10% Owner P-Purchase A Common Stock 617,382 0.84 518.6K 7,458,805
2023-06-16 Fotopoulos Alexandros Officer S-Sale D Common Stock 4,052 0.93 3.8K 28,693
2023-06-15 Fotopoulos Alexandros Officer M-Exempt A Common Stock 12,500 0.00 32,745
2023-05-25 Woiwode Thomas Director / 10% Owner A-Award A Director Stock Option (Right to Buy) 24,000 1.00 24.0K 24,000
2023-05-25 Porter Derrell Director A-Award A Director Stock Option (Right to Buy) 24,000 1.00 24.0K 24,000
2023-05-25 Kapadia Sandip Director A-Award A Director Stock Option (Right to Buy) 24,000 1.00 24.0K 24,000
2023-05-25 Kamarck Michael E. Director A-Award A Director Stock Option (Right to Buy) 21,567 1.00 21.6K 21,567
2023-05-25 Islam Saqib Director A-Award A Director Stock Option (Right to Buy) 24,000 1.00 24.0K 24,000
2023-05-25 GOWEN MAXINE Director A-Award A Director Stock Option (Right to Buy) 24,000 1.00 24.0K 24,000
2023-05-25 Countouriotis Athena Director A-Award A Director Stock Option (Right to Buy) 24,000 1.00 24.0K 24,000
2023-04-18 King Simona Officer M-Exempt D Restricted Stock Units 6,250 0.00 18,750
2023-03-15 King Simona Officer A-Award A Employee Stock Option (right to buy) 140,000 1.08 151.2K 140,000
2023-03-15 Fotopoulos Alexandros Officer A-Award A Employee Stock Option (right to buy) 175,000 1.08 189.0K 175,000
2023-03-15 Forman Mark S Officer A-Award A Employee Stock Option (right to buy) 175,000 1.08 189.0K 175,000
2023-03-15 Chou William Director / Officer A-Award A Employee Stock Option (right to buy) 608,615 1.08 657.3K 608,615
2023-03-15 Cale Edgar B. Officer A-Award A Employee Stock Option (right to buy) 175,000 1.08 189.0K 175,000
2022-12-01 Kapadia Sandip Director S-Sale D Common Stock 5,000 1.19 6.0K 0
2022-11-22 Fotopoulos Alexandros Officer M-Exempt D Restricted Stock Units 12,500 0.00 37,500
2022-11-10 King Simona Officer A-Award A Restricted Stock Unit 50,000 0.00 50,000
2022-11-10 Fotopoulos Alexandros Officer A-Award A Restricted Stock Unit 50,000 0.00 50,000
2022-11-10 Forman Mark S Officer A-Award A Restricted Stock Unit 50,000 0.00 50,000
2022-11-10 Cale Edgar B. Officer A-Award A Restricted Stock Unit 50,000 0.00 50,000
2022-10-10 Chou William Officer A-Award A Employee Stock Option (right to buy) 885,000 0.00 885,000
2022-09-19 Toernsen Monika Maria Officer S-Sale D Common Stock 1,681 1.51 2.5K 3,319
2022-09-15 Toernsen Monika Maria Officer M-Exempt A Common Stock 5,000 0.00 5,000
2022-07-05 Kamarck Michael E. Director A-Award A Stock Option (right to buy) 48,000 0.00 48,000
2022-07-02 Kamarck Michael E. Director 0 0.00 0
2022-06-13 Toernsen Monika Maria Officer A-Award A Employee Stock Option (right to buy) 101,000 0.00 101,000
2022-06-13 King Simona Officer A-Award A Employee Stock Option (right to buy) 159,000 0.00 159,000
2022-06-13 Fotopoulos Alexandros Officer A-Award A Employee Stock Option (right to buy) 200,000 0.00 200,000
2022-06-13 Forman Mark S Officer A-Award A Employee Stock Option (right to buy) 136,000 0.00 136,000
2022-06-13 Cale Edgar B. Officer A-Award A Employee Stock Option (right to buy) 106,000 2.29 242.7K 106,000
2022-05-31 GOWEN MAXINE Director A-Award A Stock Option (Right to Buy) 40,000 1.80 72.0K 40,000
2022-05-31 Cale Edgar B. Officer A-Award A Stock Option (Right to Buy) 100,000 0.00 100,000
2022-05-27 Goldsmith Bruce A Officer A-Award A Stock Option (Right to Buy) 100,000 0.00 100,000
2022-05-26 Woiwode Thomas Director A-Award A Director Stock Option (Right to Buy) 24,000 0.00 24,000
2022-05-26 Porter Derrell Director A-Award A Director Stock Option (Right to Buy) 24,000 0.00 24,000
2022-05-26 Kapadia Sandip Director A-Award A Director Stock Option (Right to Buy) 24,000 0.00 24,000
2022-05-26 Islam Saqib Director A-Award A Director Stock Option (Right to Buy) 24,000 0.00 24,000
