Subscribe

Anavex Life Sciences Corp. (AVXL)

USD2.45 +0.02 (+0.99%)
US NASDAQ Healthcare Biotechnology
Address 51 West 52nd Street 10019
New York City, NY, US
CEO Christopher U. Missling
Website anavex.com
IPO 2006-08-02
CIK 1314052 ISIN US0327973006

Explore sections of this company profile

Also trades on London Stock Exchange · 0HFR.L (USD) NASDAQ Global Select · AVXL (USD)
Description

Operating as a clinical-stage biopharmaceutical entity, Anavex Life Sciences Corp. specializes in developing therapeutic drug candidates for various central nervous system (CNS) conditions. Its leading compound, ANAVEX 2-73, is currently in advanced development, undergoing Phase III clinical evaluation for both Alzheimer's disease and pediatric Rett syndrome. This same drug is also in Phase II trials for Parkinson's disease and is being explored in preclinical studies for a wider range of disorders, including epilepsy, infantile spasms, Fragile X syndrome, Angelman syndrome, multiple sclerosis, and tuberous sclerosis complex. Another significant drug candidate, ANAVEX 3-71, has progressed to Phase I clinical trials for frontotemporal dementia and other forms of dementia, with additional preclinical investigation underway for neurodegenerative illnesses like Alzheimer's and Parkinson's. The company's earlier-stage portfolio includes ANAVEX 1-41, a sigma-1 receptor agonist targeting depression, stroke, Parkinson's, and Alzheimer's diseases; ANAVEX 1066, a mixed sigma-1/sigma-2 ligand with potential applications in neuropathic and visceral pain; and ANAVEX 1037, aimed at treating prostate and pancreatic cancers. Anavex Life Sciences Corp. was founded in 2004 and maintains its headquarters in New York, New York.

Market Cap & Enterprise Value
Merger & Acquisition History

No mergers or acquisitions recorded for this company.

Technical Outlook
Loading outlook…
Loading forecast...
Signal Summary Loading…
Indicator 1D1W2W3W1M
Each column is computed on that timeframe's candles (1D = daily, 1W ≈ weekly, 1M ≈ monthly), not on the same last day. ▲ bullish · ▼ bearish · — neutral. The Net row counts signals per column; hover any cell (or the indicator name) to see the exact rule behind it.
Day Score & sub-scores
Statistical fingerprint & regime detail
Conditional historical analysis
Customize analysis (advanced)
Indicative levels generated algorithmically. Not financial advice.
Risk Profile
Loading risk profile…
Price Chart
Averages
Trend
Price
Levels
Draw
USD2.45 +0.02 (+0.99%)
Loading historical data…
Volume Profile
Loading…
Liquidity & share structure
Average Volume
1M
Beta
1.12
Float Shares
89.78M
Free Float %
96.9%
Price Performance
1D5D1M3M6M YTD1Y3Y5Y10YMax
-5.56% -8.38% +3.73% -21.94% -55.65% -14.04% -64.21% -66.37% -70.38% -23.50% -61.75%
Rolling Volatility
Loading…
Drawdown
Loading…
Relative Strength
Loading…
Monthly Returns Heatmap
From To
Loading…
Annual Monthly Returns
Loading…
Daily Returns Distribution
vs.
Loading histogram data…

Revenue flow

Revenue by geography

Revenue by segment

From To

Revenue composition

From To

By product

By geography

Financial Statements

Income Statement

Balance Sheet

Cash Flow Statement

Key Metrics

Financial Ratios

Employees

Financial Growth (CAGR)

Market Data

Analyst Consensus (13 ratings, all time) Buy
Price Targets & DCF
Current price
2.45
Low 11.00 +348.2%
Consensus 11.00 +348.2%
Median 11.00 +348.2%
High 11.00 +348.2%
DCF (Unlevered) 1.17 -52.5%
DCF (Levered) 1.20 -51.0%

DCF figures are point estimates: small changes in growth or discount-rate assumptions move them materially. Read them as a reference, not a precise target.

Ratings Trend (MoM) 100% Bullish
Rating 2026-05 Change
Strong Buy 0 0
Buy 2 0
Hold 0 -1
Sell 0 0
Strong Sell 0 0
Price Target Summary
Period # Analysts Avg Target
Last Month
Last Quarter
Last Year
All Time 1
11.00
+348.2%
Quality scores
Altman Z-Score
22.77
Safe zone
Piotroski F-Score
2 / 9
Weak
MOAT Score
3 / 10
No MOAT
Composite Rating
C
Overall Score
2 / 5
Medium
DCF Score
3 / 5
Medium
ROE Score
1 / 5
Low
ROA Score
1 / 5
Low
D/E Score
1 / 5
Low
P/E Score
1 / 5
Low
P/Book Score
3 / 5
Medium
Operational MOAT
✗ Below peers
  • Revenue growth Biotechnology: +1.6%
  • EPS growth Biotechnology: +29.7%
    -3.9% Q4'25: +54.4% (vs Q4'24)
  • FCF margin FCF growth · Biotechnology: +16.2%
  • EBIT margin Biotechnology: +0.0%
  • ROIC Biotechnology: -16.1%
    Q4'25: +528.7% (vs Q4'24)
  • Share dilution Biotechnology: -3.4%
    +2.2% Q4'25: +5.0% (vs Q4'24)
  • Debt / EBITDA Net debt/EBITDA · Biotechnology: 0.16×
    0.00× Q4'25: 0.00× (vs Q4'24)
Valuation Multiples From To
DCF Interactive Model (UFCF)
Projection years:
Market assumptions
WACC components (optional)
Ke (Cost of Equity) = Rf + β (1.25) × ERP
WACC = 100% × Ke + 0% × Kd (4.1%) × (1−t)

Modifying these values recalculates WACC automatically.

Business assumptions
Intrinsic value (base): 1.17 Current price: 2.45
Enterprise Value: Equity Value: Terminal Value: TV as % of EV:

Base values reflect the latest available data for this company and market conditions.

Consensus Estimates
Metric Sep 2024
actual
Sep 2025
actual
Sep 2026
2 Rev. Ana.
1 EPS Ana.
Sep 2027
2 Rev. Ana.
1 EPS Ana.
Sep 2028
1 Rev. Ana.
1 EPS Ana.
Sep 2029
1 Rev. Ana.
1 EPS Ana.
Sep 2030
1 Rev. Ana.
1 EPS Ana.
Revenue
est: 9.40M (-100.0%)
est: 14.38M (-100.0%)
776.00M
776.00M – 776.00M
+5,297.1% YoY
1.21B
1.21B – 1.21B
+55.9% YoY
348.57M
348.57M – 348.57M
-71.2% YoY
713.06M
713.06M – 713.06M
+104.6% YoY
885.11M
885.11M – 885.11M
+24.1% YoY
EBITDA
-43.00M
-46.38M
— – —
— – —
— – —
— – —
— – —
EBIT
-43.00M
-46.38M
— – —
— – —
— – —
— – —
— – —
Net Income
-43.00M
est: -46.34M (+7.2%)
-46.38M
est: -49.18M (+5.7%)
-27.86M
-27.86M – -27.86M
+43.4% YoY
-12.14M
-12.14M – -12.14M
+56.4% YoY
193.53M
193.53M – 193.53M
+1,694.6% YoY
397.45M
397.45M – 397.45M
+105.4% YoY
446.06M
446.06M – 446.06M
+12.2% YoY
SGA
11.04M
13.82M
— – —
— – —
— – —
— – —
— – —
EPS
-0.52
est: -0.54 (+4.3%)
-0.54
est: -0.58 (+6.4%)
-0.33
-0.33 – -0.33
+43.4% YoY
-0.14
-0.14 – -0.14
+56.4% YoY
2.27
2.27 – 2.27
+1,694.6% YoY
4.66
4.66 – 4.66
+105.4% YoY
5.23
5.23 – 5.23
+12.2% YoY
Historical Ratings (3M)
Date Rating Overall DCF ROE ROA D/E P/E P/B
2026-05-12 C 2/5 3/5 1/5 1/5 1/5 1/5 3/5
2026-05-11 C 2/5 3/5 1/5 1/5 1/5 1/5 3/5
2026-05-08 C 2/5 3/5 1/5 1/5 1/5 1/5 3/5
2026-05-07 C 2/5 3/5 1/5 1/5 1/5 1/5 3/5
2026-05-06 C 2/5 3/5 1/5 1/5 1/5 1/5 3/5
2026-05-05 C 2/5 3/5 1/5 1/5 1/5 1/5 3/5
2026-05-04 C 2/5 3/5 1/5 1/5 1/5 1/5 3/5
2026-05-01 C 2/5 3/5 1/5 1/5 1/5 1/5 3/5
2026-04-30 C 2/5 3/5 1/5 1/5 1/5 1/5 3/5
2026-04-29 C 2/5 3/5 1/5 1/5 1/5 1/5 3/5
2026-04-28 C 2/5 3/5 1/5 1/5 1/5 1/5 3/5
2026-04-27 C 2/5 3/5 1/5 1/5 1/5 1/5 3/5
2026-04-24 C 2/5 3/5 1/5 1/5 1/5 1/5 3/5
2026-04-23 C 2/5 3/5 1/5 1/5 1/5 1/5 3/5
2026-04-22 C 2/5 3/5 1/5 1/5 1/5 1/5 3/5
2026-04-21 C 2/5 3/5 1/5 1/5 1/5 1/5 3/5
2026-04-20 C 2/5 3/5 1/5 1/5 1/5 1/5 3/5
2026-04-17 C 2/5 3/5 1/5 1/5 1/5 1/5 3/5
2026-04-16 C 2/5 3/5 1/5 1/5 1/5 1/5 3/5

