Subscribe

Alto Neuroscience, Inc. (ANRO)

USD26.67 -1.13 (-4.06%)
US NYSE Healthcare Biotechnology
Address 369 South San Antonio Road 94022
Mountain View, CA, US
CEO Amit Etkin
IPO 2024-02-02
CIK 1999480 ISIN US02157Q1094

Explore sections of this company profile

Description

Alto Neuroscience, Inc. operates as a biopharmaceutical entity in the clinical stage, specializing in the creation of novel psychiatric medications. Its development pipeline includes ALTO-100, an investigational therapy targeting individuals affected by major depressive disorder (MDD) and post-traumatic stress disorder. Also in its portfolio is ALTO-300, a small molecule designed to function as both a melatonergic agonist and serotonergic antagonist, exhibiting antidepressant properties for MDD patients. For addressing the cognitive impairments linked with schizophrenia, Alto Neuroscience is advancing ALTO-101, an innovative small molecule phosphodiesterase 4 inhibitor. The company's therapeutic candidates further extend to ALTO-203, a pioneering small-molecule histamine H3 receptor inverse agonist intended for MDD patients experiencing heightened anhedonia, and ALTO-202, an orally available antagonist of the GluN2B subunit of the NMDA receptor, also under investigation for MDD. Beyond these individual drug candidates, the firm is engaged in developing novel drug combinations that demonstrate synergistic pharmacodynamic effects. Crucially, Alto Neuroscience leverages an advanced AI-enabled biomarker platform that synthesizes data concerning patients' brain activity and behavioral patterns. This platform's purpose is to accurately identify which individuals are most likely to respond positively to its cutting-edge product candidates. Alto Neuroscience, Inc., established in 2019, maintains its headquarters in Los Altos, California.

Market Cap & Enterprise Value
Merger & Acquisition History

No mergers or acquisitions recorded for this company.

Technical Outlook
Loading outlook…
Loading forecast...
Signal Summary Loading…
Indicator 1D1W2W3W1M
Each column is computed on that timeframe's candles (1D = daily, 1W ≈ weekly, 1M ≈ monthly), not on the same last day. ▲ bullish · ▼ bearish · — neutral. The Net row counts signals per column; hover any cell (or the indicator name) to see the exact rule behind it.
Day Score & sub-scores
Statistical fingerprint & regime detail
Conditional historical analysis
Customize analysis (advanced)
Indicative levels generated algorithmically. Not financial advice.
Risk Profile
Loading risk profile…
Price Chart
Averages
Trend
Price
Levels
Draw
USD26.67 -1.13 (-4.06%)
Loading historical data…
Volume Profile
Loading…
Liquidity & share structure
Average Volume
407.7K
Beta
1.25
Float Shares
28.72M
Free Float %
89.9%
Price Performance
1D5D1M3M6M YTD1Y3Y5Y10YMax
-7.23% -6.62% -11.26% +35.29% +101.32% +28.37% +864.14% +10.39% +10.39% +10.39% +10.39%
Rolling Volatility
Loading…
Drawdown
Loading…
Relative Strength
Loading…
Monthly Returns Heatmap
From To
Loading…
Annual Monthly Returns
Loading…
Daily Returns Distribution
vs.
Loading histogram data…

Revenue flow

Revenue by geography

Revenue by segment

From To

Revenue composition

From To

By product

By geography

Financial Statements

Income Statement

Balance Sheet

Cash Flow Statement

Key Metrics

Financial Ratios

Employees

Financial Growth (CAGR)

Market Data

Analyst Consensus (8 ratings, all time) Buy
Price Targets & DCF
Current price
26.67
Low 28.00 +5.0%
Consensus 31.50 +18.1%
Median 31.50 +18.1%
High 35.00 +31.2%
DCF (Unlevered) 5.91 -77.9%
DCF (Levered) 5.96 -77.6%

DCF figures are point estimates: small changes in growth or discount-rate assumptions move them materially. Read them as a reference, not a precise target.

Ratings Trend (MoM) 91% Bullish
Rating 2026-05 Change
Strong Buy 0 0
Buy 10 +1
Hold 1 0
Sell 0 0
Strong Sell 0 0
Price Target Summary
Period # Analysts Avg Target
Last Month
Last Quarter 2
31.50
+18.1%
Last Year 3
26.33
-1.3%
All Time 5
24.20
-9.3%
Quality scores
Altman Z-Score
13.42
Safe zone
Piotroski F-Score
2 / 9
Weak
MOAT Score
3 / 10
No MOAT
Composite Rating
C
Overall Score
2 / 5
Medium
DCF Score
3 / 5
Medium
ROE Score
1 / 5
Low
ROA Score
1 / 5
Low
D/E Score
3 / 5
Medium
P/E Score
1 / 5
Low
P/Book Score
2 / 5
Medium
Operational MOAT
✗ Below peers
  • Revenue growth Biotechnology: +1.6%
  • EPS growth Biotechnology: +29.7%
    +12.4% Q1'26: -42.9% (vs Q1'25)
  • FCF margin FCF growth · Biotechnology: +16.2%
  • EBIT margin Biotechnology: +0.0%
  • ROIC Biotechnology: -16.1%
    Q1'26: +0.0% (vs Q1'25)
  • Share dilution Biotechnology: -3.4%
    +17.3% Q1'26: +21.6% (vs Q1'25)
  • Debt / EBITDA Net debt/EBITDA · Biotechnology: 0.16×
    -0.07× Q1'26: -0.05× (vs Q1'25)
Valuation Multiples From To
Price Forecast (3Y) From To
Model
Adjust
P/E
Theoretical Return — If Invested Today

* These projections are based on analyst consensus estimates and user-defined valuation multiples. This table is for informational purposes only and does not constitute a recommendation to buy or sell any security. Past performance is not indicative of future results.

