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Maze Therapeutics, Inc. (MAZE)

USD29.05 -0.83 (-2.79%)
US NASDAQ Healthcare Biotechnology
Address 171 Oyster Point Blvd 94080
South San Francisco, CA, US
CEO Jason Coloma
Website mazetx.com
IPO 2025-01-31
CIK 1842295 ISIN US5787841007

Explore sections of this company profile

Description

Maze Therapeutics, Inc., a clinical stage biopharmaceutical company, develops small molecule precision medicines for the treatment of kidney and metabolic diseases in the United States. Its lead programs include MZE829, an oral small molecule inhibitor of apolipoprotein L1, or APOL1, which is in phase II clinical trial for the treatment of patients with APOL1 kidney disease; and MZE782, an oral small molecule inhibitor that is in phase II ready clinical trial for the treatment of phenylketonuria and chronic kidney disease. The company also develops MZE001, an investigational oral small molecule inhibitor of muscle-specific glycogen synthase clinical program for the treatment of Pompe disease. It has a license agreement with Trace Neuroscience, Inc. to discovery research program targets UNC13A; the Shionogi & Co., Ltd to research, develop, manufacture, and commercialize MZE001; and Neurocrine Biosciences, Inc. to discover research program that targets ATXN2. The company was formerly known as Modulus Therapeutics, Inc. and changed its name to Maze Therapeutics, Inc. in September 2018. The company was incorporated in 2017 and is based in South San Francisco, California.

Market Cap & Enterprise Value
Merger & Acquisition History

No mergers or acquisitions recorded for this company.

Technical Outlook
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Signal Summary Loading…
Indicator 1D1W2W3W1M
Each column is computed on that timeframe's candles (1D = daily, 1W ≈ weekly, 1M ≈ monthly), not on the same last day. ▲ bullish · ▼ bearish · — neutral. The Net row counts signals per column; hover any cell (or the indicator name) to see the exact rule behind it.
Day Score & sub-scores
Statistical fingerprint & regime detail
Conditional historical analysis
Customize analysis (advanced)
Indicative levels generated algorithmically. Not financial advice.
Risk Profile
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Price Chart
Averages
Trend
Price
Levels
Draw
USD29.05 -0.83 (-2.79%)
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Volume Profile
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Liquidity & share structure
Average Volume
744.4K
Beta
2.26
Float Shares
15.95M
Free Float %
28.9%
Price Performance
1D5D1M3M6M YTD1Y3Y5Y10YMax
+1.02% +1.30% -5.98% -43.97% -19.03% -37.77% +161.46% +61.63% +61.63% +61.63% +61.63%
Rolling Volatility
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Drawdown
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Relative Strength
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Monthly Returns Heatmap
From To
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Annual Monthly Returns
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Daily Returns Distribution
vs.
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Revenue flow

Revenue by geography

Revenue by segment

From To

Revenue composition

From To

By product

By geography

Financial Statements

Income Statement

Balance Sheet

Cash Flow Statement

Key Metrics

Financial Ratios

Employees

Financial Growth (CAGR)

Market Data

Analyst Consensus (6 ratings, all time) Buy
Price Targets & DCF
Current price
29.05
Low 46.00 +58.4%
Consensus 59.43 +104.6%
Median 55.00 +89.4%
High 97.00 +234.0%
DCF (Unlevered) 3.86 -86.7%
DCF (Levered) 3.86 -86.7%

DCF figures are point estimates: small changes in growth or discount-rate assumptions move them materially. Read them as a reference, not a precise target.

Ratings Trend (MoM) 100% Bullish
Rating 2026-05 Change
Strong Buy 1 0
Buy 11 0
Hold 0 0
Sell 0 0
Strong Sell 0 0
Price Target Summary
Period # Analysts Avg Target
Last Month 1
64.00
+120.3%
Last Quarter 3
76.33
+162.8%
Last Year 11
51.36
+76.8%
All Time 11
51.36
+76.8%
Quality scores
Altman Z-Score
9.26
Safe zone
Piotroski F-Score
2 / 9
Weak
MOAT Score
0 / 10
No MOAT
Composite Rating
C
Overall Score
2 / 5
Medium
DCF Score
3 / 5
Medium
ROE Score
1 / 5
Low
ROA Score
1 / 5
Low
D/E Score
3 / 5
Medium
P/E Score
1 / 5
Low
P/Book Score
2 / 5
Medium
Operational MOAT
✗ Below peers
  • Revenue growth Biotechnology: +1.6%
    -100.0%
  • EPS growth Biotechnology: +29.7%
    -4,020.3% Q1'26: +39.9% (vs Q1'25)
  • FCF margin FCF growth · Biotechnology: +16.2%
  • EBIT margin Biotechnology: +0.0%
  • ROIC Biotechnology: -16.1%
    -393.1% Q1'26: +0.0% (vs Q1'25)
  • Share dilution Biotechnology: -3.4%
    -1.9% Q1'26: +23.1% (vs Q1'25)
  • Debt / EBITDA Net debt/EBITDA · Biotechnology: 0.16×
    -0.17× Q1'26: -0.21× (vs Q1'25)
Valuation Multiples From To
Price Forecast (3Y) From To
Model
Adjust
P/E
Theoretical Return — If Invested Today

* These projections are based on analyst consensus estimates and user-defined valuation multiples. This table is for informational purposes only and does not constitute a recommendation to buy or sell any security. Past performance is not indicative of future results.

DCF Interactive Model (UFCF)
Projection years:
Market assumptions
WACC components (optional)
Ke (Cost of Equity) = Rf + β (2.50) × ERP
WACC = 98% × Ke + 2% × Kd (4.1%) × (1−t)

Modifying these values recalculates WACC automatically.