Owner Earnings

Owner's Earnings (history) From To
Owner alignment
Owner's Earnings TTM
-30.38M
OE per share TTM
-0.44
Owner's Yield
-11.15%
Maintenance CapEx ratio
Maint CapEx / Avg PPE
-0.2%

Ownership Overview

Ownership breakdown
At a glance
Institutional holders
76
Total invested
27.65M
Insider transactions (90d)
0
Beneficial owners (>5%)
9
Beneficial owners (>5%)
# Reporting person Amount owned % of class Sole voting Shared voting Sole dispositive Shared dispositive Type Citizenship Filing date SEC filing
1 (1) BlackRock, Inc. 5.26M 6.90% 5.20M 5.26M HC Delaware 2022-02-03
2 The Vanguard Group - 23-1945930 3.84M 5.05% 3.65M IA Pennsylvania 2022-02-09
3 STATE STREET CORPORATION 3.83M 5.04% 3.71M 3.83M HC 2022-02-09
4 DAFNA Capital Management, LLC 0.00% IA Delaware 2016-02-16
5 Fariba Ghodsian 0.00% HC, IN United States of America 2016-02-16
6 Nathan Fischel 0.00% HC, IN Austria citizen (U.S. permanent resident) 2016-02-16
7 Park West Asset Management LLC 0.00% IA (4) Citizenship or Place of Organization 2021-02-16
8 Park West Investors Master Fund, Limited 0.00% CO (4) Citizenship or Place of Organization 2021-02-16
9 Peter S. Park 0.00% IN (4) Citizenship or Place of Organization 2021-02-16

Institutional Activity (13F)

