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Arcturus Therapeutics Holdings Inc. (ARCT)

USD6.38 +0.01 (+0.16%)
US NASDAQ Healthcare Biotechnology
Address 10628 Science Center Drive 92121
San Diego, CA, US
CEO Joseph E. Payne
IPO 2013-05-22
CIK 1768224 ISIN US03969T1097

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Description

Arcturus Therapeutics Holdings Inc. is a biotechnology company focused on RNA-based medicines, developing a pipeline of vaccines for infectious diseases alongside treatments for rare liver and respiratory conditions across the United States. Its notable development programs encompass LUNAR-OTC, designed for ornithine transcarbamylase (OTC) deficiency, and LUNAR-CF, targeting cystic fibrosis lung disease caused by specific CFTR gene mutations. The company also advances vaccine initiatives such as LUNAR-COV19 and LUNAR-FLU. Arcturus has cultivated a range of strategic collaborations, including partnerships with Vinbiocare Biotechnology Joint Stock Company for manufacturing COVID-19 vaccines; Janssen Pharmaceuticals, Inc., to create nucleic acid-based therapies for hepatitis B virus; Ultragenyx Pharmaceutical, Inc., for developing mRNA therapeutics aimed at rare disease targets; CureVac AG, to progress mRNA therapeutic and vaccine candidates across various indications; the Singapore Economic Development Board and Duke-NUS Medical School, specifically for the LUNAR-COV19 vaccine; and Millennium Pharmaceuticals, Inc., focused on discovering siRNA medicines for non-alcoholic steatohepatitis (NASH). Founded in 2013, Arcturus Therapeutics maintains its corporate headquarters in San Diego, California.

Market Cap & Enterprise Value
Merger & Acquisition History
Target company Ticker Date Filing
NASDAQ ADHD 2019-03-15 View
Technical Outlook
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Signal Summary Loading…
Indicator 1D1W2W3W1M
Each column is computed on that timeframe's candles (1D = daily, 1W ≈ weekly, 1M ≈ monthly), not on the same last day. ▲ bullish · ▼ bearish · — neutral. The Net row counts signals per column; hover any cell (or the indicator name) to see the exact rule behind it.
Day Score & sub-scores
Statistical fingerprint & regime detail
Conditional historical analysis
Customize analysis (advanced)
Indicative levels generated algorithmically. Not financial advice.
Risk Profile
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Price Chart
Averages
Trend
Price
Levels
Draw
USD6.38 +0.01 (+0.16%)
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Volume Profile
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Liquidity & share structure
Average Volume
433.2K
Beta
2.36
Float Shares
26.28M
Free Float %
92.5%
Price Performance
1D5D1M3M6M YTD1Y3Y5Y10YMax
-4.46% +0.36% -2.48% +14.42% +6.18% +34.58% -30.44% -73.07% -68.01% -70.76% -84.39%
Rolling Volatility
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Drawdown
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Relative Strength
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Monthly Returns Heatmap
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Annual Monthly Returns
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Daily Returns Distribution
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Revenue flow

Revenue by geography

Revenue by segment

From To

Revenue composition

From To

By product

By geography

Financial Statements

Income Statement

Balance Sheet

Cash Flow Statement

Key Metrics

Financial Ratios

Employees

Financial Growth (CAGR)

Market Data

Analyst Consensus (21 ratings, all time) Buy
Price Targets & DCF
Current price
6.38
Low 20.00 +213.5%
Consensus 22.50 +252.7%
Median 22.50 +252.7%
High 25.00 +291.8%
Ratings Trend (MoM) 77% Bullish
Rating 2026-05 Change
Strong Buy 2 0
Buy 8 0
Hold 3 0
Sell 0 0
Strong Sell 0 0
Price Target Summary
Period # Analysts Avg Target
Last Month
Last Quarter 1
25.00
+291.8%
Last Year 4
32.75
+413.3%
All Time 14
22.93
+259.4%
Quality scores
Altman Z-Score
-0.31
Distress
Piotroski F-Score
1 / 9
Weak
MOAT Score
2 / 10
No MOAT
Composite Rating
C+
Overall Score
2 / 5
Medium
DCF Score
1 / 5
Low
ROE Score
1 / 5
Low
ROA Score
1 / 5
Low
D/E Score
3 / 5
Medium
P/E Score
1 / 5
Low
P/Book Score
5 / 5
High
Operational MOAT
✗ Below peers
  • Revenue growth Biotechnology: +1.6%
    -51.4% Q1'26: -97.9% (vs Q1'25)
  • EPS growth Biotechnology: +29.7%
    +20.0% Q1'26: -82.7% (vs Q1'25)
  • FCF margin FCF growth · Biotechnology: +16.2%
    -165.7% Q1'26: -3,187.0% (vs Q1'25)
  • EBIT margin Biotechnology: +0.0%
    -111.5% Q1'26: -4,882.0% (vs Q1'25)
  • ROIC Biotechnology: -16.1%
    -928.4% Q1'26: +35,771.8% (vs Q1'25)
  • Share dilution Biotechnology: -3.4%
    +1.4% Q1'26: +4.8% (vs Q1'25)
  • Debt / EBITDA Net debt/EBITDA · Biotechnology: 0.16×
    -0.35× Q1'26: -0.17× (vs Q1'25)
Valuation Multiples From To
Price Forecast (3Y) From To
Model
Adjust
P/E
Theoretical Return — If Invested Today

* These projections are based on analyst consensus estimates and user-defined valuation multiples. This table is for informational purposes only and does not constitute a recommendation to buy or sell any security. Past performance is not indicative of future results.

DCF Interactive Model (UFCF)
Projection years:
Market assumptions
WACC components (optional)
Ke (Cost of Equity) = Rf + β (2.43) × ERP
WACC = 91% × Ke + 9% × Kd (4.0%) × (1−t)

Modifying these values recalculates WACC automatically.

Business assumptions
Current price: 6.38
Enterprise Value: Equity Value: Terminal Value: TV as % of EV:

Base values reflect the latest available data for this company and market conditions.

