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Amylyx Pharmaceuticals, Inc. (AMLX)

USD17.41 -0.36 (-2.03%)
US NASDAQ Healthcare Biotechnology
Address 43 Thorndike Street 2141
Cambridge, MA, US
CEO Joshua Cohen
Website amylyx.com
IPO 2022-01-07
CIK 1658551 ISIN US03237H1014

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Description

Amylyx Pharmaceuticals, Inc. operates as a clinical-stage biopharmaceutical firm, primarily focused on creating therapies for amyotrophic lateral sclerosis (ALS) and various other neurodegenerative conditions. A key asset in its developmental pipeline is AMX0035, a proprietary dual UPR-Bax apoptosis inhibitor. This compound, which integrates sodium phenylbutyrate and taurursodiol, is under investigation for treating ALS, and its application is also being explored for other neurodegenerative diseases. The company was established in 2013 and is based in Cambridge, Massachusetts.

Market Cap & Enterprise Value
Merger & Acquisition History

No mergers or acquisitions recorded for this company.

Technical Outlook
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Signal Summary Loading…
Indicator 1D1W2W3W1M
Each column is computed on that timeframe's candles (1D = daily, 1W ≈ weekly, 1M ≈ monthly), not on the same last day. ▲ bullish · ▼ bearish · — neutral. The Net row counts signals per column; hover any cell (or the indicator name) to see the exact rule behind it.
Day Score & sub-scores
Statistical fingerprint & regime detail
Conditional historical analysis
Customize analysis (advanced)
Indicative levels generated algorithmically. Not financial advice.
Risk Profile
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Price Chart
Averages
Trend
Price
Levels
Draw
USD17.41 -0.36 (-2.03%)
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Volume Profile
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Liquidity & share structure
Average Volume
1M
Beta
-0.16
Float Shares
55.26M
Free Float %
66.5%
Price Performance
1D5D1M3M6M YTD1Y3Y5Y10YMax
-2.96% -5.00% -12.33% +2.27% +16.26% +19.54% +221.60% -48.69% -20.09% -20.09% -20.09%
Rolling Volatility
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Drawdown
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Relative Strength
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Monthly Returns Heatmap
From To
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Annual Monthly Returns
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Daily Returns Distribution
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Revenue flow

Revenue by geography

Revenue by segment

From To

Revenue composition

From To

By product

By geography

Financial Statements

Income Statement

Balance Sheet

Cash Flow Statement

Key Metrics

Financial Ratios

Employees

Financial Growth (CAGR)

Market Data

Analyst Consensus (11 ratings, all time) Buy
Price Targets & DCF
Current price
17.41
Low 21.00 +20.6%
Consensus 24.50 +40.7%
Median 24.50 +40.7%
High 28.00 +60.8%
DCF (Unlevered) 2.30 -86.8%
DCF (Levered) 2.33 -86.6%

DCF figures are point estimates: small changes in growth or discount-rate assumptions move them materially. Read them as a reference, not a precise target.

Ratings Trend (MoM) 92% Bullish
Rating 2026-05 Change
Strong Buy 0 0
Buy 11 0
Hold 1 0
Sell 0 0
Strong Sell 0 0
Price Target Summary
Period # Analysts Avg Target
Last Month 1
21.00
+20.6%
Last Quarter 3
22.67
+30.2%
Last Year 7
20.71
+19.0%
All Time 16
12.63
-27.5%
Quality scores
Altman Z-Score
31.98
Safe zone
Piotroski F-Score
3 / 9
Average
MOAT Score
4 / 10
Developing
Composite Rating
C
Overall Score
2 / 5
Medium
DCF Score
3 / 5
Medium
ROE Score
1 / 5
Low
ROA Score
1 / 5
Low
D/E Score
3 / 5
Medium
P/E Score
1 / 5
Low
P/Book Score
1 / 5
Low
Operational MOAT
✗ Below peers
  • Revenue growth Biotechnology: +1.6%
    -100.0%
  • EPS growth Biotechnology: +29.7%
    +65.5% Q1'26: +11.9% (vs Q1'25)
  • FCF margin FCF growth · Biotechnology: +16.2%
  • EBIT margin Biotechnology: +0.0%
  • ROIC Biotechnology: -16.1%
    Q1'26: +17,942.2% (vs Q1'25)
  • Share dilution Biotechnology: -3.4%
    +38.8% Q1'26: +29.0% (vs Q1'25)
  • Debt / EBITDA Net debt/EBITDA · Biotechnology: 0.16×
    -0.04× Q1'26: -0.03× (vs Q1'25)
Valuation Multiples From To
Price Forecast (3Y) From To
Model
Adjust
P/E
Theoretical Return — If Invested Today

* These projections are based on analyst consensus estimates and user-defined valuation multiples. This table is for informational purposes only and does not constitute a recommendation to buy or sell any security. Past performance is not indicative of future results.

DCF Interactive Model (UFCF)
Projection years:
Market assumptions
WACC components (optional)
Ke (Cost of Equity) = Rf + β (-0.10) × ERP
WACC = 100% × Ke + 0% × Kd (4.0%) × (1−t)

Modifying these values recalculates WACC automatically.

Business assumptions
Intrinsic value (base): 2.30 Current price: 17.41
Enterprise Value: Equity Value: Terminal Value: TV as % of EV:

Base values reflect the latest available data for this company and market conditions.

