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Structure Therapeutics Inc. (GPCR)

USD53.45 +1.33 (+2.55%)
US NASDAQ Healthcare Biotechnology
Address 611 Gateway Boulevard 94080
South San Francisco, CA, US
CEO Raymond C. Stevens
IPO 2023-02-03
CIK 1888886 ISIN US86366E1064

Explore sections of this company profile

Description

Structure Therapeutics Inc., an international biopharmaceutical company currently in its clinical development phase, is committed to creating and providing groundbreaking oral therapies for various chronic diseases that lack adequate treatment options. The company's primary investigational drug, GSBR-1290, is an orally administered, biased small molecule agonist designed to target the glucagon-like-peptide-1 receptor (GLP-1R). This G-protein-coupled receptor (GPCR) is a recognized and validated therapeutic target for managing both type-2 diabetes mellitus and obesity. Furthermore, Structure Therapeutics is developing other oral small molecule treatments that act on different GPCRs, addressing pulmonary and cardiovascular conditions. For example, ANPA-0073 is a biased agonist aimed at the apelin receptor, a GPCR linked to diseases like idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension. Another compound in their pipeline is LTSE-2578, an oral small molecule that acts as a lysophosphatidic acid 1 receptor antagonist, also being explored for the treatment of IPF. Established in 2016, the company was formerly known as ShouTi Inc. and is headquartered in South San Francisco, California.

Market Cap & Enterprise Value
Merger & Acquisition History

No mergers or acquisitions recorded for this company.

Technical Outlook
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Signal Summary Loading…
Indicator 1D1W2W3W1M
Each column is computed on that timeframe's candles (1D = daily, 1W ≈ weekly, 1M ≈ monthly), not on the same last day. ▲ bullish · ▼ bearish · — neutral. The Net row counts signals per column; hover any cell (or the indicator name) to see the exact rule behind it.
Day Score & sub-scores
Statistical fingerprint & regime detail
Conditional historical analysis
Customize analysis (advanced)
Indicative levels generated algorithmically. Not financial advice.
Risk Profile
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Price Chart
Averages
Trend
Price
Levels
Draw
USD53.45 +1.33 (+2.55%)
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Volume Profile
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Liquidity & share structure
Average Volume
856.2K
Beta
-1.42
Float Shares
54.72M
Free Float %
95.1%
Price Performance
1D5D1M3M6M YTD1Y3Y5Y10YMax
-1.25% -6.84% -30.58% -47.47% +5.35% -45.59% +53.70% +43.33% +45.54% +45.54% +45.54%
Rolling Volatility
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Drawdown
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Relative Strength
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Monthly Returns Heatmap
From To
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Annual Monthly Returns
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Daily Returns Distribution
vs.
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Revenue flow

Revenue by geography

Revenue by segment

From To

Revenue composition

From To

By product

By geography

Financial Statements

Income Statement

Balance Sheet

Cash Flow Statement

Key Metrics

Financial Ratios

Employees

Financial Growth (CAGR)

Market Data

Analyst Consensus (14 ratings, all time) Buy
Price Targets & DCF
Current price
53.45
Low 90.00 +68.4%
Consensus 114.75 +114.7%
Median 113.50 +112.3%
High 145.00 +171.3%
DCF (Unlevered) 13.17 -75.4%
DCF (Levered) 13.40 -74.9%

DCF figures are point estimates: small changes in growth or discount-rate assumptions move them materially. Read them as a reference, not a precise target.

Ratings Trend (MoM) 94% Bullish
Rating 2026-05 Change
Strong Buy 4 0
Buy 12 0
Hold 1 0
Sell 0 0
Strong Sell 0 0
Price Target Summary
Period # Analysts Avg Target
Last Month 1
101.00
+89.0%
Last Quarter 2
123.00
+130.1%
Last Year 10
102.80
+92.3%
All Time 15
99.33
+85.8%
Quality scores
Altman Z-Score
21.90
Safe zone
Piotroski F-Score
2 / 9
Weak
MOAT Score
3 / 10
No MOAT
Composite Rating
C+
Overall Score
2 / 5
Medium
DCF Score
3 / 5
Medium
ROE Score
1 / 5
Low
ROA Score
1 / 5
Low
D/E Score
4 / 5
High
P/E Score
1 / 5
Low
P/Book Score
3 / 5
Medium
Operational MOAT
✗ Below peers
  • Revenue growth Biotechnology: +1.6%
  • EPS growth Biotechnology: +29.7%
    -2.6% Q1'26: -29.6% (vs Q1'25)
  • FCF margin FCF growth · Biotechnology: +16.2%
  • EBIT margin Biotechnology: +0.0%
  • ROIC Biotechnology: -16.1%
    -183.5% Q1'26: +0.0% (vs Q1'25)
  • Share dilution Biotechnology: -3.4%
    +12.5% Q1'26: +26.3% (vs Q1'25)
  • Debt / EBITDA Net debt/EBITDA · Biotechnology: 0.16×
    -0.05× Q1'26: -0.02× (vs Q1'25)
Valuation Multiples From To
DCF Interactive Model (UFCF)
Projection years:
Market assumptions
WACC components (optional)
Ke (Cost of Equity) = Rf + β (-1.39) × ERP
WACC = 100% × Ke + 0% × Kd (4.0%) × (1−t)

Modifying these values recalculates WACC automatically.

Business assumptions
Intrinsic value (base): 13.17 Current price: 53.45
Enterprise Value: Equity Value: Terminal Value: TV as % of EV:

Base values reflect the latest available data for this company and market conditions.