Institutional ownership trend From To
13F snapshot — 2026 Q1
Investors holding
76
-121 vs prev Q
New positions
10
Closed positions
120
Increased
39
Reduced
18
Put/Call ratio
0.00
Calls held
Puts held
Top institutional holders
# Investor Shares / Δ Mkt value / Δ Own% / Δ Weight% / Δ Avg px / Perf. Hold / Status
1 BLACKROCK, INC. 7.53M +337.9K (+4.7%) 26.79M -37.2M (-58.1%) 8.45% +0.034 pp 0.00% -0.001 pp USD5.86 -39.2% 6 qtrs
2 VANGUARD GROUP INC 5.03M -76.0K (-1.5%) 17.90M -27.5M (-60.6%) 5.65% -0.330 pp 0.00% 0.000 pp USD7.90 -54.9% 41 qtrs
3 STATE STREET CORP 4.38M +1.1M (+33.4%) 15.60M -13.7M (-46.7%) 4.92% +1.074 pp 0.00% -0.001 pp USD7.57 -53.0% 41 qtrs
4 GEODE CAPITAL MANAGEMENT, LLC 2.02M -4.4K (-0.2%) 7.20M -10.8M (-60.1%) 2.27% -0.102 pp 0.00% -0.001 pp USD8.76 -59.4% 41 qtrs
5 TWO SIGMA INVESTMENTS, LP 1.65M +616.7K (+59.5%) 5.89M -3.3M (-36.2%) 1.86% +0.643 pp 0.01% -0.005 pp USD4.99 -28.7% 16 qtrs
6 NWAM LLC 870.8K -3.5K (-0.4%) 4.37M -3.8M (-46.6%) 1.02% -0.003 pp 0.24% -0.200 pp USD6.02 -40.9% 12 qtrs
7 TWO SIGMA ADVISERS, LP 1.21M +451.1K (+59.5%) 4.31M -2.4M (-36.2%) 1.36% +0.470 pp 0.01% -0.005 pp USD5.22 -31.8% 16 qtrs
8 SUMMIT FINANCIAL, LLC 903.4K +459.1K (+103.3%) 3.22M -737.9K (-18.7%) 1.01% +0.494 pp 0.05% -0.013 pp USD6.27 -43.2% 3 qtrs
9 GOLDMAN SACHS GROUP INC 873.0K +569.6K (+187.7%) 3.11M +407.6K (+15.1%) 0.98% +0.625 pp 0.00% +0.000 pp USD4.94 -27.9% 24 qtrs
10 JANE STREET GROUP, LLC 769.0K +550.7K (+252.4%) 2.74M +795.3K (+41.0%) 0.86% +0.608 pp 0.00% +0.000 pp USD5.08 -29.9% 22 qtrs
11 NORTHERN TRUST CORP 738.2K -34.8K (-4.5%) 2.63M -4.3M (-61.8%) 0.83% -0.076 pp 0.00% -0.001 pp USD5.70 -37.5% 41 qtrs
12 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 669.0K -48.4K (-6.7%) 2.38M -4.0M (-62.7%) 0.75% -0.089 pp 0.00% -0.001 pp USD12.45 -71.4% 28 qtrs
13 LPL FINANCIAL LLC 528.8K -5.5K (-1.0%) 1.88M -2.9M (-60.4%) 0.59% -0.032 pp 0.00% -0.001 pp USD8.98 -60.4% 19 qtrs
14 BANK OF AMERICA CORP /DE/ 524.2K +353.3K (+206.7%) 1.87M +345.2K (+22.7%) 0.59% +0.389 pp 0.00% +0.000 pp USD4.90 -27.3% 41 qtrs
15 BARCLAYS PLC 493.2K +338.0K (+217.8%) 1.76M +874.3K (+99.2%) 0.55% +0.372 pp 0.00% +0.000 pp USD5.06 -29.6% 28 qtrs
16 MORGAN STANLEY 474.9K -85.3K (-15.2%) 1.69M -3.3M (-66.1%) 0.53% -0.123 pp 0.00% 0.000 pp USD8.50 -58.1% 41 qtrs
17 UBS GROUP AG 459.4K -32.6K (-6.6%) 1.64M -2.7M (-62.6%) 0.52% -0.060 pp 0.00% 0.000 pp USD9.33 -61.8% 41 qtrs
18 PRIVATE ADVISOR GROUP, LLC 419.8K -35.3K (-7.8%) 1.49M -2.6M (-63.1%) 0.47% -0.062 pp 0.01% -0.013 pp USD8.94 -60.2% 16 qtrs
19 QUBE RESEARCH & TECHNOLOGIES LTD 388.7K +388.7K (+100.0%) 1.38M +1.4M (+100.0%) 0.44% +0.437 pp 0.00% +0.001 pp USD3.56 +0.0% 1 qtrs NEW
20 FEDERATED HERMES, INC. 367.8K +367.8K (+100.0%) 1.31M +1.3M (+100.0%) 0.41% +0.413 pp 0.00% +0.002 pp USD3.56 +0.0% 3 qtrs
21 SUSQUEHANNA INTERNATIONAL GROUP, LLP 364.5K -332.9K (-47.7%) 1.30M -4.9M (-79.1%) 0.41% -0.407 pp 0.00% -0.001 pp USD9.08 -60.8% 41 qtrs
22 CAPTION MANAGEMENT, LLC 354.8K +354.8K (+100.0%) 1.26M +1.3M (+100.0%) 0.40% +0.399 pp 0.01% +0.009 pp USD3.56 +0.0% 1 qtrs NEW
23 NATIONAL BANK OF CANADA /FI/ 305.2K -88.0K (-22.4%) 1.09M -2.4M (-68.9%) 0.34% -0.118 pp 0.00% -0.003 pp USD8.68 -59.0% 17 qtrs
24 POINT72 ASSET MANAGEMENT, L.P. 278.0K +278.0K (+100.0%) 989.7K +989.7K (+100.0%) 0.31% +0.312 pp 0.00% +0.001 pp USD3.56 +0.0% 1 qtrs NEW
25 WELLINGTON MANAGEMENT GROUP LLP 272.2K -16.6K (-5.7%) 969.1K -1.6M (-62.3%) 0.31% -0.033 pp 0.00% 0.000 pp USD9.89 -64.0% 5 qtrs
26 BANK OF NEW YORK MELLON CORP 244.1K -4.0K (-1.6%) 868.8K -1.3M (-60.6%) 0.27% -0.016 pp 0.00% 0.000 pp USD8.43 -57.8% 41 qtrs
27 CITADEL ADVISORS LLC 222.1K +141.6K (+175.9%) 790.7K +74.2K (+10.4%) 0.25% +0.155 pp 0.00% +0.000 pp USD5.42 -34.3% 37 qtrs
28 PVG ASSET MANAGEMENT CORP 216.3K +83.1K (+62.4%) 770.0K -415.0K (-35.0%) 0.25% +0.098 pp 1.64% -2.725 pp USD7.25 -50.9% 6 qtrs
29 MARSHALL WACE, LLP 182.2K +— (+0.0%) 648.6K -972.9K (-60.0%) 0.20% -0.009 pp 0.00% -0.001 pp USD10.25 -65.3% 7 qtrs
30 NUVEEN, LLC 168.4K +— (+0.0%) 599.4K -899.1K (-60.0%) 0.19% -0.008 pp 0.00% 0.000 pp USD8.58 -58.5% 4 qtrs
31 SWISS NATIONAL BANK 164.4K +— (+0.0%) 585.3K -877.9K (-60.0%) 0.18% -0.008 pp 0.00% -0.001 pp USD8.58 -58.5% 4 qtrs
32 UBS ASSET MANAGEMENT AMERICAS INC 162.1K +71.0 (+0.0%) 577.2K -865.1K (-60.0%) 0.18% -0.008 pp 0.00% 0.000 pp USD8.94 -60.2% 4 qtrs
33 RAFFERTY ASSET MANAGEMENT, LLC 156.3K +47.9K (+44.2%) 556.4K -408.6K (-42.3%) 0.18% +0.049 pp 0.00% -0.001 pp USD6.66 -46.5% 20 qtrs
34 SCULPTOR CAPITAL LP 155.9K +— (+0.0%) 555.0K -832.5K (-60.0%) 0.18% -0.008 pp 0.01% -0.011 pp USD9.22 -61.4% 8 qtrs
35 GSA CAPITAL PARTNERS LLP 155.9K +92.8K (+147.1%) 555.0K -6.0K (-1.1%) 0.18% +0.101 pp 0.05% +0.001 pp USD5.72 -37.8% 8 qtrs
36 AQR CAPITAL MANAGEMENT LLC 149.8K +121.8K (+434.4%) 533.3K +283.8K (+113.7%) 0.17% +0.135 pp 0.00% +0.000 pp USD3.94 -9.6% 24 qtrs
37 DIADEMA PARTNERS LP 140.6K +800.0 (+0.6%) 500.5K -743.7K (-59.8%) 0.16% -0.006 pp 0.09% -0.232 pp USD8.87 -59.9% 2 qtrs
38 APELLA CAPITAL, LLC 138.0K +38.5K (+38.7%) 491.3K -405.4K (-45.2%) 0.16% +0.045 pp 0.01% -0.010 pp USD7.18 -50.4% 4 qtrs
39 WELLS FARGO & COMPANY/MN 133.8K +20.0K (+17.5%) 476.4K -537.0K (-53.0%) 0.15% +0.017 pp 0.00% 0.000 pp USD7.18 -50.4% 41 qtrs
40 SHEETS SMITH WEALTH MANAGEMENT 117.7K +117.7K (+100.0%) 419.0K +419.0K (+100.0%) 0.14% +0.138 pp 0.05% +0.046 pp USD3.56 +0.0% 1 qtrs NEW
41 180 WEALTH ADVISORS, LLC 117.4K +74.3K (+172.8%) 417.9K +34.9K (+9.1%) 0.14% +0.087 pp 0.05% +0.001 pp USD5.56 -36.0% 4 qtrs
42 ALLIANCEBERNSTEIN L.P. 115.2K +— (+0.0%) 410.1K -615.2K (-60.0%) 0.13% -0.006 pp 0.00% 0.000 pp USD13.44 -73.5% 24 qtrs
43 RHUMBLINE ADVISERS 107.4K -16.6K (-13.4%) 382.3K -721.2K (-65.4%) 0.12% -0.025 pp 0.00% -0.001 pp USD8.17 -56.4% 27 qtrs
44 STIFEL FINANCIAL CORP 101.0K +49.2K (+95.1%) 359.6K -101.3K (-22.0%) 0.11% +0.053 pp 0.00% 0.000 pp USD6.16 -42.2% 4 qtrs
45 XTX TOPCO LTD 99.1K +17.4K (+21.2%) 352.6K -374.5K (-51.5%) 0.11% +0.016 pp 0.01% -0.029 pp USD7.96 -55.3% 2 qtrs
46 CANADA PENSION PLAN INVESTMENT BOARD 95.9K +95.9K (+100.0%) 341.4K +341.4K (+100.0%) 0.11% +0.108 pp 0.00% +0.000 pp USD3.56 +0.0% 1 qtrs NEW