Consensus Estimates
Metric Dec 2021
actual
Dec 2022
actual
Dec 2023
actual
Dec 2024
actual
Dec 2025
actual
Dec 2026
6 Rev. Ana.
7 EPS Ana.
Dec 2027
6 Rev. Ana.
6 EPS Ana.
Dec 2028
8 Rev. Ana.
6 EPS Ana.
Dec 2029
7 Rev. Ana.
4 EPS Ana.
Dec 2030
7 Rev. Ana.
2 EPS Ana.
Revenue
est: 528.3K (-100.0%)
22.23M
est: 4.42M (+402.7%)
380.79M
est: 398.00M (-4.3%)
87.37M
est: 88.03M (-0.7%)
est: 114.53M (-100.0%)
80.6K
16.3K – 173.7K
-99.9% YoY
44.69M
16.87M – 73.55M
+55,323.5% YoY
153.24M
153.24M – 153.24M
+242.9% YoY
321.42M
64.98M – 692.42M
+109.7% YoY
538.32M
108.83M – 1.16B
+67.5% YoY
EBITDA
-82.64M
est: -200.3K (-41,163.7%)
-200.85M
est: -1.68M (-11,881.7%)
39.89M
est: 8.34M (+378.4%)
-290.98M
est: 1.84M (-15,877.1%)
-144.16M
est: 2.40M (-6,107.9%)
1.7K
341.00 – 3.6K
-99.9% YoY
936.2K
353.5K – 1.54M
+55,330.3% YoY
3.21M
3.21M – 3.21M
+242.9% YoY
6.73M
1.36M – 14.51M
+109.7% YoY
11.28M
2.28M – 24.30M
+67.5% YoY
EBIT
-82.69M
est: -200.6K (-41,127.5%)
-201.34M
est: -1.68M (-11,892.6%)
38.80M
est: 8.11M (+378.4%)
-291.88M
est: 1.79M (-16,369.9%)
-144.69M
est: 2.33M (-6,298.8%)
1.6K
332.00 – 3.5K
-99.9% YoY
910.7K
343.9K – 1.50M
+55,327.9% YoY
3.12M
3.12M – 3.12M
+242.9% YoY
6.55M
1.32M – 14.11M
+109.7% YoY
10.97M
2.22M – 23.63M
+67.5% YoY
Net Income
-87.93M
est: -1.05B (+91.6%)
-198.38M
est: -237.86M (+16.6%)
49.27M
est: -71.10M (+169.3%)
-301.74M
est: -406.36M (+25.7%)
-144.74M
est: -150.11M (+3.6%)
-137.08M
-154.58M – -119.58M
+8.7% YoY
-147.88M
-167.61M – -71.83M
-7.9% YoY
-83.04M
-83.30M – 24.16M
+43.8% YoY
55.32M
-2.06M – 138.33M
+166.6% YoY
183.77M
-6.83M – 459.53M
+232.2% YoY
SGA
38.93M
est: 3.35M (+1,062.6%)
127.13M
est: 28.03M (+353.5%)
188.36M
est: 757.95M (-75.1%)
114.33M
est: 167.64M (-31.8%)
62.89M
est: 218.11M (-71.2%)
153.5K
31.0K – 330.8K
-99.9% YoY
85.10M
32.13M – 140.07M
+55,323.8% YoY
291.84M
291.84M – 291.84M
+242.9% YoY
612.11M
123.75M – 1.32B
+109.7% YoY
1.03B
207.26M – 2.21B
+67.5% YoY
EPS
-1.52
est: -15.35 (+90.1%)
-2.98
est: -3.49 (+14.6%)
0.73
est: -1.05 (+169.3%)
-4.43
est: -4.33 (-2.3%)
-1.53
est: -1.55 (+1.4%)
-1.43
-1.63 – -1.26
+7.9% YoY
-1.29
-1.77 – -0.76
+9.9% YoY
-0.59
-0.88 – 0.26
+54.4% YoY
0.59
-0.02 – 1.46
+199.6% YoY
1.94
-0.07 – 4.86
+232.2% YoY
Recent Grade Changes (3M)
Date Firm Previous New Grade Action
2026-04-28 Mizuho Outperform Outperform Maintain
Historical Ratings (3M)
Date Rating Overall DCF ROE ROA D/E P/E P/B
2026-05-07 C 2/5 3/5 1/5 1/5 3/5 1/5 1/5
2026-05-06 C 2/5 3/5 1/5 1/5 3/5 1/5 2/5
2026-05-05 C 2/5 3/5 1/5 1/5 3/5 1/5 2/5
2026-05-04 C 2/5 3/5 1/5 1/5 3/5 1/5 2/5
2026-05-01 C 2/5 3/5 1/5 1/5 3/5 1/5 2/5
2026-04-30 C 2/5 3/5 1/5 1/5 3/5 1/5 2/5
2026-04-29 C 2/5 3/5 1/5 1/5 3/5 1/5 2/5
2026-04-28 C 2/5 3/5 1/5 1/5 3/5 1/5 2/5
2026-04-27 C 2/5 3/5 1/5 1/5 3/5 1/5 2/5
2026-04-24 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5
2026-04-23 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5
2026-04-22 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5
2026-04-21 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5
2026-04-20 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5
2026-04-17 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5
2026-04-16 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5
2026-04-15 C 2/5 3/5 1/5 1/5 2/5 1/5 2/5

Owner Earnings

Owner's Earnings (history) From To
Owner alignment
Owner's Earnings TTM
-120.47M
OE per share TTM
-1.24
Owner's Yield
-7.17%
Maintenance CapEx ratio
Maint CapEx / Avg PPE
4.8%

Ownership Overview

Ownership breakdown
At a glance
Institutional holders
24
Total invested
6.61M
Insider transactions (90d)
0
Beneficial owners (>5%)
31
Beneficial owners (>5%)
# Reporting person Amount owned % of class Sole voting Shared voting Sole dispositive Shared dispositive Type Citizenship Filing date SEC filing
1 David C. Ott 7.17M 12.40% 7.17M 7.17M IN Delaware 2022-01-21
2 O. Andreas Halvorsen 7.17M 12.40% 7.17M 7.17M IN Delaware 2022-01-21
3 Rose S. Shabet 7.17M 12.40% 7.17M 7.17M IN Delaware 2022-01-21
4 Viking Global Investors LP 7.17M 12.40% 7.17M 7.17M PN Delaware 2022-01-21
5 Viking Global Opportunities GP LLC 7.17M 12.40% 7.17M 7.17M OO Delaware 2022-01-21
6 Viking Global Opportunities Parent GP LLC 7.17M 12.40% 7.17M 7.17M OO Delaware 2022-01-21
7 Viking Global Opportunities Illiquid Investments Sub-Master LP 4.87M 8.40% 4.87M 4.87M PN Delaware 2022-01-21
8 Viking Global Opportunities Portfolio GP LLC 4.87M 8.40% 4.87M 4.87M OO Delaware 2022-01-21
9 Chen Yu 4.64M 6.80% 4.64M 4.64M IN Delaware 2024-08-26
10 TCG Crossover Fund II, L.P. 4.64M 6.80% 4.64M 4.64M PN Delaware 2024-08-26
11 TCG Crossover GP II, LLC 4.64M 6.80% 4.64M 4.64M OO Delaware 2024-08-26
12 Joseph Edelman 4.46M 6.50% 4.46M 4.46M IN Delaware 2024-10-25
13 Perceptive Advisors LLC 4.46M 6.50% 4.46M 4.46M IA Delaware 2024-10-25
14 Perceptive Life Sciences Master Fund, Ltd. 4.46M 6.50% 4.46M 4.46M CO Delaware 2024-10-25
15 The Vanguard Group - 23-1945930 4.36M 6.58% 35.4K 50.8K IA Pennsylvania 2023-02-09
16 James Huang 4.20M 6.20% 4.20M 4.20M IN Cayman Islands 2024-03-11
17 Panacea Innovation Limited 4.20M 6.20% 4.20M 4.20M CO Cayman Islands 2024-03-11
18 Panacea Venture Healthcare Fund II GP Company, Ltd. 4.20M 6.20% 4.20M 4.20M CO Cayman Islands 2024-03-11
19 Panacea Venture Healthcare Fund II, L.P. 4.20M 6.20% 4.20M 4.20M PN Cayman Islands 2024-03-11
20 (1) BlackRock, Inc. 4.00M 5.90% 3.95M 4.00M HC Delaware 2024-01-29
21 GOLDMAN SACHS & CO. LLC 3.65M 5.40% 3.65M 3.65M BD, IA, OO Delaware 2023-06-09
22 THE GOLDMAN SACHS GROUP, INC. 3.65M 5.40% 3.65M 3.65M HC, CO Delaware 2023-06-09
23 Steven A. Cohen 3.47M 5.10% 3.47M IN United States 2023-12-11
24 Point72 Asset Management, L.P. 3.18M 4.70% 3.18M PN Delaware 2023-12-11
25 Point72 Capital Advisors, Inc. 3.18M 4.70% 3.18M CO Delaware 2023-12-11
26 2 2.97M 5.10% 2.97M 2.97M IA Delaware 2022-06-21
27 DRAGSA 96 LLC 2.30M 4.00% 2.30M 2.30M OO Delaware 2022-01-21
28 Israel A. Englander 1.62M 2.80% 1.62M 1.62M IN 2022-09-21
29 Millennium Group Management LLC 1.62M 2.80% 1.62M 1.62M OO 2022-09-21
30 Millennium Management LLC 1.62M 2.80% 1.62M 1.62M OO 2022-09-21
31 Cubist Systematic Strategies, LLC 294.6K 0.40% 294.6K OO Delaware 2023-12-11