Business assumptions
Intrinsic value (base): 3.86 Current price: 29.05
Enterprise Value: Equity Value: Terminal Value: TV as % of EV:

Base values reflect the latest available data for this company and market conditions.

Consensus Estimates
Metric Dec 2024
actual
Dec 2025
actual
Dec 2026
8 Rev. Ana.
7 EPS Ana.
Dec 2027
8 Rev. Ana.
7 EPS Ana.
Dec 2028
8 Rev. Ana.
6 EPS Ana.
Dec 2029
7 Rev. Ana.
4 EPS Ana.
Dec 2030
7 Rev. Ana.
2 EPS Ana.
Revenue
167.50M
est: 167.67M (-0.1%)
est: 3.13M (-100.0%)
12.50M
11.74M – 13.26M
+300.0% YoY
6.22M
5.43M – 7.00M
-50.3% YoY
4.12M
3.87M – 4.37M
-33.7% YoY
42.65M
40.05M – 45.24M
+935.0% YoY
208.30M
195.63M – 220.96M
+388.4% YoY
EBITDA
60.88M
est: 140.99M (-56.8%)
-140.50M
est: 2.63M (-5,446.7%)
10.51M
9.87M – 11.15M
+300.0% YoY
5.23M
4.57M – 5.89M
-50.3% YoY
3.46M
3.25M – 3.68M
-33.7% YoY
35.86M
33.68M – 38.04M
+935.0% YoY
175.15M
164.50M – 185.80M
+388.4% YoY
EBIT
57.59M
est: 140.16M (-58.9%)
-142.90M
est: 2.61M (-5,570.2%)
10.45M
9.81M – 11.08M
+300.0% YoY
5.20M
4.54M – 5.85M
-50.3% YoY
3.44M
3.23M – 3.65M
-33.7% YoY
35.65M
33.48M – 37.82M
+935.0% YoY
174.13M
163.54M – 184.71M
+388.4% YoY
Net Income
52.23M
est: -338.76M (+115.4%)
-131.12M
est: -131.12M (+0.0%)
-123.63M
-143.64M – -103.61M
+5.7% YoY
-187.82M
-203.56M – -107.21M
-51.9% YoY
-177.99M
-240.16M – -115.81M
+5.2% YoY
-163.47M
-176.39M – -150.55M
+8.2% YoY
-99.01M
-106.83M – -91.18M
+39.4% YoY
SGA
26.42M
est: 132.36M (-80.0%)
34.45M
est: 2.47M (+1,296.5%)
9.87M
9.27M – 10.47M
+300.0% YoY
4.91M
4.29M – 5.53M
-50.3% YoY
3.25M
3.05M – 3.45M
-33.7% YoY
33.67M
31.62M – 35.71M
+935.0% YoY
164.44M
154.44M – 174.44M
+388.4% YoY
EPS
0.08
est: -7.88 (+101.0%)
-3.05
est: -3.12 (+2.2%)
-2.84
-3.34 – -2.41
+9.0% YoY
-3.27
-4.74 – -2.49
-15.3% YoY
-3.68
-5.59 – -2.69
-12.4% YoY
-3.80
-4.10 – -3.50
-3.3% YoY
-2.30
-2.49 – -2.12
+39.4% YoY
Historical Ratings (3M)
Date Rating Overall DCF ROE ROA D/E P/E P/B
2026-05-12 C 2/5 3/5 1/5 1/5 3/5 1/5 2/5
2026-05-11 C 2/5 3/5 1/5 1/5 3/5 1/5 2/5
2026-05-08 C 2/5 3/5 1/5 1/5 3/5 1/5 2/5
2026-05-07 C 2/5 3/5 1/5 1/5 3/5 1/5 2/5
2026-05-06 C 2/5 3/5 1/5 1/5 3/5 1/5 2/5
2026-05-05 C 2/5 3/5 1/5 1/5 3/5 1/5 2/5
2026-05-04 C 2/5 3/5 1/5 1/5 3/5 1/5 2/5
2026-05-01 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5
2026-04-30 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5
2026-04-29 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5
2026-04-28 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5
2026-04-27 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5
2026-04-24 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5
2026-04-23 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5
2026-04-22 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5
2026-04-21 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5
2026-04-20 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5
2026-04-17 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5
2026-04-16 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5

Owner Earnings

Owner's Earnings (history) From To
Owner alignment
Owner's Earnings TTM
-253.29M
OE per share TTM
-5.59
Owner's Yield
-18.23%
Maintenance CapEx ratio
Maint CapEx / Avg PPE
78.4%

Ownership Overview

Ownership breakdown
At a glance
Institutional holders
57
Total invested
370.13M
Insider transactions (90d)
3
Beneficial owners (>5%)
0
Beneficial owners (>5%)

No beneficial ownership filings recorded.

Institutional Activity (13F)