Consensus Estimates
Metric Dec 2024
actual
Dec 2025
actual
Dec 2026
8 Rev. Ana.
10 EPS Ana.
Dec 2027
11 Rev. Ana.
9 EPS Ana.
Dec 2028
8 Rev. Ana.
7 EPS Ana.
Dec 2029
7 Rev. Ana.
2 EPS Ana.
Dec 2030
7 Rev. Ana.
5 EPS Ana.
Revenue
est: 21.35M (-100.0%)
31.25M
31.25M – 31.25M
+46.4% YoY
38.5K
38.5K – 38.5K
-99.9% YoY
186.40M
186.40M – 186.40M
+484,542.5% YoY
539.38M
539.38M – 539.38M
+189.4% YoY
831.55M
831.55M – 831.55M
+54.2% YoY
EBITDA
-157.24M
-136.79M
— – —
— – —
— – —
— – —
— – —
EBIT
-158.23M
-140.69M
— – —
— – —
— – —
— – —
— – —
Net Income
-122.53M
est: -46.08M (-165.9%)
-141.20M
est: -63.26M (-123.2%)
-28.14M
-125.54M – 69.26M
+55.5% YoY
-111.00M
-147.78M – -74.22M
-294.5% YoY
-87.13M
-111.43M – -62.82M
+21.5% YoY
-21.21M
-21.21M – -21.21M
+75.7% YoY
60.03M
60.03M – 60.03M
+383.0% YoY
SGA
49.41M
61.55M
— – —
— – —
— – —
— – —
— – —
EPS
-2.34
est: -0.81 (-188.5%)
-2.40
est: -1.06 (-126.3%)
-1.42
-2.12 – 1.17
-34.0% YoY
-1.98
-2.50 – -1.25
-39.3% YoY
-1.59
-1.88 – -1.06
+19.5% YoY
-0.36
-0.36 – -0.36
+77.5% YoY
1.01
1.01 – 1.01
+383.0% YoY
Historical Ratings (3M)
Date Rating Overall DCF ROE ROA D/E P/E P/B
2026-05-07 C+ 2/5 3/5 1/5 1/5 4/5 1/5 3/5
2026-05-06 C+ 2/5 3/5 1/5 1/5 4/5 1/5 3/5
2026-05-05 C+ 2/5 3/5 1/5 1/5 3/5 1/5 3/5
2026-05-04 C+ 2/5 3/5 1/5 1/5 3/5 1/5 3/5
2026-05-01 C+ 2/5 3/5 1/5 1/5 3/5 1/5 3/5
2026-04-30 C+ 2/5 3/5 1/5 1/5 3/5 1/5 3/5
2026-04-29 C+ 2/5 3/5 1/5 1/5 3/5 1/5 3/5
2026-04-28 C+ 2/5 3/5 1/5 1/5 3/5 1/5 3/5
2026-04-27 C+ 2/5 3/5 1/5 1/5 3/5 1/5 3/5
2026-04-24 C+ 2/5 3/5 1/5 1/5 3/5 1/5 3/5
2026-04-23 C 2/5 3/5 1/5 1/5 2/5 1/5 3/5
2026-04-22 C 2/5 3/5 1/5 1/5 2/5 1/5 3/5
2026-04-21 C 2/5 3/5 1/5 1/5 2/5 1/5 3/5
2026-04-20 C 2/5 3/5 1/5 1/5 2/5 1/5 3/5
2026-04-17 C 2/5 3/5 1/5 1/5 2/5 1/5 3/5
2026-04-16 C 2/5 3/5 1/5 1/5 2/5 1/5 3/5
2026-04-15 C 2/5 3/5 1/5 1/5 2/5 1/5 3/5

Owner Earnings

Owner's Earnings (history)

Owner's Earnings history not available.

Owner alignment
Owner's Earnings TTM
OE per share TTM
Owner's Yield
Maintenance CapEx ratio
Maint CapEx / Avg PPE

Ownership Overview

Ownership breakdown
At a glance
Institutional holders
38
Total invested
163.15M
Insider transactions (90d)
0
Beneficial owners (>5%)
12
Beneficial owners (>5%)
# Reporting person Amount owned % of class Sole voting Shared voting Sole dispositive Shared dispositive Type Citizenship Filing date SEC filing
1 Wellington Group Holdings LLP 13.12M 9.43% 12.27M HC Delaware 2024-02-08
2 Wellington Investment Advisors Holdings LLP 13.12M 9.43% 12.27M HC Delaware 2024-02-08
3 Wellington Management Group LLP 13.12M 9.43% 12.27M HC Massachusetts 2024-02-08
4 Wellington Management Company LLP 12.87M 9.25% 12.21M IA Delaware 2024-02-08
5 David Kroin 7.94M 7.61% 7.94M HC, IN United States 2023-02-03
6 Deep Track Biotechnology Master Fund, Ltd. 7.94M 7.61% 7.94M CO Cayman Islands 2023-02-03
7 Deep Track Capital, LP 7.94M 7.61% 7.94M IA, OO Delaware 2023-02-03
8 s 7.23M 5.20% 7.23M HC, IN Delaware 2024-05-30
9 Avoro Capital Advisors LLC 7.00M 5.00% 7.00M 7.00M IA, OO Delaware 2024-02-14
10 Behzad Aghazadeh 7.00M 5.00% 7.00M 7.00M IN United States 2024-02-14
11 EIN #00-0000000 3.96M 6.90% 3.96M 3.96M IA, HC Jersey, Channel Islands 2024-11-14
12 95-1411037 13.00 6.20% 10.59M 10.59M IA Delaware 2024-11-12

Institutional Activity (13F)