Institutional Activity (13F)

Institutional ownership trend From To
13F snapshot — 2026 Q1
Investors holding
24
-166 vs prev Q
New positions
6
Closed positions
162
Increased
11
Reduced
4
Put/Call ratio
0.00
Calls held
Puts held
Top institutional holders
# Investor Shares / Δ Mkt value / Δ Own% / Δ Weight% / Δ Avg px / Perf. Hold / Status
1 44.2K +44.2K (+100.0%) 534.21M +534.2M (+100.0%) 0.05% +0.047 pp 0.47% +0.467 pp USD12.08 +0.0% 1 qtrs NEW
2 FMR LLC 16.52M +5.1M (+45.2%) 199.54M +44.9M (+29.0%) 17.70% +4.933 pp 0.01% +0.002 pp USD11.61 +4.0% 16 qtrs
3 BLACKROCK, INC. 9.05M +1.9M (+26.8%) 109.38M +12.3M (+12.7%) 9.70% +1.690 pp 0.00% +0.000 pp USD8.07 +49.7% 6 qtrs
4 PERCEPTIVE ADVISORS LLC 8.28M -667.5K (-7.5%) 100.08M -21.6M (-17.7%) 8.88% -1.167 pp 1.78% -1.729 pp USD4.78 +152.7% 16 qtrs
5 TCG CROSSOVER MANAGEMENT, LLC 6.24M +— (+0.0%) 75.43M -9.4M (-11.1%) 6.69% -0.315 pp 2.50% -1.678 pp USD3.80 +217.9% 6 qtrs
6 VANGUARD GROUP INC 5.80M +531.2K (+10.1%) 70.12M -1.5M (-2.2%) 6.22% +0.303 pp 0.00% 0.000 pp USD16.00 -24.5% 16 qtrs
7 COMMODORE CAPITAL LP 5.65M +1.6M (+38.6%) 68.25M +12.9M (+23.2%) 6.05% +1.482 pp 4.54% +1.840 pp USD13.17 -8.3% 2 qtrs
8 SATURN V CAPITAL MANAGEMENT LLC 4.50M -108.4K (-2.4%) 54.32M -8.3M (-13.2%) 4.82% -0.348 pp 9.97% -3.756 pp USD7.04 +71.6% 5 qtrs
9 JANUS HENDERSON GROUP PLC 4.47M +1.9M (+76.1%) 53.99M +19.5M (+56.7%) 4.78% +1.940 pp 0.02% +0.008 pp USD12.94 -6.6% 2 qtrs
10 FIRST LIGHT ASSET MANAGEMENT, LLC 3.36M -343.0 (0.0%) 40.53M -5.1M (-11.1%) 3.60% -0.170 pp 3.10% -1.200 pp USD13.59 -11.1% 2 qtrs
11 DRIEHAUS CAPITAL MANAGEMENT LLC 3.11M +688.7K (+28.5%) 37.56M +4.7M (+14.2%) 3.33% +0.616 pp 0.26% +0.020 pp USD10.33 +16.9% 3 qtrs
12 ADAGE CAPITAL PARTNERS GP, L.L.C. 2.78M -4.0M (-59.3%) 33.55M -59.1M (-63.8%) 2.98% -4.672 pp 0.05% -0.096 pp USD4.55 +165.5% 4 qtrs
13 GOLDMAN SACHS GROUP INC 2.61M +602.6K (+30.0%) 31.57M +4.2M (+15.5%) 2.80% +0.544 pp 0.00% +0.001 pp USD12.88 -6.2% 14 qtrs
14 MORGAN STANLEY 2.36M +409.5K (+21.0%) 28.51M +2.0M (+7.6%) 2.53% +0.341 pp 0.00% +0.000 pp USD14.41 -16.2% 16 qtrs
15 GEODE CAPITAL MANAGEMENT, LLC 2.17M +353.5K (+19.5%) 26.16M +1.5M (+6.2%) 2.32% +0.287 pp 0.00% +0.000 pp USD11.25 +7.4% 16 qtrs
16 ALMITAS CAPITAL LLC 2.12M +— (+0.0%) 25.64M -3.2M (-11.1%) 2.27% -0.107 pp 5.65% -0.957 pp USD2.04 +492.2% 7 qtrs
17 STATE STREET CORP 2.07M +448.6K (+27.7%) 25.00M +3.0M (+13.5%) 2.22% +0.399 pp 0.00% +0.000 pp USD10.52 +14.8% 16 qtrs
18 GREAT POINT PARTNERS LLC 1.75M +50.0K (+2.9%) 21.14M -2.0M (-8.5%) 1.88% -0.032 pp 6.85% -2.673 pp USD4.05 +198.3% 4 qtrs
19 683 CAPITAL MANAGEMENT, LLC 1.65M -110.0K (-6.3%) 19.93M -4.0M (-16.7%) 1.77% -0.207 pp 0.87% -0.382 pp USD2.48 +387.1% 7 qtrs
20 EVENTIDE ASSET MANAGEMENT, LLC 1.51M +648.0 (+0.0%) 18.28M -2.3M (-11.1%) 1.62% -0.076 pp 0.29% -0.052 pp USD13.59 -11.1% 2 qtrs
21 BANK OF AMERICA CORP /DE/ 1.34M +906.5K (+211.1%) 16.14M +10.3M (+176.5%) 1.43% +0.950 pp 0.00% +0.001 pp USD9.63 +25.4% 16 qtrs
22 DEUTSCHE BANK AG\ 1.33M -32.3K (-2.4%) 16.11M -2.5M (-13.2%) 1.43% -0.103 pp 0.01% -0.001 pp USD13.92 -13.2% 16 qtrs
23 FRANKLIN RESOURCES INC 1.20M +1.2M (+100.0%) 14.50M +14.5M (+100.0%) 1.29% +1.286 pp 0.00% +0.004 pp USD12.08 +0.0% 1 qtrs NEW