DCF Interactive Model (UFCF)
Projection years:
Market assumptions
WACC components (optional)
Ke (Cost of Equity) = Rf + β (1.65) × ERP
WACC = 99% × Ke + 1% × Kd (56.0%) × (1−t)

Modifying these values recalculates WACC automatically.

Business assumptions
Intrinsic value (base): 5.91 Current price: 26.67
Enterprise Value: Equity Value: Terminal Value: TV as % of EV:

Base values reflect the latest available data for this company and market conditions.

Consensus Estimates
Metric Dec 2024
actual
Dec 2025
actual
Dec 2026
6 EPS Ana.
Dec 2027
5 EPS Ana.
Dec 2028
6 Rev. Ana.
6 EPS Ana.
Dec 2029
5 Rev. Ana.
4 EPS Ana.
Dec 2030
3 Rev. Ana.
2 EPS Ana.
Revenue
— – —
— – —
9.30M
9.30M – 9.30M
46.69M
46.69M – 46.69M
+402.1% YoY
281.25M
281.25M – 281.25M
+502.4% YoY
EBITDA
-68.61M
-65.70M
— – —
— – —
5.58M
5.58M – 5.58M
28.01M
28.01M – 28.01M
+402.1% YoY
168.75M
168.75M – 168.75M
+502.4% YoY
EBIT
-62.81M
-66.36M
— – —
— – —
5.58M
5.58M – 5.58M
28.01M
28.01M – 28.01M
+402.1% YoY
168.75M
168.75M – 168.75M
+502.4% YoY
Net Income
-61.43M
est: -63.18M (+2.8%)
-63.24M
est: -63.24M (+0.0%)
-89.27M
-114.72M – -50.02M
-41.2% YoY
-121.15M
-122.94M – -56.24M
-35.7% YoY
-90.31M
-118.58M – -62.03M
+25.5% YoY
-70.54M
-70.54M – -70.54M
+21.9% YoY
24.58M
24.58M – 24.58M
+134.8% YoY
SGA
21.61M
20.75M
— – —
— – —
40.66M
40.66M – 40.66M
204.15M
204.15M – 204.15M
+402.1% YoY
1.23B
1.23B – 1.23B
+502.4% YoY
EPS
-2.50
est: -2.59 (+3.3%)
-2.19
est: -2.24 (+2.2%)
-2.42
-3.98 – -1.73
-8.0% YoY
-2.93
-4.26 – -1.95
-21.0% YoY
-2.88
-4.11 – -2.15
+1.8% YoY
-2.45
-2.45 – -2.45
+15.0% YoY
0.85
0.85 – 0.85
+134.8% YoY
Recent Grade Changes (3M)
Date Firm Previous New Grade Action
2026-05-11 HC Wainwright & Co. Buy Buy Maintain
2026-04-22 Chardan Capital Buy Buy Maintain
Historical Ratings (3M)
Date Rating Overall DCF ROE ROA D/E P/E P/B
2026-05-13 C 2/5 3/5 1/5 1/5 3/5 1/5 2/5
2026-05-12 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5
2026-05-11 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5
2026-05-08 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5
2026-05-07 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5
2026-05-06 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5
2026-05-05 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5
2026-05-04 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5
2026-05-01 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5
2026-04-30 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5
2026-04-29 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5
2026-04-28 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5
2026-04-27 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5
2026-04-24 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5
2026-04-23 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5
2026-04-22 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5
2026-04-21 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5
2026-04-20 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5
2026-04-17 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5
2026-04-16 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5

Owner Earnings

Owner's Earnings (history) From To
Owner alignment
Owner's Earnings TTM
-62.30M
OE per share TTM
-2.06
Owner's Yield
-8.29%
Maintenance CapEx ratio
Maint CapEx / Avg PPE
8,371.0%

Ownership Overview

Ownership breakdown
At a glance
Institutional holders
23
Total invested
44.41M
Insider transactions (90d)
0
Beneficial owners (>5%)
18
Beneficial owners (>5%)
# Reporting person Amount owned % of class Sole voting Shared voting Sole dispositive Shared dispositive Type Citizenship Filing date SEC filing
1 Alpha Wave Global, LP 3.71M 13.80% 3.71M IA Delaware 2024-02-09
2 Alpha Wave Ventures GP, Ltd 3.71M 13.80% 3.71M OO Cayman Islands 2024-02-09
3 Chimera Investment LLC 3.71M 13.80% 3.71M OO United Arab Emirates 2024-02-09
4 Lunate Holding RSC LTD 3.71M 13.80% 3.71M OO United Arab Emirates 2024-02-09
5 Abigail P. Johnson 2.36M 8.77% 2.36M IN Delaware 2024-11-12
6 FMR LLC 2.36M 8.77% 2.36M 2.36M HC Delaware 2024-11-12
7 Steven A. Cohen 1.69M 6.30% 1.69M IN United States 2024-02-07
8 Amit Etkin 1.46M 5.40% 1.46M 1.46M IN 2024-11-14
9 (1) BlackRock, Inc. 1.45M 5.40% 1.43M 1.45M HC Delaware 2024-11-08
10 Peter Kolchinsky 1.39M 5.20% 1.39M HC, IN Delaware 2024-03-29
11 RA Capital Healthcare Fund, L.P. 1.39M 5.20% 1.39M PN Delaware 2024-03-29
12 RA Capital Management, L.P. 1.39M 5.20% 1.39M IA, PN Delaware 2024-03-29
13 Rajeev Shah 1.39M 5.20% 1.39M HC, IN Delaware 2024-03-29
14 Point72 Asset Management, L.P. 1.03M 3.80% 1.03M PN Delaware 2024-02-07
15 Point72 Capital Advisors, Inc. 1.03M 3.80% 1.03M CO Delaware 2024-02-07
16 72 Investment Holdings, LLC 667.8K 2.50% 667.8K OO Delaware 2024-02-07
17 Differentiated Ventures Investments, LLC 667.8K 2.50% 667.8K OO Delaware 2024-02-07
18 Point72 Biotech Private Investments, LLC 667.8K 2.50% 667.8K OO Delaware 2024-02-07

