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Aprea Therapeutics, Inc. (APRE)

USD0.70 -0.03 (-4.20%)
US NASDAQ Healthcare Biotechnology
Address 535 Boylston St. 2116
Boston, MA, US
CEO Oren Gilad
IPO 2019-10-03
CIK 1781983 ISIN US03836J2015

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Description

Aprea Therapeutics, Inc. is a biopharmaceutical company in its clinical development stage, dedicated to discovering and marketing innovative cancer treatments. Their therapeutic approach centers on modulating DNA damage response pathways. The company's primary drug candidate, ATRN-119, is an oral ATR inhibitor currently undergoing Phase 1/2a clinical trials for patients with advanced solid tumors. Beyond this lead compound, Aprea's developmental pipeline includes ATRN-Backup, which is also an ATR inhibitor; ATRN-W1051, being explored for its anti-tumor effects; and ATRN-DDRi. Aprea Therapeutics, Inc. is headquartered in Boston, Massachusetts.

Market Cap & Enterprise Value
Merger & Acquisition History

No mergers or acquisitions recorded for this company.

Technical Outlook
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Signal Summary Loading…
Indicator 1D1W2W3W1M
Each column is computed on that timeframe's candles (1D = daily, 1W ≈ weekly, 1M ≈ monthly), not on the same last day. ▲ bullish · ▼ bearish · — neutral. The Net row counts signals per column; hover any cell (or the indicator name) to see the exact rule behind it.
Day Score & sub-scores
Statistical fingerprint & regime detail
Conditional historical analysis
Customize analysis (advanced)
Indicative levels generated algorithmically. Not financial advice.
Risk Profile
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Price Chart
Averages
Trend
Price
Levels
Draw
USD0.70 -0.03 (-4.20%)
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Volume Profile
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Liquidity & share structure
Average Volume
210.1K
Beta
1.56
Float Shares
4.85M
Free Float %
74.7%
Price Performance
1D5D1M3M6M YTD1Y3Y5Y10YMax
-2.22% -5.38% +3.90% +44.40% -26.05% +3.17% -41.33% -75.96% -98.91% -99.79% -99.79%
Rolling Volatility
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Drawdown
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Relative Strength
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Monthly Returns Heatmap
From To
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Annual Monthly Returns
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Daily Returns Distribution
vs.
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Revenue flow

Revenue by geography

Revenue by segment

From To

Revenue composition

From To

By product

By geography

Financial Statements

Income Statement

Balance Sheet

Cash Flow Statement

Key Metrics

Financial Ratios

Employees

Financial Growth (CAGR)

Market Data

Analyst Consensus (8 ratings, all time) Buy
Price Targets & DCF
Current price
0.70
DCF (Unlevered) 2.13 +205.9%
DCF (Levered) 2.23 +220.0%

DCF figures are point estimates: small changes in growth or discount-rate assumptions move them materially. Read them as a reference, not a precise target.

Ratings Trend (MoM) 100% Bullish
Rating 2026-05 Change
Strong Buy 1 0
Buy 2 0
Hold 0 0
Sell 0 0
Strong Sell 0 0
Quality scores
Altman Z-Score
-9.10
Distress
Piotroski F-Score
2 / 9
Weak
MOAT Score
0 / 10
No MOAT
Composite Rating
B-
Overall Score
2 / 5
Medium
DCF Score
5 / 5
High
ROE Score
1 / 5
Low
ROA Score
1 / 5
Low
D/E Score
1 / 5
Low
P/E Score
1 / 5
Low
P/Book Score
5 / 5
High
Operational MOAT
✗ Below peers
  • Revenue growth Biotechnology: +1.6%
    -100.0% Q1'26: -100.0% (vs Q1'25)
  • EPS growth Biotechnology: +29.7%
    +17.9% Q1'26: +66.7% (vs Q1'25)
  • FCF margin FCF growth · Biotechnology: +16.2%
  • EBIT margin Biotechnology: +0.0%
  • ROIC Biotechnology: -16.1%
    Q1'26: +0.0% (vs Q1'25)
  • Share dilution Biotechnology: -3.4%
    +18.7% Q1'26: +145.0% (vs Q1'25)
  • Debt / EBITDA Net debt/EBITDA · Biotechnology: 0.16×
    0.00× Q1'26: 0.00× (vs Q1'25)
Valuation Multiples From To
Price Forecast (3Y) From To
Model
Adjust
P/E
Theoretical Return — If Invested Today

* These projections are based on analyst consensus estimates and user-defined valuation multiples. This table is for informational purposes only and does not constitute a recommendation to buy or sell any security. Past performance is not indicative of future results.

DCF Interactive Model (UFCF)
Projection years:
Market assumptions
WACC components (optional)
Ke (Cost of Equity) = Rf + β (1.52) × ERP
WACC = 100% × Ke + 0% × Kd (4.1%) × (1−t)

Modifying these values recalculates WACC automatically.

Business assumptions
Intrinsic value (base): 2.13 Current price: 0.70
Enterprise Value: Equity Value: Terminal Value: TV as % of EV:

Base values reflect the latest available data for this company and market conditions.