24 CONNOR, CLARK & LUNN INVESTMENT MANAGEMENT LTD. 1.00M -103.0K (-9.3%) 12.13M -2.9M (-19.4%) 1.08% -0.166 pp 0.03% -0.016 pp USD5.87 +105.8% 10 qtrs
25 LOGOS GLOBAL MANAGEMENT LP 950.0K -500.0K (-34.5%) 11.48M -8.2M (-41.8%) 1.02% -0.609 pp 0.69% -1.073 pp USD13.59 -11.1% 2 qtrs
26 NORTHERN TRUST CORP 937.8K +115.5K (+14.1%) 11.33M +154.0K (+1.4%) 1.00% +0.082 pp 0.00% +0.000 pp USD9.08 +33.0% 16 qtrs
27 ADAR1 CAPITAL MANAGEMENT, LLC 890.4K +24.2K (+2.8%) 10.76M -1.0M (-8.6%) 0.95% -0.018 pp 0.79% -0.316 pp USD3.77 +220.4% 9 qtrs
28 BALYASNY ASSET MANAGEMENT L.P. 858.7K -617.6K (-41.8%) 10.37M -9.7M (-48.3%) 0.92% -0.736 pp 0.01% -0.012 pp USD13.59 -11.1% 16 qtrs
29 WOODLINE PARTNERS LP 845.4K +118.0 (+0.0%) 10.21M -1.3M (-11.1%) 0.91% -0.043 pp 0.04% -0.015 pp USD3.54 +241.2% 4 qtrs
30 NANTAHALA CAPITAL MANAGEMENT, LLC 835.7K -100.0K (-10.7%) 10.10M -2.6M (-20.6%) 0.90% -0.154 pp 0.33% -0.108 pp USD3.40 +255.3% 6 qtrs
31 BOXER CAPITAL MANAGEMENT, LLC 800.0K -100.0K (-11.1%) 9.66M -2.6M (-21.0%) 0.86% -0.153 pp 2.12% -1.783 pp USD3.78 +219.6% 5 qtrs
32 DIMENSIONAL FUND ADVISORS LP 771.2K +261.5K (+51.3%) 9.32M +2.4M (+34.3%) 0.83% +0.254 pp 0.00% +0.001 pp USD9.16 +31.9% 5 qtrs
33 CHARLES SCHWAB INVESTMENT MANAGEMENT INC 713.0K +67.8K (+10.5%) 8.61M -155.1K (-1.8%) 0.76% +0.040 pp 0.00% 0.000 pp USD12.64 -4.4% 16 qtrs
34 STEMPOINT CAPITAL LP 565.1K +288.3K (+104.1%) 6.83M +3.1M (+81.5%) 0.61% +0.295 pp 1.17% +0.417 pp USD12.82 -5.8% 2 qtrs
35 UBS GROUP AG 543.3K -861.1K (-61.3%) 6.56M -12.5M (-65.6%) 0.58% -0.994 pp 0.00% -0.002 pp USD4.68 +158.1% 16 qtrs
36 SOFINNOVA INVESTMENTS, INC. 527.1K +527.1K (+100.0%) 6.37M +6.4M (+100.0%) 0.56% +0.565 pp 0.27% +0.275 pp USD12.08 +0.0% 1 qtrs NEW
37 SILVERARC CAPITAL MANAGEMENT, LLC 506.2K -193.8K (-27.7%) 6.12M -3.4M (-35.7%) 0.54% -0.243 pp 0.85% -0.434 pp USD13.59 -11.1% 2 qtrs
38 AMERIPRISE FINANCIAL INC 502.4K +368.9K (+276.3%) 6.07M +4.3M (+234.5%) 0.54% +0.389 pp 0.00% +0.001 pp USD11.05 +9.3% 5 qtrs
39 ROCK SPRINGS CAPITAL MANAGEMENT LP 499.8K +— (+0.0%) 6.04M -754.6K (-11.1%) 0.54% -0.025 pp 0.31% -0.087 pp USD4.44 +172.1% 4 qtrs
40 FEDERATED HERMES, INC. 457.4K +245.0K (+115.4%) 5.53M +2.6M (+91.4%) 0.49% +0.252 pp 0.01% +0.004 pp USD14.02 -13.8% 14 qtrs
41 QUBE RESEARCH & TECHNOLOGIES LTD 412.9K +245.8K (+147.1%) 4.99M +2.7M (+119.6%) 0.44% +0.255 pp 0.01% +0.003 pp USD9.21 +31.2% 12 qtrs
42 CORMORANT ASSET MANAGEMENT, LP 400.0K -100.0K (-20.0%) 4.83M -2.0M (-28.9%) 0.43% -0.132 pp 0.22% -0.245 pp USD13.59 -11.1% 2 qtrs
43 PARKMAN HEALTHCARE PARTNERS LLC 381.8K -197.4K (-34.1%) 4.61M -3.3M (-41.4%) 0.41% -0.241 pp 0.44% -0.382 pp USD6.41 +88.5% 3 qtrs
44 PATIENT SQUARE CAPITAL LP 350.0K +33.7K (+10.7%) 4.23M -70.7K (-1.6%) 0.38% +0.020 pp 0.91% -0.245 pp USD13.44 -10.1% 2 qtrs
45 CITADEL ADVISORS LLC 345.0K +110.3K (+47.0%) 4.17M +978.0K (+30.7%) 0.37% +0.106 pp 0.00% +0.000 pp USD11.08 +9.0% 16 qtrs
46 TWO SIGMA INVESTMENTS, LP 344.4K +246.0K (+249.9%) 4.16M +2.8M (+211.1%) 0.37% +0.259 pp 0.01% +0.004 pp USD9.60 +25.8% 9 qtrs
47 POINT72 ASSET MANAGEMENT, L.P. 335.0K -2.5M (-88.0%) 4.05M -33.9M (-89.3%) 0.36% -2.771 pp 0.00% -0.059 pp USD5.83 +107.2% 15 qtrs