Institutional Activity (13F)

Institutional ownership trend From To
13F snapshot — 2026 Q1
Investors holding
23
-78 vs prev Q
New positions
7
Closed positions
82
Increased
8
Reduced
8
Put/Call ratio
0.00
Calls held
Puts held
Top institutional holders
# Investor Shares / Δ Mkt value / Δ Own% / Δ Weight% / Δ Avg px / Perf. Hold / Status
1 222.8K +222.8K (+100.0%) 3.97B +4.0B (+100.0%) 0.82% +0.822 pp 1.31% +1.311 pp USD17.80 +0.0% 1 qtrs NEW
2 ALPHA WAVE GLOBAL, LP 3.71M +— (+0.0%) 66.00M +51.1M (+342.8%) 13.68% -0.016 pp 8.09% +6.581 pp USD14.56 +22.3% 8 qtrs
3 VESTAL POINT CAPITAL, LP 2.49M +1.5M (+161.6%) 44.23M +40.4M (+1,058.2%) 9.17% +5.659 pp 1.50% +1.331 pp USD14.78 +20.4% 8 qtrs
4 COMMODORE CAPITAL LP 1.82M +1.8M (+100.0%) 32.45M +32.5M (+100.0%) 6.73% +6.727 pp 2.16% +2.160 pp USD17.80 +0.0% 1 qtrs NEW
5 PERCEPTIVE ADVISORS LLC 1.78M +1.6M (+1,048.5%) 31.76M +31.1M (+4,985.4%) 6.58% +6.010 pp 0.57% +0.548 pp USD16.60 +7.2% 2 qtrs
6 POINT72 ASSET MANAGEMENT, L.P. 1.61M +274.5K (+20.6%) 28.60M +23.2M (+434.0%) 5.93% +1.007 pp 0.03% +0.023 pp USD11.04 +61.2% 8 qtrs
7 ARMISTICE CAPITAL, LLC 1.54M -100.0K (-6.1%) 27.34M +20.8M (+315.7%) 5.67% -0.376 pp 0.33% +0.228 pp USD3.00 +493.3% 5 qtrs
8 VANGUARD GROUP INC 1.37M +260.4K (+23.6%) 24.31M +19.9M (+447.1%) 5.04% +0.956 pp 0.00% +0.000 pp USD13.58 +31.1% 8 qtrs
9 FRANKLIN RESOURCES INC 1.12M -43.0K (-3.7%) 19.93M +15.3M (+326.4%) 4.13% -0.164 pp 0.00% +0.004 pp USD13.04 +36.5% 8 qtrs
10 VIVO CAPITAL, LLC 1.04M +1.0M (+100.0%) 18.43M +18.4M (+100.0%) 3.82% +3.821 pp 1.19% +1.192 pp USD17.80 +0.0% 1 qtrs NEW
11 72 INVESTMENT HOLDINGS, LLC 667.8K +— (+0.0%) 11.89M +9.2M (+342.8%) 2.46% -0.003 pp 23.50% +19.552 pp USD14.56 +22.3% 8 qtrs
12 MILLENNIUM MANAGEMENT LLC 630.0K +314.2K (+99.5%) 11.21M +9.9M (+783.4%) 2.32% +1.158 pp 0.00% +0.004 pp USD10.02 +77.6% 4 qtrs
13 BLACKROCK, INC. 607.9K +240.0K (+65.2%) 10.82M +9.3M (+631.6%) 2.24% +0.884 pp 0.00% +0.000 pp USD13.85 +28.5% 6 qtrs
14 NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO 212.7K +211.2K (+14,567.0%) 10.73M +10.7M (+183,967.7%) 0.78% +0.779 pp 0.01% +0.007 pp USD17.71 +0.5% 2 qtrs
15 IKARIAN CAPITAL, LLC 515.0K +405.0K (+368.2%) 9.17M +8.7M (+1,973.0%) 1.90% +1.494 pp 0.72% +0.671 pp USD14.90 +19.5% 5 qtrs
16 ALKEON CAPITAL MANAGEMENT LLC 477.1K +— (+0.0%) 8.49M +6.6M (+342.8%) 1.76% -0.002 pp 0.01% +0.011 pp USD11.40 +56.1% 7 qtrs
17 NORTHERN TRUST CORP 474.4K +13.1K (+2.8%) 8.44M +6.6M (+355.3%) 1.75% +0.046 pp 0.00% +0.001 pp USD7.02 +153.6% 8 qtrs
18 INTEGRAL HEALTH ASSET MANAGEMENT, LLC 375.0K -25.0K (-6.3%) 6.68M +5.1M (+315.1%) 1.38% -0.094 pp 0.33% +0.223 pp USD3.71 +379.8% 5 qtrs
19 DRIEHAUS CAPITAL MANAGEMENT LLC 336.8K +336.8K (+100.0%) 5.99M +6.0M (+100.0%) 1.24% +1.243 pp 0.04% +0.041 pp USD17.80 +0.0% 1 qtrs NEW
20 GEODE CAPITAL MANAGEMENT, LLC 287.4K +49.5K (+20.8%) 5.12M +4.2M (+434.9%) 1.06% +0.182 pp 0.00% +0.000 pp USD12.51 +42.3% 8 qtrs
21 PEAPOD LANE CAPITAL LLC 254.0K -28.0K (-9.9%) 4.52M +3.4M (+297.9%) 0.94% -0.104 pp 3.85% +2.830 pp USD2.22 +701.8% 3 qtrs
22 AWM INVESTMENT COMPANY, INC. 225.0K -55.5K (-19.8%) 4.01M +2.9M (+255.2%) 0.83% -0.206 pp 0.39% +0.281 pp USD9.25 +92.4% 8 qtrs