Institutional ownership trend From To
13F snapshot — 2026 Q1
Investors holding
57
-87 vs prev Q
New positions
15
Closed positions
103
Increased
36
Reduced
9
Put/Call ratio
0.69
Calls held
19.5K
Puts held
13.4K
Top institutional holders
# Investor Shares / Δ Mkt value / Δ Own% / Δ Weight% / Δ Avg px / Perf. Hold / Status
1 MASS GENERAL BRIGHAM, INC 240.0K +240.0K (+100.0%) 9.94B +9.9B (+100.0%) 0.52% +0.524 pp 1.23% +1.228 pp USD41.43 +0.0% 1 qtrs NEW
2 FRAZIER LIFE SCIENCES MANAGEMENT, L.P. 4.57M +— (+0.0%) 189.22M +70.8M (+59.8%) 9.98% -0.439 pp 5.08% +1.534 pp USD11.13 +272.2% 4 qtrs
3 TRV GP IV, LLC 4.47M -1.6M (-26.3%) 185.36M +27.9M (+17.7%) 9.77% -4.079 pp 72.65% +15.163 pp USD11.01 +276.3% 4 qtrs
4 DEEP TRACK CAPITAL, LP 4.25M +297.5K (+7.5%) 175.93M +73.5M (+71.8%) 9.28% +0.271 pp 3.14% +0.279 pp USD13.34 +210.6% 4 qtrs
5 ARCH VENTURE MANAGEMENT, LLC 4.12M +— (+0.0%) 170.69M +63.9M (+59.8%) 9.00% -0.396 pp 26.19% +4.495 pp USD11.01 +276.3% 4 qtrs
6 JANUS HENDERSON GROUP PLC 3.14M +2.4M (+318.0%) 130.20M +110.7M (+568.1%) 6.86% +5.150 pp 0.06% +0.049 pp USD34.19 +21.2% 4 qtrs
7 BLACKROCK, INC. 2.29M +971.1K (+73.8%) 94.76M +60.6M (+177.7%) 5.00% +1.995 pp 0.00% +0.001 pp USD28.52 +45.3% 4 qtrs
8 AH CAPITAL MANAGEMENT, L.L.C. 1.70M +— (+0.0%) 70.52M +26.4M (+59.8%) 3.72% -0.164 pp 4.46% +1.300 pp USD11.01 +276.3% 4 qtrs
9 VANGUARD GROUP INC 1.70M +362.1K (+27.1%) 70.31M +35.7M (+103.1%) 3.71% +0.663 pp 0.00% +0.001 pp USD25.55 +62.2% 4 qtrs
10 VR ADVISER, LLC 1.55M +317.8K (+25.8%) 64.16M +32.2M (+101.0%) 3.38% +0.576 pp 3.17% +1.373 pp USD29.11 +42.3% 2 qtrs
11 ALPHABET INC. 1.39M -1.0M (-42.4%) 57.53M -5.0M (-8.0%) 3.03% -2.468 pp 2.23% -0.367 pp USD11.01 +276.3% 4 qtrs
12 GENERAL CATALYST GROUP MANAGEMENT, LLC 1.04M +— (+0.0%) 42.92M +16.1M (+59.8%) 2.26% -0.100 pp 19.35% +18.471 pp USD11.01 +276.3% 4 qtrs
13 WOODLINE PARTNERS LP 1.04M +— (+0.0%) 42.89M +16.0M (+59.8%) 2.26% -0.100 pp 0.17% +0.040 pp USD12.39 +234.4% 4 qtrs
14 TRV GP V, LLC 950.8K +— (+0.0%) 39.39M +14.7M (+59.8%) 2.08% -0.091 pp 9.18% +2.204 pp USD11.01 +276.3% 4 qtrs
15 LOGOS GLOBAL MANAGEMENT LP 950.0K -277.3K (-22.6%) 39.36M +7.5M (+23.7%) 2.08% -0.724 pp 2.38% -0.474 pp USD18.49 +124.1% 4 qtrs
16 BELLEVUE GROUP AG 887.7K +887.7K (+100.0%) 36.78M +36.8M (+100.0%) 1.94% +1.939 pp 0.70% +0.697 pp USD41.43 +0.0% 1 qtrs NEW
17 MARSHALL WACE, LLP 847.5K +69.8K (+9.0%) 35.11M +14.9M (+74.1%) 1.85% +0.078 pp 0.03% +0.012 pp USD26.86 +54.2% 4 qtrs
18 ARROWMARK COLORADO HOLDINGS LLC 767.4K +222.3K (+40.8%) 31.79M +17.7M (+124.9%) 1.68% +0.433 pp 0.70% +0.437 pp USD30.42 +36.2% 2 qtrs
19 CASDIN CAPITAL, LLC 758.9K +— (+0.0%) 31.44M +11.8M (+59.8%) 1.66% -0.073 pp 1.95% +0.312 pp USD11.01 +276.3% 4 qtrs
20 FMR LLC 728.6K +73.0K (+11.1%) 30.19M +13.2M (+77.6%) 1.59% +0.097 pp 0.00% +0.001 pp USD16.13 +156.9% 4 qtrs
21 IKARIAN CAPITAL, LLC 644.7K -96.1K (-13.0%) 26.71M +7.5M (+39.0%) 1.41% -0.281 pp 2.09% +0.146 pp USD20.64 +100.7% 4 qtrs
22 CALIGAN PARTNERS LP 550.2K +550.2K (+100.0%) 22.79M +22.8M (+100.0%) 1.20% +1.202 pp 1.88% +1.876 pp USD41.43 +0.0% 1 qtrs NEW
23 STATE STREET CORP 533.0K +148.3K (+38.6%) 22.08M +12.1M (+121.4%) 1.16% +0.287 pp 0.00% +0.000 pp USD26.38 +57.1% 4 qtrs
24 GEODE CAPITAL MANAGEMENT, LLC 527.3K +53.7K (+11.3%) 21.85M +9.6M (+77.9%) 1.15% +0.072 pp 0.00% +0.001 pp USD21.01 +97.2% 4 qtrs