Institutional ownership trend From To
13F snapshot — 2026 Q1
Investors holding
38
-172 vs prev Q
New positions
8
Closed positions
169
Increased
23
Reduced
7
Put/Call ratio
0.00
Calls held
Puts held
Top institutional holders
# Investor Shares / Δ Mkt value / Δ Own% / Δ Weight% / Δ Avg px / Perf. Hold / Status
1 MACQUARIE MANAGEMENT HOLDINGS, INC. 82.6K +82.6K (+100.0%) 5.75B +5.7B (+100.0%) 0.14% +0.141 pp 0.01% +0.009 pp USD69.55 +0.0% 1 qtrs NEW
2 50.0K +50.0K (+100.0%) 3.48B +3.5B (+100.0%) 0.09% +0.086 pp 1.93% +1.928 pp USD69.55 +0.0% 1 qtrs NEW
3 FMR LLC 8.71M +3.5M (+65.9%) 605.94M +458.9M (+312.2%) 14.90% +5.919 pp 0.03% +0.023 pp USD50.44 +37.9% 12 qtrs
4 WELLINGTON MANAGEMENT GROUP LLP 7.12M +1.4M (+25.2%) 495.33M +336.0M (+210.9%) 12.18% +2.450 pp 0.09% +0.059 pp USD46.96 +48.1% 12 qtrs
5 AVORO CAPITAL ADVISORS LLC 6.56M +1.4M (+27.2%) 455.94M +311.6M (+215.8%) 11.21% +2.394 pp 4.48% +2.615 pp USD36.87 +88.6% 2 qtrs
6 JANUS HENDERSON GROUP PLC 5.09M +641.3K (+14.4%) 354.01M +229.4M (+184.1%) 8.70% +1.097 pp 0.16% +0.102 pp USD44.90 +54.9% 12 qtrs
7 DEEP TRACK CAPITAL, LP 4.11M -104.0K (-2.5%) 285.97M +167.9M (+142.3%) 7.03% -0.178 pp 5.10% +1.805 pp USD26.49 +162.6% 12 qtrs
8 BVF INC/IL 3.48M +275.1K (+8.6%) 241.97M +152.3M (+169.7%) 5.95% +0.470 pp 8.15% +4.509 pp USD34.70 +100.4% 12 qtrs
9 MORGAN STANLEY 2.09M +1.5M (+261.4%) 145.21M +129.0M (+797.6%) 3.57% +2.582 pp 0.01% +0.008 pp USD57.20 +21.6% 12 qtrs
10 PRICE T ROWE ASSOCIATES INC /MD/ 1.67M +1.4M (+477.5%) 116.23M +108.1M (+1,334.2%) 2.86% +2.362 pp 0.01% +0.012 pp USD64.27 +8.2% 12 qtrs
11 DRIEHAUS CAPITAL MANAGEMENT LLC 1.64M +768.9K (+88.0%) 114.23M +89.8M (+367.1%) 2.81% +1.315 pp 0.78% +0.601 pp USD52.11 +33.5% 12 qtrs
12 BAKER BROS. ADVISORS LP 1.43M -123.6K (-7.9%) 99.63M +56.1M (+128.7%) 2.45% -0.211 pp 0.58% +0.269 pp USD22.23 +212.9% 6 qtrs
13 PRINCIPAL FINANCIAL GROUP INC 1.28M +496.7K (+63.1%) 89.32M +67.3M (+305.1%) 2.20% +0.849 pp 0.05% +0.035 pp USD48.93 +42.1% 7 qtrs
14 CASDIN CAPITAL, LLC 1.18M -380.0K (-24.4%) 81.72M +38.2M (+87.7%) 2.01% -0.650 pp 5.08% +1.446 pp USD28.25 +146.2% 12 qtrs
15 ORBIMED ADVISORS LLC 1.16M +22.5K (+2.0%) 80.80M +48.9M (+153.3%) 1.99% +0.039 pp 1.66% +0.904 pp USD29.95 +132.2% 7 qtrs
16 SIREN, L.L.C. 1.08M +51.9K (+5.1%) 75.02M +46.3M (+160.9%) 1.84% +0.089 pp 2.24% +1.113 pp USD30.00 +131.8% 2 qtrs
17 TCG CROSSOVER MANAGEMENT, LLC 920.9K -142.1K (-13.4%) 64.05M +34.3M (+115.2%) 1.57% -0.243 pp 2.12% +0.655 pp USD43.45 +60.1% 12 qtrs
18 CAPITOLIS LIQUID GLOBAL MARKETS LLC 878.3K +878.3K (+100.0%) 61.09M +61.1M (+100.0%) 1.50% +1.502 pp 0.36% +0.364 pp USD69.55 +0.0% 1 qtrs NEW
19 FRANKLIN RESOURCES INC 870.6K +124.8K (+16.7%) 60.55M +39.7M (+190.0%) 1.49% +0.214 pp 0.01% +0.010 pp USD39.53 +75.9% 12 qtrs
20 ALLIANCEBERNSTEIN L.P. 848.9K +819.3K (+2,771.7%) 59.04M +58.2M (+7,033.1%) 1.45% +1.401 pp 0.02% +0.018 pp USD67.91 +2.4% 7 qtrs
21 DEUTSCHE BANK AG\ 841.2K +841.2K (+100.0%) 58.50M +58.5M (+100.0%) 1.44% +1.438 pp 0.02% +0.019 pp USD69.55 +0.0% 1 qtrs NEW
22 CITADEL ADVISORS LLC 772.5K +328.7K (+74.1%) 53.73M +41.3M (+332.4%) 1.32% +0.562 pp 0.01% +0.006 pp USD50.33 +38.2% 12 qtrs