23 MARSHALL WACE, LLP 193.1K -632.1K (-76.6%) 3.44M +119.9K (+3.6%) 0.71% -2.336 pp 0.00% 0.000 pp USD4.01 +343.9% 5 qtrs
24 TWO SIGMA ADVISERS, LP 160.1K +10.2K (+6.8%) 2.85M +2.2M (+372.9%) 0.59% +0.037 pp 0.01% +0.004 pp USD3.96 +349.5% 4 qtrs
25 GOLDMAN SACHS GROUP INC 156.3K +66.1K (+73.2%) 2.78M +2.4M (+666.9%) 0.58% +0.243 pp 0.00% +0.000 pp USD10.53 +69.0% 7 qtrs
26 TWO SIGMA INVESTMENTS, LP 140.3K +23.7K (+20.4%) 2.50M +2.0M (+432.9%) 0.52% +0.087 pp 0.00% +0.003 pp USD6.72 +164.9% 6 qtrs
27 BOOTHBAY FUND MANAGEMENT, LLC 139.3K +106.8K (+329.0%) 2.48M +2.3M (+1,799.5%) 0.51% +0.394 pp 0.04% +0.035 pp USD14.64 +21.6% 5 qtrs
28 STATE STREET CORP 130.7K +27.5K (+26.6%) 2.33M +1.9M (+460.7%) 0.48% +0.101 pp 0.00% +0.000 pp USD11.23 +58.5% 8 qtrs
29 ORBIMED ADVISORS LLC 125.0K -125.0K (-50.0%) 2.23M +1.2M (+121.4%) 0.46% -0.462 pp 0.05% +0.022 pp USD4.23 +320.8% 5 qtrs
30 D. E. SHAW & CO., INC. 124.8K +124.8K (+100.0%) 2.22M +2.2M (+100.0%) 0.46% +0.460 pp 0.00% +0.001 pp USD17.80 +0.0% 1 qtrs NEW
31 SUSQUEHANNA INTERNATIONAL GROUP, LLP 118.2K -37.5K (-24.1%) 2.10M +1.5M (+236.1%) 0.44% -0.139 pp 0.00% +0.000 pp USD3.67 +385.0% 5 qtrs
32 QUBE RESEARCH & TECHNOLOGIES LTD 112.8K +112.8K (+100.0%) 2.01M +2.0M (+100.0%) 0.42% +0.416 pp 0.00% +0.002 pp USD17.80 +0.0% 1 qtrs NEW
33 RENAISSANCE TECHNOLOGIES LLC 97.4K +21.6K (+28.5%) 1.73M +1.4M (+469.2%) 0.36% +0.080 pp 0.00% +0.002 pp USD6.43 +176.8% 3 qtrs
34 STIFEL FINANCIAL CORP 87.2K -34.8K (-28.6%) 1.55M +1.1M (+216.3%) 0.32% -0.129 pp 0.00% +0.001 pp USD4.21 +322.8% 5 qtrs
35 ALMITAS CAPITAL LLC 78.5K -116.6K (-59.8%) 1.40M +613.2K (+78.2%) 0.29% -0.431 pp 0.31% +0.128 pp USD4.23 +320.8% 5 qtrs
36 BRIDGEWAY CAPITAL MANAGEMENT, LLC 77.7K +— (+0.0%) 1.38M +1.1M (+342.8%) 0.29% 0.000 pp 0.03% +0.022 pp USD2.74 +549.6% 4 qtrs
37 IEQ CAPITAL, LLC 75.3K +12.3K (+19.6%) 1.34M +1.1M (+429.4%) 0.28% +0.045 pp 0.00% +0.003 pp USD12.48 +42.6% 6 qtrs
38 WELLINGTON MANAGEMENT GROUP LLP 69.0K +69.0K (+100.0%) 1.23M +1.2M (+100.0%) 0.25% +0.255 pp 0.00% +0.000 pp USD17.80 +0.0% 1 qtrs NEW
39 MORGAN STANLEY 65.6K +4.5K (+7.4%) 1.17M +922.0K (+375.8%) 0.24% +0.017 pp 0.00% +0.000 pp USD6.61 +169.3% 8 qtrs
40 683 CAPITAL MANAGEMENT, LLC 64.8K +64.8K (+100.0%) 1.15M +1.2M (+100.0%) 0.24% +0.239 pp 0.05% +0.050 pp USD17.80 +0.0% 1 qtrs NEW
41 ACADIAN ASSET MANAGEMENT LLC 57.5K +43.0K (+296.2%) 1.02M +962.0K (+1,658.6%) 0.21% +0.159 pp 0.00% +0.002 pp USD13.86 +28.4% 3 qtrs
42 JANE STREET GROUP, LLC 47.7K +47.7K (+100.0%) 849.1K +849.1K (+100.0%) 0.18% +0.176 pp 0.00% +0.000 pp USD17.80 +0.0% 1 qtrs NEW
43 ADVISORSHARES INVESTMENTS LLC 44.1K +44.1K (+100.0%) 784.6K +784.6K (+100.0%) 0.16% +0.163 pp 0.13% +0.131 pp USD17.80 +0.0% 1 qtrs NEW
44 ALLIANZ ASSET MANAGEMENT GMBH 43.0K +6.0K (+16.2%) 765.4K +616.7K (+414.6%) 0.16% +0.022 pp 0.00% +0.001 pp USD9.81 +81.4% 6 qtrs
45 QUANTINNO CAPITAL MANAGEMENT LP 35.6K +— (+0.0%) 633.3K +490.3K (+342.8%) 0.13% 0.000 pp 0.00% +0.001 pp USD2.20 +709.1% 3 qtrs
46 HUDSON BAY CAPITAL MANAGEMENT LP 34.8K +34.8K (+100.0%) 619.2K +619.2K (+100.0%) 0.13% +0.128 pp 0.00% +0.002 pp USD17.80 +0.0% 1 qtrs NEW