Consensus Estimates
Metric Dec 2022
actual
Dec 2023
actual
Dec 2024
actual
Dec 2025
actual
Dec 2026
2 Rev. Ana.
2 EPS Ana.
Dec 2027
2 Rev. Ana.
2 EPS Ana.
Dec 2028
3 Rev. Ana.
3 EPS Ana.
Dec 2029
2 Rev. Ana.
1 EPS Ana.
Dec 2030
1 Rev. Ana.
1 EPS Ana.
Revenue
est: 249.7K (-100.0%)
583.2K
est: 1.28M (-54.3%)
1.50M
est: 1.34M (+12.2%)
est: 293.7K (-100.0%)
150.0K
150.0K – 150.0K
-48.9% YoY
1.61M
1.61M – 1.61M
+971.3% YoY
3.41M
3.41M – 3.41M
+112.2% YoY
65.72M
65.72M – 65.72M
+1,826.9% YoY
145.23M
145.23M – 145.23M
+121.0% YoY
EBITDA
-37.37M
est: 49.9K (-74,929.6%)
-14.28M
est: -255.1K (-5,496.9%)
-14.30M
est: -267.7K (-5,240.1%)
-13.21M
est: -58.7K (-22,395.2%)
-30.0K
-30.0K – -30.0K
+48.9% YoY
-321.4K
-321.4K – -321.4K
-971.4% YoY
-682.1K
-682.1K – -682.1K
-112.2% YoY
-13.14M
-13.14M – -13.14M
-1,826.9% YoY
-29.05M
-29.05M – -29.05M
-121.0% YoY
EBIT
-37.37M
est: 49.9K (-74,938.4%)
-14.29M
est: -255.1K (-5,499.6%)
-14.32M
est: -267.7K (-5,248.5%)
-13.23M
est: -58.7K (-22,432.2%)
-30.0K
-30.0K – -30.0K
+48.9% YoY
-321.4K
-321.4K – -321.4K
-971.4% YoY
-682.1K
-682.1K – -682.1K
-112.2% YoY
-13.14M
-13.14M – -13.14M
-1,826.9% YoY
-29.05M
-29.05M – -29.05M
-121.0% YoY
Net Income
-112.66M
est: -400.57M (+71.9%)
-14.29M
est: -19.20M (+25.6%)
-12.96M
est: -16.38M (+20.9%)
-12.60M
est: -13.01M (+3.2%)
-4.47M
-5.00M – -3.95M
+65.6% YoY
-3.96M
-5.52M – -2.40M
+11.5% YoY
-5.37M
-7.32M – -3.42M
-35.7% YoY
882.7K
882.7K – 882.7K
+116.4% YoY
6.64M
6.64M – 6.64M
+651.9% YoY
SGA
20.97M
est: 1.09M (+1,831.9%)
8.42M
est: 11.07M (-24.0%)
6.46M
est: 11.62M (-44.4%)
6.48M
est: 2.55M (+154.1%)
1.30M
1.30M – 1.30M
-48.9% YoY
13.95M
13.95M – 13.95M
+971.3% YoY
29.60M
29.60M – 29.60M
+112.2% YoY
570.44M
570.44M – 570.44M
+1,826.9% YoY
1.26B
1.26B – 1.26B
+121.0% YoY
EPS
-1,359.79
est: -72.70 (-1,770.4%)
-3.95
est: -2.94 (-34.5%)
-2.35
est: -2.51 (+6.4%)
-1.93
est: -1.99 (+3.0%)
-0.70
-0.76 – -0.60
+64.8% YoY
-0.65
-0.84 – -0.37
+7.9% YoY
-0.73
-1.12 – -0.52
-13.2% YoY
0.14
0.14 – 0.14
+118.5% YoY
1.02
1.02 – 1.02
+651.9% YoY
Historical Ratings (3M)
Date Rating Overall DCF ROE ROA D/E P/E P/B
2026-05-13 B- 2/5 5/5 1/5 1/5 1/5 1/5 5/5
2026-05-12 B- 2/5 5/5 1/5 1/5 1/5 1/5 5/5
2026-05-11 B- 2/5 5/5 1/5 1/5 1/5 1/5 5/5
2026-05-08 B- 2/5 5/5 1/5 1/5 1/5 1/5 5/5
2026-05-07 B- 2/5 5/5 1/5 1/5 1/5 1/5 5/5
2026-05-06 B- 2/5 5/5 1/5 1/5 1/5 1/5 5/5
2026-05-05 B- 2/5 5/5 1/5 1/5 1/5 1/5 5/5
2026-05-04 B- 2/5 5/5 1/5 1/5 1/5 1/5 5/5
2026-05-01 B- 2/5 5/5 1/5 1/5 1/5 1/5 5/5
2026-04-30 B- 2/5 5/5 1/5 1/5 1/5 1/5 5/5
2026-04-29 B- 2/5 5/5 1/5 1/5 1/5 1/5 5/5
2026-04-28 B- 2/5 5/5 1/5 1/5 1/5 1/5 5/5
2026-04-27 B- 2/5 5/5 1/5 1/5 1/5 1/5 5/5
2026-04-24 B- 2/5 5/5 1/5 1/5 1/5 1/5 5/5
2026-04-23 B- 2/5 5/5 1/5 1/5 1/5 1/5 5/5
2026-04-22 B- 2/5 5/5 1/5 1/5 1/5 1/5 5/5
2026-04-21 B- 2/5 5/5 1/5 1/5 1/5 1/5 5/5
2026-04-20 B- 2/5 5/5 1/5 1/5 1/5 1/5 5/5
2026-04-17 B- 2/5 5/5 1/5 1/5 1/5 1/5 5/5
2026-04-16 B- 2/5 5/5 1/5 1/5 1/5 1/5 5/5

Owner Earnings

Owner's Earnings (history) From To
Owner alignment
Owner's Earnings TTM
-12.89M
OE per share TTM
-1.71
Owner's Yield
-99.71%
Maintenance CapEx ratio
Maint CapEx / Avg PPE
57.5%