2022-05-26 GOWEN MAXINE Director A-Award A Director Stock Option (Right to Buy) 24,000 1.76 42.2K 24,000
2022-05-26 Countouriotis Athena Director A-Award A Director Stock Option (Right to Buy) 24,000 1.76 42.2K 24,000
2022-05-04 ORBIMED ADVISORS LLC 10% Owner P-Purchase A Common Stock 303,500 1.94 588.8K 6,841,423
2022-05-03 OrbiMed Capital GP VII LLC Director P-Purchase A Common Stock 221,500 1.93 427.5K 6,537,923
2022-05-03 ORBIMED ADVISORS LLC 10% Owner P-Purchase A Common Stock 221,500 1.93 427.5K 6,537,923
2022-04-18 King Simona Officer A-Award A Restricted Stock Unit 25,000 0.00 25,000
2022-04-18 Forman Mark S Officer A-Award A Employee Stock Options (right to buy) 136,000 0.00 136,000
2022-03-30 Forman Mark S Officer 0 0.00 0
2022-03-21 Goldsmith Bruce A Officer P-Purchase A Common Stock 10,000 3.15 31.5K 15,983
2022-02-10 Toernsen Monika Maria Officer A-Award A Stock Option (right to buy) 101,000 4.52 456.5K 101,000
2022-02-10 Salinas Eliseo Oreste Officer A-Award A Stock Option (right to buy) 157,500 4.52 711.9K 157,500
2022-02-10 King Simona Officer A-Award A Stock Option (right to buy) 159,000 4.52 718.7K 159,000
2022-02-10 Goldsmith Bruce A Director / Officer A-Award A Stock Option (right to buy) 400,000 4.52 1.81M 400,000
2022-02-10 Fotopoulos Alexandros Officer A-Award A Stock Option (right to buy) 163,900 4.52 740.8K 163,900
2022-02-10 Forman Mark S Officer A-Award A Restricted Stock Unit 15,000 0.00 15,000
2022-02-10 Cale Edgar B. Officer A-Award A Stock Option (right to buy) 106,000 4.52 479.1K 106,000
2022-01-20 ORBIMED ADVISORS LLC 10% Owner P-Purchase A Common Stock 50,800 5.00 254.0K 6,316,423
2022-01-19 ORBIMED ADVISORS LLC 10% Owner P-Purchase A Common Stock 43,300 5.11 221.3K 6,265,623
2022-01-18 ORBIMED ADVISORS LLC 10% Owner P-Purchase A Common Stock 114,700 5.46 626.3K 6,222,323
2022-01-14 ORBIMED ADVISORS LLC 10% Owner P-Purchase A Common Stock 10,300 5.60 57.7K 6,107,623
2022-01-13 ORBIMED ADVISORS LLC 10% Owner P-Purchase A Common Stock 41,800 5.52 230.7K 6,097,323
2022-01-12 ORBIMED ADVISORS LLC 10% Owner P-Purchase A Common Stock 100,000 5.65 565.0K 6,055,523
2022-01-11 ORBIMED ADVISORS LLC 10% Owner P-Purchase A Common Stock 8,200 5.53 45.3K 5,955,523
2021-12-08 Quigley Jill M. Officer M-Exempt A Common Stock 71,975 0.23 16.6K 368,754
2021-08-23 King Simona Officer A-Award A Employee Stock Option (Right to Buy) 360,000 11.43 4.11M 360,000
2021-08-16 Forman Mark S Officer A-Award A Employee Stock Option (right to buy) 130,000 10.84 1.41M 130,000
2021-07-19 Toernsen Monika Maria Officer A-Award A Restricted Stock Units 20,000 0.00 20,000
2021-05-30 Burkavage Brian Officer D Employee Stock Option (Right to Buy) 24,000 22.63 543.1K 0
2021-05-27 Yamada Tadataka Director A-Award A Director Stock Option (Right to Buy) 16,918 13.83 234.0K 16,918
2021-05-27 Woiwode Thomas Director / 10% Owner A-Award A Director Stock Option (Right to Buy) 16,918 13.83 234.0K 16,918
2021-05-27 Ratcliffe Liam Director A-Award A Director Stock Option (Right to Buy) 16,918 13.83 234.0K 16,918
2021-05-27 Porter Derrell Director A-Award A Director Stock Option (Right to Buy) 33,836 13.83 468.0K 33,836
2021-05-27 Kapadia Sandip Director A-Award A Director Stock Option (Right to Buy) 16,918 13.83 234.0K 16,918
2021-05-27 Islam Saqib Director A-Award A Director Stock Option (Right to Buy) 16,918 13.83 234.0K 16,918
2021-05-27 GOWEN MAXINE Director A-Award A Director Stock Option (Right to Buy) 4,542 13.83 62.8K 4,542
2021-05-27 Countouriotis Athena Director A-Award A Director Stock Option (Right to Buy) 16,918 13.83 234.0K 16,918
2021-05-21 Morris Richard Steven Officer P-Purchase A Common Stock 2,171 13.82 30.0K 5,454
2021-05-21 Goldsmith Bruce A Director / Officer P-Purchase A Common Stock 2,000 13.12 26.2K 5,983