47 ENVESTNET ASSET MANAGEMENT INC 87.7K +27.7K (+46.3%) 312.1K -221.4K (-41.5%) 0.10% +0.028 pp 0.00% 0.000 pp USD6.40 -44.4% 6 qtrs
48 LEGAL & GENERAL GROUP PLC 86.9K +35.0 (+0.0%) 309.7K -463.4K (-59.9%) 0.10% -0.004 pp 0.00% 0.000 pp USD8.88 -59.9% 27 qtrs
49 HIKARI POWER LTD 85.6K +— (+0.0%) 305.0K -457.0K (-60.0%) 0.10% +0.000 pp 0.02% -0.037 pp USD2.64 +34.8% 29 qtrs
50 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 78.0K -350.0 (-0.4%) 277.7K -419.7K (-60.2%) 0.09% -0.004 pp 0.00% 0.000 pp USD8.44 -57.8% 27 qtrs
51 ALPS ADVISORS INC 73.4K +34.8K (+90.0%) 261.2K -82.4K (-24.0%) 0.08% +0.037 pp 0.00% 0.000 pp USD8.47 -58.0% 17 qtrs
52 CREATIVE PLANNING 72.7K -4.4K (-5.7%) 259.0K -427.5K (-62.3%) 0.08% -0.009 pp 0.00% 0.000 pp USD9.00 -60.4% 17 qtrs
53 FRANKLIN RESOURCES INC 72.6K -302.7K (-80.7%) 258.3K -10.8M (-97.7%) 0.08% -0.358 pp 0.00% -0.003 pp USD8.39 -57.6% 11 qtrs
54 DEUTSCHE BANK AG\ 69.5K -3.1K (-4.3%) 247.6K -399.2K (-61.7%) 0.08% -0.004 pp 0.00% 0.000 pp USD10.33 -65.5% 41 qtrs
55 AMERIPRISE FINANCIAL INC 68.5K -17.3K (-20.1%) 243.9K -519.6K (-68.1%) 0.08% -0.024 pp 0.00% 0.000 pp USD8.29 -57.1% 26 qtrs
56 GLADSTONE INSTITUTIONAL ADVISORY LLC 68.5K +9.0K (+15.1%) 243.9K -285.9K (-54.0%) 0.08% +0.007 pp 0.01% -0.011 pp USD8.96 -60.3% 5 qtrs
57 CARNEGIE CAPITAL ASSET MANAGEMENT, LLC 67.6K -15.2K (-18.4%) 240.6K -496.1K (-67.3%) 0.08% -0.018 pp 0.00% -0.009 pp USD8.74 -59.3% 13 qtrs
58 ZURCHER KANTONALBANK (ZURICH CANTONALBANK) 64.9K +21.1K (+48.2%) 231.2K -158.7K (-40.7%) 0.08% +0.025 pp 0.00% 0.000 pp USD7.35 -51.6% 19 qtrs
59 PNC FINANCIAL SERVICES GROUP, INC. 63.7K -341.0 (-0.5%) 226.7K -343.1K (-60.2%) 0.07% -0.004 pp 0.00% 0.000 pp USD7.59 -53.1% 19 qtrs
60 SIG BROKERAGE, LP 62.0K +— (+0.0%) 220.7K -331.1K (-60.0%) 0.07% -0.003 pp 0.01% -0.009 pp USD8.85 -59.8% 4 qtrs
61 PROFUND ADVISORS LLC 58.0K +34.1K (+142.6%) 206.4K -6.3K (-3.0%) 0.07% +0.040 pp 0.01% -0.001 pp USD5.21 -31.7% 12 qtrs
62 JPMORGAN CHASE & CO 56.5K +11.5K (+25.5%) 201.3K -199.8K (-49.8%) 0.07% +0.013 pp 0.00% +0.000 pp USD9.09 -60.8% 27 qtrs
63 SQUAREPOINT OPS LLC 56.4K +56.4K (+100.0%) 200.7K +200.7K (+100.0%) 0.06% +0.063 pp 0.00% +0.000 pp USD3.56 +0.0% 14 qtrs
64 FOSTER VICTOR WEALTH ADVISORS, LLC 39.9K -553.0 (-1.4%) 200.0K -203.1K (-50.4%) 0.05% -0.001 pp 0.01% -0.013 pp USD9.11 -60.9% 26 qtrs
65 MAN GROUP PLC 55.2K +30.8K (+126.5%) 196.6K -20.4K (-9.4%) 0.06% +0.034 pp 0.00% +0.000 pp USD5.92 -39.9% 2 qtrs
66 BREVAN HOWARD CAPITAL MANAGEMENT LP 54.7K +37.5K (+217.7%) 194.8K +41.5K (+27.1%) 0.06% +0.041 pp 0.00% +0.001 pp USD5.24 -32.1% 4 qtrs
67 INDEPENDENT ADVISOR ALLIANCE 50.1K +2.3K (+4.8%) 178.3K -247.1K (-58.1%) 0.06% +0.003 pp 0.00% -0.007 pp USD7.84 -54.6% 12 qtrs
68 MIRAE ASSET GLOBAL ETFS HOLDINGS LTD. 47.9K +3.8K (+8.7%) 172.8K -218.1K (-55.8%) 0.05% +0.002 pp 0.00% 0.000 pp USD4.48 -20.5% 7 qtrs
69 GENEOS WEALTH MANAGEMENT INC. 48.2K +5.8K (+13.7%) 171.6K -205.8K (-54.5%) 0.06% +0.007 pp 0.00% -0.005 pp USD6.90 -48.4% 30 qtrs
70 PRICE T ROWE ASSOCIATES INC /MD/ 46.3K +669.0 (+1.5%) 165.0K -241.0K (-59.4%) 0.05% -0.001 pp 0.00% +0.000 pp USD8.31 -57.2% 38 qtrs
71 OCTOBER EFFECT LTD 46.3K -198.9K (-81.1%) 164.8K -2.0M (-92.5%) 0.05% -0.233 pp 0.18% -2.224 pp USD9.05 -60.7% 3 qtrs
72 SCHONFELD STRATEGIC ADVISORS LLC 46.2K +46.2K (+100.0%) 164.5K +164.5K (+100.0%) 0.05% +0.052 pp 0.00% +0.001 pp USD3.56 +0.0% 1 qtrs NEW
73 QUANTINNO CAPITAL MANAGEMENT LP 45.7K +11.4K (+33.4%) 162.7K -142.3K (-46.7%) 0.05% +0.011 pp 0.00% -0.001 pp USD7.43 -52.1% 4 qtrs
74 INVESCO LTD. 45.5K -11.2K (-19.8%) 161.9K -342.7K (-67.9%) 0.05% -0.015 pp 0.00% 0.000 pp USD10.23 -65.2% 23 qtrs
75 D. E. SHAW & CO., INC. 45.0K +45.0K (+100.0%) 160.2K +160.2K (+100.0%) 0.05% +0.051 pp 0.00% +0.000 pp USD3.56 +0.0% 1 qtrs NEW
76 CETERA INVESTMENT ADVISERS 42.9K +14.6K (+51.7%) 152.6K -98.9K (-39.3%) 0.05% +0.015 pp 0.00% 0.000 pp USD7.52 -52.7% 5 qtrs
77 SNOWDEN CAPITAL ADVISORS LLC 42.7K +42.7K (+100.0%) 152.1K +152.1K (+100.0%) 0.05% +0.048 pp 0.00% +0.004 pp USD3.56 +0.0% 1 qtrs NEW
78 MANUFACTURERS LIFE INSURANCE COMPANY, THE 39.5K -2.2K (-5.3%) 140.7K -230.7K (-62.1%) 0.04% -0.005 pp 0.00% 0.000 pp USD10.40 -65.8% 27 qtrs
79 MARINER, LLC 38.8K +12.5K (+47.3%) 138.2K -96.4K (-41.1%) 0.04% +0.013 pp 0.00% 0.000 pp USD7.19 -50.5% 2 qtrs
80 OPUS CAPITAL GROUP, LLC 37.7K +3.0K (+8.6%) 134.0K -175.0K (-56.6%) 0.04% +0.004 pp 0.01% -0.020 pp USD8.61 -58.7% 22 qtrs
81 JANUS HENDERSON GROUP PLC 37.0K +— (+0.0%) 131.9K -197.2K (-59.9%) 0.04% -0.002 pp 0.00% 0.000 pp USD8.58 -58.5% 4 qtrs
82 INTECH INVESTMENT MANAGEMENT LLC 36.9K +— (+0.0%) 131.5K -197.3K (-60.0%) 0.04% -0.002 pp 0.00% -0.002 pp USD8.37 -57.5% 6 qtrs
83 METLIFE INVESTMENT MANAGEMENT, LLC 35.7K -8.9K (-19.9%) 127.2K -269.8K (-68.0%) 0.04% -0.012 pp 0.00% -0.001 pp USD8.90 -60.0% 23 qtrs
84 LMR PARTNERS LLP 35.2K +35.2K (+100.0%) 125.3K +125.3K (+100.0%) 0.04% +0.040 pp 0.00% +0.000 pp USD3.56 +0.0% 1 qtrs NEW
85 WALLEYE CAPITAL LLC 35.0K +35.0K (+100.0%) 124.6K +124.6K (+100.0%) 0.04% +0.039 pp 0.00% +0.000 pp USD3.56 +0.0% 1 qtrs NEW
86 CHOREO, LLC 32.0K -957.0 (-2.9%) 121.6K -171.7K (-58.5%) 0.04% -0.001 pp 0.00% -0.002 pp USD8.79 -59.5% 4 qtrs
87 BANK OF MONTREAL /CAN/ 32.4K +9.5K (+41.3%) 115.5K -88.8K (-43.5%) 0.04% +0.010 pp 0.00% +0.000 pp USD5.67 -37.2% 12 qtrs
88 ADVISOR GROUP HOLDINGS, INC. 31.7K -10.7K (-25.2%) 113.0K -287.1K (-71.8%) 0.04% -0.014 pp 0.00% 0.000 pp USD9.44 -62.3% 24 qtrs
89 FORUM FINANCIAL MANAGEMENT, LP 30.1K +— (+0.0%) 107.3K -160.9K (-60.0%) 0.04% +0.000 pp 0.00% -0.002 pp USD8.58 -58.5% 6 qtrs
90 HSBC HOLDINGS PLC 28.8K +28.8K (+100.0%) 103.6K +103.6K (+100.0%) 0.03% +0.032 pp 0.00% +0.000 pp USD3.56 +0.0% 1 qtrs NEW
91 NEWEDGE ADVISORS, LLC 28.2K +26.6K (+1,636.2%) 100.5K +86.0K (+594.5%) 0.03% +0.030 pp 0.00% +0.000 pp USD3.89 -8.5% 3 qtrs
92 DIMENSIONAL FUND ADVISORS LP 27.2K +27.2K (+100.0%) 96.9K +96.9K (+100.0%) 0.03% +0.031 pp 0.00% +0.000 pp USD3.56 +0.0% 9 qtrs
93 CITIGROUP INC 25.6K +14.2K (+123.2%) 91.3K -11.0K (-10.7%) 0.03% +0.015 pp 0.00% +0.000 pp USD5.57 -36.1% 39 qtrs
94 AXQ CAPITAL, LP 25.0K +5.9K (+30.9%) 89.0K -81.0K (-47.7%) 0.03% +0.007 pp 0.02% -0.045 pp USD7.64 -53.4% 4 qtrs
Ownership breakdown by holder