47 SCS CAPITAL MANAGEMENT LLC 33.4K -33.4K (-50.0%) 594.3K +325.9K (+121.4%) 0.12% -0.124 pp 0.01% +0.003 pp USD2.16 +724.1% 4 qtrs
48 BNP PARIBAS ARBITRAGE, SNC 33.2K +32.7K (+6,366.0%) 591.6K +589.5K (+28,534.2%) 0.12% +0.121 pp 0.00% +0.000 pp USD17.60 +1.1% 7 qtrs
49 DIMENSIONAL FUND ADVISORS LP 31.2K +31.2K (+100.0%) 554.9K +554.9K (+100.0%) 0.12% +0.115 pp 0.00% +0.000 pp USD17.80 +0.0% 1 qtrs NEW
50 BARCLAYS PLC 30.4K +793.0 (+2.7%) 541.0K +202.4K (+59.8%) 0.11% +0.003 pp 0.00% +0.000 pp USD4.38 +306.4% 8 qtrs
51 PRICE T ROWE ASSOCIATES INC /MD/ 30.2K -29.2K (-49.1%) 539.0K +300.0K (+125.5%) 0.11% -0.108 pp 0.00% +0.000 pp USD12.44 +43.1% 8 qtrs
52 ARTIA GLOBAL PARTNERS LP 29.2K +29.2K (+100.0%) 519.6K +519.6K (+100.0%) 0.11% +0.108 pp 0.08% +0.083 pp USD17.80 +0.0% 1 qtrs NEW
53 CITIZENS FINANCIAL GROUP INC/RI 28.2K -11.8K (-29.5%) 501.8K +341.0K (+212.1%) 0.10% -0.044 pp 0.01% +0.005 pp USD2.46 +623.6% 4 qtrs
54 ALPS ADVISORS INC 25.5K +25.5K (+100.0%) 454.0K +454.0K (+100.0%) 0.09% +0.094 pp 0.00% +0.003 pp USD17.80 +0.0% 1 qtrs NEW
55 BROWN ADVISORY INC 25.0K +— (+0.0%) 445.0K +344.5K (+342.8%) 0.09% 0.000 pp 0.00% +0.001 pp USD4.23 +320.8% 5 qtrs
56 UNIVERSITY OF TEXAS/TEXAS AM INVESTMENT MANAGMENT CO 22.2K +— (+0.0%) 394.7K +305.6K (+342.8%) 0.08% 0.000 pp 0.06% +0.043 pp USD14.56 +22.3% 8 qtrs
57 XTX TOPCO LTD 20.8K +5.1K (+32.2%) 370.7K +307.4K (+485.6%) 0.08% +0.019 pp 0.01% +0.006 pp USD7.38 +141.2% 2 qtrs
58 ALPHACORE CAPITAL LLC 20.0K +10.0K (+100.0%) 356.0K +315.8K (+785.6%) 0.07% +0.037 pp 0.01% +0.007 pp USD9.99 +78.2% 4 qtrs
59 EXODUSPOINT CAPITAL MANAGEMENT, LP 18.8K +18.8K (+100.0%) 334.4K +334.4K (+100.0%) 0.07% +0.069 pp 0.00% +0.003 pp USD17.80 +0.0% 1 qtrs NEW
60 UBS GROUP AG 18.5K -120.5K (-86.7%) 329.1K -229.8K (-41.1%) 0.07% -0.445 pp 0.00% +0.000 pp USD4.29 +314.9% 8 qtrs
61 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 17.1K +17.1K (+100.0%) 303.7K +303.7K (+100.0%) 0.06% +0.063 pp 0.00% +0.000 pp USD17.80 +0.0% 8 qtrs
62 CITADEL ADVISORS LLC 16.8K +16.8K (+100.0%) 299.0K +299.0K (+100.0%) 0.06% +0.062 pp 0.00% +0.000 pp USD17.80 +0.0% 1 qtrs NEW
63 VANGUARD PERSONALIZED INDEXING MANAGEMENT, LLC 16.5K -560.0 (-3.3%) 293.4K +224.9K (+328.2%) 0.06% -0.002 pp 0.00% +0.002 pp USD2.42 +635.5% 3 qtrs
64 AMERIPRISE FINANCIAL INC 13.5K +— (+0.0%) 240.1K +185.9K (+342.8%) 0.05% 0.000 pp 0.00% +0.000 pp USD10.99 +62.0% 6 qtrs
65 CITIGROUP INC 12.6K +12.6K (+100.0%) 223.7K +223.7K (+100.0%) 0.05% +0.046 pp 0.00% +0.000 pp USD17.80 +0.0% 8 qtrs
66 OMERS ADMINISTRATION CORP 12.4K +12.4K (+100.0%) 220.7K +220.7K (+100.0%) 0.05% +0.046 pp 0.00% +0.002 pp USD17.80 +0.0% 1 qtrs NEW
67 BANK OF MONTREAL /CAN/ 11.4K +13.0 (+0.1%) 202.1K +156.5K (+343.3%) 0.04% +0.000 pp 0.00% +0.000 pp USD2.22 +701.8% 3 qtrs
68 BALYASNY ASSET MANAGEMENT L.P. 11.1K +11.1K (+100.0%) 197.9K +197.9K (+100.0%) 0.04% +0.041 pp 0.00% +0.000 pp USD17.80 +0.0% 1 qtrs NEW
69 BANK OF AMERICA CORP /DE/ 11.1K +11.0K (+8,845.2%) 197.4K +196.9K (+39,546.0%) 0.04% +0.041 pp 0.00% +0.000 pp USD17.70 +0.6% 8 qtrs
70 AMERICAN CENTURY COMPANIES INC 10.4K +10.4K (+100.0%) 184.4K +184.4K (+100.0%) 0.04% +0.038 pp 0.00% +0.000 pp USD17.80 +0.0% 1 qtrs NEW