25 FORESITE CAPITAL MANAGEMENT IV, LLC 522.7K +— (+0.0%) 21.65M +8.1M (+59.8%) 1.14% -0.050 pp 9.43% +2.005 pp USD11.01 +276.3% 4 qtrs
26 490.0K +490.0K (+100.0%) 20.30M +20.3M (+100.0%) 1.07% +1.070 pp 8.60% +8.603 pp USD41.43 +0.0% 1 qtrs NEW
27 BESSEMER GROUP INC 481.8K +— (+0.0%) 19.96M +7.5M (+59.8%) 1.05% -0.046 pp 0.03% +0.012 pp USD11.01 +276.3% 4 qtrs
28 MATRIX CAPITAL MANAGEMENT COMPANY, LP 480.0K -1.2M (-71.0%) 19.89M -23.0M (-53.6%) 1.05% -2.723 pp 34.52% -5.656 pp USD11.01 +276.3% 4 qtrs
29 HHLR ADVISORS, LTD. 457.5K +— (+0.0%) 18.96M +7.1M (+59.8%) 1.00% -0.044 pp 0.61% +0.321 pp USD11.01 +276.3% 4 qtrs
30 CITADEL ADVISORS LLC 448.2K +448.2K (+100.0%) 18.57M +18.6M (+100.0%) 0.98% +0.979 pp 0.00% +0.003 pp USD41.43 +0.0% 1 qtrs NEW
31 BOOTHBAY FUND MANAGEMENT, LLC 409.4K +57.5K (+16.3%) 16.96M +7.8M (+85.9%) 0.89% +0.092 pp 0.25% +0.120 pp USD25.35 +63.4% 4 qtrs
32 DRIEHAUS CAPITAL MANAGEMENT LLC 378.0K +— (+0.0%) 15.66M +5.9M (+59.8%) 0.83% -0.036 pp 0.11% +0.036 pp USD18.50 +123.9% 4 qtrs
33 EVENTIDE ASSET MANAGEMENT, LLC 324.0K +324.0K (+100.0%) 13.43M +13.4M (+100.0%) 0.71% +0.708 pp 0.21% +0.210 pp USD41.43 +0.0% 1 qtrs NEW
34 WASHINGTON UNIVERSITY 280.8K +70.1K (+33.3%) 11.63M +6.2M (+113.0%) 0.61% +0.133 pp 5.88% +2.821 pp USD29.80 +39.0% 2 qtrs
35 MORGAN STANLEY 258.1K +45.3K (+21.3%) 10.69M +5.2M (+93.8%) 0.56% +0.079 pp 0.00% +0.000 pp USD26.85 +54.3% 4 qtrs
36 PARKMAN HEALTHCARE PARTNERS LLC 209.3K +9.3K (+4.6%) 8.67M +3.5M (+67.2%) 0.46% +0.001 pp 0.83% +0.284 pp USD26.62 +55.6% 2 qtrs
37 BALYASNY ASSET MANAGEMENT L.P. 199.2K -234.5K (-54.1%) 8.25M -3.0M (-26.6%) 0.44% -0.554 pp 0.01% -0.004 pp USD25.93 +59.8% 2 qtrs
38 ALYESKA INVESTMENT GROUP, L.P. 196.1K +71.1K (+56.9%) 8.13M +4.9M (+150.7%) 0.43% +0.143 pp 0.02% +0.013 pp USD22.04 +88.0% 4 qtrs
39 ENSIGN PEAK ADVISORS, INC 185.8K +115.1K (+162.9%) 7.70M +5.9M (+320.1%) 0.41% +0.245 pp 0.01% +0.011 pp USD34.17 +21.2% 3 qtrs
40 ADAR1 CAPITAL MANAGEMENT, LLC 179.5K +153.5K (+589.3%) 7.44M +6.8M (+1,001.4%) 0.39% +0.333 pp 0.55% +0.483 pp USD39.18 +5.7% 2 qtrs
41 NORTHERN TRUST CORP 176.3K -631.0 (-0.4%) 7.30M +2.7M (+59.2%) 0.39% -0.018 pp 0.00% +0.000 pp USD18.82 +120.1% 4 qtrs
42 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 176.0K +8.0K (+4.8%) 7.29M +2.9M (+67.4%) 0.38% +0.001 pp 0.00% +0.000 pp USD20.29 +104.2% 4 qtrs
43 TCG CROSSOVER MANAGEMENT, LLC 173.8K +173.8K (+100.0%) 7.20M +7.2M (+100.0%) 0.38% +0.380 pp 0.24% +0.238 pp USD41.43 +0.0% 1 qtrs NEW
44 HIGHVISTA STRATEGIES LLC 170.4K +170.4K (+100.0%) 7.06M +7.1M (+100.0%) 0.37% +0.372 pp 1.82% +1.818 pp USD41.43 +0.0% 1 qtrs NEW
45 MILLENNIUM MANAGEMENT LLC 154.5K +154.5K (+100.0%) 6.40M +6.4M (+100.0%) 0.34% +0.337 pp 0.00% +0.003 pp USD41.43 +0.0% 1 qtrs NEW
46 INVESCO LTD. 134.0K +2.0K (+1.5%) 5.55M +2.1M (+62.2%) 0.29% -0.008 pp 0.00% +0.000 pp USD24.11 +71.8% 4 qtrs
47 STEMPOINT CAPITAL LP 125.9K +125.9K (+100.0%) 5.22M +5.2M (+100.0%) 0.28% +0.275 pp 0.89% +0.894 pp USD41.43 +0.0% 1 qtrs NEW
48 FREESTONE GROVE PARTNERS LP 118.9K +118.9K (+100.0%) 4.93M +4.9M (+100.0%) 0.26% +0.260 pp 0.04% +0.036 pp USD41.43 +0.0% 1 qtrs NEW
49 PRICE T ROWE ASSOCIATES INC /MD/ 115.7K +105.2K (+1,004.7%) 4.79M +4.5M (+1,662.5%) 0.25% +0.229 pp 0.00% +0.001 pp USD40.03 +3.5% 2 qtrs