Consensus Estimates
Metric Dec 2018
actual
Dec 2019
actual
Dec 2020
actual
Dec 2021
actual
Dec 2022
actual
Dec 2023
actual
Dec 2024
actual
Dec 2025
actual
Dec 2026
9 Rev. Ana.
8 EPS Ana.
Dec 2027
8 Rev. Ana.
9 EPS Ana.
Dec 2028
8 Rev. Ana.
7 EPS Ana.
Dec 2029
7 Rev. Ana.
2 EPS Ana.
Dec 2030
7 Rev. Ana.
5 EPS Ana.
Revenue
15.75M
est: 11.47M (+37.4%)
20.79M
est: 21.45M (-3.1%)
9.54M
est: 9.76M (-2.2%)
12.36M
est: 23.84M (-48.2%)
205.76M
est: 53.87M (+281.9%)
157.75M
est: 124.53M (+26.7%)
138.39M
est: 169.49M (-18.4%)
67.22M
est: 90.77M (-25.9%)
16.99M
7.98M – 26.60M
-81.3% YoY
41.23M
11.14M – 125.99M
+142.6% YoY
121.78M
115.24M – 128.31M
+195.4% YoY
275.91M
125.91M – 1.15B
+126.6% YoY
431.11M
196.74M – 1.79B
+56.2% YoY
EBITDA
-20.72M
est: -6.07M (-241.3%)
-24.45M
est: -11.35M (-115.5%)
-70.64M
est: -5.16M (-1,268.3%)
-201.66M
est: -163.99M (-23.0%)
13.70M
est: -188.69M (+107.3%)
-24.17M
est: -65.90M (+63.3%)
-77.40M
est: -89.69M (+13.7%)
-71.93M
est: -48.03M (-49.8%)
-8.99M
-14.07M – -4.22M
+81.3% YoY
-21.82M
-66.67M – -5.90M
-142.6% YoY
-64.44M
-67.90M – -60.98M
-195.4% YoY
-146.01M
-606.49M – -66.63M
-126.6% YoY
-228.13M
-947.64M – -104.11M
-56.2% YoY
EBIT
-21.30M
est: -6.19M (-244.2%)
-25.14M
est: -11.57M (-117.2%)
-71.52M
est: -5.26M (-1,258.7%)
-202.85M
est: -165.05M (-22.9%)
12.18M
est: -188.42M (+106.5%)
-27.12M
est: -67.19M (+59.6%)
-80.95M
est: -91.45M (+11.5%)
-74.96M
est: -48.97M (-53.1%)
-9.17M
-14.35M – -4.30M
+81.3% YoY
-22.25M
-67.97M – -6.01M
-142.6% YoY
-65.70M
-69.23M – -62.17M
-195.4% YoY
-148.86M
-618.36M – -67.94M
-126.6% YoY
-232.60M
-966.18M – -106.15M
-56.2% YoY
Net Income
-21.79M
est: -68.47M (+68.2%)
-25.99M
est: -49.14M (+47.1%)
-72.15M
est: -81.43M (+11.4%)
-203.67M
est: -166.49M (-22.3%)
9.35M
est: -191.63M (+104.9%)
-29.73M
est: -107.30M (+72.3%)
-80.94M
est: -68.20M (-18.7%)
-65.78M
est: -54.76M (-20.1%)
-121.37M
-144.60M – -80.71M
-121.6% YoY
-124.50M
-146.75M – 11.01M
-2.6% YoY
-36.93M
-234.99M – 660.29M
+70.3% YoY
47.72M
13.99M – 243.38M
+229.2% YoY
157.61M
46.22M – 803.80M
+230.3% YoY
SGA
20.58M
est: 15.89M (+29.5%)
12.66M
est: 29.72M (-57.4%)
25.12M
est: 13.52M (+85.8%)
41.45M
est: 33.04M (+25.5%)
46.07M
est: 42.07M (+9.5%)
52.87M
est: 124.03M (-57.4%)
52.82M
est: 168.82M (-68.7%)
46.08M
est: 90.41M (-49.0%)
16.93M
7.95M – 26.49M
-81.3% YoY
41.07M
11.10M – 125.49M
+142.6% YoY
121.29M
114.78M – 127.81M
+195.4% YoY
274.82M
125.42M – 1.14B
+126.6% YoY
429.40M
195.96M – 1.78B
+56.2% YoY
EPS
-2.16
est: -2.54 (+14.8%)
-2.13
est: -1.82 (-17.0%)
-3.55
est: -3.02 (-17.7%)
-7.74
est: -7.87 (+1.6%)
0.35
est: -5.83 (+106.0%)
-1.12
est: -4.02 (+72.1%)
-3.00
est: -2.43 (-23.3%)
-2.40
est: -2.06 (-16.3%)
-4.01
-5.28 – -2.95
-94.5% YoY
-3.74
-5.36 – 0.40
+6.8% YoY
-1.65
-8.58 – 24.11
+55.8% YoY
1.74
0.51 – 8.89
+205.4% YoY
5.76
1.69 – 29.35
+230.3% YoY
Historical Ratings (3M)
Date Rating Overall DCF ROE ROA D/E P/E P/B
2026-05-07 C+ 2/5 1/5 1/5 1/5 3/5 1/5 5/5
2026-05-06 C+ 2/5 1/5 1/5 1/5 3/5 1/5 5/5
2026-05-05 C+ 2/5 1/5 1/5 1/5 3/5 1/5 5/5
2026-05-04 C+ 2/5 1/5 1/5 1/5 3/5 1/5 5/5
2026-05-01 C 2/5 1/5 1/5 1/5 2/5 1/5 4/5
2026-04-30 C 2/5 1/5 1/5 1/5 2/5 1/5 4/5
2026-04-29 C 2/5 1/5 1/5 1/5 2/5 1/5 4/5
2026-04-28 C 2/5 1/5 1/5 1/5 2/5 1/5 4/5
2026-04-27 C 2/5 1/5 1/5 1/5 2/5 1/5 4/5
2026-04-24 C 2/5 1/5 1/5 1/5 2/5 1/5 4/5
2026-04-23 C 2/5 1/5 1/5 1/5 2/5 1/5 4/5
2026-04-22 C 2/5 1/5 1/5 1/5 2/5 1/5 4/5
2026-04-21 C 2/5 1/5 1/5 1/5 2/5 1/5 4/5
2026-04-20 C 2/5 1/5 1/5 1/5 2/5 1/5 4/5
2026-04-17 C 2/5 1/5 1/5 1/5 2/5 1/5 4/5
2026-04-16 C 2/5 1/5 1/5 1/5 2/5 1/5 4/5

Owner Earnings

Owner's Earnings (history) From To
Owner alignment
Owner's Earnings TTM
-84.49M
OE per share TTM
-3.06
Owner's Yield
-33.40%
Maintenance CapEx ratio
Maint CapEx / Avg PPE
29.0%

Ownership Overview

Ownership breakdown
At a glance
Institutional holders
25
Total invested
19.77M
Insider transactions (90d)
1
Beneficial owners (>5%)
32
Beneficial owners (>5%)
# Reporting person Amount owned % of class Sole voting Shared voting Sole dispositive Shared dispositive Type Citizenship Filing date SEC filing
1 Federated Hermes, Inc. 3.69M 14.02% 3.69M 3.69M HC Citizenship or place of Organization 2022-02-14
2 J. Christopher Donahue 3.69M 14.02% 3.69M 3.69M IN Citizenship or place of Organization 2022-02-14
3 Rhodora J. Donahue 3.69M 14.02% 3.69M 3.69M IN Citizenship or place of Organization 2022-02-14
4 Thomas R. Donahue 3.69M 14.02% 3.69M 3.69M IN Citizenship or place of Organization 2022-02-14
5 Voting Shares Irrevocable Trust 3.69M 14.02% 3.69M 3.69M OO Citizenship or place of Organization 2022-02-14
6 STATE STREET CORPORATION 3.22M 12.20% 3.17M 3.22M HC BOSTON, MASSACHUSETTS 2022-04-11
7 ARK Investment Management LLC 2.85M 10.84% 2.85M 2.85M IA Delaware, United States 2021-11-09
8 SSGA FUNDS MANAGEMENT, INC. 2.78M 10.52% 2.77M 2.78M IA BOSTON, MASSACHUSETTS 2022-04-11
9 Nikko Asset Management Americas, Inc. 2.32M 8.56% 2.04M 2.32M IA USA 2024-11-08
10 Nikko Asset Management Co., Ltd. (“NAM”) 2.32M 8.56% 2.32M FI, IA, HC Japan 2024-11-05
11 Sumitomo Mitsui Trust Group, Inc.  (“SMTG”) 2.32M 8.56% 2.32M FI, HC Japan 2024-11-05
12 (1) BlackRock, Inc. 1.76M 6.70% 1.72M 1.76M HC Delaware 2022-02-03
13 The Vanguard Group - 23-1945930 1.45M 5.46% 1.39M 56.2K IA Pennsylvania 2023-02-09
14 Sumitomo Mitsui Trust Holdings, Inc.  (“SMTH”) 1.36M 5.14% 1.36M 1.36M FI, HC Japan 2022-02-04
15 27-2546083 1.20M 4.60% 1.20M 1.20M CO 2021-10-26
16 Arcturus Therapeutics Holdings Inc. 843.8K 12.38% 843.8K 843.8K CO United States 2022-02-15
17 52-0556948 15.0K 0.00% 3.8K IA Maryland 2022-02-14
18 Arthur Cohen 0.00% IN United States 2021-02-12
19 Bihua Chen 0.00% IN Cayman Islands 2021-02-16
20 Cormorant Asset Management, LP 0.00% PN Cayman Islands 2021-02-16
21 Cormorant Global Healthcare GP, LLC 0.00% OO Cayman Islands 2021-02-16
22 Cormorant Global Healthcare Master Fund, LP 0.00% PN Cayman Islands 2021-02-16
23 HealthCor Associates, LLC 0.00% OO CITIZENship or place of organization 2021-02-12
24 HealthCor Group, LLC 0.00% OO CITIZENship or place of organization 2021-02-12
25 HealthCor Management, L.P. 0.00% PN CITIZENship or place of organization 2021-02-12
26 HealthCor Offshore GP, LLC 0.00% OO CITIZENship or place of organization 2021-02-12
27 HealthCor Offshore II GP, LLC 0.00% OO Delaware 2021-02-12
28 HealthCor Offshore Master Fund, L.P. 0.00% PN CITIZENship or place of organization 2021-02-12
29 HealthCor Sanatate Offshore Master Fund, L.P. 0.00% PN Cayman Islands 2021-02-12
30 HealthCor Therapeutics GP, LLC 0.00% OO Delaware 2021-02-12
31 HealthCor Therapeutics Master Fund, L.P. 0.00% PN Cayman Islands 2021-02-12
32 Joseph Healey 0.00% IN United States 2021-02-12

Institutional Activity (13F)