Ownership Overview

Ownership breakdown
At a glance
Institutional holders
11
Total invested
1.32M
Insider transactions (90d)
0
Beneficial owners (>5%)
37
Beneficial owners (>5%)
# Reporting person Amount owned % of class Sole voting Shared voting Sole dispositive Shared dispositive Type Citizenship Filing date SEC filing
1 HealthCap VII GP S.A. 2.37M 11.20% 2.37M 2.37M OO 2021-10-15
2 HealthCap VII, L.P. 2.37M 11.20% 2.37M 2.37M PN 2021-10-15
3 KCIF Co-Investment Fund KB 1.78M 8.40% 1.78M 1.78M OO Sweden 2021-02-16
4 KDev Investments AB 1.78M 8.40% 1.78M 1.78M OO Sweden 2021-02-16
5 Karolinska Development AB 1.78M 8.40% 1.78M 1.78M OO Sweden 2021-02-16
6 5AM Partners IV, LLC 619.2K 2.90% 619.2K 10.00 OO Delaware 2021-02-16
7 Andrew J. Schwab 619.2K 2.90% 619.2K 10.00 IN United States 2021-02-16
8 Dr. John D. Diekman 619.2K 2.90% 619.2K 10.00 IN United States 2021-02-16
9 Dr. Scott M. Rocklage 619.2K 2.90% 619.2K 10.00 IN United States 2021-02-16
10 5AM Ventures IV, L.P. 594.4K 2.80% 594.4K 10.00 PN Delaware 2021-02-16
11 Jon M. Plexico 365.4K 11.00% 365.4K 365.4K HC, IN U.S.A. 2024-10-10
12 Stonepine Capital Management, LLC 365.4K 11.00% 365.4K 365.4K IA, OO Delaware 2024-10-10
13 Stonepine Capital, L.P. 365.4K 11.00% 365.4K 365.4K PN Delaware 2024-10-10
14 Stonepine GP, LLC 365.4K 11.00% 365.4K 365.4K OO Delaware 2024-10-10
15 (. 345.0K 9.20% 345.0K IN United States 2023-03-03
16 27-4413262 345.0K 9.20% 345.0K OO Maryland 2023-03-03
17 Sio Capital Management, LLC   20-4586565 280.0K 7.49% 280.0K IA Delaware 2024-02-14
18 Morgan Stanley 185.0K 0.90% 184.0K 185.0K HC, CO Delaware. 2021-10-12
19 Morgan Stanley Capital Services LLC 184.0K 0.90% 184.0K 184.0K CO Delaware. 2021-10-12
20 Jérôme G. Pfund 163.7K 0.77% 163.7K 163.7K IN Swiss 2021-02-12
21 Michael L. Sjöström 163.7K 0.77% 163.7K 163.7K IN Swiss 2021-02-12
22 Opportunities Fund III, L.P 163.7K 0.77% 163.7K 163.7K PN Sectoral GP III, L.P.: Canada 2021-02-12
23 Sectoral Asset Management Inc. 163.7K 0.77% 163.7K 163.7K IA Canada 2021-02-12
24 5AM Opportunities I (GP), LLC 138.5K 0.70% 138.5K 10.00 OO Delaware 2020-11-19
25 13G 36.8K 0.20% 36.8K 36.8K PN 2021-02-16
26 5AM Co-Investors IV, L.P. 24.8K 0.10% 24.8K 10.00 PN Delaware 2021-02-16
27 5AM Opportunities I, L.P. 0.00% 10.00 PN Delaware 2021-02-16
28 EIN #00-0000000 0.00% IA, HC Jersey Channel Islands 2021-02-11
29 GP-GP 0.00% CO 2022-02-11
30 Jeremy C. Green 0.00% HC, IN United Kingdom 2022-02-14
31 Redmile Group, LLC 0.00% IA, OO Delaware 2022-02-14
32 Versant Affiliates Fund V, L.P. 0.00% PN 2022-02-11
33 Versant Ophthalmic Affiliates Fund I, L.P. 0.00% PN 2022-02-11
34 Versant Venture Capital V (Canada) LP 0.00% PN 2022-02-11
35 Versant Venture Capital V, L.P. 0.00% PN 2022-02-11
36 Versant Ventures V (Canada), L.P. 0.00% PN 2022-02-11
37 Versant Ventures V, LLC 0.00% OO 2022-02-11

Institutional Activity (13F)