50 GOLDMAN SACHS GROUP INC 114.5K +114.5K (+100.0%) 4.74M +4.7M (+100.0%) 0.25% +0.250 pp 0.00% +0.001 pp USD41.43 +0.0% 1 qtrs NEW
51 INTEGRAL HEALTH ASSET MANAGEMENT, LLC 100.0K +100.0K (+100.0%) 4.14M +4.1M (+100.0%) 0.22% +0.218 pp 0.21% +0.206 pp USD41.43 +0.0% 1 qtrs NEW
52 AMERIPRISE FINANCIAL INC 96.7K +96.7K (+100.0%) 4.01M +4.0M (+100.0%) 0.21% +0.211 pp 0.00% +0.001 pp USD41.43 +0.0% 1 qtrs NEW
53 FORESITE CAPITAL MANAGEMENT V, LLC 86.3K +— (+0.0%) 3.58M +1.3M (+59.8%) 0.19% -0.008 pp 2.17% +0.117 pp USD11.01 +276.3% 4 qtrs
54 BIOIMPACT CAPITAL LLC 81.1K +81.1K (+100.0%) 3.36M +3.4M (+100.0%) 0.18% +0.177 pp 0.38% +0.385 pp USD41.43 +0.0% 1 qtrs NEW
55 SPHERA FUNDS MANAGEMENT LTD. 71.8K -82.5K (-53.5%) 2.98M -1.0M (-25.6%) 0.16% -0.195 pp 0.58% -0.269 pp USD11.01 +276.3% 4 qtrs
56 SUMMITTX CAPITAL, L.P. 69.6K +69.6K (+100.0%) 2.88M +2.9M (+100.0%) 0.15% +0.152 pp 0.09% +0.087 pp USD41.43 +0.0% 1 qtrs NEW
57 RAYMOND JAMES FINANCIAL INC 67.7K +67.7K (+100.0%) 2.81M +2.8M (+100.0%) 0.15% +0.148 pp 0.00% +0.001 pp USD41.43 +0.0% 1 qtrs NEW
58 WELLINGTON MANAGEMENT GROUP LLP 61.2K +61.2K (+100.0%) 2.54M +2.5M (+100.0%) 0.13% +0.134 pp 0.00% +0.000 pp USD41.43 +0.0% 1 qtrs NEW
59 BANK OF NEW YORK MELLON CORP 60.4K +15.2K (+33.6%) 2.50M +1.3M (+113.4%) 0.13% +0.029 pp 0.00% +0.000 pp USD24.60 +68.4% 4 qtrs
60 ADVISOR GROUP HOLDINGS, INC. 59.8K +29.2K (+95.8%) 2.48M +1.7M (+212.8%) 0.13% +0.061 pp 0.00% +0.003 pp USD33.50 +23.7% 3 qtrs
61 NUVEEN, LLC 57.3K +27.0K (+88.9%) 2.37M +1.6M (+201.9%) 0.13% +0.056 pp 0.00% +0.000 pp USD30.26 +36.9% 4 qtrs
62 FRANKLIN RESOURCES INC 55.2K +37.0K (+203.5%) 2.29M +1.8M (+384.9%) 0.12% +0.079 pp 0.00% +0.000 pp USD36.32 +14.1% 2 qtrs
63 TREXQUANT INVESTMENT LP 52.5K +52.5K (+100.0%) 2.17M +2.2M (+100.0%) 0.11% +0.115 pp 0.02% +0.019 pp USD41.43 +0.0% 1 qtrs NEW
64 SEVEN GRAND MANAGERS, LLC 50.0K +50.0K (+100.0%) 2.07M +2.1M (+100.0%) 0.11% +0.109 pp 0.16% +0.158 pp USD41.43 +0.0% 1 qtrs NEW
65 SCHONFELD STRATEGIC ADVISORS LLC 48.2K -65.8K (-57.7%) 2.00M -960.4K (-32.5%) 0.11% -0.155 pp 0.01% -0.008 pp USD25.93 +59.8% 2 qtrs
66 BARCLAYS PLC 39.5K +12.0K (+43.6%) 1.64M +923.3K (+129.4%) 0.09% +0.024 pp 0.00% +0.000 pp USD25.11 +65.0% 4 qtrs
67 D. E. SHAW & CO., INC. 33.7K +33.7K (+100.0%) 1.40M +1.4M (+100.0%) 0.07% +0.074 pp 0.00% +0.001 pp USD41.43 +0.0% 1 qtrs NEW
68 ALLIANCEBERNSTEIN L.P. 33.2K -26.9K (-44.7%) 1.38M -182.1K (-11.7%) 0.07% -0.065 pp 0.00% 0.000 pp USD18.04 +129.7% 4 qtrs
69 XTX TOPCO LTD 33.0K +6.2K (+22.9%) 1.37M +671.4K (+96.4%) 0.07% +0.011 pp 0.04% 0.000 pp USD28.82 +43.8% 2 qtrs
70 MIRAE ASSET GLOBAL ETFS HOLDINGS LTD. 31.3K +22.2K (+244.7%) 1.30M +1.1M (+450.8%) 0.07% +0.048 pp 0.00% +0.002 pp USD34.60 +19.7% 4 qtrs
71 CINCTIVE CAPITAL MANAGEMENT LP 29.1K +29.1K (+100.0%) 1.21M +1.2M (+100.0%) 0.06% +0.064 pp 0.07% +0.065 pp USD41.43 +0.0% 1 qtrs NEW
72 UBS GROUP AG 28.7K +905.0 (+3.3%) 1.19M +468.3K (+65.0%) 0.06% -0.001 pp 0.00% +0.000 pp USD11.97 +246.1% 4 qtrs
73 AQR CAPITAL MANAGEMENT LLC 27.4K -176.0 (-0.6%) 1.14M +420.7K (+58.8%) 0.06% -0.003 pp 0.00% +0.000 pp USD12.34 +235.7% 3 qtrs
74 RENAISSANCE TECHNOLOGIES LLC 27.1K -59.0K (-68.5%) 1.12M -1.1M (-49.7%) 0.06% -0.137 pp 0.00% -0.001 pp USD25.93 +59.8% 2 qtrs