Institutional ownership trend From To
13F snapshot — 2026 Q1
Investors holding
25
-106 vs prev Q
New positions
5
Closed positions
102
Increased
17
Reduced
4
Put/Call ratio
0.00
Calls held
1.3K
Puts held
Top institutional holders
# Investor Shares / Δ Mkt value / Δ Own% / Δ Weight% / Δ Avg px / Perf. Hold / Status
1 NVERSES CAPITAL, LLC 22.9K +22.9K (+100.0%) 140.40M +140.4M (+100.0%) 0.08% +0.084 pp 0.31% +0.315 pp USD6.13 +0.0% 1 qtrs NEW
2 FEDERATED HERMES, INC. 3.30M -1.4M (-29.6%) 20.25M -66.3M (-76.6%) 12.15% -5.152 pp 0.03% -0.119 pp USD36.71 -83.3% 23 qtrs
3 BLACKROCK, INC. 2.62M +55.0K (+2.1%) 16.06M -31.2M (-66.0%) 9.64% +0.182 pp 0.00% -0.001 pp USD22.77 -73.1% 6 qtrs
4 ARK INVESTMENT MANAGEMENT LLC 2.61M +738.4K (+39.4%) 16.01M -18.5M (-53.6%) 9.60% +2.701 pp 0.11% -0.099 pp USD21.57 -71.6% 27 qtrs
5 VANGUARD GROUP INC 2.09M +204.0K (+10.8%) 12.81M -21.9M (-63.1%) 7.69% +0.735 pp 0.00% 0.000 pp USD28.19 -78.3% 26 qtrs
6 SUMITOMO MITSUI TRUST HOLDINGS, INC. 2.03M +78.8K (+4.0%) 12.42M -23.5M (-65.4%) 7.45% +0.274 pp 0.01% -0.013 pp USD27.33 -77.6% 27 qtrs
7 NIKKO ASSET MANAGEMENT AMERICAS, INC. 2.03M +78.8K (+4.0%) 12.40M -23.5M (-65.4%) 7.45% +0.274 pp 0.14% -0.204 pp USD27.33 -77.6% 27 qtrs
8 GEODE CAPITAL MANAGEMENT, LLC 618.1K +6.3K (+1.0%) 3.79M -7.5M (-66.4%) 2.27% +0.018 pp 0.00% -0.001 pp USD29.86 -79.5% 27 qtrs
9 STATE STREET CORP 564.3K -481.4K (-46.0%) 3.46M -15.8M (-82.1%) 2.08% -1.779 pp 0.00% -0.001 pp USD34.47 -82.2% 23 qtrs
10 TWO SIGMA INVESTMENTS, LP 546.7K +457.5K (+512.7%) 3.35M +1.7M (+103.8%) 2.01% +1.682 pp 0.00% +0.002 pp USD7.73 -20.7% 12 qtrs
11 TWO SIGMA ADVISERS, LP 511.0K +472.5K (+1,227.4%) 3.13M +2.4M (+341.5%) 1.88% +1.738 pp 0.01% +0.005 pp USD6.65 -7.8% 3 qtrs
12 DIMENSIONAL FUND ADVISORS LP 490.4K -65.0K (-11.7%) 3.01M -7.2M (-70.6%) 1.80% -0.244 pp 0.00% -0.002 pp USD25.99 -76.4% 17 qtrs
13 ACADIAN ASSET MANAGEMENT LLC 427.9K +191.5K (+81.0%) 2.62M -1.7M (-39.8%) 1.57% +0.703 pp 0.00% -0.003 pp USD10.80 -43.2% 6 qtrs
14 EMPIRE LIFE INVESTMENTS INC. 412.4K -5.2K (-1.2%) 2.53M -5.2M (-67.2%) 1.52% -0.022 pp 0.14% -0.308 pp USD19.63 -68.8% 6 qtrs
15 GOLDMAN SACHS GROUP INC 391.2K +246.5K (+170.3%) 2.40M -269.1K (-10.1%) 1.44% +0.906 pp 0.00% +0.000 pp USD13.32 -54.0% 25 qtrs
16 MILLENNIUM MANAGEMENT LLC 304.8K +265.0K (+665.8%) 1.87M +1.1M (+154.7%) 1.12% +0.974 pp 0.00% +0.001 pp USD7.74 -20.8% 15 qtrs
17 JACOBS LEVY EQUITY MANAGEMENT, INC 293.1K -12.6K (-4.1%) 1.80M -3.8M (-68.1%) 1.08% -0.049 pp 0.01% -0.015 pp USD16.81 -63.5% 11 qtrs
18 HENNION & WALSH ASSET MANAGEMENT, INC. 240.3K +161.9K (+206.5%) 1.47M +28.3K (+2.0%) 0.88% +0.595 pp 0.05% -0.002 pp USD10.93 -43.9% 19 qtrs
19 UBS GROUP AG 227.9K +67.4K (+42.0%) 1.40M -1.6M (-52.8%) 0.84% +0.247 pp 0.00% 0.000 pp USD16.88 -63.7% 27 qtrs
20 POINT72 ASSET MANAGEMENT, L.P. 222.2K +222.2K (+100.0%) 1.36M +1.4M (+100.0%) 0.82% +0.817 pp 0.00% +0.002 pp USD6.13 +0.0% 4 qtrs
21 MORGAN STANLEY 213.4K -491.5K (-69.7%) 1.31M -11.7M (-89.9%) 0.78% -1.813 pp 0.00% -0.001 pp USD21.07 -70.9% 27 qtrs
22 JPMORGAN CHASE & CO 206.2K +2.6K (+1.3%) 1.26M -2.5M (-66.3%) 0.76% +0.008 pp 0.00% 0.000 pp USD36.56 -83.2% 27 qtrs
23 DEKABANK DEUTSCHE GIROZENTRALE 43.9K +— (+0.0%) 1.24M +12.0K (+1.0%) 0.16% 0.000 pp 0.00% +0.000 pp USD28.58 -78.6% 11 qtrs
24 NORTHERN TRUST CORP 200.8K -17.1K (-7.8%) 1.23M -2.8M (-69.3%) 0.74% -0.065 pp 0.00% 0.000 pp USD35.67 -82.8% 26 qtrs
25 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 183.9K -25.6K (-12.2%) 1.13M -2.7M (-70.8%) 0.68% -0.096 pp 0.00% 0.000 pp USD35.42 -82.7% 23 qtrs
26 BNP PARIBAS ARBITRAGE, SNC 146.8K +139.9K (+2,043.2%) 899.7K +773.5K (+612.9%) 0.54% +0.515 pp 0.00% +0.000 pp USD6.65 -7.8% 23 qtrs
27 RENAISSANCE TECHNOLOGIES LLC 119.9K +119.9K (+100.0%) 735.0K +735.0K (+100.0%) 0.44% +0.441 pp 0.00% +0.001 pp USD6.13 +0.0% 1 qtrs NEW
28 ATOM INVESTORS LP 106.4K +106.4K (+100.0%) 652.2K +652.2K (+100.0%) 0.39% +0.391 pp 0.05% +0.052 pp USD6.13 +0.0% 1 qtrs NEW
29 JANE STREET GROUP, LLC 106.3K +82.4K (+344.8%) 651.6K +211.1K (+47.9%) 0.39% +0.303 pp 0.00% +0.000 pp USD7.68 -20.2% 6 qtrs
30 INVESCO LTD. 103.1K +38.6K (+59.9%) 632.1K -556.4K (-46.8%) 0.38% +0.142 pp 0.00% 0.000 pp USD13.88 -55.8% 23 qtrs
31 SUSQUEHANNA PORTFOLIO STRATEGIES, LLC 103.1K +7.2K (+7.5%) 631.9K -1.1M (-64.3%) 0.38% +0.026 pp 0.01% -0.018 pp USD13.31 -53.9% 3 qtrs
32 D. E. SHAW & CO., INC. 97.8K +37.6K (+62.5%) 599.7K -510.1K (-46.0%) 0.36% +0.138 pp 0.00% 0.000 pp USD13.12 -53.3% 3 qtrs
33 IQ EQ FUND MANAGEMENT (IRELAND) LTD 91.6K +47.6K (+108.2%) 561.4K -249.1K (-30.7%) 0.34% +0.175 pp 0.04% -0.016 pp USD10.13 -39.5% 4 qtrs
34 CITADEL ADVISORS LLC 86.2K +35.3K (+69.4%) 528.4K -409.7K (-43.7%) 0.32% +0.129 pp 0.00% 0.000 pp USD13.56 -54.8% 23 qtrs
35 XTX TOPCO LTD 82.2K +82.2K (+100.0%) 503.6K +503.6K (+100.0%) 0.30% +0.302 pp 0.01% +0.013 pp USD6.13 +0.0% 1 qtrs NEW
36 BANK OF NEW YORK MELLON CORP 76.3K -12.4K (-13.9%) 467.7K -1.2M (-71.4%) 0.28% -0.046 pp 0.00% 0.000 pp USD33.38 -81.6% 23 qtrs
37 SUSQUEHANNA INTERNATIONAL GROUP, LLP 74.7K -459.3K (-86.0%) 458.1K -9.4M (-95.3%) 0.27% -1.694 pp 0.00% -0.001 pp USD18.29 -66.5% 27 qtrs
38 SCHONFELD STRATEGIC ADVISORS LLC 69.8K -598.1K (-89.6%) 427.6K -11.9M (-96.5%) 0.26% -2.205 pp 0.00% -0.068 pp USD21.93 -72.0% 10 qtrs
39 ENGINEERS GATE MANAGER LP 68.2K +68.2K (+100.0%) 417.9K +417.9K (+100.0%) 0.25% +0.251 pp 0.01% +0.005 pp USD6.13 +0.0% 1 qtrs NEW
40 WOODLINE PARTNERS LP 66.6K +— (+0.0%) 408.1K -818.9K (-66.7%) 0.24% -0.001 pp 0.00% -0.004 pp USD18.73 -67.3% 14 qtrs
41 AMERICAN CENTURY COMPANIES INC 66.5K +2.0K (+3.2%) 407.6K -780.1K (-65.7%) 0.24% +0.007 pp 0.00% 0.000 pp USD26.05 -76.5% 11 qtrs
42 HSBC HOLDINGS PLC 66.1K +42.1K (+175.7%) 402.1K -38.0K (-8.6%) 0.24% +0.155 pp 0.00% +0.000 pp USD11.10 -44.8% 9 qtrs
43 MASSACHUSETTS FINANCIAL SERVICES CO /MA/ 61.4K -2.0K (-3.2%) 376.1K -792.1K (-67.8%) 0.23% -0.008 pp 0.00% 0.000 pp USD25.10 -75.6% 11 qtrs
44 NUVEEN, LLC 52.2K +— (+0.0%) 320.1K -642.3K (-66.7%) 0.19% 0.000 pp 0.00% 0.000 pp USD10.59 -42.1% 4 qtrs
45 QUANTINNO CAPITAL MANAGEMENT LP 52.1K +52.1K (+100.0%) 319.5K +319.5K (+100.0%) 0.19% +0.192 pp 0.00% +0.001 pp USD6.13 +0.0% 1 qtrs NEW