48 ACUTA CAPITAL PARTNERS, LLC 333.3K +— (+0.0%) 4.03M -503.2K (-11.1%) 0.36% -0.017 pp 2.73% -1.947 pp USD13.59 -11.1% 2 qtrs
49 TWO SIGMA ADVISERS, LP 328.4K +185.4K (+129.7%) 3.97M +2.0M (+104.1%) 0.35% +0.191 pp 0.01% +0.004 pp USD8.19 +47.5% 8 qtrs
50 ALPHA WAVE GLOBAL, LP 317.7K -9.6K (-2.9%) 3.84M -610.6K (-13.7%) 0.34% -0.027 pp 0.47% +0.020 pp USD5.76 +109.7% 6 qtrs
51 BARCLAYS PLC 295.2K +210.6K (+249.0%) 3.57M +3.3M (+1,201.3%) 0.32% +0.221 pp 0.00% +0.001 pp USD10.69 +13.0% 16 qtrs
52 NUVEEN, LLC 283.9K +123.5K (+77.0%) 3.43M +1.2M (+57.3%) 0.30% +0.124 pp 0.00% +0.000 pp USD9.00 +34.2% 3 qtrs
53 TFG ASSET MANAGEMENT GP LTD 272.8K +14.6K (+5.6%) 3.30M -213.7K (-6.1%) 0.29% +0.003 pp 0.69% +0.226 pp USD7.75 +55.9% 3 qtrs
54 JANE STREET GROUP, LLC 263.2K +263.2K (+100.0%) 3.18M +3.2M (+100.0%) 0.28% +0.282 pp 0.00% +0.001 pp USD12.08 +0.0% 16 qtrs
55 ACADIAN ASSET MANAGEMENT LLC 254.3K -113.0K (-30.8%) 3.07M -1.9M (-38.5%) 0.27% -0.140 pp 0.01% -0.004 pp USD4.67 +158.7% 7 qtrs
56 HIGHVISTA STRATEGIES LLC 238.8K +238.8K (+100.0%) 2.88M +2.9M (+100.0%) 0.26% +0.256 pp 0.74% +0.743 pp USD12.08 +0.0% 1 qtrs NEW
57 WELLINGTON MANAGEMENT GROUP LLP 225.8K -10.4K (-4.4%) 2.73M -482.5K (-15.0%) 0.24% -0.023 pp 0.00% 0.000 pp USD3.71 +225.6% 5 qtrs
58 SUMMITTX CAPITAL, L.P. 218.4K +50.4K (+30.0%) 2.64M +355.1K (+15.6%) 0.23% +0.046 pp 0.08% -0.015 pp USD13.24 -8.8% 2 qtrs
59 BANK OF NEW YORK MELLON CORP 217.3K +34.4K (+18.8%) 2.63M +139.2K (+5.6%) 0.23% +0.028 pp 0.00% +0.000 pp USD8.37 +44.3% 3 qtrs
60 ALDEBARAN CAPITAL, LLC 198.5K -6.0K (-2.9%) 2.40M -380.8K (-13.7%) 0.21% -0.017 pp 2.15% -0.402 pp USD1.88 +542.6% 7 qtrs
61 RENAISSANCE TECHNOLOGIES LLC 192.5K +172.6K (+867.3%) 2.33M +2.1M (+759.9%) 0.21% +0.184 pp 0.00% +0.003 pp USD11.23 +7.6% 10 qtrs
62 XTX TOPCO LTD 189.7K +189.7K (+100.0%) 2.29M +2.3M (+100.0%) 0.20% +0.203 pp 0.06% +0.060 pp USD12.08 +0.0% 1 qtrs NEW
63 INVESCO LTD. 175.9K -634.7K (-78.3%) 2.13M -8.9M (-80.7%) 0.19% -0.721 pp 0.00% -0.001 pp USD8.23 +46.8% 4 qtrs
64 SWISS NATIONAL BANK 161.7K +161.7K (+100.0%) 1.95M +2.0M (+100.0%) 0.17% +0.173 pp 0.00% +0.001 pp USD12.08 +0.0% 1 qtrs NEW
65 VOLORIDGE INVESTMENT MANAGEMENT, LLC 153.4K +153.4K (+100.0%) 1.85M +1.9M (+100.0%) 0.16% +0.164 pp 0.01% +0.007 pp USD12.08 +0.0% 1 qtrs NEW
66 WELLS FARGO & COMPANY/MN 146.3K +52.6K (+56.2%) 1.77M +494.2K (+38.8%) 0.16% +0.052 pp 0.00% +0.000 pp USD11.21 +7.8% 16 qtrs
67 ATOM INVESTORS LP 139.4K +139.4K (+100.0%) 1.68M +1.7M (+100.0%) 0.15% +0.149 pp 0.13% +0.134 pp USD12.08 +0.0% 1 qtrs NEW
68 BANK OF MONTREAL /CAN/ 138.5K -5.2K (-3.6%) 1.67M -280.2K (-14.3%) 0.15% -0.013 pp 0.00% 0.000 pp USD2.26 +434.5% 7 qtrs
69 PFM HEALTH SCIENCES, LP 134.5K -301.6K (-69.2%) 1.63M -4.3M (-72.6%) 0.14% -0.345 pp 0.16% -0.294 pp USD3.54 +241.2% 4 qtrs
70 NUMERAI GP LLC 112.6K +45.5K (+67.7%) 1.36M +448.2K (+49.1%) 0.12% +0.045 pp 0.16% +0.035 pp USD12.98 -6.9% 2 qtrs
71 PRICE T ROWE ASSOCIATES INC /MD/ 107.5K +7.1K (+7.1%) 1.30M -66.0K (-4.8%) 0.12% +0.003 pp 0.00% +0.000 pp USD11.39 +6.1% 13 qtrs
72 RHUMBLINE ADVISERS 99.3K +617.0 (+0.6%) 1.20M -141.5K (-10.6%) 0.11% -0.004 pp 0.00% 0.000 pp USD6.45 +87.3% 3 qtrs
73 UBS ASSET MANAGEMENT AMERICAS INC 98.8K +98.8K (+100.0%) 1.19M +1.2M (+100.0%) 0.11% +0.106 pp 0.00% +0.000 pp USD12.08 +0.0% 1 qtrs NEW