75 TUDOR INVESTMENT CORP ET AL 24.1K +24.1K (+100.0%) 996.8K +996.8K (+100.0%) 0.05% +0.053 pp 0.00% +0.002 pp USD41.43 +0.0% 1 qtrs NEW
76 WELLS FARGO & COMPANY/MN 24.0K +9.2K (+62.4%) 994.7K +611.4K (+159.6%) 0.05% +0.019 pp 0.00% +0.000 pp USD28.45 +45.6% 4 qtrs
77 RHUMBLINE ADVISERS 23.7K +2.8K (+13.2%) 983.2K +439.4K (+80.8%) 0.05% +0.004 pp 0.00% +0.000 pp USD22.91 +80.8% 4 qtrs
78 GILDER GAGNON HOWE & CO LLC 23.3K +23.3K (+100.0%) 964.6K +964.6K (+100.0%) 0.05% +0.051 pp 0.01% +0.010 pp USD41.43 +0.0% 1 qtrs NEW
79 RUSSELL INVESTMENTS GROUP, LTD. 22.5K +20.6K (+1,082.2%) 934.0K +884.6K (+1,788.9%) 0.05% +0.045 pp 0.00% +0.001 pp USD40.01 +3.5% 3 qtrs
80 VERITION FUND MANAGEMENT LLC 22.5K +22.5K (+100.0%) 932.7K +932.7K (+100.0%) 0.05% +0.049 pp 0.00% +0.004 pp USD41.43 +0.0% 1 qtrs NEW
81 AMERICAN CENTURY COMPANIES INC 21.5K +21.5K (+100.0%) 891.1K +891.1K (+100.0%) 0.05% +0.047 pp 0.00% +0.000 pp USD41.43 +0.0% 1 qtrs NEW
82 JPMORGAN CHASE & CO 20.0K +12.1K (+153.6%) 828.9K +624.3K (+305.2%) 0.04% +0.026 pp 0.00% +0.000 pp USD32.06 +29.2% 4 qtrs
83 ACUTA CAPITAL PARTNERS, LLC 20.0K +20.0K (+100.0%) 828.6K +828.6K (+100.0%) 0.04% +0.044 pp 0.56% +0.563 pp USD41.43 +0.0% 1 qtrs NEW
84 SUSQUEHANNA INTERNATIONAL GROUP, LLP 19.4K +19.4K (+100.0%) 803.7K +803.7K (+100.0%) 0.04% +0.042 pp 0.00% +0.000 pp USD41.43 +0.0% 1 qtrs NEW
85 BANK OF AMERICA CORP /DE/ 18.4K +8.8K (+92.0%) 761.5K +513.3K (+206.8%) 0.04% +0.018 pp 0.00% +0.000 pp USD28.76 +44.1% 4 qtrs
86 DEUTSCHE BANK AG\ 15.5K +6.6K (+74.7%) 643.1K +412.7K (+179.1%) 0.03% +0.014 pp 0.00% +0.000 pp USD24.02 +72.5% 4 qtrs
87 LOS ANGELES CAPITAL MANAGEMENT LLC 19.1K +19.1K (+100.0%) 634.5K +634.5K (+100.0%) 0.04% +0.042 pp 0.00% +0.002 pp USD41.43 +0.0% 1 qtrs NEW
88 TWO SIGMA ADVISERS, LP 14.8K +14.8K (+100.0%) 613.2K +613.2K (+100.0%) 0.03% +0.032 pp 0.00% +0.001 pp USD41.43 +0.0% 1 qtrs NEW
89 METLIFE INVESTMENT MANAGEMENT, LLC 11.8K +— (+0.0%) 488.9K +182.9K (+59.8%) 0.03% -0.001 pp 0.00% +0.001 pp USD25.93 +59.8% 2 qtrs
90 CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD. 11.4K +9.4K (+472.1%) 474.0K +422.1K (+814.0%) 0.03% +0.020 pp 0.04% +0.032 pp USD38.72 +7.0% 2 qtrs
91 CITIGROUP INC 11.3K +11.0K (+4,082.9%) 466.2K +459.2K (+6,582.5%) 0.02% +0.024 pp 0.00% +0.000 pp USD40.72 +1.7% 4 qtrs
92 STRS OHIO 11.2K -6.7K (-37.4%) 464.0K -131.0 (0.0%) 0.02% -0.016 pp 0.00% +0.000 pp USD12.23 +238.8% 4 qtrs
93 FALCON WEALTH PLANNING 10.0K +10.0K (+100.0%) 415.5K +415.5K (+100.0%) 0.02% +0.022 pp 0.04% +0.035 pp USD41.43 +0.0% 1 qtrs NEW
94 PEAK6 LLC 9.2K +9.2K (+100.0%) 381.2K +381.2K (+100.0%) 0.02% +0.020 pp 0.00% +0.001 pp USD41.43 +0.0% 1 qtrs NEW
95 SG AMERICAS SECURITIES, LLC 8.5K +3.5K (+69.4%) 352.0K +222.0K (+170.8%) 0.02% +0.007 pp 0.00% +0.000 pp USD32.28 +28.3% 2 qtrs
96 TWO SIGMA INVESTMENTS, LP 7.2K -3.9K (-35.0%) 300.2K +11.0K (+3.8%) 0.02% -0.010 pp 0.00% +0.000 pp USD25.93 +59.8% 2 qtrs
97 MANUFACTURERS LIFE INSURANCE COMPANY, THE 6.9K +6.9K (+100.0%) 285.7K +285.7K (+100.0%) 0.02% +0.015 pp 0.00% +0.000 pp USD41.43 +0.0% 1 qtrs NEW
98 VIRTUS INVESTMENT ADVISERS, INC. 6.8K -1.6K (-18.5%) 283.6K +65.9K (+30.3%) 0.02% -0.004 pp 0.08% +0.015 pp USD14.64 +183.0% 3 qtrs
99 NEW YORK STATE COMMON RETIREMENT FUND 6.7K +— (+0.0%) 277.6K +103.9K (+59.8%) 0.01% -0.001 pp 0.00% +0.000 pp USD20.81 +99.1% 4 qtrs
Ownership breakdown by holder