Institutional ownership trend From To
13F snapshot — 2026 Q1
Investors holding
11
-11 vs prev Q
New positions
2
Closed positions
13
Increased
5
Reduced
2
Put/Call ratio
0.00
Calls held
Puts held
Top institutional holders
# Investor Shares / Δ Mkt value / Δ Own% / Δ Weight% / Δ Avg px / Perf. Hold / Status
1 AIGH CAPITAL MANAGEMENT LLC 370.5K -168.8K (-31.3%) 316.1K -479.4K (-60.3%) 5.81% -3.051 pp 0.08% -0.148 pp USD5.10 -83.3% 12 qtrs
2 MURCHINSON LTD. 340.1K +340.1K (+100.0%) 290.1K +290.1K (+100.0%) 5.34% +5.337 pp 0.05% +0.047 pp USD0.85 +0.0% 1 qtrs NEW
3 SPHERA FUNDS MANAGEMENT LTD. 270.0K +— (+0.0%) 230.3K -167.9K (-42.2%) 4.24% -0.202 pp 0.04% -0.040 pp USD6.35 -86.6% 8 qtrs
4 NANTAHALA CAPITAL MANAGEMENT, LLC 205.8K +— (+0.0%) 175.5K -128.0K (-42.2%) 3.23% -0.154 pp 0.01% -0.005 pp USD6.35 -86.6% 8 qtrs
5 DRW SECURITIES, LLC 120.7K +120.7K (+100.0%) 102.9K +102.9K (+100.0%) 1.89% +1.893 pp 0.00% +0.003 pp USD0.85 +0.0% 1 qtrs NEW
6 MORGAN STANLEY 77.0K +11.2K (+17.1%) 65.7K -31.4K (-32.3%) 1.21% +0.127 pp 0.00% +0.000 pp USD2.81 -69.8% 12 qtrs
7 VANGUARD GROUP INC 58.1K -100.2K (-63.3%) 49.5K -183.9K (-78.8%) 0.91% -1.690 pp 0.00% +0.000 pp USD4.76 -82.1% 12 qtrs
8 CITADEL ADVISORS LLC 51.0K +51.0K (+100.0%) 43.5K +43.5K (+100.0%) 0.80% +0.801 pp 0.00% +0.000 pp USD0.85 +0.0% 1 qtrs NEW
9 JANE STREET GROUP, LLC 46.6K +46.6K (+100.0%) 39.8K +39.8K (+100.0%) 0.73% +0.732 pp 0.00% +0.000 pp USD0.85 +0.0% 1 qtrs NEW
10 GEODE CAPITAL MANAGEMENT, LLC 41.0K -3.7K (-8.2%) 34.9K -30.9K (-46.9%) 0.64% -0.091 pp 0.00% +0.000 pp USD3.55 -76.1% 11 qtrs
11 BNP PARIBAS ARBITRAGE, SNC 27.3K +10.2K (+59.5%) 23.3K -2.0K (-7.7%) 0.43% +0.147 pp 0.00% +0.000 pp USD2.14 -60.3% 5 qtrs
12 LPL FINANCIAL LLC 26.1K +10.0K (+62.3%) 22.2K -1.5K (-6.1%) 0.41% +0.145 pp 0.00% +0.000 pp USD2.30 -63.0% 5 qtrs
13 XTX TOPCO LTD 24.3K +24.3K (+100.0%) 20.7K +20.7K (+100.0%) 0.38% +0.381 pp 0.00% +0.001 pp USD0.85 +0.0% 1 qtrs NEW
14 HIGHTOWER ADVISORS, LLC 13.9K +— (+0.0%) 11.8K -8.6K (-42.2%) 0.22% -0.010 pp 0.00% +0.000 pp USD6.35 -86.6% 8 qtrs
15 BLACKROCK, INC. 8.5K +— (+0.0%) 7.3K -5.3K (-42.2%) 0.13% -0.006 pp 0.00% +0.000 pp USD2.75 -69.1% 6 qtrs
16 TOWER RESEARCH CAPITAL LLC (TRC) 7.8K +7.3K (+1,278.0%) 6.7K +5.8K (+696.7%) 0.12% +0.114 pp 0.00% +0.000 pp USD1.01 -15.8% 12 qtrs
17 BANK OF AMERICA CORP /DE/ 3.3K -1.6K (-32.1%) 2.8K -4.4K (-60.8%) 0.05% -0.028 pp 0.00% +0.000 pp USD4.07 -79.1% 12 qtrs
18 UBS GROUP AG 2.5K +2.5K (+81,933.3%) 2.1K +2.1K (+52,400.0%) 0.04% +0.039 pp 0.00% +0.000 pp USD0.85 +0.0% 12 qtrs
19 GROUP ONE TRADING, L.P. 577.00 +— (+0.0%) 492.00 -359.0 (-42.2%) 0.01% 0.000 pp 0.00% +0.000 pp USD4.44 -80.9% 12 qtrs
20 ADVISOR GROUP HOLDINGS, INC. 300.00 -100.0 (-25.0%) 255.00 -354.0 (-58.1%) 0.00% -0.002 pp 0.00% +0.000 pp USD2.34 -63.7% 12 qtrs
21 WEALTHCOLLAB, LLC 158.00 +— (+0.0%) 135.00 -99.0 (-42.3%) 0.00% 0.000 pp 0.00% 0.000 pp USD4.70 -81.9% 9 qtrs
22 SBI SECURITIES CO., LTD. 15.00 -27.0 (-64.3%) 13.00 -49.0 (-79.0%) 0.00% -0.001 pp 0.00% +0.000 pp USD3.13 -72.8% 5 qtrs
23 MB, LEVIS & ASSOCIATES, LLC -806.0 (-100.0%) -1.2K (-100.0%) 0.00% -0.013 pp 0.00% -0.001 pp USD 11 qtrs SOLD
24 LANDSCAPE CAPITAL MANAGEMENT, L.L.C. -10.5K (-100.0%) -15.5K (-100.0%) 0.00% -0.173 pp 0.00% -0.001 pp USD 5 qtrs SOLD
25 HRT FINANCIAL LP -12.3K (-100.0%) -18.0K (-100.0%) 0.00% -0.202 pp 0.00% 0.000 pp USD 2 qtrs SOLD
26 DAFNA CAPITAL MANAGEMENT LLC -137.2K (-100.0%) -202.3K (-100.0%) 0.00% -2.255 pp 0.00% -0.050 pp USD 8 qtrs SOLD
27 CITIGROUP INC -5.0 (-100.0%) -7.0 (-100.0%) 0.00% 0.000 pp 0.00% +0.000 pp USD 2 qtrs SOLD
28 SIO CAPITAL MANAGEMENT, LLC -112.2K (-100.0%) -165.5K (-100.0%) 0.00% -1.845 pp 0.00% -0.042 pp USD 12 qtrs SOLD
Ownership breakdown by holder

ETF Ownership

Top ETFs holding this stock Held by 1 ETFs in our universe
# ETF Weight Est. AUM exposure TER
1 Vanguard Extended Market ETF VXF 0.00% 17.1K 0.05%