46 BARCLAYS PLC 50.6K -16.8K (-25.0%) 310.1K -1.3M (-80.2%) 0.19% -0.062 pp 0.00% 0.000 pp USD16.88 -63.7% 26 qtrs
47 KOVACK ADVISORS, INC. 46.0K +46.0K (+100.0%) 282.1K +282.1K (+100.0%) 0.17% +0.169 pp 0.01% +0.013 pp USD6.13 +0.0% 1 qtrs NEW
48 RUSSELL INVESTMENTS GROUP, LTD. 44.4K +22.8K (+105.3%) 272.3K -126.6K (-31.7%) 0.16% +0.084 pp 0.00% 0.000 pp USD8.89 -31.0% 12 qtrs
49 JAIN GLOBAL LLC 44.1K +44.1K (+100.0%) 270.2K +270.2K (+100.0%) 0.16% +0.162 pp 0.00% +0.001 pp USD6.13 +0.0% 1 qtrs NEW
50 AQR CAPITAL MANAGEMENT LLC 43.4K +43.4K (+100.0%) 266.1K +266.1K (+100.0%) 0.16% +0.160 pp 0.00% +0.000 pp USD6.13 +0.0% 11 qtrs
51 WELLS FARGO & COMPANY/MN 41.3K +8.1K (+24.3%) 253.3K -359.2K (-58.6%) 0.15% +0.030 pp 0.00% 0.000 pp USD20.78 -70.5% 27 qtrs
52 PANAGORA ASSET MANAGEMENT INC 34.8K +34.8K (+100.0%) 213.1K +213.1K (+100.0%) 0.13% +0.128 pp 0.00% +0.001 pp USD6.13 +0.0% 1 qtrs NEW
53 SQUAREPOINT OPS LLC 34.3K +34.3K (+100.0%) 210.2K +210.2K (+100.0%) 0.13% +0.126 pp 0.00% +0.000 pp USD6.13 +0.0% 10 qtrs
54 BANK OF AMERICA CORP /DE/ 34.1K -586.0K (-94.5%) 209.0K -11.2M (-98.2%) 0.13% -2.160 pp 0.00% -0.001 pp USD15.56 -60.6% 24 qtrs
55 MIRAE ASSET GLOBAL ETFS HOLDINGS LTD. 33.2K +3.2K (+10.8%) 203.3K -349.0K (-63.2%) 0.12% +0.012 pp 0.00% -0.001 pp USD16.85 -63.6% 7 qtrs
56 CANADA PENSION PLAN INVESTMENT BOARD 30.9K +30.9K (+100.0%) 189.4K +189.4K (+100.0%) 0.11% +0.114 pp 0.00% +0.000 pp USD6.13 +0.0% 1 qtrs NEW
57 RHUMBLINE ADVISERS 30.7K -9.1K (-22.8%) 188.0K -544.4K (-74.3%) 0.11% -0.034 pp 0.00% 0.000 pp USD32.72 -81.3% 23 qtrs
58 FORMIDABLE ASSET MANAGEMENT, LLC 10.1K -200.0 (-1.9%) 186.1K +52.1K (+38.9%) 0.04% -0.001 pp 0.03% +0.006 pp USD34.26 -82.1% 20 qtrs
59 AXQ CAPITAL, LP 28.7K +28.7K (+100.0%) 175.7K +175.7K (+100.0%) 0.11% +0.105 pp 0.04% +0.040 pp USD6.13 +0.0% 1 qtrs NEW
60 GREEN ALPHA ADVISORS, LLC 28.3K +6.8K (+31.9%) 173.4K -221.8K (-56.1%) 0.10% +0.025 pp 0.16% -0.223 pp USD9.51 -35.5% 4 qtrs
61 MGO ONE SEVEN LLC 28.1K -6.3K (-18.3%) 172.4K -462.1K (-72.8%) 0.10% -0.024 pp 0.00% -0.011 pp USD22.15 -72.3% 26 qtrs
62 28.1K +28.1K (+100.0%) 172.1K +172.1K (+100.0%) 0.10% +0.103 pp 0.09% +0.092 pp USD6.13 +0.0% 1 qtrs NEW
63 ALLIANCEBERNSTEIN L.P. 27.7K -3.4K (-10.9%) 169.9K -403.6K (-70.4%) 0.10% -0.013 pp 0.00% 0.000 pp USD27.89 -78.0% 23 qtrs
64 ARISTIDES CAPITAL LLC 26.3K +26.3K (+100.0%) 161.1K +161.1K (+100.0%) 0.10% +0.097 pp 0.03% +0.029 pp USD6.13 +0.0% 1 qtrs NEW
65 PRICE T ROWE ASSOCIATES INC /MD/ 26.1K -1.8K (-6.6%) 161.0K -355.0K (-68.8%) 0.10% -0.007 pp 0.00% +0.000 pp USD29.36 -79.1% 23 qtrs
66 BREVAN HOWARD CAPITAL MANAGEMENT LP 24.7K -3.4K (-12.2%) 151.3K -366.5K (-70.8%) 0.09% -0.013 pp 0.00% -0.001 pp USD18.43 -66.7% 2 qtrs
67 683 CAPITAL MANAGEMENT, LLC 24.0K +24.0K (+100.0%) 147.1K +147.1K (+100.0%) 0.09% +0.088 pp 0.01% +0.006 pp USD6.13 +0.0% 1 qtrs NEW
68 QUEST PARTNERS LLC 23.7K +11.4K (+91.9%) 145.4K -82.4K (-36.2%) 0.09% +0.042 pp 0.01% -0.007 pp USD9.80 -37.4% 9 qtrs
69 ALPS ADVISORS INC 23.3K +10.2K (+78.0%) 143.0K -98.5K (-40.8%) 0.09% +0.038 pp 0.00% -0.001 pp USD18.00 -65.9% 11 qtrs
70 FREESTONE CAPITAL HOLDINGS, LLC 18.7K +— (+0.0%) 114.4K -229.5K (-66.7%) 0.07% 0.000 pp 0.00% -0.007 pp USD23.66 -74.1% 7 qtrs
71 DEUTSCHE BANK AG\ 18.4K +946.0 (+5.4%) 112.6K -208.6K (-64.9%) 0.07% +0.003 pp 0.00% 0.000 pp USD19.78 -69.0% 25 qtrs
72 COMMONWEALTH EQUITY SERVICES, LLC 18.2K -3.2K (-14.9%) 111.6K -282.4K (-71.7%) 0.07% -0.012 pp 0.00% 0.000 pp USD26.89 -77.2% 8 qtrs
73 BYRNE ASSET MANAGEMENT LLC 18.1K +17.7K (+4,412.5%) 110.6K +103.3K (+1,400.9%) 0.07% +0.065 pp 0.06% +0.057 pp USD6.42 -4.5% 17 qtrs
74 DIVERSIFY ADVISORY SERVICES, LLC 15.0K +— (+0.0%) 109.4K -30.2K (-21.6%) 0.06% 0.000 pp 0.00% -0.001 pp USD12.81 -52.1% 4 qtrs
75 TEXAS YALE CAPITAL CORP. 16.0K +— (+0.0%) 98.1K -196.8K (-66.7%) 0.06% 0.000 pp 0.00% -0.006 pp USD23.66 -74.1% 7 qtrs
76 TOCQUEVILLE ASSET MANAGEMENT L.P. 13.6K -12.9K (-48.7%) 83.4K -405.0K (-82.9%) 0.05% -0.048 pp 0.00% -0.006 pp USD20.05 -69.4% 12 qtrs
77 WALLEYE TRADING LLC 12.4K +600.0 (+5.1%) 76.0K -141.5K (-65.0%) 0.05% +0.002 pp 0.00% 0.000 pp USD13.03 -53.0% 3 qtrs
78 GREAT WEST LIFE ASSURANCE CO /CAN/ 12.0K +4.7K (+65.1%) 73.0K -63.0K (-46.3%) 0.04% +0.017 pp 0.00% 0.000 pp USD18.04 -66.0% 23 qtrs
79 INTECH INVESTMENT MANAGEMENT LLC 11.4K +11.4K (+100.0%) 69.8K +69.8K (+100.0%) 0.04% +0.042 pp 0.00% +0.001 pp USD6.13 +0.0% 4 qtrs
80 WALLEYE CAPITAL LLC 11.2K -6.2K (-35.6%) 68.7K -252.0K (-78.6%) 0.04% -0.023 pp 0.00% -0.001 pp USD13.38 -54.2% 8 qtrs
81 MERCER GLOBAL ADVISORS INC /ADV 10.5K +10.5K (+100.0%) 64.4K +64.4K (+100.0%) 0.04% +0.039 pp 0.00% +0.000 pp USD6.13 +0.0% 1 qtrs NEW
82 METLIFE INVESTMENT MANAGEMENT, LLC 9.4K -6.9K (-42.6%) 57.4K -243.0K (-80.9%) 0.03% -0.026 pp 0.00% -0.001 pp USD33.20 -81.5% 23 qtrs
83 NEW YORK STATE COMMON RETIREMENT FUND 8.5K +— (+0.0%) 52.1K -104.5K (-66.7%) 0.03% 0.000 pp 0.00% 0.000 pp USD45.12 -86.4% 23 qtrs
84 PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO 7.7K +— (+0.0%) 46.9K -94.1K (-66.7%) 0.03% 0.000 pp 0.00% 0.000 pp USD13.01 -52.9% 3 qtrs
85 POLICE & FIREMEN'S RETIREMENT SYSTEM OF NEW JERSEY 7.0K +— (+0.0%) 42.6K -85.6K (-66.7%) 0.03% 0.000 pp 0.00% -0.001 pp USD17.46 -64.9% 5 qtrs
86 CITIGROUP INC 5.7K +3.0K (+109.1%) 35.1K -15.4K (-30.5%) 0.02% +0.011 pp 0.00% +0.000 pp USD13.05 -53.0% 27 qtrs
87 CHINA UNIVERSAL ASSET MANAGEMENT CO., LTD. 4.6K -3.1K (-40.3%) 28.4K -114.6K (-80.2%) 0.02% -0.012 pp 0.00% -0.010 pp USD24.28 -74.8% 14 qtrs
88 LOS ANGELES CAPITAL MANAGEMENT LLC 2.4K +2.4K (+100.0%) 22.8K +22.8K (+100.0%) 0.01% +0.009 pp 0.00% +0.000 pp USD6.13 +0.0% 1 qtrs NEW
89 FMR LLC 3.2K -130.6K (-97.6%) 19.8K -2.4M (-99.2%) 0.01% -0.482 pp 0.00% 0.000 pp USD32.20 -81.0% 26 qtrs
90 LEGAL & GENERAL GROUP PLC 2.5K +— (+0.0%) 15.3K -30.8K (-66.7%) 0.01% +0.000 pp 0.00% +0.000 pp USD32.01 -80.8% 23 qtrs
91 AMERITAS INVESTMENT PARTNERS, INC. 2.3K +— (+0.0%) 14.2K -28.5K (-66.7%) 0.01% +0.000 pp 0.00% -0.001 pp USD39.60 -84.5% 23 qtrs
92 SIGNATUREFD, LLC 2.2K +— (+0.0%) 13.4K -26.9K (-66.7%) 0.01% +0.000 pp 0.00% 0.000 pp USD18.43 -66.7% 19 qtrs
Ownership breakdown by holder