2021-05-17 Fotopoulos Alexandros Officer A-Award A Restricted Stock Unit (RSU) 50,000 0.00 50,000
2021-03-22 Salinas Eliseo Oreste Officer 0 0.00 0
2021-03-15 Romano Gary Officer M-Exempt D Employee Stock Option (right to buy) 10,000 8.07 80.7K 300,821
2021-02-18 GOWEN MAXINE Director A-Award A Stock Option (right to buy) 33,836 21.46 726.1K 33,836
2021-02-16 Romano Gary Officer A-Award A Stock Option (right to buy) 105,000 21.85 2.29M 105,000
2021-02-16 Quigley Jill M. Officer A-Award A Stock Option (right to buy) 105,000 21.85 2.29M 105,000
2021-02-16 Morris Richard Steven Officer A-Award A Stock Option (right to buy) 50,000 21.85 1.09M 50,000
2021-02-16 Goldsmith Bruce A Director / Officer A-Award A Stock Option (right to buy) 262,000 21.85 5.72M 262,000
2021-02-16 Fotopoulos Alexandros Officer A-Award A Stock Option (right to buy) 105,000 21.85 2.29M 105,000
2021-02-16 Cale Edgar B. Officer A-Award A Stock Option (right to buy) 170,997 21.85 3.74M 170,997
2021-01-20 Quigley Jill M. Officer S-Sale D Common Stock 1,300 30.01 39.0K 295,284
2021-01-14 Quigley Jill M. Officer S-Sale A Common Stock 16,298 30.10 490.6K 296,584
2020-03-24 Countouriotis Athena Director P-Purchase A Common Stock 10,000 14.98 149.8K 18,900
2020-03-03 Yamada Tadataka Director P-Purchase A Common Stock 6,500 18.00 117.0K 656,149
2020-03-03 Woiwode Thomas Director / 10% Owner C-Conversion A Common Stock 708,352 0.00 708,352
2020-03-03 Versant Venture Capital VI, L.P. 10% Owner C-Conversion A Common Stock 1,049,175 0.00 4,026,417
2020-03-03 Ratcliffe Liam Director P-Purchase A Common Stock 2,800 18.00 50.4K 2,800
2020-03-03 Quigley Jill M. Officer P-Purchase A Common Stock 1,000 18.00 18.0K 1,000
2020-03-03 ORBIMED ADVISORS LLC 10% Owner C-Conversion A Common Stock 541,002 0.00 5,947,323
2020-03-03 Morris Richard Steven Officer P-Purchase A Common Stock 400 18.00 7.2K 400
2020-03-03 Kapadia Sandip Director P-Purchase A Common Stock 5,000 18.00 90.0K 5,000
2020-03-03 Islam Saqib Director P-Purchase A Common Stock 5,000 18.00 90.0K 5,000
2020-03-03 Heron Patrick J Director / 10% Owner C-Conversion A Common Stock 2,977,242 0.00 2,977,242
2020-03-03 Goldsmith Bruce A Director / Officer P-Purchase A Common Stock 1,100 18.00 19.8K 1,100
2020-03-03 Frazier Life Sciences IX, L.P. 10% Owner C-Conversion A Common Stock 432,802 0.00 4,459,219
2020-03-03 Fotopoulos Alexandros Officer P-Purchase A Common Stock 5,500 18.00 99.0K 5,500
2020-03-03 Countouriotis Athena Director P-Purchase A Common Stock 8,900 18.00 160.2K 8,900
2020-03-03 Cale Edgar B. Officer P-Purchase A Common Stock 2,000 18.00 36.0K 2,000
2020-02-28 ORBIMED ADVISORS LLC 10% Owner P-Purchase A Common Stock 373,300 18.00 6.72M 373,300
2020-02-27 Yamada Tadataka Director D Common Stock 0 0.00 649,649
2020-02-27 Woiwode Thomas Director / 10% Owner I Series B Preferred Stock 708,352 0.00 0
2020-02-27 Versant Venture Capital VI, L.P. 10% Owner D Series A-1 Preferred Stock 2,977,242 0.00 0
2020-02-27 SQUINTO STEPHEN P Director / Officer D Common Stock 0 0.00 668,575
2020-02-27 Romano Gary Officer D Employee Stock Option (Right to Buy) 54,850 11.00 603.4K 0
2020-02-27 Ratcliffe Liam Director 0 0.00 0
2020-02-27 Quigley Jill M. Officer D Common Stock 0 0.00 309,994
2020-02-27 ORBIMED ADVISORS LLC 10% Owner I Series B Preferred Stock 541,002 0.00 0
2020-02-27 Morris Richard Steven Officer D Employee Stock Option (Right to Buy) 310,821 8.07 2.51M 0
2020-02-27 Kapadia Sandip Director D Director Stock Option (Right to Buy) 63,992 11.00 703.9K 0
2020-02-27 Islam Saqib Director D Director Stock Option (Right to Buy) 82,221 8.07 663.5K 0
2020-02-27 Heron Patrick J Director / 10% Owner I Series A-2 Preferred Stock 1,049,175 0.00 0