71 FMR LLC 6.4K -1.3K (-17.0%) 113.5K +82.6K (+267.7%) 0.02% -0.005 pp 0.00% +0.000 pp USD14.45 +23.2% 8 qtrs
72 QUEST PARTNERS LLC 3.8K +3.8K (+100.0%) 68.0K +68.0K (+100.0%) 0.01% +0.014 pp 0.00% +0.004 pp USD17.80 +0.0% 1 qtrs NEW
73 ROTHSCHILD INVESTMENT LLC 2.9K +— (+0.0%) 51.4K +39.8K (+342.8%) 0.01% +0.000 pp 0.00% +0.002 pp USD11.44 +55.6% 6 qtrs
74 WHITTIER TRUST CO OF NEVADA INC 2.5K +— (+0.0%) 37.4K +20.3K (+118.9%) 0.01% +0.000 pp 0.00% +0.000 pp USD4.23 +320.8% 5 qtrs
75 TOWER RESEARCH CAPITAL LLC (TRC) 2.0K -403.0 (-16.9%) 35.4K +25.8K (+268.1%) 0.01% -0.002 pp 0.00% +0.001 pp USD5.56 +220.1% 8 qtrs
76 GROUP ONE TRADING, L.P. 1.4K -1.2K (-46.8%) 25.2K +14.5K (+135.4%) 0.01% -0.005 pp 0.00% +0.000 pp USD3.45 +415.9% 4 qtrs
77 PNC FINANCIAL SERVICES GROUP, INC. 1.3K -159.0 (-10.8%) 23.3K +17.4K (+294.8%) 0.00% -0.001 pp 0.00% +0.000 pp USD2.20 +709.1% 4 qtrs
78 SIGNATUREFD, LLC 1.1K +1.1K (+100.0%) 19.0K +19.0K (+100.0%) 0.00% +0.004 pp 0.00% +0.000 pp USD17.80 +0.0% 1 qtrs NEW
79 FEDERATED HERMES, INC. 770.00 -2.6K (-77.0%) 13.7K +251.0 (+1.9%) 0.00% -0.010 pp 0.00% +0.000 pp USD3.60 +394.4% 3 qtrs
80 WELLS FARGO & COMPANY/MN 765.00 +765.0 (+100.0%) 13.6K +13.6K (+100.0%) 0.00% +0.003 pp 0.00% +0.000 pp USD17.80 +0.0% 8 qtrs
81 EVERSOURCE WEALTH ADVISORS, LLC 661.00 -64.0 (-8.8%) 11.8K +8.9K (+303.6%) 0.00% 0.000 pp 0.00% +0.000 pp USD2.45 +626.5% 4 qtrs
82 FORTITUDE FAMILY OFFICE, LLC 511.00 +— (+0.0%) 9.1K +7.0K (+342.8%) 0.00% +0.000 pp 0.00% +0.002 pp USD2.98 +497.3% 3 qtrs
83 NISA INVESTMENT ADVISORS, LLC 338.00 +— (+0.0%) 6.0K +4.7K (+342.7%) 0.00% +0.000 pp 0.00% +0.000 pp USD2.17 +720.3% 6 qtrs
84 RUSSELL INVESTMENTS GROUP, LTD. 306.00 +— (+0.0%) 5.4K +4.2K (+342.8%) 0.00% +0.000 pp 0.00% +0.000 pp USD2.20 +709.1% 5 qtrs
85 NORTH STAR INVESTMENT MANAGEMENT CORP. 174.00 +— (+0.0%) 3.1K +2.4K (+343.1%) 0.00% +0.000 pp 0.00% +0.000 pp USD4.02 +342.8% 2 qtrs
86 CWM, LLC 154.00 -770.0 (-83.3%) 3.0K -1.0K (-25.0%) 0.00% -0.003 pp 0.00% +0.000 pp USD2.49 +614.9% 6 qtrs
87 GLOBAL RETIREMENT PARTNERS, LLC 150.00 +150.0 (+100.0%) 2.7K +2.7K (+100.0%) 0.00% +0.001 pp 0.00% +0.000 pp USD17.80 +0.0% 1 qtrs NEW
88 JPMORGAN CHASE & CO 146.00 +146.0 (+100.0%) 2.6K +2.6K (+100.0%) 0.00% +0.001 pp 0.00% +0.000 pp USD17.79 +0.1% 1 qtrs NEW
89 US BANCORP \DE\ 113.00 +113.0 (+100.0%) 2.0K +2.0K (+100.0%) 0.00% +0.000 pp 0.00% +0.000 pp USD17.80 +0.0% 1 qtrs NEW
90 ROYAL BANK OF CANADA 34.00 -161.0 (-82.6%) 1.0K +— (+0.0%) 0.00% -0.001 pp 0.00% +0.000 pp USD2.79 +538.0% 7 qtrs
91 JONES FINANCIAL COMPANIES LLLP 33.00 +33.0 (+100.0%) 587.00 +587.0 (+100.0%) 0.00% +0.000 pp 0.00% +0.000 pp USD17.79 +0.1% 1 qtrs NEW
92 FARTHER FINANCE ADVISORS, LLC 31.00 +31.0 (+100.0%) 552.00 +552.0 (+100.0%) 0.00% +0.000 pp 0.00% +0.000 pp USD17.77 +0.2% 1 qtrs NEW
93 OPTIVER HOLDING B.V. 20.00 +— (+0.0%) 356.00 +276.0 (+345.0%) 0.00% +0.000 pp 0.00% +0.000 pp USD4.00 +345.0% 2 qtrs
94 SBI SECURITIES CO., LTD. 12.00 +9.0 (+300.0%) 214.00 +202.0 (+1,683.3%) 0.00% +0.000 pp 0.00% +0.000 pp USD14.00 +27.1% 5 qtrs
Ownership breakdown by holder