ETF Ownership

Top ETFs holding this stock Held by 60 ETFs in our universe
# ETF Weight Est. AUM exposure TER
1 ARK Genomic Revolution ETF ARKG 1.14% 14.85M 0.75%
2 WisdomTree BioRevolution UCITS ETF - USD Acc WDNA.L 0.59% 131.0K 0.45%
3 AXS Green Alpha ETF NXTE 0.22% 126.5K 1.00%
4 ALPS Medical Breakthroughs ETF SBIO 0.10% 216.3K 0.50%
5 iShares Micro-Cap ETF IWC 0.04% 628.4K 0.60%
6 Invesco RAFI US 1500 Small-Mid ETF PRFZ 0.02% 619.4K 0.34%
7 Goldman Sachs ActiveBeta U.S. Small Cap Equity ETF GSSC 0.02% 226.4K 0.20%
8 iShares Biotechnology ETF IBB 0.01% 1.30M 0.44%
9 Invesco NASDAQ Biotech UCITS ETF SBIO.L 0.01% 63.1K 0.40%
10 iShares Nasdaq US Biotechnology UCITS ETF BTEE.L 0.01% 10.0K 0.35%

Insider Activity

Insider Activity — Latest Quarter
Ratio by transactions
0.00
Bearish
Buys
4
Sells
0
Shares acquired
293.0K
Shares disposed
Cash buys
Cash sales
Net activity
+293,000
Insider buys vs sells (history) From To
Recent insider transactions From To
Date Person Role Transaction A/D Security Shares Price Value Owned after D/I Filing
2026-05-01 MULROY DENNIS Officer A-Award A Employee Stock Option (right to buy) 100,000 8.63 863.0K 100,000 D
2025-12-17 Roberts Joseph Officer A-Award A Employee Stock Option (right to buy) 10,000 6.52 65.2K 10,000 D
2025-12-17 Payne Joseph E Director / Officer A-Award A Employee Stock Option (right to buy) 175,000 6.52 1.14M 175,000 D
2025-12-17 Kurata Lance Officer A-Award A Employee Stock Option (right to buy) 54,000 6.52 352.1K 54,000 D
2025-12-17 Chivukula Pad Officer A-Award A Employee Stock Option (right to buy) 54,000 6.52 352.1K 54,000 D
2025-12-12 Roberts Joseph Officer Stock Option (Right to Buy) 9,000 16.24 146.2K 0 D
2025-08-15 SASSINE ANDY Director / Officer P-Purchase A Common Stock 1,238 16.56 20.5K 221,764 D
2025-06-09 Slaoui Moncef Director A-Award A Stock option (right to buy) 15,000 12.54 188.1K 15,000 D
2025-06-09 Marquet Magda Director A-Award A Stock option (right to buy) 15,000 12.54 188.1K 15,000 D
2025-06-09 Markels John Director A-Award A Stock option (right to buy) 15,000 12.54 188.1K 15,000 D
2025-06-09 Marantz Jing L. Director A-Award A Stock option (right to buy) 15,000 12.54 188.1K 15,000 D
2025-06-09 HOLMES EDWARD W Director A-Award A Stock option (right to buy) 15,000 12.54 188.1K 15,000 D
2025-06-09 FARRELL PETER C Director A-Award A Stock option (right to buy) 15,000 12.54 188.1K 15,000 D
2025-06-09 BARLOW JAMES F Director A-Award A Stock option (right to buy) 15,000 12.54 188.1K 15,000 D
2024-12-16 SASSINE ANDY Director / Officer A-Award A Employee Stock Option (right to buy) 60,000 16.24 974.4K 60,000 D
2024-12-16 Payne Joseph E Director / Officer A-Award A Employee Stock Option (right to buy) 196,000 16.24 3.18M 196,000 D
2024-12-16 Kurata Lance Officer A-Award A Employee Stock Option (right to buy) 60,000 16.24 974.4K 60,000 D
2024-12-16 Chivukula Pad Officer A-Award A Employee Stock Option (right to buy) 60,000 16.24 974.4K 60,000 D
2024-10-15 Chivukula Pad Officer S-Sale D Common Stock 12,000 20.76 249.1K 435,334 D
2024-06-19 Slaoui Moncef Director A-Award A Stock option (right to buy) 14,794 25.96 384.1K 14,794
2024-06-14 Marquet Magda Director M-Exempt D Deferred Stock Units 3,131 0.00 0
2024-06-14 Markels John Director M-Exempt D Deferred Stock Units 3,131 0.00 0
2024-06-14 Marantz Jing L. Director M-Exempt D Deferred Stock Units 3,131 0.00 0
2024-06-14 HOLMES EDWARD W Director M-Exempt D Deferred Stock Units 3,131 0.00 0
2024-06-14 FARRELL PETER C Director M-Exempt D Deferred Stock Units 3,131 0.00 0
2024-06-14 BARLOW JAMES F Director M-Exempt D Deferred Stock Units 3,131 0.00 0
2024-06-12 SASSINE ANDY Director / Officer S-Sale D Common Stock 50,000 32.03 1.60M 220,526
2024-06-05 Chivukula Pad Officer S-Sale D Common Stock 114 45.00 5.1K 447,334
2024-06-03 Chivukula Pad Officer S-Sale D Common Stock 26,000 40.01 1.04M 447,448
2024-03-25 Chivukula Pad Officer S-Sale D Common Stock 17,435 35.02 610.6K 473,448
2024-03-19 Chivukula Pad Officer S-Sale D Common Stock 8,565 35.01 299.8K 490,883
2023-12-15 SASSINE ANDY Director / Officer A-Award A Employee Stock Option (right to buy) 75,000 28.88 2.17M 75,000
2023-12-15 Payne Joseph E Director / Officer A-Award A Employee Stock Option (right to buy) 200,000 28.88 5.78M 200,000
2023-12-15 Kurata Lance Officer A-Award A Employee Stock Option (right to buy) 75,000 28.88 2.17M 75,000
2023-12-15 Kummerfeld Keith C Officer A-Award A Employee Stock Option (right to buy) 30,000 28.88 866.4K 30,000
2023-12-15 Chivukula Pad Officer A-Award A Employee Stock Option (right to buy) 125,000 28.88 3.61M 125,000
2023-11-01 Chivukula Pad Officer S-Sale D Common Stock 5,000 18.72 93.6K 499,448
2023-10-02 Chivukula Pad Officer S-Sale D Common Stock 5,000 25.61 128.1K 504,448
2023-09-01 Chivukula Pad Officer S-Sale D Common Stock 5,000 31.45 157.3K 509,448
2023-08-15 SASSINE ANDY Director / Officer A-Award A Common Stock 1,223 17.37 21.2K 270,526
2023-08-01 Marquet Magda Director A-Award A Stock option (right to buy) 11,869 34.92 414.5K 11,869
2023-08-01 Markels John Director A-Award A Deferred Stock Units 3,131 0.00 3,131
2023-08-01 Marantz Jing L. Director A-Award A Deferred Stock Units 3,131 0.00 3,131
2023-08-01 HOLMES EDWARD W Director A-Award A Stock Option (right to buy) 11,869 34.92 414.5K 11,869
2023-08-01 FARRELL PETER C Director A-Award A Deferred Stock Units 3,131 0.00 3,131
2023-08-01 Chivukula Pad Officer S-Sale D Common Stock 5,000 34.91 174.6K 514,448
2023-08-01 BARLOW JAMES F Director A-Award A Deferred Stock Units 3,131 0.00 3,131
2023-07-14 Kummerfeld Keith C Officer M-Exempt D Employee Stock Option (right to buy) 1,437 4.99 7.2K 7,126
2023-07-14 Chivukula Pad Officer S-Sale D Common Stock 25,000 35.01 875.3K 519,448
2023-07-03 Chivukula Pad Officer S-Sale D Common Stock 5,000 28.75 143.8K 544,448
2023-06-01 Chivukula Pad Officer S-Sale D Common Stock 5,000 27.16 135.8K 549,448