23 DEERFIELD MANAGEMENT COMPANY, L.P. (SERIES C) 768.0K +394.6K (+105.7%) 53.41M +43.0M (+410.9%) 1.31% +0.675 pp 0.68% +0.523 pp USD52.67 +32.0% 12 qtrs
24 ROCK SPRINGS CAPITAL MANAGEMENT LP 748.2K -202.9K (-21.3%) 52.04M +25.4M (+95.4%) 1.28% -0.347 pp 2.67% +1.112 pp USD39.23 +77.3% 9 qtrs
25 PACIFIC HEIGHTS ASSET MANAGEMENT LLC 700.0K +— (+0.0%) 48.69M +29.1M (+148.4%) 1.20% +0.000 pp 1.82% +0.956 pp USD23.23 +199.4% 3 qtrs
26 LOGOS GLOBAL MANAGEMENT LP 600.0K -250.0K (-29.4%) 41.73M +17.9M (+75.3%) 1.03% -0.427 pp 2.52% +0.388 pp USD29.49 +135.8% 12 qtrs
27 AMERICAN CENTURY COMPANIES INC 507.0K +20.2K (+4.1%) 35.26M +21.6M (+158.7%) 0.87% +0.035 pp 0.02% +0.011 pp USD40.86 +70.2% 8 qtrs
28 HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND 467.8K +467.8K (+100.0%) 32.54M +32.5M (+100.0%) 0.80% +0.800 pp 0.05% +0.054 pp USD69.55 +0.0% 1 qtrs NEW
29 FARALLON CAPITAL MANAGEMENT LLC 454.0K +454.0K (+100.0%) 31.58M +31.6M (+100.0%) 0.78% +0.776 pp 0.15% +0.149 pp USD69.55 +0.0% 1 qtrs NEW
30 BLACKROCK, INC. 430.1K +166.1K (+62.9%) 29.91M +22.5M (+304.8%) 0.74% +0.284 pp 0.00% +0.000 pp USD53.04 +31.1% 6 qtrs
31 SC CHINA HOLDING LTD 266.1K +— (+0.0%) 24.44M +19.8M (+430.4%) 0.45% +0.000 pp 1.29% +1.052 pp USD50.42 +37.9% 10 qtrs
32 STEMPOINT CAPITAL LP 351.1K +221.7K (+171.4%) 24.42M +20.8M (+574.2%) 0.60% +0.379 pp 4.19% +3.461 pp USD54.24 +28.2% 2 qtrs
33 ECOR1 CAPITAL, LLC 334.4K +334.4K (+100.0%) 23.26M +23.3M (+100.0%) 0.57% +0.572 pp 1.06% +1.055 pp USD69.55 +0.0% 1 qtrs NEW
34 AMERIPRISE FINANCIAL INC 285.5K -938.6K (-76.7%) 19.86M -14.4M (-42.1%) 0.49% -1.605 pp 0.00% -0.003 pp USD36.95 +88.2% 9 qtrs
35 ARROWMARK COLORADO HOLDINGS LLC 271.2K -52.0K (-16.1%) 18.86M +9.8M (+108.5%) 0.46% -0.089 pp 0.42% +0.247 pp USD33.39 +108.3% 12 qtrs
36 NATIONAL BANK OF CANADA /FI/ 265.4K +121.4K (+84.3%) 18.46M +14.4M (+357.8%) 0.45% +0.208 pp 0.02% +0.013 pp USD47.00 +48.0% 6 qtrs
37 ABRDN PLC 264.9K -322.0K (-54.9%) 18.42M +2.0M (+12.1%) 0.45% -0.551 pp 0.03% +0.003 pp USD28.85 +141.1% 7 qtrs
38 CATALIO CAPITAL MANAGEMENT, LP 252.9K -398.9K (-61.2%) 17.59M -661.4K (-3.6%) 0.43% -0.682 pp 3.11% -0.265 pp USD25.23 +175.7% 5 qtrs
39 CAPRICORN FUND MANAGERS LTD 252.6K +252.6K (+100.0%) 17.57M +17.6M (+100.0%) 0.43% +0.432 pp 4.23% +4.235 pp USD69.55 +0.0% 1 qtrs NEW
40 VOLORIDGE INVESTMENT MANAGEMENT, LLC 250.0K +250.0K (+100.0%) 17.39M +17.4M (+100.0%) 0.43% +0.427 pp 0.06% +0.061 pp USD69.55 +0.0% 1 qtrs NEW
41 SUSQUEHANNA INTERNATIONAL GROUP, LLP 236.1K -800.0 (-0.3%) 16.42M +9.8M (+147.6%) 0.40% -0.001 pp 0.00% +0.001 pp USD28.73 +142.1% 9 qtrs
42 MONASHEE INVESTMENT MANAGEMENT LLC 225.0K +25.0K (+12.5%) 15.65M +10.0M (+179.4%) 0.38% +0.043 pp 8.82% +6.026 pp USD30.95 +124.7% 12 qtrs
43 GOLDMAN SACHS GROUP INC 224.3K -280.1K (-55.5%) 15.60M +1.5M (+10.5%) 0.38% -0.479 pp 0.00% +0.000 pp USD33.94 +104.9% 10 qtrs
44 BALYASNY ASSET MANAGEMENT L.P. 216.2K -245.4K (-53.2%) 15.04M +2.1M (+16.4%) 0.37% -0.420 pp 0.02% +0.003 pp USD28.00 +148.4% 4 qtrs
45 UBS GROUP AG 202.5K -5.6K (-2.7%) 14.08M +8.3M (+141.7%) 0.35% -0.010 pp 0.00% +0.001 pp USD29.28 +137.5% 11 qtrs
46 SIO CAPITAL MANAGEMENT, LLC 201.5K +201.5K (+100.0%) 14.01M +14.0M (+100.0%) 0.34% +0.345 pp 2.20% +2.204 pp USD69.55 +0.0% 1 qtrs NEW