ETF Ownership

Top ETFs holding this stock Held by 84 ETFs in our universe
# ETF Weight Est. AUM exposure TER
1 State Street SPDR S&P Pharmaceuticals ETF XPH 1.91% 9.00M 0.35%
2 ALPS Medical Breakthroughs ETF SBIO 0.86% 1.84M 0.50%
3 Virtus Biotech Clinical Trials ETF BBC 0.78% 450.3K 0.65%
4 Direxion Daily Pharmaceutical & Medical Bull 3X ETF PILL 0.40% 92.5K 1.22%
5 iShares Micro-Cap ETF IWC 0.24% 3.63M 0.60%
6 iShares U.S. Pharmaceuticals ETF IHE 0.19% 2.59M 0.38%
7 Invesco NASDAQ Biotech UCITS ETF SBIO.L 0.12% 538.7K 0.40%
8 Invesco Nasdaq Biotechnology ETF IBBQ 0.12% 86.9K 0.19%
9 iShares Nasdaq US Biotechnology UCITS ETF BTEE.L 0.12% 85.2K 0.35%
10 iShares Nasdaq US Biotechnology UCITS ETF BTEC.L 0.12% 1.27M 0.35%

Insider Activity

Insider Activity — Latest Quarter
Ratio by transactions
0.42
Bearish
Ratio by volume
0.55
Neutral
Buys
5
Sells
12
Shares acquired
39.3K
Shares disposed
71.7K
Cash buys
Cash sales
6.00
Net activity
-32,422
Insider buys vs sells (history) From To
Recent insider transactions From To
Date Person Role Transaction A/D Security Shares Price Value Owned after D/I Filing
2026-05-04 HOMCY CHARLES J Director G-Gift D Common Stock 7,422 0.00 31,113 D
2026-05-04 Dandekar Atul Officer M-Exempt D Stock Option (Right to Buy) 5,985 10.42 62.4K 27,725 D
2026-04-29 Dandekar Atul Officer M-Exempt D Stock Option (Right to Buy) 7,500 10.42 78.2K 44,143 D
2026-04-01 Bernstein Harold Officer S-Sale D Common Stock 300 31.07 9.3K 0 D
2026-04-01 Bachrodt Amy Officer S-Sale D Common Stock 300 30.34 9.1K 12,965 D
2026-03-30 Dandekar Atul Officer M-Exempt A Common Stock 7,500 10.42 78.2K 18,003 D
2026-03-27 Kumar Neil Director A-Award A Stock Option (Right to Buy) 33,417 30.38 1.02M 33,417 D
2026-03-20 Bernstein Harold Officer M-Exempt D Stock Option (Right to Buy) 15,000 10.42 156.3K 252,407 D
2026-03-10 Bernstein Harold Officer M-Exempt A Common Stock 30,000 10.42 312.6K 30,000 D
2026-03-02 Courtney Phillips Officer A-Award A Stock Option (Right to Buy) 32,000 45.61 1.46M 32,000 D
2026-03-02 Coloma Jason V Director / Officer A-Award A Stock Option (Right to Buy) 150,000 45.61 6.84M 150,000 D
2026-02-02 Bernstein Harold Officer S-Sale D Common Stock 100 47.23 4.7K 0 D
2026-02-02 Bachrodt Amy Officer S-Sale D Common Stock 4,064 46.03 187.1K 13,701 D
2026-01-29 Dandekar Atul Officer S-Sale D Common Stock 1,200 43.18 51.8K 16,803 D
2026-01-22 Bachrodt Amy Officer M-Exempt A Common Stock 2,503 10.42 26.1K 17,965 D
2026-01-07 Sohn Catherine A. Director M-Exempt A Common Stock 3,281 10.42 34.2K 26,920 D
2026-01-07 Bernstein Harold Officer M-Exempt A Common Stock 25,156 10.42 262.1K 25,156 D
2026-01-06 Sohn Catherine A. Director M-Exempt D Stock Option (Right to Buy) 2,493 10.42 26.0K 3,211 D
2026-01-05 Bernstein Harold Officer M-Exempt D Stock Option (Right to Buy) 412 10.42 4.3K 337,563 D
2026-01-02 Bernstein Harold Officer S-Sale D Common Stock 4,432 40.43 179.2K 0 D
2026-01-02 Bachrodt Amy Officer M-Exempt A Common Stock 204 10.42 2.1K 13,169 D
2025-12-30 Dandekar Atul Officer M-Exempt A Common Stock 100 10.42 1.0K 10,603 D
2025-12-30 Bachrodt Amy Officer M-Exempt A Common Stock 2,605 10.42 27.1K 17,965 D
2025-12-29 Dandekar Atul Officer S-Sale D Common Stock 6,035 41.13 248.2K 10,503 D
2025-12-29 Bernstein Harold Officer S-Sale D Common Stock 17,200 40.93 703.9K 0 D
2025-12-29 Bachrodt Amy Officer M-Exempt D Stock Option (Right to Buy) 124 10.42 1.3K 2,396 D
2025-11-19 HOMCY CHARLES J Director J-Other A Common Stock 1,489 0.00 31,113 D
2025-11-04 Third Rock Ventures IV, L.P. 10% Owner J-Other D Common Stock 1,600,000 0.00 4,473,958 D
2025-10-23 HOMCY CHARLES J Director G-Gift D Common Stock 28,423 0.00 29,624 D
2025-10-06 Hoppenot Herve Director A-Award A Stock Option (Right to Buy) 36,000 27.52 990.7K 36,000 D
2025-09-22 Sohn Catherine A. Director A-Award A Stock Option (Right to Buy) 18,000 23.67 426.1K 18,000 D
2025-09-22 SPIEGELMAN DANIEL K Director A-Award A Stock Option (Right to Buy) 18,000 23.67 426.1K 18,000 D
2025-09-22 SCHELLER RICHARD H Director A-Award A Stock Option (Right to Buy) 18,000 23.67 426.1K 18,000 D
2025-09-22 Lim Jonathan E Director A-Award A Stock Option (Right to Buy) 18,000 23.67 426.1K 18,000 D
2025-09-22 Kathiresan Sekar Director A-Award A Stock Option (Right to Buy) 18,000 23.67 426.1K 18,000 D
2025-09-22 HOMCY CHARLES J Director A-Award A Stock Option (Right to Buy) 18,000 23.67 426.1K 18,000 D
2025-09-22 Exter Neil Director A-Award A Stock Option (Right to Buy) 18,000 23.67 426.1K 18,000 D
2025-09-22 Dandekar Atul Officer A-Award A Restricted Stock Units 25,000 0.00 25,000 D
2025-09-22 Courtney Phillips Officer A-Award A Restricted Stock Units 22,000 0.00 22,000 D
2025-09-22 Coloma Jason V Director / Officer A-Award A Restricted Stock Units 100,000 0.00 100,000 D
2025-09-22 Bernstein Harold Officer A-Award A Restricted Stock Units 40,000 0.00 40,000 D
2025-09-22 Bachrodt Amy Officer A-Award A Restricted Stock Units 22,000 0.00 22,000 D
2025-09-22 Andrews Nancy C Director A-Award A Stock Option (Right to Buy) 18,000 23.67 426.1K 18,000 D
2025-09-15 SCHELLER RICHARD H Director S-Sale D Common Stock 20,744 22.37 464.0K 0 D
2025-09-02 Tahir Misbah Officer A-Award A Stock Option (Right to Buy) 325,000 15.32 4.98M 325,000 D
2025-08-17 Exter Neil Director A-Award A Stock Option (Right to Buy) 16,000 13.35 213.6K 16,000 D