ETF Ownership

Top ETFs holding this stock Held by 63 ETFs in our universe
# ETF Weight Est. AUM exposure TER
1 ALPS Medical Breakthroughs ETF SBIO 0.12% 253.0K 0.50%
2 iShares Micro-Cap ETF IWC 0.05% 775.1K 0.60%
3 iShares U.S. Small-Cap Equity Factor ETF SMLF 0.03% 1.04M 0.15%
4 iShares Biotechnology ETF IBB 0.02% 1.61M 0.44%
5 iShares Nasdaq US Biotechnology UCITS ETF BTEC.L 0.02% 188.0K 0.35%
6 iShares Nasdaq US Biotechnology UCITS ETF BTEE.L 0.02% 12.6K 0.35%
7 Invesco NASDAQ Biotech UCITS ETF SBIO.L 0.02% 73.7K 0.40%
8 Invesco Nasdaq Biotechnology ETF IBBQ 0.02% 11.9K 0.19%
9 Vanguard Russell 2000 Growth ETF VTWG 0.01% 246.2K 0.06%
10 iShares Russell 2000 Value ETF IWN 0.01% 1.82M 0.24%

Insider Activity

Insider Activity — Latest Quarter
Ratio by transactions
0.00
Bearish
Buys
2
Sells
0
Shares acquired
137.5K
Shares disposed
Cash buys
Cash sales
Net activity
+137,500
Insider buys vs sells (history) From To
Recent insider transactions From To
Date Person Role Transaction A/D Security Shares Price Value Owned after D/I Filing
2026-02-23 Paeger Axel Director 0 0.00 0
2026-01-06 MISSLING CHRISTOPHER U Director / Officer A-Award A Stock Option (Right to Buy) 125,000 8.58 1.07M 125,000 D
2026-01-06 Boenisch Sandra Officer A-Award A Stock Option (Right to Buy) 12,500 8.58 107.3K 12,500 D
2025-10-02 MISSLING CHRISTOPHER U Director / Officer A-Award A Stock Option (Right to Buy) 125,000 5.36 670.0K 250,000 D
2025-10-02 Boenisch Sandra Officer A-Award A Stock Option (Right to Buy) 12,500 5.36 67.0K 25,000 D
2025-09-11 MISSLING CHRISTOPHER U Director / Officer M-Exempt A Common Stock 187,500 5.04 945.0K 1,655,213 D
2025-08-20 MISSLING CHRISTOPHER U Director / Officer A-Award A Stock Option (Right to Buy) 125,000 8.58 1.07M 125,000 D
2025-08-20 Boenisch Sandra Officer A-Award A Stock Option (Right to Buy) 12,500 8.58 107.3K 12,500 D
2025-06-05 Thomas Steffen Director M-Exempt A Common stock 50,000 1.76 88.0K 55,000 D
2025-04-28 MISSLING CHRISTOPHER U Director / Officer A-Award A Stock Option (Right to Buy) 125,000 8.57 1.07M 125,000 D
2025-04-28 Boenisch Sandra Officer A-Award A Stock Option (Right to Buy) 12,500 8.57 107.1K 12,500 D
2025-03-31 Velden Claus Vander Director A-Award A Stock Option (Right to Buy) 50,000 8.58 429.0K 50,000 D
2025-03-31 Thomas Steffen Director A-Award A Stock Option (Right to Buy) 50,000 8.58 429.0K 50,000 D
2025-03-31 Skarpelos Athanasios Director A-Award A Stock Option (Right to Buy) 50,000 8.58 429.0K 50,000 D
2025-03-31 Ma Jiong Director A-Award A Stock Option (Right to Buy) 50,000 8.58 429.0K 50,000 D
2025-03-31 Donhauser Peter D.O. Director A-Award A Stock Option (Right to Buy) 50,000 8.58 429.0K 50,000 D
2025-03-24 MISSLING CHRISTOPHER U Director / Officer M-Exempt A Common Stock 500,000 0.92 460.0K 1,750,210 D
2025-01-15 MISSLING CHRISTOPHER U Director / Officer A-Award A Stock Option (Right to Buy) 166,666 7.54 1.26M 166,000 D
2025-01-15 Boenisch Sandra Officer A-Award A Stock Option (Right to Buy) 12,500 8.57 107.1K 12,500 D
2024-12-19 MISSLING CHRISTOPHER U Director / Officer A-Award A Stock Option (Right to Buy) 125,000 5.36 670.0K 125,000 D
2024-12-19 Boenisch Sandra Officer A-Award A Stock Option (Right to Buy) 12,500 5.36 67.0K 12,500 D
2024-11-19 MISSLING CHRISTOPHER U Director / Officer A-Award A Stock Option (Right to Buy) 125,000 10.09 1.26M 250,000 D
2024-11-19 Boenisch Sandra Officer A-Award A Stock Option (Right to Buy) 10,000 10.09 100.9K 20,000 D
2024-06-14 Donhauser Peter D.O. Director P-Purchase A Common Stock 2,835 3.64 10.3K 5,000
2024-05-15 Thomas Steffen Director P-Purchase A Common Stock 5,000 4.52 22.6K 5,000
2024-03-28 MISSLING CHRISTOPHER U Director / Officer M-Exempt A Common Stock 73,380 1.32 96.9K 1,323,590
2024-02-20 Velden Claus Vander Director A-Award A Stock Option (Right to Buy) 50,000 5.36 268.0K 50,000
2024-02-20 Thomas Steffen Director A-Award A Stock Option (Right to Buy) 50,000 5.36 268.0K 50,000
2024-02-20 Skarpelos Athanasios Director A-Award A Stock Option (Right to Buy) 50,000 5.36 268.0K 50,000
2024-02-20 Ma Jiong Director A-Award A Stock Option (Right to Buy) 50,000 5.36 268.0K 50,000
2024-02-20 Donhauser Peter D.O. Director A-Award A Stock Option (Right to Buy) 50,000 5.36 268.0K 50,000
2024-01-02 MISSLING CHRISTOPHER U Director / Officer A-Award D Stock Option (Right to Buy) 125,000 10.09 1.26M 125,000
2024-01-02 Boenisch Sandra Officer A-Award A Stock Option (Right to Buy) 10,000 10.09 100.9K 10,000
2023-06-29 MISSLING CHRISTOPHER U Director / Officer M-Exempt D Stock Option (Right to Buy) 232,000 1.60 371.2K 0
2023-06-28 MISSLING CHRISTOPHER U Director / Officer S-Sale D Common Stock 268,000 7.98 2.14M 1,018,210
2023-03-31 Velden Claus Vander Director A-Award A Stock Option (Right to Buy) 50,000 8.57 428.5K 50,000
2023-03-31 Thomas Steffen Director A-Award A Stock Option (Right to Buy) 50,000 8.57 428.5K 50,000
2023-03-31 Skarpelos Athanasios Director A-Award A Stock Option (Right to Buy) 50,000 8.57 428.5K 50,000
2023-03-31 Ma Jiong Director A-Award A Stock Option (Right to Buy) 50,000 8.57 428.5K 50,000
2023-03-31 Donhauser Peter D.O. Director A-Award A Stock Option (Right to Buy) 50,000 8.57 428.5K 50,000
2022-06-27 Velden Claus Vander Director A-Award A Stock Option (Right to Buy) 50,000 0.00 50,000
2022-06-27 Thomas Steffen Director A-Award A Stock Option (Right to Buy) 50,000 0.00 50,000
2022-06-27 Skarpelos Athanasios Director A-Award A Stock Option (Right to Buy) 50,000 0.00 50,000
2022-06-27 Ma Jiong Director A-Award A Stock Option (Right to Buy) 50,000 0.00 50,000
2022-06-27 Donhauser Peter D.O. Director A-Award A Stock Option (Right to Buy) 50,000 10.09 504.5K 50,000
2022-05-25 Skarpelos Athanasios Director S-Sale D Common Stock 50,000 9.06 453.0K 1,306,458
2021-08-02 Velden Claus Vander Director A-Award A Stock Option (Right to Buy) 25,000 18.11 452.8K 25,000
2021-08-02 Thomas Steffen Director A-Award A Stock Option (Right to Buy) 25,000 18.11 452.8K 25,000
2021-08-02 Skarpelos Athanasios Director A-Award A Stock Option (Right to Buy) 25,000 18.11 452.8K 25,000
2021-08-02 Ma Jiong Director A-Award A Stock Option (Right to Buy) 25,000 18.11 452.8K 25,000
2021-08-02 MISSLING CHRISTOPHER U Director / Officer A-Award A Stock Option (Right to Buy) 500,000 18.11 9.06M 500,000
2021-08-02 Donhauser Peter D.O. Director A-Award A Stock Option (Right to Buy) 25,000 18.11 452.8K 25,000
2021-08-02 Boenisch Sandra Officer A-Award A Stock Option (Right to Buy) 40,000 18.11 724.4K 40,000
2021-06-29 MISSLING CHRISTOPHER U Director / Officer M-Exempt D Stock Option (Right to Buy) 51,620 1.32 68.1K 73,380
2021-06-29 Boenisch Sandra Officer M-Exempt A Common Stock 106,696 3.28 350.0K 154,659
2021-06-02 Ma Jiong Director D Stock Option (Right to Buy) 35,000 13.01 455.4K 0