47 HIGHVISTA STRATEGIES LLC 193.0K -43.2K (-18.3%) 13.42M +6.8M (+102.9%) 0.33% -0.074 pp 3.46% +1.836 pp USD27.54 +152.5% 10 qtrs
48 DIADEMA PARTNERS LP 191.7K +191.7K (+100.0%) 13.33M +13.3M (+100.0%) 0.33% +0.328 pp 2.30% +2.297 pp USD69.55 +0.0% 1 qtrs NEW
49 TD ASSET MANAGEMENT INC 174.7K +138.6K (+384.0%) 12.15M +11.1M (+1,102.3%) 0.30% +0.237 pp 0.01% +0.009 pp USD63.72 +9.1% 12 qtrs
50 MARSHALL WACE, LLP 168.6K +168.6K (+100.0%) 11.73M +11.7M (+100.0%) 0.29% +0.288 pp 0.01% +0.011 pp USD69.55 +0.0% 10 qtrs
51 MILLENNIUM MANAGEMENT LLC 152.6K -1.1M (-88.0%) 10.61M -25.1M (-70.3%) 0.26% -1.918 pp 0.00% -0.011 pp USD32.39 +114.7% 12 qtrs
52 RHENMAN & PARTNERS ASSET MANAGEMENT AB 147.6K -32.5K (-18.0%) 10.27M +5.2M (+103.6%) 0.25% -0.056 pp 0.96% +0.401 pp USD21.22 +227.8% 4 qtrs
53 JANE STREET GROUP, LLC 147.2K +147.2K (+100.0%) 10.24M +10.2M (+100.0%) 0.25% +0.252 pp 0.00% +0.002 pp USD69.55 +0.0% 1 qtrs NEW
54 BELLEVUE GROUP AG 145.2K -170.7K (-54.0%) 10.10M +1.3M (+14.2%) 0.25% -0.292 pp 0.19% +0.008 pp USD33.73 +106.2% 10 qtrs
55 EVERSEPT PARTNERS, LP 127.6K -38.8K (-23.3%) 8.87M +4.2M (+90.4%) 0.22% -0.066 pp 0.45% +0.126 pp USD23.67 +193.8% 3 qtrs
56 WOODLINE PARTNERS LP 123.9K +58.5K (+89.3%) 8.62M +6.8M (+370.3%) 0.21% +0.100 pp 0.03% +0.025 pp USD49.59 +40.3% 12 qtrs
57 RENAISSANCE TECHNOLOGIES LLC 115.2K -38.7K (-25.1%) 8.01M +3.7M (+85.9%) 0.20% -0.066 pp 0.01% +0.007 pp USD22.37 +210.9% 4 qtrs
58 ALYESKA INVESTMENT GROUP, L.P. 115.0K -129.8K (-53.0%) 8.00M +1.1M (+16.7%) 0.20% -0.222 pp 0.02% +0.002 pp USD28.00 +148.4% 2 qtrs
59 JEFFERIES FINANCIAL GROUP INC. 103.0K -67.4K (-39.5%) 7.16M +2.4M (+50.2%) 0.18% -0.115 pp 0.04% +0.014 pp USD28.00 +148.4% 2 qtrs
60 RTW INVESTMENTS, LP 100.0K +100.0K (+100.0%) 6.96M +7.0M (+100.0%) 0.17% +0.171 pp 0.07% +0.070 pp USD69.55 +0.0% 1 qtrs NEW
61 JAIN GLOBAL LLC 100.0K +100.0K (+100.0%) 6.95M +7.0M (+100.0%) 0.17% +0.171 pp 0.03% +0.034 pp USD69.55 +0.0% 4 qtrs
62 SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC 99.6K +— (+0.0%) 6.93M +4.1M (+148.4%) 0.17% +0.000 pp 0.24% +0.127 pp USD17.31 +301.8% 4 qtrs
63 TWO SIGMA INVESTMENTS, LP 95.5K -87.4K (-47.8%) 6.65M +1.5M (+29.7%) 0.16% -0.149 pp 0.01% +0.002 pp USD28.00 +148.4% 2 qtrs
64 SUMMITTX CAPITAL, L.P. 94.7K +94.7K (+100.0%) 6.58M +6.6M (+100.0%) 0.16% +0.162 pp 0.20% +0.198 pp USD69.55 +0.0% 1 qtrs NEW
65 MANUFACTURERS LIFE INSURANCE COMPANY, THE 96.4K +67.9K (+237.8%) 6.53M +5.7M (+717.8%) 0.16% +0.116 pp 0.01% +0.005 pp USD61.47 +13.1% 11 qtrs
66 SIMPLEX TRADING, LLC 92.7K +67.5K (+268.3%) 6.45M +5.7M (+815.5%) 0.16% +0.115 pp 0.00% +0.003 pp USD60.04 +15.8% 9 qtrs
67 SOLEUS CAPITAL MANAGEMENT, L.P. 90.0K +90.0K (+100.0%) 6.26M +6.3M (+100.0%) 0.15% +0.154 pp 0.23% +0.231 pp USD69.55 +0.0% 1 qtrs NEW
68 B GROUP, INC. 90.0K +90.0K (+100.0%) 6.26M +6.3M (+100.0%) 0.15% +0.154 pp 4.62% +4.622 pp USD69.55 +0.0% 1 qtrs NEW
69 BIRCHVIEW CAPITAL, LP 90.0K +12.0K (+15.4%) 6.26M +4.1M (+186.6%) 0.15% +0.021 pp 3.66% +2.016 pp USD30.64 +127.0% 3 qtrs
70 TREXQUANT INVESTMENT LP 89.9K +69.8K (+345.4%) 6.26M +5.7M (+1,006.5%) 0.15% +0.119 pp 0.06% +0.050 pp USD58.98 +17.9% 8 qtrs
71 PLATINUM INVESTMENT MANAGEMENT LTD 87.9K -34.9K (-28.4%) 6.11M +2.7M (+77.8%) 0.15% -0.060 pp 1.41% +1.190 pp USD34.47 +101.8% 12 qtrs