Insider Activity

Insider Activity — Latest Quarter
Ratio by transactions
0.00
Bearish
Buys
12
Sells
0
Shares acquired
528.7K
Shares disposed
Cash buys
8.00
Cash sales
Net activity
+528,736
Insider buys vs sells (history) From To
Recent insider transactions From To
Date Person Role Transaction A/D Security Shares Price Value Owned after D/I Filing
2026-03-31 Peters Richard Director P-Purchase A Pre-Funded Warrant 123,915 0.00 123.92 123,915 D
2026-03-31 Hamill John P. Officer P-Purchase A Pre-Funded Warrant 30,978 0.00 30.98 30,978 D
2026-03-12 Hamill John P. Officer A-Award A Common Stock 10,095 0.00 43,528 D
2026-03-12 Gilad Oren Director / Officer A-Award A Common Stock 20,175 0.00 393,895 D
2026-01-30 Hamill John P. Officer P-Purchase A Common Stock 5,700 0.89 5.1K 33,433 D
2026-01-30 Gilad Oren Director / Officer P-Purchase A Common Stock 28,100 0.89 25.0K 373,720 D
2025-12-10 Hamill John P. Officer P-Purchase A Common Warrant 5,000 1.04 5.2K 5,000 D
2025-12-10 Gilad Oren Director / Officer P-Purchase A Pre-Funded Warrant 21,459 0.00 2.15 21,459 D
2025-12-10 Duey Marc Director P-Purchase A Common Stock 21,459 1.17 25.0K 256,155 D
2025-06-05 Seizinger Bernd R. Director A-Award A Common Stock 1,045 0.00 45,775 D
2025-06-05 Peters Richard Director A-Award A Common Stock 1,045 0.00 3,119 D
2025-06-05 Pamukcu Rifat Director A-Award A Stock Options (Right to Buy) 4,185 1.81 7.6K 4,185 D
2025-06-05 HENNEMAN JOHN B III Director A-Award A Stock Options (Right to Buy) 4,185 1.81 7.6K 4,185 D
2025-06-05 Gruia Gabriela Director A-Award A Stock Options (Right to Buy) 4,185 1.81 7.6K 4,185 D
2025-06-05 Grissinger Michael Director A-Award A Common Stock 1,045 0.00 2,889 D
2025-06-05 Duey Marc Director A-Award A Stock Options (Right to Buy) 4,185 1.81 7.6K 4,185 D
2025-06-05 BIZZARI JEAN-PIERRE Director A-Award A Common Stock 1,045 0.00 1,045 D
2025-04-03 Gilad Oren Director / Officer P-Purchase A Common Stock 2,497 1.80 4.5K 345,620 D
2025-03-27 Hamill John P. Officer A-Award A Common Stock 3,365 0.00 22,733 D
2025-03-27 Gilad Oren Director / Officer A-Award A Common Stock 6,725 0.00 340,120 D
2024-10-23 Gilad Oren Director / Officer P-Purchase A Common Stock 500 3.92 2.0K 333,395 D
2024-10-18 Duey Marc Director S-Sale D Common Stock 6,462 4.58 29.6K 233,651 D
2024-10-16 Duey Marc Director P-Purchase A Common Stock 30,000 4.39 131.7K 240,113 D
2024-10-15 Gilad Oren Director / Officer P-Purchase A Common Stock 250 2.90 725.00 332,895 D
2024-10-14 Gilad Oren Director / Officer P-Purchase A Common Stock 1,000 2.59 2.6K 332,645 D
2024-10-14 Duey Marc Director P-Purchase A Common Stock 190 2.58 490.20 210,113 D
2024-10-11 Seizinger Bernd R. Director P-Purchase A Common Stock 10,000 2.68 26.8K 44,730 D
2024-10-11 Hamill John P. Officer P-Purchase A Common Stock 50 2.46 123.19 19,368 D
2024-10-10 Hamill John P. Officer P-Purchase A Common Stock 450 2.61 1.2K 19,318 D
2024-10-10 Gilad Oren Director / Officer P-Purchase A Common Stock 150 2.54 381.00 331,645 D
2024-06-20 Seizinger Bernd R. Director A-Award A Stock Options (Right to Buy) 4,185 4.07 17.0K 4,185
2024-06-20 Peters Richard Director A-Award A Common Stock 1,045 0.00 2,074
2024-06-20 Pamukcu Rifat Director A-Award A Stock Options (Right to Buy) 4,185 4.07 17.0K 4,185
2024-06-20 HENNEMAN JOHN B III Director A-Award A Stock Options (Right to Buy) 4,185 4.07 17.0K 4,185
2024-06-20 Grissinger Michael Director A-Award A Common Stock 1,045 0.00 1,844
2024-06-20 Duey Marc Director A-Award A Stock Options (Right to Buy) 4,185 4.07 17.0K 4,185
2024-05-01 Mirza Nadeem Q. Officer A-Award A Stock Options (Right to Purchase) 26,920 5.25 141.3K 26,920
2024-03-28 Hamill John P. Officer A-Award A Common Stock 3,365 0.00 18,868
2024-03-28 Gilad Oren Director / Officer A-Award A Common Stock 6,725 0.00 331,495
2024-03-13 Seizinger Bernd R. Director P-Purchase A Tranche B Warrant 3,430 0.00 3,430
2024-03-13 Hamill John P. Officer P-Purchase A Tranche A Warrant 505 0.00 505
2024-03-13 HENNEMAN JOHN B III Director P-Purchase A Tranche B Warrant 3,430 0.00 3,430
2024-03-13 Gilad Oren Director / Officer P-Purchase A Common Stock 2,000 7.29 14.6K 324,770
2023-08-23 Seizinger Bernd R. Director A-Award A Stock Options (Right to Buy) 2,000 3.65 7.3K 2,000
2023-08-23 Peters Richard Director A-Award A Common Stock 500 0.00 1,029
2023-08-23 Pamukcu Rifat Director A-Award A Stock Options (Right to Buy) 2,000 3.65 7.3K 2,000