74 ALPS ADVISORS INC 90.2K +90.2K (+100.0%) 1.09M +1.1M (+100.0%) 0.10% +0.097 pp 0.01% +0.006 pp USD12.08 +0.0% 1 qtrs NEW
75 STATE OF WISCONSIN INVESTMENT BOARD 84.1K +70.3K (+506.4%) 1.02M +827.9K (+439.1%) 0.09% +0.075 pp 0.00% +0.002 pp USD12.33 -2.0% 2 qtrs
76 CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 79.1K +74.8K (+1,726.1%) 955.4K +896.5K (+1,523.2%) 0.08% +0.080 pp 0.00% +0.001 pp USD11.77 +2.6% 3 qtrs
77 CAMPBELL & CO INVESTMENT ADVISER LLC 78.8K +54.3K (+221.7%) 951.5K +618.7K (+186.0%) 0.08% +0.057 pp 0.05% +0.021 pp USD12.55 -3.7% 2 qtrs
78 SQUAREPOINT OPS LLC 76.6K +76.6K (+100.0%) 924.9K +924.9K (+100.0%) 0.08% +0.082 pp 0.00% +0.001 pp USD12.08 +0.0% 16 qtrs
79 D. E. SHAW & CO., INC. 73.2K +4.3K (+6.3%) 884.5K -51.5K (-5.5%) 0.08% +0.001 pp 0.00% +0.000 pp USD15.35 -21.3% 14 qtrs
80 LEGAL & GENERAL GROUP PLC 72.6K +5.4K (+8.0%) 877.2K -36.3K (-4.0%) 0.08% +0.002 pp 0.00% +0.000 pp USD12.75 -5.3% 3 qtrs
81 ALLIANCEBERNSTEIN L.P. 71.5K +— (+0.0%) 863.7K -108.0K (-11.1%) 0.08% -0.004 pp 0.00% +0.000 pp USD10.52 +14.8% 3 qtrs
82 SUSQUEHANNA INTERNATIONAL GROUP, LLP 68.9K +68.9K (+100.0%) 832.2K +832.2K (+100.0%) 0.07% +0.074 pp 0.00% +0.000 pp USD12.08 +0.0% 16 qtrs
83 JPMORGAN CHASE & CO 66.5K +30.7K (+85.7%) 803.9K +316.8K (+65.0%) 0.07% +0.031 pp 0.00% +0.000 pp USD8.47 +42.6% 16 qtrs
84 RUSSELL INVESTMENTS GROUP, LTD. 65.4K +10.0K (+18.1%) 790.5K +37.5K (+5.0%) 0.07% +0.008 pp 0.00% +0.000 pp USD12.30 -1.8% 12 qtrs
85 KENNONDALE CAPITAL MANAGEMENT LLC 53.4K -55.2K (-50.8%) 645.4K -830.7K (-56.3%) 0.06% -0.065 pp 0.47% -0.655 pp USD4.92 +145.5% 5 qtrs
86 EAM INVESTORS, LLC 53.3K -21.9K (-29.1%) 643.3K -377.4K (-37.0%) 0.06% -0.027 pp 0.07% -0.045 pp USD6.41 +88.5% 3 qtrs
87 SEI INVESTMENTS CO 52.9K +52.9K (+100.0%) 638.5K +638.5K (+100.0%) 0.06% +0.057 pp 0.00% +0.001 pp USD12.08 +0.0% 1 qtrs NEW
88 METLIFE INVESTMENT MANAGEMENT, LLC 49.7K +6.7K (+15.7%) 599.8K +16.4K (+2.8%) 0.05% +0.005 pp 0.00% +0.000 pp USD7.18 +68.2% 3 qtrs
89 TREXQUANT INVESTMENT LP 48.1K -174.8K (-78.4%) 581.2K -2.4M (-80.8%) 0.05% -0.199 pp 0.01% -0.026 pp USD13.59 -11.1% 2 qtrs
90 MILLENNIUM MANAGEMENT LLC 46.5K -371.3K (-88.9%) 561.2K -5.1M (-90.1%) 0.05% -0.419 pp 0.00% -0.002 pp USD6.07 +99.0% 16 qtrs
91 MARINER, LLC 46.3K -1.7K (-3.5%) 559.9K -92.8K (-14.2%) 0.05% -0.004 pp 0.00% 0.000 pp USD30.00 -59.7% 13 qtrs
92 MIRAE ASSET GLOBAL ETFS HOLDINGS LTD. 41.2K +9.2K (+28.6%) 497.3K +62.4K (+14.4%) 0.04% +0.008 pp 0.00% +0.000 pp USD7.67 +57.5% 3 qtrs
93 CITIGROUP INC 38.0K -51.0 (-0.1%) 459.4K -58.1K (-11.2%) 0.04% -0.002 pp 0.00% +0.000 pp USD9.04 +33.6% 16 qtrs
94 GSA CAPITAL PARTNERS LLP 36.8K -15.3K (-29.5%) 444.0K -264.0K (-37.3%) 0.04% -0.019 pp 0.04% -0.021 pp USD6.04 +100.0% 5 qtrs
95 ZURCHER KANTONALBANK (ZURICH CANTONALBANK) 35.9K +34.0K (+1,782.3%) 433.4K +407.5K (+1,573.1%) 0.04% +0.036 pp 0.00% +0.001 pp USD11.63 +3.9% 4 qtrs
96 FOX RUN MANAGEMENT, L.L.C. 35.4K +35.4K (+100.0%) 427.7K +427.7K (+100.0%) 0.04% +0.038 pp 0.07% +0.066 pp USD12.08 +0.0% 1 qtrs NEW
97 INTECH INVESTMENT MANAGEMENT LLC 32.0K +12.5K (+64.2%) 386.6K +121.7K (+45.9%) 0.03% +0.012 pp 0.00% +0.001 pp USD8.63 +40.0% 3 qtrs
Ownership breakdown by holder