2021-05-21 FAVUS ELLIOT Director M-Exempt D Stock Option (Right to Buy) 1,500 5.66 8.5K 0
2021-05-17 Donhauser Peter D.O. Director P-Purchase A Common Stock 1,000 10.93 10.9K 2,165
2021-02-24 FAVUS ELLIOT Director M-Exempt D Stock Option (Right to Buy) 45,500 2.58 117.4K 0
2021-02-19 Donhauser Peter D.O. Director P-Purchase A Common Stock 165 12.97 2.1K 1,165
2020-12-30 Velden Claus Vander Director A-Award A Stock Option (Right to Buy) 35,000 5.49 192.2K 35,000
2020-12-30 Thomas Steffen Director A-Award A Stock Option (Right to Buy) 35,000 5.49 192.2K 35,000
2020-12-30 Skarpelos Athanasios Director A-Award A Stock Option (Right to Buy) 35,000 5.49 192.2K 35,000
2020-12-30 MISSLING CHRISTOPHER U Director / Officer A-Award A Stock Option (Right to Buy) 550,000 5.49 3.02M 550,000
2020-12-30 FAVUS ELLIOT Director A-Award A Stock Option (Right to Buy) 35,000 5.49 192.2K 35,000
2020-12-30 Donhauser Peter D.O. Director A-Award A Stock Option (Right to Buy) 35,000 5.49 192.2K 35,000
2020-12-30 Boenisch Sandra Officer A-Award A Stock Option (Right to Buy) 50,000 5.49 274.5K 50,000
2020-01-06 Velden Claus Vander Director A-Award A Stock Option (Right to Buy) 50,000 2.96 148.0K 50,000
2020-01-06 Thomas Steffen Director A-Award A Stock Option (Right to Buy) 50,000 2.96 148.0K 50,000
2020-01-06 Skarpelos Athanasios Director A-Award A Stock Option (Right to Buy) 50,000 2.96 148.0K 50,000
2020-01-06 MISSLING CHRISTOPHER U Director / Officer A-Award A Stock Option (Right to Buy) 550,000 2.96 1.63M 550,000
2020-01-06 FAVUS ELLIOT Director A-Award A Stock Option (Right to Buy) 50,000 2.96 148.0K 50,000
2020-01-06 Donhauser Peter D.O. Director A-Award A Stock Option (Right to Buy) 50,000 2.96 148.0K 50,000
2020-01-06 Boenisch Sandra Officer A-Award A Stock Option (Right to Buy) 70,000 2.96 207.2K 70,000
2019-06-04 Boenisch Sandra Officer A-Award A Stock Option (Right to Buy) 35,000 2.93 102.6K 35,000
2019-05-03 MISSLING CHRISTOPHER U Director / Officer A-Award A Stock Option (Right to Buy) 750,000 3.15 2.36M 750,000
2018-10-01 Velden Claus Vander Director A-Award A Stock Option (Right to Buy) 45,500 2.58 117.4K 45,500
2018-10-01 Thomas Steffen Director A-Award A Stock Option (Right to Buy) 45,500 2.58 117.4K 45,500
2018-10-01 Skarpelos Athanasios Director A-Award A Stock Option (Right to Buy) 45,500 2.58 117.4K 45,500
2018-10-01 MISSLING CHRISTOPHER U Director / Officer A-Award A Stock Option (Right to Buy) 409,500 2.58 1.06M 409,500
2018-10-01 FAVUS ELLIOT Director A-Award A Stock Option (Right to Buy) 45,500 2.58 117.4K 45,500
2018-10-01 Donhauser Peter D.O. Director A-Award A Stock Option (Right to Buy) 45,500 2.58 117.4K 45,500
2018-10-01 Boenisch Sandra Officer A-Award A Stock Option (Right to Buy) 27,300 2.58 70.4K 27,300
2018-05-15 MISSLING CHRISTOPHER U Director / Officer A-Award A Stock Option (Right to Buy) 450,000 2.30 1.04M 450,000
2018-05-15 Boenisch Sandra Officer A-Award A Stock Option (Right to Buy) 30,000 2.30 69.0K 30,000
2018-03-07 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common Stock 1,360 2.92 4.0K 1,018,210
2018-03-06 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common Stock 1,450 2.73 4.0K 1,016,850
2018-03-05 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common Stock 1,500 2.63 3.9K 1,015,400
2018-03-02 Velden Claus Vander Director D Stock Option (Right to Buy) 50,000 2.60 130.0K 0
2018-03-02 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common Stock 1,650 2.41 4.0K 1,013,900
2017-12-13 MISSLING CHRISTOPHER U Director / Officer A-Award A Stock Option (Right to Buy) 400,000 3.30 1.32M 400,000
2017-12-13 Boenisch Sandra Officer A-Award A Stock Option (Right to Buy) 30,000 3.30 99.0K 30,000
2017-10-25 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common Stock 375 4.39 1.6K 1,012,250
2017-10-24 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common Stock 375 4.92 1.8K 1,011,875
2017-10-19 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common Stock 375 4.49 1.7K 1,011,500
2017-10-17 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common Stock 375 4.27 1.6K 1,011,125
2017-10-13 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common Stock 750 4.22 3.2K 1,010,750
2017-10-05 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common Stock 375 4.30 1.6K 1,010,000
2017-10-02 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common Stock 375 4.20 1.6K 1,009,625
2017-09-28 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common Stock 375 4.21 1.6K 1,009,250
2017-09-26 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common Stock 375 3.88 1.5K 1,008,875
2017-09-20 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common Stock 375 4.23 1.6K 1,008,500
2017-09-18 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common Stock 375 4.40 1.7K 1,008,125
2017-09-14 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common Stock 375 4.58 1.7K 1,007,750
2017-09-11 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common Stock 375 4.81 1.8K 1,007,375
2017-09-07 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common Stock 375 4.76 1.8K 1,007,000
2017-09-05 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common Stock 375 4.90 1.8K 1,006,625
2017-08-31 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common Stock 375 4.48 1.7K 1,006,250
2017-08-28 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common Stock 375 4.44 1.7K 1,005,875
2017-08-24 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common Stock 375 4.54 1.7K 1,005,500
2017-08-21 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common Stock 375 4.07 1.5K 1,005,125
2017-08-18 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common Stock 375 3.81 1.4K 1,004,750
2017-08-14 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common Stock 375 3.70 1.4K 1,004,375
2017-08-11 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common Stock 750 3.55 2.7K 1,004,000
2017-05-12 MISSLING CHRISTOPHER U Director / Officer A-Award A Stock Option (Right to Buy) 450,000 5.92 2.66M 450,000
2017-05-12 Boenisch Sandra Officer A-Award A Stock Option (Right to Buy) 35,000 5.92 207.2K 35,000
2017-02-08 Donhauser Peter D.O. Director D Stock Option (Right to Buy) 50,000 5.39 269.5K 0
2016-09-22 Thomas Steffen Director A-Award A Stock Option (Right to Buy) 100,000 3.28 328.0K 100,000
2016-09-22 Skarpelos Athanasios Director A-Award A Stock Option (Right to Buy) 100,000 3.28 328.0K 100,000
2016-09-22 MISSLING CHRISTOPHER U Director / Officer A-Award A Stock Option (Right to Buy) 500,000 3.28 1.64M 500,000
2016-09-22 METZNER BERND Director A-Award A Stock Option (Right to Buy) 100,000 3.28 328.0K 100,000
2016-09-22 FAVUS ELLIOT Director A-Award A Stock Option (Right to Buy) 100,000 3.28 328.0K 100,000
2016-09-22 Boenisch Sandra Officer A-Award A Stock Option (Right to Buy) 106,696 3.28 350.0K 106,696