2023-08-23 HENNEMAN JOHN B III Director A-Award A Common Stock 500 0.00 1,279
2023-08-23 Grissinger Michael Director A-Award A Common Stock 500 0.00 799
2023-08-23 Duey Marc Director A-Award A Stock Options (Right to Buy) 2,000 3.65 7.3K 2,000
2023-08-23 BIZZARI JEAN-PIERRE Director A-Award A Stock Options (Right to Buy) 12,500 3.65 45.6K 12,500
2023-06-07 Seizinger Bernd R. Director P-Purchase A Common Stock 6,029 3.68 22.2K 26,325
2023-06-06 Seizinger Bernd R. Director P-Purchase A Common Stock 4,068 3.63 14.8K 20,296
2023-05-05 Gruia Gabriela Director A-Award A Stock Options (Right to Buy) 12,500 3.90 48.7K 12,500
2023-03-09 Gilad Oren Director / Officer A-Award A Common Stock 4,000 0.00 322,770
2023-02-27 Hamill John P. Officer A-Award A Common Stock 1,000 5.25 5.3K 14,493
2023-01-30 Hamill John P. Officer A-Award A Employee Stock Option (Right to Buy) 539,758 0.00 539,758
2022-08-23 Pamukcu Rifat Director C-Conversion D Series A Non-Voting Convertible Preferred Stock 27,187 0.00 0
2022-08-23 Gilad Oren Director / Officer C-Conversion A Common Stock 6,045,100 0.00 6,375,414
2022-08-23 Duey Marc Director C-Conversion A Common Stock 11,610 0.00 602
2022-07-28 Seizinger Bernd R. Director A-Award A Stock Option (right to Buy) 29,575 1.09 32.2K 29,575
2022-07-28 SCHADE CHRISTIAN S Director A-Award A Stock Option (right to Buy) 47,600 1.09 51.9K 47,600
2022-07-28 Peters Richard Director A-Award A Common Stock 5,995 0.00 10,605
2022-07-28 Korbel Gregory Alan Officer A-Award A Common Stock 24,300 0.00 45,762
2022-07-28 HENNEMAN JOHN B III Director A-Award A Common Stock 5,995 0.00 15,605
2022-07-28 Grissinger Michael Director A-Award A Common Stock 5,995 0.00 5,995
2022-07-28 Coiante Scott M Officer A-Award A Stock Option (right to Buy) 89,200 1.09 97.2K 89,200
2022-06-03 SCHADE CHRISTIAN S Director / Officer F-InKind D Common Stock 65,770 0.81 52.9K 226,846
2022-06-03 Korbel Gregory Alan Director / Officer F-InKind D Common Stock 8,390 0.81 6.8K 21,462
2022-06-03 Coiante Scott M Director / Officer F-InKind D Common Stock 35,284 0.81 28.4K 84,265
2022-05-18 Seizinger Bernd R. Director P-Purchase A Common Stock 50,000 0.71 35.5K 318,580
2022-05-18 SCHADE CHRISTIAN S Director / Officer P-Purchase A Common Stock 37,500 0.64 24.1K 292,616
2022-05-16 Grissinger Michael Director D Stock Option (right to buy) 72,638 0.44 32.0K 0
2022-03-10 SCHADE CHRISTIAN S Director / Officer A-Award A Stock Option (right to Buy) 427,700 1.82 778.4K 427,700
2022-03-10 Korbel Gregory Alan Director / Officer F-InKind D Common Stock 1,989 1.82 3.6K 29,852
2022-03-10 Coiante Scott M Director / Officer A-Award A Common Stock 42,900 0.00 119,549
2022-03-10 Abrahmsen Lars B. Officer A-Award A Common Stock 24,700 0.00 43,700
2022-02-25 SCHADE CHRISTIAN S Director / Officer F-InKind D Common Stock 21,644 1.74 37.7K 155,016
2022-02-25 Korbel Gregory Alan Officer F-InKind D Common Stock 1,326 1.74 2.3K 15,841
2022-02-25 Coiante Scott M Officer F-InKind D Common Stock 14,817 1.74 25.8K 76,649
2021-12-01 Korbel Gregory Alan Officer M-Exempt D Stock Option (right to Buy) 27,500 0.92 25.3K 2,335
2021-11-01 Korbel Gregory Alan Officer M-Exempt D Stock Option (right to Buy) 2,255 0.92 2.1K 29,835
2021-10-01 Korbel Gregory Alan Officer M-Exempt A Common Stock 27,500 0.92 25.3K 44,667
2021-10-01 Abrahmsen Lars B. Officer M-Exempt A Common Stock 50,000 0.92 46.0K 69,000
2021-09-20 Korbel Gregory Alan Officer S-Sale D Common Stock 27,500 4.97 136.7K 17,167
2021-09-20 Abrahmsen Lars B. Officer M-Exempt A Common Stock 25,000 0.92 23.0K 44,000
2021-09-10 Korbel Gregory Alan Officer F-InKind D Common Stock 1,724 4.59 7.9K 22,627
2021-08-25 Korbel Gregory Alan Officer F-InKind D Common Stock 1,149 3.98 4.6K 24,351
2021-08-25 Coiante Scott M Officer F-InKind D Common Stock 7,534 3.98 30.0K 91,466
2021-06-30 Seizinger Bernd R. Director A-Award A Common Stock 4,610 0.00 268,580
2021-06-30 Peters Richard Director A-Award A Stock Option (Right to Buy) 22,750 4.88 111.0K 22,750
2021-06-30 Namouni Fouad Director A-Award A Stock Option (Right to Buy) 22,750 4.88 111.0K 22,750
2021-06-30 HENNEMAN JOHN B III Director A-Award A Stock Option (Right to Buy) 22,750 4.88 111.0K 22,750
2021-03-10 Korbel Gregory Alan Officer A-Award A Common Stock 15,000 0.00 25,500
2021-02-25 SCHADE CHRISTIAN S Director / Officer A-Award A Common Stock 77,000 0.00 77,160