Insider Activity

Insider Activity — Latest Quarter
Ratio by transactions
0.18
Bearish
Ratio by volume
0.48
Bearish
Buys
4
Sells
22
Shares acquired
400.0K
Shares disposed
834.1K
Cash buys
Cash sales
17.00
Net activity
-434,093
Insider buys vs sells (history) From To
Recent insider transactions From To
Date Person Role Transaction A/D Security Shares Price Value Owned after D/I Filing
2026-03-05 Mazzariello Gina Officer A-Award A Stock Option (Right to Buy) 111,990 14.10 1.58M 111,990 D
2026-03-05 Klee Justin B. Director / Officer A-Award A Stock Option (Right to Buy) 373,295 14.10 5.26M 373,295 D
2026-03-05 FRATES JAMES M Officer A-Award A Stock Option (right to buy) 143,985 14.10 2.03M 143,985 D
2026-03-05 Cohen Joshua B Director / Officer A-Award A Common Stock 248,865 0.00 3,583,548 D
2026-03-05 Bedrosian Camille L Officer A-Award A Stock Option (Right to Buy) 143,985 14.10 2.03M 143,985 D
2026-03-02 Mazzariello Gina Officer S-Sale D Common Stock 6,844 14.52 99.4K 134,430 D
2026-03-02 Klee Justin B. Director / Officer S-Sale D Common Stock 29,282 14.47 423.8K 3,334,616 D
2026-03-02 FRATES JAMES M Officer S-Sale D Common Stock 7,909 14.52 114.9K 165,638 D
2026-03-02 Cohen Joshua B Director / Officer S-Sale D Common Stock 29,282 14.48 424.1K 3,334,683 D
2026-03-02 Bedrosian Camille L Officer S-Sale D Common Stock 6,461 14.58 94.2K 169,295 D
2026-02-23 Mazzariello Gina Officer S-Sale D Common Stock 3,419 14.14 48.4K 141,274 D
2026-02-02 Mazzariello Gina Officer S-Sale D Common Stock 3,448 14.65 50.5K 144,693 D
2026-02-02 Klee Justin B. Director / Officer S-Sale D Common Stock 15,500 14.69 227.6K 3,363,898 D
2026-02-02 FRATES JAMES M Officer S-Sale D Common Stock 3,557 14.65 52.1K 173,547 D
2026-02-02 Cohen Joshua B Director / Officer S-Sale D Common Stock 15,500 14.68 227.6K 3,363,965 D
2026-01-16 Klee Justin B. Director / Officer M-Exempt A Common Stock 2,847 7.57 21.6K 3,381,393 D
2026-01-16 Cohen Joshua B Director / Officer M-Exempt A Common Stock 2,818 7.57 21.3K 3,381,439 D
2026-01-15 Klee Justin B. Director / Officer M-Exempt D Stock Option (Right to Buy) 197,153 7.57 1.49M 2,847 D
2026-01-15 Cohen Joshua B Director / Officer M-Exempt D Stock Option (Right to Buy) 197,182 7.57 1.49M 2,818 D
2026-01-12 MILNE GEORGE M JR Director G-Gift D Common Stock 17,780 0.00 812,881 D
2026-01-06 Klee Justin B. Director / Officer S-Sale D Common Stock 7,715 11.09 85.6K 3,317,586 D
2026-01-06 FRATES JAMES M Officer S-Sale D Common Stock 3,326 11.11 37.0K 177,104 D
2026-01-06 Cohen Joshua B Director / Officer S-Sale D Common Stock 7,715 11.09 85.6K 3,317,632 D
2025-12-23 Firestone Karen Director P-Purchase A Common Stock 8,100 12.45 100.8K 63,100 D
2025-12-01 Bedrosian Camille L Officer S-Sale D Common Stock 6,580 14.35 94.4K 175,756 D
2025-09-30 Mazzariello Gina Officer S-Sale D Common Stock 8,828 14.58 128.7K 148,141 D
2025-09-30 Klee Justin B. Director / Officer S-Sale D Common Stock 200 15.01 3.0K 3,325,301 D
2025-09-30 FRATES JAMES M Officer S-Sale D Common Stock 10,558 14.65 154.7K 280,430 D
2025-09-30 Cohen Joshua B Director / Officer S-Sale D Common Stock 200 15.00 3.0K 3,325,347 D
2025-09-30 Bedrosian Camille L Officer S-Sale D Common Stock 12,039 14.58 175.5K 182,336 D
2025-08-13 Mazzariello Gina Officer S-Sale D Common Stock 15,000 8.34 125.0K 156,969 D
2025-08-12 Mazzariello Gina Officer S-Sale D Common Stock 15,000 8.07 121.1K 171,969 D
2025-06-05 Zeiher Bernhardt G Director A-Award A Stock Option (right to buy) 25,000 5.05 126.3K 25,000 D
2025-06-05 Quimi Daphne Director A-Award A Stock Option (right to buy) 25,000 5.05 126.3K 25,000 D
2025-06-05 MILNE GEORGE M JR Director A-Award A Stock Option (right to buy) 25,000 5.05 126.3K 25,000 D
2025-06-05 Firestone Karen Director A-Award A Stock Option (right to buy) 25,000 5.05 126.3K 25,000 D
2025-06-05 FONTEYNE PAUL R. Director A-Award A Stock Option (right to buy) 25,000 5.05 126.3K 25,000 D
2025-05-22 Mazzariello Gina Officer G-Gift D Common Stock 1,000 0.00 186,969 D
2025-03-31 Mazzariello Gina Officer S-Sale D Common Stock 9,192 3.48 32.0K 187,969 D
2025-03-31 Klee Justin B. Director / Officer S-Sale D Common Stock 21,490 3.46 74.5K 3,355,276 D
2025-03-31 FRATES JAMES M Officer S-Sale D Common Stock 10,896 3.47 37.8K 290,988 D
2025-03-31 Cohen Joshua B Director / Officer S-Sale D Common Stock 21,490 3.47 74.5K 3,355,280 D
2025-03-31 Bedrosian Camille L Officer S-Sale D Common Stock 12,425 3.47 43.1K 194,375 D
2025-03-20 Zeiher Bernhardt G Director P-Purchase A Common Stock 10,000 3.70 37.0K 10,000 D
2025-03-06 Mazzariello Gina Officer A-Award A Stock Option (right to buy) 95,777 3.61 345.8K 95,777 D
2025-03-06 Klee Justin B. Director / Officer A-Award A Stock Option (right to buy) 270,177 3.61 975.3K 270,177 D
2025-03-06 FRATES JAMES M Officer A-Award A Stock Option (right to buy) 102,630 3.61 370.5K 102,630 D
2025-03-06 Cohen Joshua B Director / Officer A-Award A Stock Option (Right to Buy) 270,177 3.61 975.3K 270,177 D
2025-03-06 Bedrosian Camille L Officer A-Award A Stock Option (Right to Buy) 102,630 3.61 370.5K 102,630 D
2025-03-03 Mazzariello Gina Officer S-Sale D Common Stock 1,611 3.12 5.0K 133,310 D
2025-03-03 Klee Justin B. Director / Officer S-Sale D Common Stock 4,595 3.15 14.5K 3,196,648 D
2025-03-03 Cohen Joshua B Director / Officer S-Sale D Common Stock 4,595 3.17 14.5K 3,196,652 D
2025-02-24 Mazzariello Gina Officer S-Sale D Common Stock 4,169 3.15 13.1K 134,921 D
2025-02-05 Klee Justin B. Director / Officer M-Exempt D Stock Option (right to buy) 36,310 1.57 57.0K 0 D