2016-07-18 MISSLING CHRISTOPHER U Director / Officer A-Award A Stock Option (Right to Buy) 861,429 7.06 6.08M 861,429
2016-07-05 MISSLING CHRISTOPHER U Director / Officer A-Award A Stock Option (Right to Buy) 379,625 6.26 2.38M 379,625
2016-06-30 FAVUS ELLIOT Director A-Award A Stock Option (Right to Buy) 1,500 6.11 9.2K 1,500
2016-04-27 FAVUS ELLIOT Director A-Award A Stock Option (Right to Buy) 1,500 5.66 8.5K 1,500
2016-03-31 FAVUS ELLIOT Director A-Award A Stock Option (Right to Buy) 1,500 4.90 7.4K 1,500
2015-12-31 FAVUS ELLIOT Director A-Award A Stock Option/Right to Buy 4,500 1.68 7.6K 92,000
2015-10-01 Boenisch Sandra Officer D Stock Option (Right to Buy) 100,000 1.42 142.0K 0
2015-09-30 FAVUS ELLIOT Director A-Award A Stock Option (Right to Buy) 1,500 5.64 8.5K 1,500
2015-09-18 MISSLING CHRISTOPHER U Director / Officer A-Award A Stock option 187,500 5.04 945.0K 187,500
2015-07-14 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common stock 1,000 0.52 518.40 4,013,000
2015-07-13 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common stock 1,000 0.53 529.50 4,012,000
2015-07-07 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common stock 1,000 0.51 509.90 4,011,000
2015-07-06 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common stock 1,000 0.47 469.50 4,010,000
2015-07-01 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common stock 1,000 0.45 454.80 3,009,000
2015-06-30 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common stock 1,000 0.44 444.60 3,008,000
2015-06-23 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common stock 1,000 0.47 468.00 3,007,000
2015-06-22 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common stock 1,000 0.42 415.00 3,006,000
2015-06-16 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common stock 1,000 0.44 442.00 3,005,000
2015-06-15 Thomas Steffen Director D Stock Option (Right to Buy) 200,000 0.42 84.0K 0
2015-06-15 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common stock 1,000 0.43 428.00 3,004,000
2015-06-10 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common stock 1,000 0.36 355.00 3,003,000
2015-06-08 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common stock 1,000 0.35 352.00 3,002,000
2015-06-04 MISSLING CHRISTOPHER U Director / Officer P-Purchase A Common stock 1,000 0.37 368.50 3,001,000
2015-04-02 Skarpelos Athanasios Director A-Award A Stock Option (Right to Buy) 50,000 0.92 46.0K 50,000
2015-04-02 MISSLING CHRISTOPHER U Director / Officer A-Award A Stock option 500,000 0.92 460.0K 500,000
2015-04-02 METZNER BERND Director A-Award A Stock Option (Right to Buy) 50,000 0.92 46.0K 87,500
2015-04-02 FAVUS ELLIOT Director A-Award A Stock Option/Right to Buy 50,000 0.92 46.0K 87,500
2014-05-07 METZNER BERND Director D Stock Option (Right to Buy) 150,000 0.30 45.0K 0
2014-05-07 FAVUS ELLIOT Director D Stock Option (Right to Buy) 150,000 0.30 45.0K 0
2013-11-28 Skarpelos Athanasios Director / 10% Owner G-Gift D Common Stock 300,000 0.00 5,225,832
2013-10-29 Skarpelos Athanasios Director / 10% Owner G-Gift D Common Stock 200,000 0.00 5,525,832
2013-10-01 Skarpelos Athanasios Director / 10% Owner G-Gift D Common Stock 1,000,000 0.00 5,725,832
2013-07-05 MISSLING CHRISTOPHER U Director / Officer D Common Stock 0 0.00 4,000,000
2012-10-10 TIDMARSH GEORGE F Director / Officer D stock options 500,000 1.50 750.0K 0
2012-05-29 Lalach Harvey Director / Officer S-Sale D common stock 8,572 1.05 9.0K 550,000
2012-05-24 Lalach Harvey Director / Officer S-Sale D common stock 10,000 0.80 8.0K 558,572
2012-02-24 Lowry William Sean Director D stock options 150,000 3.72 558.0K 0
2012-02-09 TIDMARSH GEORGE F Director / Officer J-Other A common stock 8,000 1.25 10.0K 8,000
2011-06-15 Lalach Harvey Director / Officer S-Sale D common stock 3,000 2.84 8.5K 571,572
2011-06-14 Lalach Harvey Director / Officer S-Sale D common stock 3,200 2.90 9.3K 574,572
2011-06-13 Lalach Harvey Director / Officer S-Sale D common stock 2,100 3.05 6.4K 577,772
2011-05-13 Chisholm John Robert Director 0 0.00 0
2011-04-14 Lalach Harvey Director / Officer S-Sale D common stock 10,000 2.75 27.5K 579,872
2011-03-10 Lalach Harvey Director / Officer S-Sale D common stock 5,500 3.68 20.2K 589,872
2011-02-18 Lalach Harvey Director / Officer S-Sale D common stock 3,000 3.75 11.3K 597,000
2011-02-03 Durrant Cameron Director / Officer 0 0.00 0
2010-09-01 Tousley David L. Director A-Award A stock options 200,000 3.45 690.0K 400,000
2010-06-29 Tousley David L. Director A-Award A stock options 50,000 3.50 175.0K 200,000
2010-06-29 Lalach Harvey Director / Officer A-Award A stock options 50,000 3.50 175.0K 200,000
2010-06-29 Durrant Cameron Director A-Award A stock options 50,000 3.50 175.0K 1,000,000
2010-06-29 Ayers Alison E. Director A-Award A stock options 50,000 3.50 175.0K 200,000
2010-06-12 KERGROHEN HERVE DE Officer D stock options 700,000 2.25 1.58M 0
2010-03-26 Tousley David L. Director 0 0.00 0
2010-03-26 Lalach Harvey Director / Officer 0 0.00 0
2010-03-26 Durrant Cameron Director 0 0.00 0
2010-03-26 Ayers Alison E. Director 0 0.00 0
2009-10-29 Skarpelos Athanasios 10% Owner S-Sale D common stock 111,112 2.25 250.0K 6,725,832
2009-08-08 Skarpelos Athanasios 10% Owner S-Sale D common stock 111,112 2.25 250.0K 6,836,944
2009-06-29 Skarpelos Athanasios 10% Owner S-Sale D common stock 619,444 2.25 1.39M 6,948,056
2009-06-18 Durrant Cameron Director J-Other D common stock 75,000 0.00 0
2009-05-13 Durrant Cameron Director A-Award A stock options 400,000 2.50 1.00M 950,000
2008-06-03 Tousley David L. Director D Stock Option 150,000 5.00 750.0K 0
2008-06-03 Lalach Harvey Director / Officer A-Award A Stock Options 150,000 5.00 750.0K 150,000
2008-06-03 Ayers Alison E. Director A-Award A Stock Options 150,000 5.00 750.0K 150,000
2008-05-20 Durrant Cameron Director A-Award A stock options 400,000 5.25 2.10M 550,000
2008-05-20 Ayers Alison E. Director 0 0.00 0
2007-12-03 Durrant Cameron Director D Stock Option 150,000 3.85 577.5K 0
2007-10-26 Skarpelos Athanasios 10% Owner S-Sale D Common shares 950,000 1.70 1.62M 7,567,500
2007-09-17 Skarpelos Athanasios 10% Owner P-Purchase A Common Shares 92,500 3.60 333.0K 8,517,500
2007-07-30 Skarpelos Athanasios 10% Owner S-Sale D common shares 950,000 1.70 1.62M 8,425,000
2007-02-08 Vernadaki Angela Officer P-Purchase A Stock Option 150,000 3.00 450.0K 150,000
2007-02-08 Kontzalis Panos Director / Officer P-Purchase A Stock Option 200,000 3.00 600.0K 200,000
2007-02-08 Kalkanis George Officer P-Purchase A Stock Option 150,000 3.00 450.0K 150,000
2007-02-07 Vernadaki Angela Officer 0 0.00 0
2007-02-07 Kalkanis George Officer D Common 0 0.00 900,000
2007-01-31 Vamvakides Alexandre Director / Officer 0 0.00 0
2007-01-25 Kontzalis Panos Director / Officer 0 0.00 0