2021-02-25 Korbel Gregory Alan Officer A-Award A Stock Option (right to Buy) 41,100 6.00 246.6K 41,100
2021-02-25 Coiante Scott M Officer A-Award A Common Stock 33,000 0.00 35,500
2021-02-25 Abrahmsen Lars B. Officer A-Award A Stock Option (right to Buy) 82,000 6.00 492.0K 82,000
2020-12-28 Redmile Group, LLC 10% Owner S-Sale D Common Stock 494,137 5.58 2.76M 1,774,581
2020-10-05 5AM Ventures IV, L.P. 10% Owner S-Sale D Common Stock 175,000 25.30 4.43M 138,497
2020-07-07 KDev Investments AB 10% Owner S-Sale D Common Stock 241,703 34.55 8.35M 1,992,586
2020-06-30 Seizinger Bernd R. Director A-Award A Stock Option (right to Buy) 5,600 38.78 217.2K 5,600
2020-06-30 ROCKLAGE SCOTT M Director A-Award A Stock Option (right to Buy) 5,600 38.78 217.2K 5,600
2020-06-30 Hepple Jonathan Director A-Award A Stock Option (right to Buy) 5,600 38.78 217.2K 5,600
2020-06-26 Peters Richard 0 0.00 0
2020-06-26 Namouni Fouad 0 0.00 0
2020-06-16 ROCKLAGE SCOTT M Director / 10% Owner S-Sale D Common Stock 115,357 33.30 3.84M 1,823,192
2020-06-16 5AM Ventures IV, L.P. 10% Owner S-Sale D Common Stock 115,357 33.30 3.84M 1,823,192
2020-06-11 ROCKLAGE SCOTT M Director / 10% Owner S-Sale D Common Stock 235,200 28.75 6.76M 1,938,549
2020-06-11 5AM Ventures IV, L.P. 10% Owner S-Sale D Common Stock 235,200 28.75 6.76M 1,938,549
2020-05-19 ROCKLAGE SCOTT M Director S-Sale D Common Stock 244,800 35.15 8.60M 2,173,748
2020-05-19 5AM Ventures IV, L.P. 10% Owner S-Sale D Common Stock 10,200 35.15 358.5K 90,572
2020-05-18 Versant Vantage I, L.P. 10% Owner J-Other D Common Stock 116,664 0.00 216,669
2020-05-18 Versant V Luxco S.a r.l. 10% Owner J-Other A Common Stock 1,178 0.00 1,178
2020-04-13 KDev Investments AB 10% Owner S-Sale D Common Stock 210,548 31.25 6.58M 2,234,289
2020-04-09 Versant V Luxco S.a r.l. 10% Owner J-Other A Common Stock 66,506 0.00 66,506
2020-03-24 SCHADE CHRISTIAN S Director / Officer A-Award A Stock Option (right to Buy) 127,000 35.50 4.51M 127,000
2020-03-24 Korbel Gregory Alan Officer A-Award A Stock Option (right to Buy) 12,800 35.50 454.4K 12,800
2020-03-24 Coiante Scott M Officer A-Award A Stock Option (right to Buy) 55,000 35.50 1.95M 55,000
2020-03-24 Abrahmsen Lars B. Officer A-Award A Stock Option (right to Buy) 31,600 35.50 1.12M 31,600
2019-10-07 Versant Vantage I, L.P. 10% Owner C-Conversion A Common Stock 512,995 0.00 2,519,323
2019-10-07 Versant V Luxco S.a r.l. 10% Owner P-Purchase A Common Stock 333,333 15.00 5.00M 333,333
2019-10-07 Seizinger Bernd R. Director M-Exempt D Stock Option (right to buy) 263,970 0.07 18.5K 0
2019-10-07 SCHADE CHRISTIAN S Director / Officer A-Award A Stock Option (right to Buy) 306,085 15.00 4.59M 306,085
2019-10-07 Redmile Group, LLC 10% Owner C-Conversion A Common Stock 1,868,718 0.00 1,868,718
2019-10-07 ROCKLAGE SCOTT M Director C-Conversion D Series C Convertible Preferred Stock 20,519 0.00 0
2019-10-07 Magni Guido Director P-Purchase A Common Stock 6,500 15.00 97.5K 6,500
2019-10-07 Korbel Gregory Alan Officer A-Award A Stock Option (right to Buy) 64,322 15.00 964.8K 64,322
2019-10-07 KDev Investments AB 10% Owner C-Conversion A Common Stock 1,600,559 0.00 2,444,837
2019-10-07 Coiante Scott M Officer P-Purchase A Common Stock 2,500 15.00 37.5K 2,500
2019-10-07 Abrahmsen Lars B. Officer A-Award A Stock Option (right to Buy) 77,630 15.00 1.16M 77,630
2019-10-07 5AM Ventures IV, L.P. 10% Owner C-Conversion A Common Stock 492,475 0.00 2,418,548
2019-10-02 Versant V Luxco S.a r.l. 10% Owner D Common Stock 0 0.00 12,670
2019-10-02 Seizinger Bernd R. Director D Stock Option (right to buy) 263,970 0.07 18.5K 0
2019-10-02 SCHADE CHRISTIAN S Director / Officer D Common Stock 0 0.00 160
2019-10-02 Redmile Group, LLC 10% Owner I Series C Preferred Stock 1,868,718 0.00 0
2019-10-02 ROCKLAGE SCOTT M Director I Series C Convertible Preferred Stock 20,519 0.00 0
2019-10-02 Magni Guido 0 0.00 0
2019-10-02 Korbel Gregory Alan Officer D Stock Option (right to buy) 82,631 3.19 263.6K 0
2019-10-02 KDev Investments AB 10% Owner I Series A Convertible Preferred Stock 579,647 0.00 0
2019-10-02 Hepple Jonathan 0 0.00 0
2019-10-02 Coiante Scott M Officer D Stock Option (right to buy) 186,539 10.95 2.04M 0
2019-10-02 Abrahmsen Lars B. Officer D Stock Option (right to buy) 101,083 3.19 322.5K 0
2019-10-02 5AM Ventures IV, L.P. 10% Owner I Series C Convertible Preferred Stock 20,519 0.00 0