2023-05-11 Chivukula Pad Officer S-Sale D Common Stock 7,925 30.24 239.7K 554,448
2023-05-10 Chivukula Pad Officer S-Sale D Common Stock 17,075 30.00 512.3K 562,373
2023-05-01 Chivukula Pad Officer S-Sale D Common Stock 5,000 25.93 129.7K 579,448
2023-04-18 Kummerfeld Keith C Officer M-Exempt A Common Stock 1,031 14.12 14.6K 1,981
2023-04-17 Kummerfeld Keith C Officer M-Exempt D Employee Stock Option (right to buy) 1,031 14.12 14.6K 8,969
2023-04-03 Chivukula Pad Officer S-Sale D Common Stock 5,000 25.38 126.9K 584,448
2023-03-06 Chivukula Pad Officer S-Sale D Common Stock 5,000 16.07 80.4K 589,448
2022-12-15 Marquet Magda Director P-Purchase A Common Stock 2,222 18.00 40.0K 24,942
2022-12-09 SASSINE ANDY Officer A-Award A Employee Stock Option (right to buy) 125,000 0.00 125,000
2022-12-09 Payne Joseph E Officer A-Award A Employee Stock Option (right to buy) 250,000 0.00 250,000
2022-12-09 Kurata Lance Officer A-Award A Employee Stock Option (right to buy) 125,000 0.00 125,000
2022-12-09 Kummerfeld Keith C Officer A-Award A Employee Stock Option (right to buy) 40,000 0.00 40,000
2022-12-09 Chivukula Pad Officer A-Award A Employee Stock Option (right to buy) 125,000 0.00 125,000
2022-12-08 Markels John 0
2022-11-23 Payne Joseph E Officer P-Purchase A Common Stock 5,000 16.51 82.6K 1,480,097
2022-08-15 SASSINE ANDY Officer A-Award A Common Stock 1,068 18.42 19.7K 269,303
2022-06-23 Marquet Magda Director A-Award A Stock Option (right to buy) 15,000 0.00 15,000
2022-06-23 Marantz Jing L. Director A-Award A Stock Option (right to buy) 15,000 16.02 240.3K 15,000
2022-06-23 HOLMES EDWARD W Director A-Award A Stock Option (right to buy) 15,000 0.00 15,000
2022-06-23 FARRELL PETER C Director A-Award A Stock Option (right to buy) 15,000 16.02 240.3K 15,000
2022-06-23 BARLOW JAMES F Director A-Award A Stock Option (right to buy) 15,000 16.02 240.3K 15,000
2022-06-21 SASSINE ANDY Director / Officer A-Award A Employee Stock Option (right to buy) 85,000 34.57 2.94M 85,000
2022-06-21 Payne Joseph E Officer A-Award A Employee Stock Option (right to buy) 150,000 0.00 150,000
2022-06-21 Kurata Lance Officer A-Award A Employee Stock Option (right to buy) 50,000 0.00 50,000
2022-06-21 Kummerfeld Keith C Officer A-Award A Employee Stock Option (right to buy) 33,000 0.00 33,000
2022-06-21 Chivukula Pad Officer A-Award A Employee Stock Option (right to buy) 85,000 34.57 2.94M 85,000
2022-01-04 Chivukula Pad Officer S-Sale D Common Stock 8,100 40.00 324.0K 594,448
2021-12-16 Chivukula Pad Officer S-Sale D Common Stock 3,633 40.00 145.3K 602,548
2021-12-08 Chivukula Pad Officer S-Sale D Common Stock 6,367 40.00 254.7K 606,181
2021-12-07 Marantz Jing L. Director A-Award A Stock option (right to buy) 20,000 38.54 770.8K 20,000
2021-11-01 Chivukula Pad Officer S-Sale D Common Stock 10,000 44.41 444.1K 612,548
2021-10-01 Chivukula Pad Officer S-Sale D Common Stock 10,000 44.36 443.6K 622,548
2021-09-01 Chivukula Pad Officer S-Sale D Common Stock 10,000 55.86 558.6K 632,548
2021-08-11 Ultragenyx Pharmaceutical Inc. Director S-Sale D Common Stock 75,000 45.83 3.44M 1,400,000
2021-08-10 Ultragenyx Pharmaceutical Inc. Director S-Sale D Common Stock 725,000 55.44 40.19M 1,475,000
2021-08-03 Chivukula Pad Officer S-Sale D Common Stock 10,000 40.07 400.7K 642,548
2021-06-18 Parschauer Karah Herdman Director A-Award A Stock Option (right to buy) 15,000 35.09 526.4K 15,000
2021-06-18 Marquet Magda Director A-Award A Stock Option (right to buy) 15,000 35.09 526.4K 15,000
2021-06-18 HOLMES EDWARD W Director A-Award A Stock Option (right to buy) 15,000 35.09 526.4K 15,000
2021-06-18 FARRELL PETER C Director A-Award A Stock Option (right to buy) 15,000 35.09 526.4K 15,000
2021-06-18 BARLOW JAMES F Director A-Award A Stock Option (right to buy) 15,000 35.09 526.4K 15,000
2021-04-01 Chivukula Pad Officer S-Sale D Common Stock 10,000 42.95 429.5K 652,548
2021-03-01 Chivukula Pad Officer S-Sale D Common Stock 10,000 54.23 542.3K 662,548
2021-02-01 Chivukula Pad Officer S-Sale D Common Stock 10,000 75.31 753.1K 672,548
2021-01-04 Chivukula Pad Officer S-Sale D Common Stock 10,000 46.40 464.0K 682,548
2020-12-18 SASSINE ANDY Director / Officer A-Award A Stock Option (right to buy) 100,000 99.29 9.93M 100,000
2020-12-18 Payne Joseph E Director / Officer / 10% Owner A-Award A Stock Option (right to buy) 175,000 99.29 17.38M 175,000
2020-12-18 Kurata Lance Officer A-Award A Stock Option (right to buy) 25,000 99.29 2.48M 25,000
2020-12-18 Kummerfeld Keith C Officer A-Award A Stock Option (right to buy) 45,000 99.29 4.47M 45,000
2020-12-18 Hughes Steven George Officer A-Award A Stock Option (right to buy) 50,000 99.29 4.96M 50,000
2020-12-18 Chivukula Pad Officer A-Award A Stock Option (right to buy) 100,000 99.29 9.93M 100,000
2020-12-09 Ultragenyx Pharmaceutical Inc. Director / 10% Owner S-Sale D Common Stock 357,745 94.97 33.98M 2,200,000
2020-12-08 Ultragenyx Pharmaceutical Inc. Director / 10% Owner S-Sale D Common Stock 442,255 105.54 46.68M 2,557,745
2020-12-01 Chivukula Pad Officer S-Sale D Common Stock 10,000 96.19 961.9K 692,548
2020-11-02 Chivukula Pad Officer S-Sale D Common Stock 10,000 55.28 552.8K 702,548
2020-10-01 Chivukula Pad Officer S-Sale D Common Stock 10,000 42.83 428.3K 712,548
2020-09-03 Chivukula Pad Officer S-Sale D Common Stock 10,000 45.16 451.6K 722,548
2020-08-10 Kurata Lance Officer A-Award A Stock Option (right to buy) 90,000 58.91 5.30M 90,000
2020-06-22 Parschauer Karah Herdman Director A-Award A Stock Option (right to buy) 15,000 40.70 610.5K 15,000
2020-06-22 Marquet Magda Director A-Award A Stock Option (right to buy) 15,000 40.70 610.5K 15,000
2020-06-22 HOLMES EDWARD W Director A-Award A Stock Option (right to buy) 15,000 40.70 610.5K 15,000
2020-06-22 FARRELL PETER C Director A-Award A Stock Option (right to buy) 15,000 40.70 610.5K 15,000