ETF Ownership

Top ETFs holding this stock Held by 58 ETFs in our universe
# ETF Weight Est. AUM exposure TER
1 State Street SPDR S&P Pharmaceuticals ETF XPH 1.16% 5.49M 0.35%
2 Virtus Biotech Clinical Trials ETF BBC 0.76% 436.9K 0.65%
3 ALPS Medical Breakthroughs ETF SBIO 0.48% 1.01M 0.50%
4 Direxion Daily Pharmaceutical & Medical Bull 3X ETF PILL 0.24% 56.4K 1.22%
5 iShares Micro-Cap ETF IWC 0.16% 2.33M 0.60%
6 Innovator U.S. Small Cap Managed Floor ETF RFLR 0.09% 81.1K 0.89%
7 iShares Biotechnology ETF IBB 0.06% 5.98M 0.44%
8 Goldman Sachs ActiveBeta U.S. Small Cap Equity ETF GSSC 0.05% 483.4K 0.20%
9 iShares Russell 2000 Growth ETF IWO 0.04% 6.38M 0.24%
10 State Street SPDR Russell 2000 U.S. Small Cap UCITS ETF (Acc) R2US.L 0.02% 1.35M 0.30%

Insider Activity

Insider Activity — Latest Quarter
Ratio by transactions
4.00
Bullish
Ratio by volume
3.00
Bullish
Buys
8
Sells
2
Shares acquired
781.5K
Shares disposed
9.0K
Cash buys
Cash sales
Net activity
+772,433
Insider buys vs sells (history) From To
Recent insider transactions From To
Date Person Role Transaction A/D Security Shares Price Value Owned after D/I Filing
2026-03-01 Smith Nicholas Conrad Officer F-InKind D Common Stock 2,806 19.69 55.3K 24,060 D
2026-03-01 Etkin Amit Director / Officer F-InKind D Common Stock 6,227 19.69 122.6K 1,233,949 D
2026-02-11 Smith Nicholas Conrad Officer A-Award A Employee Stock Option (Right to Buy) 200,000 16.71 3.34M 200,000 D
2026-02-11 Savitz Adam Officer A-Award A Employee Stock Option (Right to Buy) 124,000 16.71 2.07M 124,000 D
2026-02-11 Hanley Jr. Michael Conick Officer A-Award A Employee Stock Option (Right to Buy) 131,000 16.71 2.19M 131,000 D
2026-02-11 Etkin Amit Director / Officer A-Award A Employee Stock Option (Right to Buy) 306,000 16.71 5.11M 306,000 D
2026-01-02 York Gwill Director A-Award A Stock Option (right to buy) 5,243 16.59 87.0K 5,243 D
2026-01-02 Sanchez Ramiro Director A-Award A Stock Option (right to buy) 3,806 16.59 63.1K 3,806 D
2026-01-02 Manji Husseini Director A-Award A Employee Stock Option (right to buy) 4,228 16.59 70.1K 4,228 D
2026-01-02 Cox Christopher Nixon Director A-Award A Stock Option (right to buy) 7,189 16.59 119.3K 7,189 D
2025-08-12 Sanchez Ramiro Director A-Award A Stock Option (right to buy) 30,574 3.18 97.2K 30,574 D
2025-07-03 Smith Nicholas Conrad Officer D-Return D Employee Stock Option (Right to Buy) 135,000 4.20 567.0K 0 D
2025-07-03 Savitz Adam Officer A-Award A Employee Stock Option (Right to Buy) 76,000 2.35 178.6K 76,000 D
2025-07-03 Hanley Jr. Michael Conick Officer A-Award A Employee Stock Option (Right to Buy) 188,000 2.35 441.8K 188,000 D
2025-07-03 Etkin Amit Director / Officer A-Award A Employee Stock Option (Right to Buy) 247,290 2.35 581.1K 247,290 D
2025-05-13 York Gwill Director A-Award A Stock Option (right to buy) 15,287 2.37 36.2K 15,287 D
2025-05-13 Manji Husseini Director A-Award A Stock Option (right to buy) 15,287 2.37 36.2K 15,287 D
2025-05-13 Dreyfus Andrew Director A-Award A Stock Option (right to buy) 15,287 2.37 36.2K 15,287 D
2025-05-13 Cox Christopher Nixon Director A-Award A Stock Option (right to buy) 15,287 2.37 36.2K 15,287 D
2025-02-05 Smith Nicholas Conrad Officer A-Award A Employee Stock Option (Right to Buy) 135,000 4.20 567.0K 135,000 D
2025-02-05 Savitz Adam Officer A-Award A Employee Stock Option (Right to Buy) 76,000 4.20 319.2K 76,000 D