Executive team

Top executives
Shares Outstanding
3.21M

Executive compensation

Executive compensation (annual)
# Year Executive Salary Bonus Stock award Option award Incentive Other Total % Stock-
based
Filing
1 2025 William Chou, M.D. President, Chief Executive Officer and Director 661.0K 234.0K 239.3K 335.0K 17.5K 1.49M 31.83%
2 2025 Kathleen Borthwick Chief Financial Officer 450.6K 117.0K 85.4K 181.3K 17.5K 851.8K 23.77%
3 2025 Edgar B. (Chip) Cale General Counsel and Corporate Secretary 221.9K 197.1K 156.9K 17.5K 593.3K 59.66%
4 2024 William Chou, M.D. President, Chief Executive Officer and Director 638.5K 646.7K 334.4K 17.3K 1.64M 39.51%
5 2024 Edgar B. (Chip) Cale General Counsel and Corporate Secretary 436.8K 255.1K 172.8K 17.3K 881.9K 28.93%
6 2024 Kathleen Borthwick Chief Financial Officer 420.7K 257.0K 166.8K 17.3K 861.7K 29.82%
7 2023 William Chou, M.D. President, Chief Executive Officer and Director 599.2K 502.8K 330.0K 16.5K 1.45M 34.71%
8 2023 Alex Fotopoulos Former Chief Technical Officer 315.8K 145.0K 840.1K 1.30M 11.15%
9 2023 Simona King Former Chief Financial Officer 304.5K 116.0K 691.9K 1.11M 10.43%
10 2023 Mark Forman, M.D., Ph.D. Chief Medical Officer 462.2K 200.0K 145.0K 187.6K 16.5K 1.01M 14.34%
11 2023 Edgar B. (Chip) Cale General Counsel and Corporate Secretary 420.0K 200.0K 145.0K 168.2K 16.5K 949.7K 15.27%
12 2022 Bruce Goldsmith, Ph.D. Former President and Chief Executive Officer 297.7K 1.00M 1.33M 2.63M 38.17%
13 2022 Alex Fotopoulos Chief Technical Officer 463.5K 66.5K 914.6K 176.9K 13.6K 1.64M 60.00%
14 2022 Alex Fotopoulos Former Chief Technical Officer 463.5K 66.5K 914.6K 176.9K 13.6K 1.64M 60.00%
15 2022 Monika (Maria) Toernsen Former Chief Commercial Officer 439.3K 527.5K 659.7K 1.63M 32.43%
16 2022 Simona King Chief Financial Officer 454.8K 131.8K 829.2K 162.0K 16.1K 1.59M 60.29%
17 2022 Simona King Former Chief Financial Officer 454.8K 131.8K 829.2K 162.0K 16.1K 1.59M 60.29%
18 2022 Edgar B. (Chip) Cale General Counsel and Former Interim Chief Executive Officer 508.1K 66.5K 682.9K 149.4K 16.9K 1.42M 52.64%
19 2022 Edgar B. (Chip) Cale General Counsel and Corporate Secretary 508.1K 66.5K 682.9K 149.4K 16.9K 1.42M 52.64%
20 2022 William Chou, M.D. President and Chief Executive Officer 111.5K 200.0K 900.7K 72.0K 11.9K 1.30M 69.49%
21 2022 William Chou, M.D. President, Chief Executive Officer and Director 111.5K 200.0K 900.7K 72.0K 11.9K 1.30M 69.49%
22 2021 Eliseo Salinas, M.D. Former Chief of Research and Development 357.9K 100.0K 1.89M 4.07M 132.9K 969.00 6.55M 90.97%
23 2021 Bruce Goldsmith, Ph.D. Former President and Chief Executive Officer 550.0K 4.48M 242.0K 15.6K 5.29M 84.73%
24 2021 Bruce Goldsmith, Ph.D. Chief Executive Officer and President 550.0K 4.48M 242.0K 15.6K 5.29M 84.73%
25 2021 Jill Quigley Former Chief Operating Officer 453.4K 1.80M 204.0K 1.14M 3.59M 50.03%
26 2021 Simona King Chief Financial Officer 151.4K 3.23M 144.5K 2.1K 3.53M 91.57%
27 2021 Edgar B. (Chip) Cale General Counsel and Former Interim Chief Executive Officer 390.0K 2.92M 130.7K 18.5K 3.46M 84.44%
28 2021 Alex Fotopoulos Chief Technical Officer 413.8K 741.0K 1.80M 151.0K 18.7K 3.12M 81.31%
29 2021 Monika (Maria) Toernsen Former Chief Commercial Officer 192.1K 50.0K 260.8K 2.03M 144.5K 4.5K 2.68M 85.40%
30 2020 Bruce Goldsmith, Ph.D. Chief Executive Officer and President 450.0K 15.99M 258.8K 12.6K 16.71M 95.68%
31 2020 Jill Quigley Former Chief Operating Officer 431.8K 3.39M 203.0K 362.9K 4.39M 77.26%
32 2020 Jill Quigley Chief Operating Officer 431.8K 3.39M 203.0K 362.9K 4.39M 77.26%
33 2020 Stephen Squinto, Ph.D. Former Interim Chief Executive Officer and former Acting Head of Research and Development 246.0K 2.98M 541.0K 3.76M 79.10%
34 2020 Gary Romano, M.D., Ph.D. Chief Medical Officer 416.3K 107.4K 1.47M 191.5K 14.3K 2.20M 66.82%
35 2019 Stephen Squinto, Ph.D. Former Interim Chief Executive Officer and former Acting Head of Research and Development 225.0K 1.79M 127.4K 2.14M 83.54%
36 2019 Gary Romano, M.D., Ph.D. Chief Medical Officer 111.1K 1.86M 49.1K 2.3K 2.02M 91.97%
CEO compensation breakdown