Executive team

Top executives
Shares Outstanding
92.67M

Executive compensation

Executive compensation (annual)
# Year Executive Salary Bonus Stock award Option award Incentive Other Total % Stock-
based
Filing
1 2024 Christopher Missling President, Chief Executive Officer and Director 700.0K 140.0K 1.93M 16.1K 2.78M 69.25%
2 2024 Sandra Boenisch Principal Financial Officer and Treasurer 201.5K 192.7K 8.1K 402.2K 47.91%
3 2023 Christopher Missling President, Chief Executive Officer and Director 700.0K 124.8K 3.07M 3.5K 3.89M 78.73%
4 2023 Sandra Boenisch Principal Financial Officer and Treasurer 186.9K 306.7K 7.5K 501.1K 61.21%
5 2022 Christopher Missling President, Chief Executive Officer and Director 586.4K 110.0K 6.05M 12.2K 6.75M 89.51%
6 2022 Christopher Missling, PhD President, Chief Executive Officer, and Director 586.4K 110.0K 6.05M 12.2K 6.75M 89.51%
7 2022 Sandra Boenisch Principal Financial Officer and Treasurer 174.9K 277.6K 452.5K 61.35%
8 2021 Christopher Missling, PhD President, Chief Executive Officer, and Director 550.0K 110.0K 8.75M 11.6K 9.42M 92.87%
9 2021 Christopher Missling President, Chief Executive Officer and Director 550.0K 110.0K 8.75M 11.6K 9.42M 92.87%
10 2021 Sandra Boenisch Principal Financial Officer and Treasurer 158.3K 724.3K 882.6K 82.06%
11 2020 Christopher Missling, PhD President, Chief Executive Officer, and Director 550.0K 55.0K 1.22M 11.4K 1.84M 66.52%
12 2020 Sandra Boenisch Principal Financial Officer and Treasurer 117.0K 22.3K 155.9K 295.2K 52.80%
13 2019 Christopher Missling, PhD President, Chief Executive Officer, and Director 512.5K 50.0K 2.81M 11.2K 3.38M 83.03%
14 2019 Sandra Boenisch Principal Financial Officer and Treasurer 72.3K 13.6K 138.7K 224.6K 61.75%
15 2018 Christopher Missling, PhD President, Chief Executive Officer, and Director 500.0K 65.0K 1.97M 2.55M 77.41%
16 2018 Christopher Missling, PhD President, Chief Executive Officer, and Director 500.0K 65.0K 1.97M 2.54M 77.75%
17 2018 Sandra Boenisch Principal Financial Officer and Treasurer 79.6K 11.4K 141.0K 232.1K 60.78%
18 2018 Sandra Boenisch Principal Financial Officer 79.6K 11.4K 141.0K 232.1K 60.78%
19 2017 Christopher Missling, PhD President, Chief Executive Officer, and Director 500.0K 2.29M 2.79M 82.05%
20 2017 Sandra Boenisch Principal Financial Officer and Treasurer 71.8K 177.8K 249.6K 71.23%
21 2017 Sandra Boenisch Principal Financial Officer 71.8K 177.8K 249.6K 71.23%
22 2016 Christopher Missling, PhD President, Chief Executive Officer, and Director 305.0K 8.50M 2.29M 11.09M 76.60%
23 2016 Christopher Missling, PhD. President, Chief Executive Officer, Chief Financial Officer and Director 305.0K 8.50M 2.29M 11.09M 76.60%
24 2016 Sandra Boenisch Principal Financial Officer 58.0K 407.4K 465.4K 87.53%
25 2016 Sandra Boenisch Principal Financial Officer and Treasurer 58.0K 407.4K 465.4K 87.54%
26 2015 Christopher Missling, PhD President, Chief Executive Officer, and Director 240.0K 1.22M 1.15M 1.13M 3.74M 63.41%
27 2015 Christopher Missling, PhD. President, Chief Executive Officer, Chief Financial Officer and Director 240.0K 1.22M 1.15M 1.13M 3.74M 63.41%
28 2015 Christopher Missling, PhD President, Chief Executive Officer, and Director 240.0K 1.22M 1.15M 1.13M 3.74M 63.41%
29 2015 Sandra Boenisch Principal Financial Officer and Treasurer
30 2015 Sandra Boenisch Principal Financial Officer
31 2014 Christopher Missling, PhD. President, Chief Executive Officer, Chief Financial Officer and Director 240.0K 400.0K 127.8K 767.8K 16.64%
32 2014 Christopher Missling, PhD President, Chief Executive Officer, and Director 240.0K 400.0K 127.8K 767.8K 16.64%
33 2014 Sandra Boenisch Principal Financial Officer
34 2008 Panos Kontzalis Former CEO 127.5K 340.6K 71.5K 539.6K 63.12%
35 2008 Harvey Lalach President, CFO and Secretary 111.5K 264.7K 376.2K 70.36%
36 2008 Alexandre Vamvakides Chief Scientific Officer 113.4K 113.4K 0.00%
37 2007 Panos Kontzalis Former CEO 136.0K 136.0K 0.00%
38 2007 Panos Kontzalis CEO 136.0K 136.0K 0.00%
39 2007 Harvey Lalach President, CFO and Secretary 56.0K 56.0K 0.00%
40 2007 Alexandre Vamvakides Chief Scientific Officer 48.0K 48.0K 0.00%
41 2007 Panos Kontzalis CEO Director 34.0K 34.0K 0.00%
42 2007 George Kalkanis VP Strategic Planning 15.0K 15.0K 0.00%
43 2007 Harvey Lalach President, CFO, Secretary Director 14.0K 14.0K 0.00%
44 2007 Alexandre Vamvakides Chief Scientific Officer Director 12.0K 12.0K 0.00%
45 2006 Harvey Lalach President, CFO and Secretary
46 2006 Panos Kontzalis Former CEO
47 2006 Panos Kontzalis CEO
48 2006 Alexandre Vamvakides Chief Scientific Officer
49 2005 Alexandre Vamvakides Chief Scientific Officer
50 2005 Harvey Lalach President, CFO and Secretary
51 2005 Panos Kontzalis CEO
CEO compensation breakdown

Proxy statements

Proxy statements (DEF 14A)
Filing date Form type Filing
2025-04-25 DEFA14A
2025-04-25 DEF 14A
2024-05-06 DEFA14A
2024-05-06 DEF 14A
2023-04-04 DEFA14A
2023-04-04 DEF 14A

Recent SEC filings

Recent SEC filings
Filing date Form type Filing
2026-05-11 NT 10-Q
2026-05-06 8-K
2026-05-01 3
2026-03-26 SC 13G/A
2026-03-25 8-K
2026-02-25 8-K
2026-02-09 8-K
2026-02-09 10-Q
2026-01-09 4
2026-01-09 4

Executive team

NameTitleCompensationGender
Christopher U. Missling President, Chief Executive Officer, Secretary & Director 876.1K
Sandra Boenisch Principal Financial Officer & Treasurer 247.1K female
Juan Carlos Lopez-Talavera Senior Vice President & Head of Research and Development
Kun Jin Vice President & Head of Biostatistics
Terrie Kellmeyer Interim Chief Executive Officer
Adebayo Laniyonu Senior Vice President of Nonclinical Development
Wolfgang Liedtke Senior VP & Global Head of Neurology
Clint Tomlinson Vice President of Corporate
ESG Rating
B
BIOTECHNOLOGY
2015
E (Environmental)
39.7 / 56.3
Company / Sector avg.
S (Social)
65.4 / 62.4
Company / Sector avg.
G (Governance)
61.9 / 60.9
Company / Sector avg.
ESG Total
55.6 / 59.9
Company / Sector avg.
ESG Score History BIOTECHNOLOGY
Benchmark vs Sector
Senate Trading Activity

No Senate trading activity found for this company.

House Trading Activity
Transaction Date Disclosed Representative District Owner Type Amount Link
2022-12-12 2023-01-20 Christopher L. Jacobs NY27 Sale (Full) $1,001 - $15,000
2022-10-12 2022-11-16 Christopher L. Jacobs NY27 Purchase $1,001 - $15,000
Market share among peers
Peer comparison — filtered group (TTM)
Your opinion

Share your view on this stock and instantly see how the community has voted over the last 6 months.

These are community opinions and do not constitute buy or sell advice to act on. The results shown are based on aggregated opinions and are not an investment recommendation, nor do they intend to influence any investment decision.

Dividend history

Earnings history

Earnings reports

Stock splits