Executive team

Top executives
Shares Outstanding
6.49M

Executive compensation

Executive compensation (annual)
# Year Executive Salary Bonus Stock award Option award Incentive Other Total % Stock-
based
Filing
1 2025 Oren Gilad, Ph.D. President and Chief Executive Officer 594.9K 14.8K 43.6K 4.0K 657.3K 8.88%
2 2025 John P. Hamill Chief Financial Officer 454.3K 7.4K 21.8K 7.2K 490.7K 5.95%
3 2024 Oren Gilad, Ph.D. President and Chief Executive Officer 572.0K 45.0K 139.6K 3.5K 760.1K 24.29%
4 2024 John P. Hamill Chief Financial Officer 437.1K 22.5K 69.9K 7.2K 536.6K 17.21%
5 2024 Nadeem Q. Mirza, M.D., M.P.H. Former Chief Medical Officer 281.4K 35.3K 105.3K 25.7K 447.7K 31.40%
6 2023 John P. Hamill Chief Financial Officer 387.9K 133.9K 197.3K 189.3K 908.4K 36.45%
7 2023 Oren Gilad, Ph.D. President and Chief Executive Officer 550.0K 20.3K 60.2K 247.0K 877.4K 9.17%
8 2023 Scott M. Coiante Former Chief Financial Officer 100.0K 300.0K 400.0K 0.00%
9 2022 Christian S. Schade Chairman and Chief Executive Officer (through July 28, 2022) 328.4K 182.2K 581.7K 281.5K 1.37M 55.60%
10 2022 Scott M. Coiante Former Chief Financial Officer 400.0K 144.4K 326.0K 160.0K 1.03M 45.65%
11 2022 Eyal C. Attar, M.D. Chief Medical Officer (through August 15, 2022) 329.0K 78.1K 252.8K 115.5K 775.4K 42.68%
12 2022 Oren Gilad, Ph.D. President and Chief Executive Officer 323.6K 110.4K 121.9K 197.3K 753.2K 30.85%
13 2022 Gregory A. Korbel, Ph.D. Former Chief Operating Officer 310.4K 55.6K 128.0K 107.3K 601.3K 30.54%
14 2021 Christian S. Schade Chairman and Chief Executive Officer 530.5K 993.0K 1.44M 265.2K 3.23M 75.39%
15 2021 Christian S. Schade Chairman and Chief Executive Officer (through July 28, 2022) 530.5K 993.0K 1.44M 265.2K 3.23M 75.39%
16 2021 Eyal C. Attar, M.D. Chief Medical Officer (through August 15, 2022) 450.9K 648.0K 627.8K 180.0K 1.91M 66.91%
17 2021 Eyal C. Attar Chief Medical Officer 450.9K 648.0K 627.8K 180.0K 1.91M 66.91%
18 2021 Scott M. Coiante Chief Financial Officer 381.1K 579.0K 627.8K 155.0K 1.74M 69.24%
19 2021 Scott M. Coiante Former Chief Financial Officer 381.1K 579.0K 627.8K 155.0K 1.74M 69.24%
20 2021 Gregory A. Korbel, Ph.D. Former Chief Operating Officer 271.9K 146.0K 180.4K 69.0K 667.2K 48.91%
21 2020 Christian S. Schade Chairman and Chief Executive Officer 515.0K 3.11M 283.3K 3.91M 79.56%
22 2020 Christian S. Schade President and Chief Executive Officer 515.0K 3.11M 283.3K 3.91M 79.56%
23 2020 Eyal C. Attar Chief Medical Officer 437.8K 1.35M 192.6K 1.98M 68.10%
24 2020 Scott M. Coiante Chief Financial Officer 370.0K 1.35M 142.5K 1.86M 72.42%
25 2019 Christian S. Schade President and Chief Executive Officer 446.4K 3.02M 210.1K 3.68M 82.15%
26 2019 Scott M. Coiante Chief Financial Officer 143.2K 50.0K 1.49M 127.6K 1.81M 82.27%
27 2019 Eyal C. Attar Chief Medical Officer 301.3K 766.2K 121.8K 1.19M 64.43%
28 2018 Christian S. Schade President and Chief Executive Officer 412.0K 181.3K 593.3K 0.00%
CEO compensation breakdown

Proxy statements

Proxy statements (DEF 14A)
Filing date Form type Filing
2026-04-30 DEFA14A
2026-04-30 DEF 14A
2026-04-20 PRE 14A
2025-04-22 DEFA14A
2025-04-22 DEF 14A

Recent SEC filings

Recent SEC filings
Filing date Form type Filing
2026-05-13 8-K
2026-05-13 10-Q
2026-04-30 DEFA14A
2026-04-30 DEF 14A
2026-04-30 ARS
2026-04-29 EFFECT
2026-04-29 424B3
2026-04-27 SC 13G/A
2026-04-22 S-3
2026-04-20 PRE 14A

Executive team

NameTitleCompensationGender
Oren Gilad Co-Founder, Chief Executive Officer, President and Director 598.9K
John Hamill Senior Vice President, Chief Financial Officer, Principal Accounting Officer & Secretary 461.4K male
Eugene Kennedy Chief Medical Advisor
Lars Abrahmsen Senior Vice President & Chief Scientific Officer
Michel Afargan Head of Pharmacology Development
Andrea Epstein Controller female
Zeev Weiss Chief Business Advisor male
Brian Wiley Senior Vice President of Corporate Development & Strategy male
ESG Rating
B
BIOTECHNOLOGY
Rank: 525 out of 662
2026
E (Environmental)
52.0 / 56.3
Company / Sector avg.
S (Social)
61.6 / 62.4
Company / Sector avg.
G (Governance)
60.3 / 60.9
Company / Sector avg.
ESG Total
57.9 / 59.9
Company / Sector avg.
ESG Score History BIOTECHNOLOGY
Benchmark vs Sector
Senate Trading Activity

No Senate trading activity found for this company.

House Trading Activity

No House trading activity found for this company.

Market share among peers
Peer comparison — filtered group (TTM)
Your opinion

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Dividend history

Earnings history

Earnings reports

Stock splits