72 BREVAN HOWARD CAPITAL MANAGEMENT LP 86.3K +86.3K (+100.0%) 5.96M +6.0M (+100.0%) 0.15% +0.148 pp 0.07% +0.065 pp USD69.55 +0.0% 1 qtrs NEW
73 PEREGRINE CAPITAL MANAGEMENT LLC 84.3K +84.3K (+100.0%) 5.86M +5.9M (+100.0%) 0.14% +0.144 pp 0.18% +0.180 pp USD69.55 +0.0% 1 qtrs NEW
74 UNIVERSAL- BETEILIGUNGS- UND SERVICEGESELLSCHAFT MBH 83.1K +67.3K (+428.5%) 5.78M +5.3M (+1,212.8%) 0.14% +0.115 pp 0.01% +0.009 pp USD61.56 +13.0% 5 qtrs
75 VERITION FUND MANAGEMENT LLC 78.1K +38.8K (+98.6%) 5.44M +4.3M (+393.3%) 0.13% +0.066 pp 0.02% +0.017 pp USD44.51 +56.3% 7 qtrs
76 BOXER CAPITAL MANAGEMENT, LLC 75.0K +75.0K (+100.0%) 5.22M +5.2M (+100.0%) 0.13% +0.128 pp 1.14% +1.142 pp USD69.55 +0.0% 1 qtrs NEW
77 WALLEYE TRADING LLC 70.2K -43.4K (-38.2%) 4.88M +1.7M (+53.5%) 0.12% -0.074 pp 0.01% +0.002 pp USD19.86 +250.2% 4 qtrs
78 PFM HEALTH SCIENCES, LP 68.2K -46.8K (-40.7%) 4.75M +1.5M (+47.3%) 0.12% -0.080 pp 0.47% +0.226 pp USD23.23 +199.4% 4 qtrs
79 SUSQUEHANNA PORTFOLIO STRATEGIES, LLC 68.1K +12.1K (+21.7%) 4.74M +3.2M (+202.3%) 0.12% +0.021 pp 0.07% +0.048 pp USD31.15 +123.3% 3 qtrs
80 LONGAEVA PARTNERS L.P. 60.0K +60.0K (+100.0%) 4.17M +4.2M (+100.0%) 0.10% +0.103 pp 0.35% +0.350 pp USD69.55 +0.0% 1 qtrs NEW
81 BURKEHILL GLOBAL MANAGEMENT, LP 60.0K +60.0K (+100.0%) 4.17M +4.2M (+100.0%) 0.10% +0.103 pp 0.27% +0.275 pp USD69.55 +0.0% 1 qtrs NEW
82 BANQUE PICTET & CIE SA 59.9K -4.3K (-6.7%) 4.16M +2.4M (+131.7%) 0.10% -0.007 pp 0.02% +0.014 pp USD41.42 +67.9% 6 qtrs
83 ADVISOR GROUP HOLDINGS, INC. 59.2K -3.6K (-5.7%) 4.12M +2.9M (+235.6%) 0.10% -0.006 pp 0.01% +0.004 pp USD23.95 +190.4% 10 qtrs
84 VOYA INVESTMENT MANAGEMENT LLC 55.3K +38.9K (+236.7%) 3.85M +3.4M (+736.3%) 0.09% +0.067 pp 0.00% +0.003 pp USD59.89 +16.1% 10 qtrs
85 GEODE CAPITAL MANAGEMENT, LLC 55.1K -2.8K (-4.8%) 3.84M +2.2M (+136.3%) 0.09% -0.005 pp 0.00% +0.000 pp USD36.82 +88.9% 11 qtrs
86 PARKMAN HEALTHCARE PARTNERS LLC 55.0K +55.0K (+100.0%) 3.83M +3.8M (+100.0%) 0.09% +0.094 pp 0.36% +0.364 pp USD69.55 +0.0% 1 qtrs NEW
87 BANK OF MONTREAL /CAN/ 54.3K -6.4K (-10.5%) 3.68M +2.0M (+116.6%) 0.09% -0.011 pp 0.00% +0.001 pp USD37.26 +86.7% 7 qtrs
88 INTEGRAL HEALTH ASSET MANAGEMENT, LLC 50.0K +50.0K (+100.0%) 3.48M +3.5M (+100.0%) 0.09% +0.086 pp 0.17% +0.173 pp USD69.55 +0.0% 1 qtrs NEW
89 SEVEN GRAND MANAGERS, LLC 50.0K +50.0K (+100.0%) 3.48M +3.5M (+100.0%) 0.09% +0.086 pp 0.26% +0.265 pp USD69.55 +0.0% 1 qtrs NEW
90 ALPS ADVISORS INC 49.7K +21.8K (+77.9%) 3.46M +2.7M (+341.8%) 0.09% +0.037 pp 0.02% +0.016 pp USD45.69 +52.2% 5 qtrs
91 PIER CAPITAL, LLC 48.8K -148.8K (-75.3%) 3.39M -2.1M (-38.7%) 0.08% -0.254 pp 0.54% -0.323 pp USD32.45 +114.3% 9 qtrs
92 STATE STREET CORP 48.2K +2.2K (+4.8%) 3.35M +2.1M (+160.3%) 0.08% +0.004 pp 0.00% +0.000 pp USD29.82 +133.2% 11 qtrs
93 ANTIPODES PARTNERS LTD 46.3K +42.2K (+1,035.1%) 3.25M +3.1M (+2,742.9%) 0.08% +0.072 pp 0.07% +0.066 pp USD65.46 +6.2% 7 qtrs
94 RAYMOND JAMES FINANCIAL INC 44.4K +44.4K (+100.0%) 3.09M +3.1M (+100.0%) 0.08% +0.076 pp 0.00% +0.001 pp USD69.55 +0.0% 3 qtrs
95 MARINER, LLC 44.2K +19.0 (+0.0%) 3.07M +1.8M (+148.5%) 0.08% +0.000 pp 0.00% +0.002 pp USD24.13 +188.2% 5 qtrs
Ownership breakdown by holder