Executive team

Top executives
Shares Outstanding
55.25M

Executive compensation

Executive compensation (annual)
# Year Executive Salary Bonus Stock award Option award Incentive Other Total % Stock-
based
Filing
1 2025 Misbah Tahir Chief Financial Officer 164.8K 50.0K 3.66M 86.7K 3.5K 3.96M 92.31%
2 2025 Jason Coloma, Ph.D. Chief Executive Officer 629.2K 2.37M 457.6K 4.5K 3.46M 68.44%
3 2025 Harold Bernstein, M.D., Ph.D. President, Research and Development and Chief Medical Officer 548.3K 946.8K 321.8K 4.5K 1.82M 51.98%
4 2024 Jason Coloma, Ph.D. Chief Executive Officer 527.3K 5.02M 280.5K 4.5K 5.84M 86.08%
5 2024 Harold Bernstein, M.D., Ph.D. President, Research and Development and Chief Medical Officer 526.7K 1.63M 233.0K 4.5K 2.40M 68.14%
CEO compensation breakdown

Proxy statements

Proxy statements (DEF 14A)
Filing date Form type Filing
2026-04-28 DEFA14A
2026-04-28 DEF 14A

Recent SEC filings

Recent SEC filings
Filing date Form type Filing
2026-05-12 POS AM
2026-05-12 8-K
2026-05-12 10-Q
2026-05-06 4
2026-05-06 4
2026-05-01 4
2026-04-28 DEFA14A
2026-04-28 DEF 14A
2026-04-28 ARS
2026-04-22 8-K

Executive team

NameTitleCompensationGender
Jason V. Coloma Chief Executive Officer & Director 1M
Harold S. Bernstein President of Research & Development and Chief Medical Officer 874.6K
Courtney J. Phillips General Counsel & Corporate Secretary 354.8K female
Misbah Tahir Chief Financial Officer 304.9K male
Matt Krause Senior Vice President of Human Resources male
Nazila Habibizad Senior Vice President of Technical Operations & Supply Chain female
Susan Limb Senior Vice President of Clinical Development female
Vipin Vijayakumar Vice President of R&D Infrastructure and Operations male
Amy Bachrodt Senior Vice President of Finance female
Winston Tse Senior Vice President of Drug Discovery male
Andrew Good VP & Corporate Controller male
Atul Dandekar Chief Strategy & Business Officer male
ESG Rating
B
BIOTECHNOLOGY
Rank: 379 out of 710
2026
E (Environmental)
56.6 / 56.3
Company / Sector avg.
S (Social)
63.5 / 62.4
Company / Sector avg.
G (Governance)
59.7 / 60.9
Company / Sector avg.
ESG Total
59.9 / 59.9
Company / Sector avg.
ESG Score History BIOTECHNOLOGY
Benchmark vs Sector
Senate Trading Activity

No Senate trading activity found for this company.

House Trading Activity

No House trading activity found for this company.

Market share among peers
Peer comparison — filtered group (TTM)
Your opinion

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Dividend history

Earnings history

Earnings reports

Stock splits