Proxy statements

Proxy statements (DEF 14A)
Filing date Form type Filing
2026-04-07 DEFA14A
2026-04-07 DEF 14A
2025-04-16 DEFA14A
2025-04-16 DEF 14A
2025-04-04 PRE 14A

Recent SEC filings

Recent SEC filings
Filing date Form type Filing
2026-04-28 8-K
2026-04-20 8-K
2026-04-07 DEFA14A
2026-04-07 DEF 14A
2026-04-07 ARS
2026-03-18 4
2026-03-18 4
2026-03-10 8-K
2026-03-04 S-8
2026-03-03 8-K

Executive team

NameTitleCompensationGender
William Chou President, Chief Executive Officer & Director 1M
Kathleen Borthwick Senior Vice President, Chief Financial Officer, Principal Financial Officer & Principal Accounting Officer 649.4K female
Eden Fucci Senior Vice President of Technical Operations male
Karl Whitney Senior Vice President of Global Regulatory Affairs
Stuart Henderson Chief Business Officer male
Sue Browne Chief Scientific Officer
ESG Rating
B
BIOTECHNOLOGY
2025
E (Environmental)
56.1 / 56.3
Company / Sector avg.
S (Social)
66.2 / 62.4
Company / Sector avg.
G (Governance)
59.5 / 60.9
Company / Sector avg.
ESG Total
60.6 / 59.9
Company / Sector avg.
ESG Score History BIOTECHNOLOGY
Benchmark vs Sector
Senate Trading Activity

No Senate trading activity found for this company.

House Trading Activity

No House trading activity found for this company.

Market share among peers
Peer comparison — filtered group (TTM)
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Dividend history

Earnings history

Earnings reports

Stock splits