Insider Activity

Insider Activity — Latest Quarter
Ratio by transactions
0.00
Bearish
Ratio by volume
0.00
Bearish
Buys
0
Sells
2
Shares acquired
Shares disposed
17.5K
Cash buys
Cash sales
2.00
Net activity
-17,452
Insider buys vs sells (history) From To
Recent insider transactions From To
Date Person Role Transaction A/D Security Shares Price Value Owned after D/I Filing
2026-04-15 Lang Matthew Officer A-Award A Share option (right to buy) 223,776 18.08 4.05M 223,776 D
2026-04-14 FMR LLC 10% Owner S-Sale D American Depositary Shares 16,085 0.00 32,171 I
2026-03-19 Yoon Jun Officer A-Award A Employee Stock Option (right to buy) 128,892 16.82 2.17M 128,892 D
2026-03-19 Stevens Raymond C Director / Officer A-Award A Employee Stock Option (right to buy) 322,230 16.82 5.42M 322,230 D
2026-03-19 Ma Yingli Officer A-Award A Ordinary Shares 32,526 0.00 139,917 D
2026-03-19 Lin Xichen Officer A-Award A Ordinary Shares 43,368 0.00 228,960 D
2026-03-19 Hall Ashley Officer A-Award A Employee Stock Option (right to buy) 59,073 16.82 993.6K 59,073 D
2026-03-19 Coll Crespo Blas Officer A-Award A Employee Stock Option (right to buy) 93,984 16.82 1.58M 93,984 D
2026-03-03 Yoon Jun Officer F-InKind D Ordinary Shares 22,305 20.99 468.2K 1,297,571 D
2026-03-03 Stevens Raymond C Director / Officer F-InKind D Ordinary Shares 53,454 20.99 1.12M 1,141,376 D
2026-03-03 Ma Yingli Officer F-InKind D Ordinary Shares 11,313 20.99 237.5K 107,391 D
2026-03-03 Lin Xichen Officer F-InKind D Ordinary Shares 18,735 20.99 393.2K 185,592 D
2026-03-03 Hall Ashley Officer F-InKind D Ordinary Shares 4,836 20.99 101.5K 107,481 D
2026-03-03 Coll Crespo Blas Officer F-InKind D Ordinary Shares 11,826 20.99 248.2K 204,981 D
2026-01-15 FMR LLC 10% Owner S-Sale D American Depositary Shares 5,477 0.00 58,864 I
2025-12-08 FMR LLC 10% Owner S-Sale D American Depositary Shares 15,535 0.00 0 I
2025-11-20 Stevens Raymond C Director / Officer A-Award A American Depositary Shares 824 0.00 1,824 D
2025-11-20 Hall Ashley Officer A-Award A American Depositary Shares 237 0.00 462 D
2025-09-18 Hall Ashley Officer F-InKind D Ordinary Shares 6,021 7.74 46.6K 112,317 D
2025-09-18 Coll Crespo Blas Officer F-InKind D Ordinary Shares 8,106 7.74 62.8K 216,807 D
2025-07-30 FMR LLC 10% Owner S-Sale D American Depositary Shares 26,310 0.00 1,515,558 I
2025-07-01 Yoon Jun Officer F-InKind D Ordinary Shares 7,089 6.84 48.5K 1,319,876 D
2025-07-01 Stevens Raymond C Director / Officer F-InKind D Ordinary Shares 16,050 6.84 109.7K 1,194,830 D
2025-07-01 Ma Yingli Officer A-Award A Ordinary Shares 24,459 0.00 123,174 D
2025-07-01 Lin Xichen Officer A-Award A Ordinary Shares 57,078 0.00 217,173 D
2025-07-01 Coll Crespo Blas Officer F-InKind D Ordinary Shares 1,434 6.84 9.8K 224,913 D
2025-06-23 Waldstreicher Joanne Director A-Award A Share Option (right to buy) 51,804 7.37 381.8K 51,804 D
2025-06-23 WELCH DANIEL G Director A-Award A Share Option (right to buy) 51,804 7.37 381.8K 51,804 D
2025-06-23 TETLOW SHARON Director A-Award A Share Option (right to buy) 51,804 7.37 381.8K 51,804 D
2025-06-23 Russell Angus C. Director A-Award A Share Option (right to buy) 42,833 7.37 315.7K 42,833 D
2025-06-23 LOVE TED W Director A-Award A Share Option (right to buy) 51,804 7.37 381.8K 51,804 D
2025-06-23 DOBMEIER ERIC Director A-Award A Share Option (right to buy) 51,804 7.37 381.8K 51,804 D
2025-05-21 Yoon Jun Officer A-Award A American Depositary Shares 831 0.00 2,946 D
2025-05-21 Stevens Raymond C Director / Officer A-Award A American Depositary Shares 1,000 0.00 1,000 D
2025-05-21 Coll Crespo Blas Officer A-Award A American Depositary Shares 429 0.00 1,157 D
2025-05-20 Hall Ashley Officer A-Award A American Depositary Shares 225 0.00 225 D
2025-03-15 Yoon Jun Officer A-Award A Ordinary Shares 170,166 0.00 1,293,299 D
2025-03-15 Stevens Raymond C Director / Officer A-Award A Ordinary Shares 340,332 0.00 1,133,678 D
2025-03-15 Ma Yingli Officer A-Award A Employee Stock Option (right to buy) 155,040 7.02 1.09M 155,040 D
2025-03-15 Lin Xichen Officer A-Award A Employee Stock Option (right to buy) 196,386 7.02 1.38M 196,386 D
2025-03-15 Hall Ashley Officer A-Award A Employee Stock Option (right to buy) 124,032 7.02 870.7K 124,032 D
2025-03-15 Coll Crespo Blas Officer A-Award A Ordinary Shares 116,988 0.00 219,588 D
2025-03-01 Yoon Jun Officer F-InKind D Ordinary Shares 5,940 7.92 47.0K 1,287,359 D
2025-03-01 Stevens Raymond C Director / Officer F-InKind D Ordinary Shares 12,495 7.92 98.9K 1,121,183 D
2025-03-01 Ma Yingli Officer F-InKind D Ordinary Shares 1,824 7.92 14.4K 98,715 D
2025-03-01 Lin Xichen Officer F-InKind D Ordinary Shares 6,441 7.92 51.0K 160,095 D
2025-03-01 Coll Crespo Blas Officer F-InKind D Ordinary Shares 1,233 7.92 9.8K 218,355 D
2025-02-06 FMR LLC 10% Owner S-Sale D American Depositary Shares 41 0.00 0 I
2024-11-20 Yoon Jun Officer A-Award A American Depositary Shares 821 0.00 2,115 D
2024-11-20 Coll Crespo Blas Officer A-Award A American Depositary Shares 363 0.00 728 D
2024-09-18 Hall Ashley 0 0.00 0
2024-09-18 Coll Crespo Blas Officer Ordinary Shares 0 0.00 12,000 D
2024-08-26 Russell Angus C. Director A-Award A Share option (right to buy) 75,000 13.53 1.01M 75,000
2024-06-25 Waldstreicher Joanne Director A-Award A Share Option (right to buy) 37,500 13.32 499.5K 37,500
2024-06-25 WELCH DANIEL G Director A-Award A Share Option (right to buy) 37,500 13.32 499.5K 37,500
2024-06-25 TETLOW SHARON Director A-Award A Share Option (right to buy) 37,500 13.32 499.5K 37,500
2024-06-25 LOVE TED W Director A-Award A Share Option (right to buy) 33,595 13.32 447.5K 33,595
2024-06-25 DOBMEIER ERIC Director A-Award A Share Option (right to buy) 37,500 13.32 499.5K 37,500
2024-06-12 Stevens Raymond C Director / Officer M-Exempt D Share Option (right to buy) 50,001 0.48 24.0K 488,766
2024-06-10 Stevens Raymond C Director / Officer C-Conversion D Ordinary Shares 555,000 0.00 643,346
2024-06-06 FMR LLC 10% Owner I Ordinary Shares 0 0.00 530,814
2024-06-03 Lin Xichen Officer C-Conversion A American Depositary Shares 35,400 0.00 35,400
2024-05-20 Yoon Jun Officer A-Award A American Depositary Shares 694 0.00 1,294 D
2024-04-17 FMR LLC 0 0.00 0
2024-03-15 Yoon Jun Officer A-Award A Stock Option (right to buy) 148,134 35.25 5.22M 148,134
2024-03-15 Stevens Raymond C Director / Officer A-Award A Stock Option (right to buy) 335,481 35.25 11.83M 335,481
2024-03-15 Ma Yingli Officer A-Award A Ordinary Shares 36,729 0.00 36,729
2024-03-15 Lin Xichen Officer A-Award A Ordinary Shares 85,707 0.00 85,707
2024-03-15 Bach Mark Allen Officer A-Award A Ordinary Shares 26,235 0.00 26,235
2024-03-14 FMR LLC 10% Owner S-Sale D American Depositary Shares 21,997 0.00 1,541,868
2024-02-13 FMR LLC 10% Owner S-Sale D American Depositary Shares 525 0.00 1,563,865
2023-12-22 FMR LLC 10% Owner J-Other D American Depositary Shares 25,410 0.00 1,564,390
2023-12-05 FMR LLC 10% Owner S-Sale D American Depositary Shares 16,086 0.00 32,169
2023-10-18 FMR LLC 10% Owner S-Sale D American Depositary Shares 16,086 0.00 48,255
2023-10-02 FMR LLC 10% Owner I Ordinary Shares 0 0.00 723,837
2023-08-03 WELCH DANIEL G Director J-Other D Stock option (right to buy) 411,000 2.60 1.07M 768,122
2023-08-03 LOVE TED W Director A-Award A Stock option (right to buy) 75,000 10.57 792.8K 75,000
2023-02-07 Farid Ramy Director C-Conversion A Ordinary Shares 642,245 0.00 3,260,495
2023-02-07 FMR LLC Other C-Conversion A Ordinary Shares 6,947 0.00 82,035
2023-02-02 TETLOW SHARON Director D Stock option (right to buy) 80,000 2.79 223.2K 0
2023-02-02 Farid Ramy Director I Ordinary Shares 0 0.00 2,618,250
2023-02-02 FMR LLC 10% Owner I Series B-1 Convertible Preferred Shares 214,663 0.00 0
2023-02-02 DOBMEIER ERIC Director D Stock option (right to buy) 80,000 3.36 268.8K 0