2020-06-22 BARLOW JAMES F Director A-Award A Stock Option (right to buy) 15,000 40.70 610.5K 15,000
2020-06-12 Kummerfeld Keith C Officer P-Purchase A Common Stock 450 33.33 15.0K 950
2020-06-10 SASSINE ANDY Director / Officer P-Purchase A Common Stock 5,000 29.74 148.7K 273,245
2020-06-10 Payne Joseph E Director / Officer P-Purchase A Common Stock 1,000 31.69 31.7K 1,475,097
2020-05-20 Ultragenyx Pharmaceutical Inc. Director / 10% Owner M-Exempt A Common Stock 600,000 16.00 9.60M 3,000,000
2020-02-18 SASSINE ANDY Director / Officer A-Award A Stock Option (right to buy) 80,000 14.12 1.13M 80,000
2020-02-18 Payne Joseph E Director / Officer / 10% Owner A-Award A Stock Option (right to buy) 100,000 14.12 1.41M 100,000
2020-02-18 Kummerfeld Keith C Officer A-Award A Stock Option (right to buy) 10,000 14.12 141.2K 10,000
2020-02-18 Hughes Steven George Officer A-Award A Stock Option (right to buy) 75,000 14.12 1.06M 75,000
2020-02-18 Chivukula Pad Officer A-Award A Stock Option (right to buy) 60,000 14.12 847.2K 60,000
2019-12-05 SASSINE ANDY Director / Officer P-Purchase A Common Stock 5,649 9.73 55.0K 268,245
2019-12-03 SASSINE ANDY Director / Officer P-Purchase A Common Stock 10,000 10.00 100.0K 257,596
2019-10-25 Parschauer Karah Herdman Director A-Award A Stock Option (right to buy) 15,000 10.23 153.5K 15,000
2019-10-25 Marquet Magda Director A-Award A Stock Option (right to buy) 15,000 10.23 153.5K 15,000
2019-10-25 HOLMES EDWARD W Director A-Award A Stock Option (right to buy) 15,000 10.23 153.5K 15,000
2019-10-25 FARRELL PETER C Director A-Award A Stock Option (right to buy) 15,000 10.23 153.5K 15,000
2019-10-25 BARLOW JAMES F Director A-Award A Stock Option (right to buy) 15,000 10.23 153.5K 15,000
2019-09-17 HOLMES EDWARD W Director 0 0.00 0
2019-09-13 Marquet Magda Director P-Purchase A Common Stock 2,300 10.58 24.3K 22,720
2019-09-12 Kummerfeld Keith C Officer P-Purchase A Common Stock 500 10.69 5.3K 500
2019-08-29 Payne Joseph E Director / Officer / 10% Owner P-Purchase A Common Stock 5,000 11.22 56.1K 1,474,097
2019-08-23 SASSINE ANDY Officer P-Purchase A Common Stock 10,000 10.90 109.0K 247,596
2019-08-20 FARRELL PETER C Director P-Purchase A Common Stock 4,432 10.85 48.1K 42,955
2019-08-19 FARRELL PETER C Director P-Purchase A Common Stock 4,681 11.02 51.6K 38,523
2019-06-19 Ultragenyx Pharmaceutical Inc. Director / 10% Owner D Common Stock 0 0.00 2,400,000
2019-06-19 Parschauer Karah Herdman Director 0 0.00 0
2019-02-07 Chivukula Pad Officer A-Award A Non-Qualified Stock Option (right to buy) 38,333 4.99 191.3K 38,333
2019-01-01 SASSINE ANDY Director / Officer D Ordinary Shares 0 0.00 237,596
2019-01-01 Marquet Magda Director D Ordinary Shares 0 0.00 20,500
2019-01-01 FARRELL PETER C Director D Ordinary Shares 0 0.00 86,452
2019-01-01 Chivukula Pad Officer D Ordinary Shares 0 0.00 732,548
2019-01-01 BARLOW JAMES F Director D Ordinary Shares 0 0.00 10,000
2018-08-24 Marquet Magda Director D STOCK OPTION (right to purchase) 2,500 8.00 20.0K 0
2018-08-24 FARRELL PETER C Director D STOCK OPTION (right to purchase) 2,500 8.00 20.0K 0
2018-08-24 BARLOW JAMES F Director D STOCK OPTION (right to purchase) 2,500 8.00 20.0K 0
2013-01-22 Stanley William G Director D-Return D Stock Option 3,000 10.00 30.0K 0
2013-01-22 SCHORSCH NICHOLAS S Director D-Return D Common Stock, par value $0.01 per share 7,540 0.00 0
2013-01-22 MICHELSON LESLIE D Director D-Return D Stock Option 3,000 10.00 30.0K 0
2013-01-22 KAHANE WILLIAM M Director / Officer D-Return D Common Stock, par value $0.01 per share 7,540 0.00 0
2013-01-22 Jones Brian D Officer D-Return D Common Stock, par value $0.01 per share 24,952 0.00 0
2013-01-22 Burns Robert Director D-Return D Common Stock, par value $0.01 per share 96,085 0.00 0
2012-06-18 Stanley William G Director A-Award A Common Stock, par value $0.01 per share 4,771 0.00 44,667
2012-06-18 MICHELSON LESLIE D Director A-Award A Common Stock, par value $0.01 per share 4,771 0.00 30,401
2012-06-18 Jones Brian D Officer A-Award A Common Stock 13,502 0.00 24,952
2012-06-18 Burns Robert Director A-Award A Common Stock, par value $0.01 per share 4,771 0.00 96,085
2012-04-18 Jones Brian D Officer P-Purchase A Common Stock, par value $0.01 per share 1,000 11.00 11.0K 11,450
2012-04-17 SCHORSCH NICHOLAS S Director P-Purchase A Common Stock, par value $0.01 per share 10,000 11.10 111.0K 993,240
2012-04-17 KAHANE WILLIAM M Director / Officer P-Purchase A Common Stock, par value $0.01 per share 10,000 11.10 111.0K 261,451
2012-03-01 Jones Brian D Officer D Common Stock, par value $0.01 0 0.00 10,450
2012-03-01 Budko Peter M 0 0.00 0
2012-03-01 BLOCK BRIAN S 0 0.00 0
2012-01-09 KAHANE WILLIAM M Director / Officer G-Gift D Common Stock, par value $0.01 per share 5,000 0.00 251,451
2011-10-01 Stanley William G Director A-Award A Common Stock, par value $0.01 per share 13,818 9.00 124.4K 26,451
2011-10-01 Burns Robert Director A-Award A Common Stock, par value $0.01 per share 9,818 9.00 88.4K 66,895
2011-05-24 Stanley William G Director A-Award A Common Stock, par value $0.01 per share 3,000 0.00 12,633
2011-05-24 MICHELSON LESLIE D Director A-Award A Common Stock, par value $0.01 per share 3,000 0.00 12,550
2011-05-24 Burns Robert Director A-Award A Common Stock, par value $0.01 per share 3,000 0.00 57,077
2010-05-17 Burns Robert Director A-Award A Stock Option 3,000 10.00 30.0K 9,000
2009-05-22 Stanley William G Director A-Award A Stock Option 3,000 10.00 30.0K 6,000
2009-05-22 MICHELSON LESLIE D Director A-Award A Stock Option 3,000 10.00 30.0K 6,000
2009-05-22 Burns Robert Director A-Award A Stock Option 3,000 10.00 30.0K 6,000
2008-01-22 Stanley William G Director A-Award A Stock Option 3,000 10.00 30.0K 3,000
2008-01-22 MICHELSON LESLIE D Director A-Award A Stock Option 3,000 10.00 30.0K 3,000
2008-01-22 Burns Robert Director A-Award A Stock Option 3,000 10.00 30.0K 3,000