2025-02-05 Hanley Jr. Michael Conick Officer A-Award A Employee Stock Option (Right to Buy) 125,000 4.20 525.0K 125,000 D
2025-02-05 Etkin Amit Director / Officer A-Award A Employee Stock Option (Right to Buy) 215,000 4.20 903.0K 215,000 D
2025-01-02 York Gwill Director A-Award A Stock Option (right to buy) 19,558 4.38 85.7K 19,558 D
2025-01-02 Manji Husseini Director A-Award A Stock Option (right to buy) 14,195 4.38 62.2K 14,195 D
2025-01-02 Cox Christopher Nixon Director A-Award A Stock Option (right to buy) 25,236 4.38 110.5K 25,236 D
2024-07-10 Savitz Adam Officer P-Purchase A Common Stock 2,931 13.22 38.7K 39,851
2024-07-09 Savitz Adam Officer P-Purchase A Common Stock 1,388 13.15 18.3K 36,920

Executive team

Top executives
Shares Outstanding
31.95M

Executive compensation

Executive compensation (annual)
# Year Executive Salary Bonus Stock award Option award Incentive Other Total % Stock-
based
Filing
1 2025 Amit Etkin, M.D., Ph.D. President, Chief Executive Officer, and Chair of the Board 650.7K 220.0K 934.2K 358.1K 25.6K 2.19M 42.69%
2 2025 Nicholas Smith Chief Financial Officer and Chief Business Officer 493.7K 220.0K 594.7K 222.3K 10.8K 1.54M 38.58%
3 2025 Michael Hanley Chief Operating Officer 488.8K 517.6K 195.5K 11.0K 1.21M 42.67%
4 2024 Amit Etkin, M.D., Ph.D. President, Chief Executive Officer, and Chair of the Board 603.1K 516.5K 2.55M 368.4K 24.5K 4.07M 75.50%
5 2024 Michael Hanley Chief Operating Officer 283.2K 1.88M 201.2K 82.0K 2.44M 76.81%
6 2024 Nicholas Smith Chief Financial Officer and Chief Business Officer 466.5K 285.0K 1.03M 203.3K 10.7K 2.00M 65.91%
CEO compensation breakdown

Proxy statements

Proxy statements (DEF 14A)
Filing date Form type Filing
2026-03-26 DEFA14A
2026-03-26 DEF 14A
2025-04-01 DEFA14A
2025-04-01 DEF 14A

Recent SEC filings

Recent SEC filings
Filing date Form type Filing
2026-05-13 8-K
2026-05-13 8-K
2026-05-13 10-Q
2026-04-20 EFFECT
2026-04-10 S-3
2026-04-01 8-K
2026-03-26 DEFA14A
2026-03-26 DEF 14A
2026-03-26 ARS
2026-03-16 S-8

Executive team

NameTitleCompensationGender
Amit Etkin Founder, Chairman of the Board, Chief Executive Officer & President 1M
Nicholas C. Smith Chief Financial Officer & Chief Business Officer 946.9K male
Michael C. Hanley Chief Operating Officer 695.3K male
Adam Savitz Chief Medical Officer 579.6K male
Erin R. McQuade General Counsel, Chief Administrative Officer & Corporate Secretary female
Dan Segal Co-Founder & Strategic Advisor male
Jessica Powell Chief Development Officer female
ESG Rating
B
BIOTECHNOLOGY
Rank: 144 out of 662
2026
E (Environmental)
49.4 / 56.3
Company / Sector avg.
S (Social)
71.6 / 62.4
Company / Sector avg.
G (Governance)
60.3 / 60.9
Company / Sector avg.
ESG Total
60.4 / 59.9
Company / Sector avg.
ESG Score History BIOTECHNOLOGY
Benchmark vs Sector
Senate Trading Activity

No Senate trading activity found for this company.

House Trading Activity

No House trading activity found for this company.

Market share among peers
Peer comparison — filtered group (TTM)
Your opinion

Share your view on this stock and instantly see how the community has voted over the last 6 months.

These are community opinions and do not constitute buy or sell advice to act on. The results shown are based on aggregated opinions and are not an investment recommendation, nor do they intend to influence any investment decision.

Dividend history

Earnings history

Earnings reports

Stock splits