Executive team

Top executives
Shares Outstanding
57.57M

Executive compensation

Executive compensation (annual)
# Year Executive Salary Bonus Stock award Option award Incentive Other Total % Stock-
based
Filing
1 2025 Raymond Stevens, Ph.D. Chief Executive Officer and Director 672.1K 2.39M 4.85M 508.9K 14.0K 8.43M 85.82%
2 2025 Jun Yoon Chief Financial Officer 530.5K 1.19M 2.42M 309.1K 10.5K 4.47M 80.97%
3 2025 Blai Coll, M.D., Ph.D. Chief Medical Officer 492.8K 820.9K 1.67M 253.2K 14.0K 3.25M 76.59%
4 2025 Xichen Lin, Ph.D. Chief Scientific Officer 505.3K 567.2K 1.15M 257.1K 2.48M 69.27%
5 2025 Yingli Ma, Ph.D. Chief Technology Officer 429.8K 447.7K 908.8K 212.6K 2.00M 67.86%
6 2024 Raymond Stevens, Ph.D. Chief Executive Officer and Director 634.2K 1.58M 3.17M 334.4K 13.8K 5.74M 82.88%
7 2024 Xichen Lin, Ph.D. Chief Scientific Officer 476.5K 1.01M 2.02M 185.8K 1.7K 3.69M 82.01%
8 2024 Blai Coll, M.D., Ph.D. Chief Medical Officer 449.1K 1.30M 1.50M 187.2K 13.8K 3.45M 81.16%
9 2024 Jun Yoon Chief Financial Officer 482.3K 698.8K 1.40M 217.1K 13.8K 2.81M 74.65%
10 2023 Raymond Stevens, Ph.D. Chief Executive Officer and Director 595.9K 6.50M 281.3K 13.2K 7.39M 87.95%
11 2023 Jun Yoon Chief Financial Officer 441.3K 3.05M 173.2K 13.2K 3.67M 82.92%
12 2023 Mark Bach, M.D., Ph.D. Chief Medical Officer 485.8K 173.0K 13.2K 672.1K 0.00%
13 2022 Raymond Stevens, Ph.D. Chief Executive Officer and Director 487.3K 247.5K 12.5K 747.3K 0.00%
14 2022 Mark Bach, M.D., Ph.D. Chief Medical Officer 466.4K 149.5K 12.5K 628.4K 0.00%
CEO compensation breakdown

Proxy statements

Proxy statements (DEF 14A)
Filing date Form type Filing
2026-04-23 DEF 14A
2025-04-24 DEF 14A

Recent SEC filings

Recent SEC filings
Filing date Form type Filing
2026-05-07 8-K
2026-05-07 424B5
2026-05-07 10-Q
2026-04-23 DEF 14A
2026-04-23 ARS
2026-04-23 4
2026-04-23 3
2026-04-16 4
2026-04-15 8-K
2026-03-23 4

Executive team

NameTitleCompensationGender
Raymond C. Stevens Chief Executive Officer & Director 1M
Jun S. Yoon Co- Founder, Chief Financial Officer & Secretary 850.1K male
Xichen Lin Chief Scientific Officer & GM of Structure Shanghai 762.4K
Blai Coll Chief Medical Officer 760.0K
Yingli Ma Chief Technology Officer 642.4K
Lani Ibarra Senior Vice President of Clinical Development Operations female
Matthew Lang COO & General Counsel male
Hui Lei Senior Vice President of Chemistry
Sam Lim Senior Vice President of Cardiopulmonary Clinical Development
Tony Peng Senior Vice President of Legal male
Fang Zhang Executive Vice President & Head of Biology
Xinglong Jiang Senior Vice President of Preclinical Development
ESG Rating
B
BIOTECHNOLOGY
2026
E (Environmental)
56.5 / 56.3
Company / Sector avg.
S (Social)
62.1 / 62.4
Company / Sector avg.
G (Governance)
60.8 / 60.9
Company / Sector avg.
ESG Total
59.8 / 59.9
Company / Sector avg.
ESG Score History BIOTECHNOLOGY
Benchmark vs Sector
Senate Trading Activity
Transaction Date Disclosed Senator State Owner Type Amount Link
2023-10-04 2023-11-02 Thomas R. Carper DE Spouse Sale (Full) $1,001 - $15,000
House Trading Activity

No House trading activity found for this company.

Market share among peers
Peer comparison — filtered group (TTM)
Your opinion

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Dividend history

Earnings history

Earnings reports

Stock splits