Executive team

Top executives
EBIT / Employee
-430.8K
Shares Outstanding
28.42M

Executive compensation

Executive compensation (annual)
# Year Executive Salary Bonus Stock award Option award Incentive Other Total % Stock-
based
Filing
1 2025 Joseph E. Payne President and Chief Executive Officer, Director 750.0K 941.0K 1.69M 55.65%
2 2025 Andy Sassine Former Chief Financial Officer 572.0K 37.5K 572.0K 1.18M 3.17%
3 2025 Dr. Padmanabh Chivukula Chief Scientific Officer, Chief Operating Officer 572.0K 290.0K 862.0K 33.64%
4 2025 Lance Kurata Chief Legal Officer 540.0K 290.0K 830.0K 34.94%
5 2025 Joe Roberts Interim Principal Financial Officer and Accounting Officer; Controller 219.6K 54.0K 273.6K 19.74%
6 2024 Joseph E. Payne President and Chief Executive Officer, Director 695.0K 367.0K 2.64M 3.70M 71.27%
7 2024 Joseph E. Payne President and Chief Executive Officer, Director 695.0K 367.0K 2.64M 3.70M 71.27%
8 2024 Andy Sassine Chief Financial Officer, Director 550.0K 261.0K 807.0K 1.62M 49.88%
9 2024 Andy Sassine Former Chief Financial Officer 550.0K 261.0K 807.0K 1.62M 49.88%
10 2024 Dr. Padmanabh Chivukula Chief Scientific Officer, Chief Operating Officer 550.0K 228.0K 807.0K 1.59M 50.91%
11 2024 Dr. Padmanabh Chivukula Chief Scientific Officer, Chief Operating Officer 550.0K 228.0K 807.0K 1.59M 50.91%
12 2024 Lance Kurata Chief Legal Officer 500.0K 180.0K 807.0K 1.49M 54.27%
13 2024 Lance Kurata Chief Legal Officer 500.0K 180.0K 807.0K 1.49M 54.27%
14 2024 Joe Roberts Interim Principal Financial Officer and Accounting Officer; Controller 211.1K 38.0K 156.6K 405.7K 38.59%
15 2023 Joseph E. Payne President and Chief Executive Officer, Director 698.0K 208.5K 3.99M 4.89M 81.47%
16 2023 Joseph E. Payne President and Chief Executive Officer, Director 698.0K 208.5K 3.99M 4.89M 81.47%
17 2023 Dr. Padmanabh Chivukula Chief Scientific Officer, Chief Operating Officer 550.0K 137.5K 2.49M 3.18M 78.37%
18 2023 Dr. Padmanabh Chivukula Chief Scientific Officer, Chief Operating Officer 550.0K 137.5K 2.49M 3.18M 78.37%
19 2023 Andy Sassine Former Chief Financial Officer 550.0K 137.5K 1.50M 2.18M 68.50%
20 2023 Andy Sassine Chief Financial Officer, Director 550.0K 137.5K 1.50M 2.18M 68.50%
21 2023 Lance Kurata Chief Legal Officer 500.0K 100.0K 1.50M 2.10M 71.36%
22 2023 Lance Kurata Chief Legal Officer 500.0K 100.0K 1.50M 2.10M 71.36%
23 2023 Joe Roberts Interim Principal Financial Officer and Accounting Officer; Controller 182.0K 16.4K 149.5K 347.9K 42.97%
24 2022 Joseph E. Payne President and Chief Executive Officer, Director 630.0K 504.0K 4.46M 5.59M 79.73%
25 2022 Andy Sassine, Chief Financial Officer, Director 525.0K 301.9K 2.32M 3.15M 73.71%
26 2022 Andy Sassine Chief Financial Officer, Director 525.0K 301.9K 2.32M 3.15M 73.71%
27 2022 Dr. Padmanabh Chivukula Chief Scientific Officer, Chief Operating Officer 525.0K 262.5K 2.32M 3.11M 74.65%
28 2022 Lance Kurata Chief Legal Officer 435.0K 304.5K 442.5K 1.18M 37.44%
29 2021 Joseph E. Payne President and Chief Executive Officer, Director 600.0K 360.0K 960.0K 0.00%
30 2021 Andy Sassine, Chief Financial Officer 500.0K 250.0K 750.0K 0.00%
31 2021 Dr. Padmanabh Chivukula Chief Scientific Officer, Chief Operating Officer 500.0K 250.0K 750.0K 0.00%
32 2021 Andy Sassine, Chief Financial Officer, Director 500.0K 250.0K 750.0K 0.00%
33 2021 Dr. Steven Hughes Former Chief Medical Officer 460.0K 184.0K 644.0K 0.00%
34 2021 Lance Kurata Chief Legal Officer 400.0K 160.0K 560.0K 0.00%
35 2020 Joseph E. Payne President and Chief Executive Officer, Director 500.0K 450.0K 11.91M 12.86M 92.61%
36 2020 Andy Sassine, Chief Financial Officer 400.0K 240.0K 7.01M 7.65M 91.64%
37 2020 Dr. Padmanabh Chivukula Chief Scientific Officer, Chief Operating Officer 400.0K 240.0K 6.83M 7.47M 91.44%
38 2020 Lance Kurata Chief Legal Officer 156.3K 67.5K 4.92M 5.14M 95.65%
39 2020 Lance Kurata Chief Legal Officer 156.3K 67.5K 4.92M 5.14M 95.65%
40 2020 Dr. Steven Hughes Chief Medical Officer 415.0K 249.0K 4.21M 4.88M 86.38%
41 2020 Dr. Steven Hughes Former Chief Medical Officer 415.0K 249.0K 4.21M 4.88M 86.38%
42 2019 Andy Sassine, Chief Financial Officer 375.0K 150.0K 801.9K 1.33M 60.43%
43 2019 Joseph E. Payne President and Chief Executive Officer, Director 450.0K 243.0K 472.8K 1.17M 40.56%
44 2019 Dr. Padmanabh Chivukula Chief Scientific Officer, Chief Operating Officer 370.0K 133.2K 133.0K 636.2K 20.90%
45 2019 Dr. Steven Hughes Chief Medical Officer 299.9K 299.9K 0.00%
46 2018 Joseph E. Payne President and Chief Executive Officer, Director 425.0K 372.5K 1.25M 2.69M 0.00%
47 2018 Dr. Padmanabh Chivukula Chief Scientific Officer, Chief Operating Officer 350.0K 83.2K 515.1K 1.37M 0.00%
48 2018 Dr. Padmanabh Chivukula Chief Scientific Officer and Chief Operating Officer 350.0K 83.2K 424.6K 515.1K 1.37M 30.93%
49 2018 Mark Herbert Interim President 307.2K 153.6K 460.8K 0.00%
50 2018 Andy Sassine, Chief Financial Officer 120.0K 246.3K 0.00%
51 2018 Andy Sassine Interim Chief Financial Officer 120.0K 126.3K 246.3K 51.29%
52 2017 Joseph E. Payne President and Chief Executive Officer, Director 384.0K 40.8K 24.0K 448.8K 0.00%
53 2017 Dr. Padmanabh Chivukula Chief Scientific Officer and Chief Operating Officer 335.0K 40.8K 72.00 375.9K 0.00%
CEO compensation breakdown

Proxy statements

Proxy statements (DEF 14A)
Filing date Form type Filing
2026-04-24 DEF 14A
2025-04-25 DEF 14A
2024-04-29 DEF 14A

Recent SEC filings

Recent SEC filings
Filing date Form type Filing
2026-05-07 SC 13G/A
2026-05-07 8-K
2026-05-07 4
2026-05-07 3
2026-05-07 10-Q
2026-04-24 DEF 14A
2026-03-26 SC 13G/A
2026-03-03 8-K
2026-03-03 10-K
2026-02-17 SC 13G/A

Executive team

NameTitleCompensationGender
Joseph E. Payne Founder, President, Chief Executive Officer & Director 750.0K male
Padmanabh Chivukula Founder, Chief Scientific Officer, Chief Operating Officer & Secretary 572.0K
Lance Kurata Chief Legal Officer 540.0K male
Joseph Roberts Principal Financial & Accounting Officer and Controller 219.6K male
Neda Safarzadeh Vice President and Head of IR/PR & Marketing female
Alan H. Cohen FAAAAI FAAP FACAAI FCCP Chief Medical Officer
Ye Zhang Chief Regulatory & Quality Assurance Officer
Igor Smolenov Chief Development Officer
Kevin T. Skol Chief Business Officer male
Natash O. Bowman Chief Human Resources Officer female
ESG Rating
B
BIOTECHNOLOGY
2025
E (Environmental)
70.5 / 56.3
Company / Sector avg.
S (Social)
69.2 / 62.4
Company / Sector avg.
G (Governance)
62.9 / 60.9
Company / Sector avg.
ESG Total
67.5 / 59.9
Company / Sector avg.
ESG Score History BIOTECHNOLOGY
Benchmark vs Sector
Senate Trading Activity

No Senate trading activity found for this company.

House Trading Activity

No House trading activity found for this company.

Market share among peers
Peer comparison — filtered group (TTM)
Your opinion

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Dividend yield history

Dividend history

Earnings history

Earnings reports

Stock splits