2025-02-03 Mazzariello Gina Officer S-Sale D Common Stock 3,678 3.49 12.8K 139,090 D
2025-02-03 Klee Justin B. Director / Officer S-Sale D Common Stock 11,855 3.47 41.1K 3,164,933 D
2025-02-03 Cohen Joshua B Director / Officer S-Sale D Common Stock 11,851 3.47 41.1K 3,201,247 D
2025-01-24 MILNE GEORGE M JR Director G-Gift D Common Stock 27,910 0.00 830,661 D
2025-01-06 Klee Justin B. Director / Officer S-Sale D Common Stock 7,471 4.04 30.2K 3,176,788 D
2025-01-06 Cohen Joshua B Director / Officer S-Sale D Common Stock 7,471 4.05 30.2K 3,213,098 D
2024-12-02 Bedrosian Camille L Officer S-Sale D Common Stock 5,421 5.54 30.0K 138,380 D
2024-11-04 Klee Justin B. Director / Officer M-Exempt D Stock Option (right to buy) 63,690 1.57 100.0K 36,310 D
2024-09-30 Mazzariello Gina Officer S-Sale D Common Stock 8,709 3.20 27.8K 142,768 D
2024-09-30 Klee Justin B. Director / Officer S-Sale D Common Stock 18,589 3.20 59.4K 3,120,569 D
2024-09-30 Cohen Joshua B Director / Officer S-Sale D Common Stock 18,589 3.20 59.4K 3,220,569 D
2024-09-30 Bedrosian Camille L Officer S-Sale D Common Stock 11,442 3.20 36.6K 143,801 D
2024-09-23 Cohen Joshua B Director / Officer M-Exempt A Common Stock 1,857 1.57 2.9K 3,239,158 D
2024-09-12 FRATES JAMES M Officer P-Purchase A Common Stock 40,000 2.53 101.4K 233,464
2024-09-12 Cohen Joshua B Director / Officer M-Exempt A Common Stock 34,449 1.57 54.1K 3,237,301
2024-09-05 Firestone Karen Director P-Purchase A Common Stock 50,000 2.13 106.6K 55,000
2024-09-03 MILNE GEORGE M JR Director P-Purchase A Common Stock 100,000 2.20 219.8K 858,571
2024-06-06 Zeiher Bernhardt G Director A-Award A Stock Option (right to buy) 5,753 1.76 10.1K 5,753
2024-06-06 Quimi Daphne Director A-Award A Stock Option (right to buy) 25,000 1.76 44.0K 25,000
2024-06-06 MILNE GEORGE M JR Director A-Award A Stock Option (right to buy) 25,000 1.76 44.0K 25,000
2024-06-06 Firestone Karen Director A-Award A Stock Option (right to buy) 25,000 1.76 44.0K 25,000
2024-06-06 FONTEYNE PAUL R. Director A-Award A Stock Option (right to buy) 25,000 1.76 44.0K 25,000
2024-05-15 Quimi Daphne Director P-Purchase A Common Stock 2,250 1.89 4.3K 5,000
2024-05-15 Mazzariello Gina Officer S-Sale D Common Stock 10,455 1.88 19.7K 151,477
2024-05-14 Quimi Daphne Director P-Purchase A Common Stock 2,750 1.89 5.2K 2,750
2024-04-16 Mazzariello Gina Officer A-Award A Common Stock 80,560 0.00 161,932
2024-04-16 Klee Justin B. Director / Officer A-Award A Stock Option (right to buy) 380,000 2.01 763.8K 380,000
2024-04-16 FRATES JAMES M Officer A-Award A Common Stock 91,180 0.00 225,964
2024-04-16 Cohen Joshua B Director / Officer A-Award A Stock Option (right to buy) 380,000 2.01 763.8K 380,000
2024-04-16 Bedrosian Camille L Officer A-Award A Stock Option (Right to Buy) 120,000 2.01 241.2K 120,000
2024-03-14 Zeiher Bernhardt G Director A-Award A Stock Option (Right to Buy) 50,000 3.17 158.5K 50,000
2024-03-05 Mazzariello Gina Officer S-Sale D Common Stock 1,540 18.73 28.8K 81,372
2024-03-05 Klee Justin B. Director / Officer S-Sale D Common Stock 4,135 18.73 77.4K 2,959,308
2024-03-05 FRATES JAMES M Officer S-Sale D Common Stock 1,792 18.73 33.6K 134,784
2024-03-05 Cohen Joshua B Director / Officer S-Sale D Common Stock 4,135 18.73 77.4K 3,023,002
2024-02-26 Mazzariello Gina Officer A-Award A Common Stock 36,667 0.00 82,912
2024-02-26 Klee Justin B. Director / Officer A-Award A Stock Option (right to buy) 190,000 17.56 3.34M 190,000
2024-02-26 FRATES JAMES M Officer A-Award A Common Stock 40,000 0.00 152,035
2024-02-26 Cohen Joshua B Director / Officer A-Award A Stock Option (right to buy) 190,000 17.56 3.34M 190,000
2024-02-23 Mazzariello Gina Officer S-Sale D Common Stock 2,838 18.76 53.2K 46,245
2024-01-25 MILNE GEORGE M JR Director G-Gift D Common Stock 9,100 0.00 758,571
2024-01-16 MILNE GEORGE M JR Director G-Gift D Common Stock 94,350 0.00 767,671
2024-01-09 Yeramian Patrick D Officer S-Sale D Common Stock 2,812 16.33 45.9K 205,605
2024-01-09 Klee Justin B. Director / Officer S-Sale D Common Stock 5,841 16.33 95.4K 2,836,776
2024-01-09 FRATES JAMES M Officer S-Sale D Common Stock 2,716 16.33 44.3K 112,035
2024-01-09 Cohen Joshua B Director / Officer S-Sale D Common Stock 5,841 16.33 95.4K 2,900,470
2023-12-27 Olinger Margaret Officer M-Exempt A Common Stock 25,000 0.37 9.3K 276,108
2023-12-15 Firestone Karen Director P-Purchase A Common Stock 4,000 14.97 59.9K 5,000
2023-11-27 Bedrosian Camille L Officer A-Award A Stock Option (Right to Buy) 162,500 12.93 2.10M 162,500
2023-11-16 Cohen Joshua B Director / Officer M-Exempt A Common Stock 63,694 1.57 100.0K 2,906,311
2023-10-31 FRATES JAMES M Officer G-Gift A Common Stock 11,072 0.00 11,072
2023-08-23 FRATES JAMES M Officer M-Exempt A Common Stock 18,165 6.88 125.0K 73,841
2023-08-15 Morningside Venture Investments Ltd 10% Owner G-Gift D Common Stock 2,000,000 0.00 4,997,302
2023-08-15 Mazzariello Gina Officer S-Sale D Common Stock 6,164 20.88 128.7K 49,083
2023-07-12 Olinger Margaret Officer M-Exempt A Common Stock 20,000 0.37 7.4K 251,108
2023-06-08 Quimi Daphne Director A-Award A Stock Option (right to buy) 16,985 26.25 445.9K 16,985
2023-06-08 MILNE GEORGE M JR Director A-Award A Stock Option (right to buy) 16,985 26.25 445.9K 16,985
2023-06-08 Firestone Karen Director A-Award A Stock Option (right to buy) 3,908 26.25 102.6K 3,908
2023-06-08 FONTEYNE PAUL R. Director A-Award A Stock Option (right to buy) 16,985 26.25 445.9K 16,985
2023-05-22 Olinger Margaret Officer G-Gift D Common Stock 1,580 0.00 231,108
2023-05-17 Mazzariello Gina Officer G-Gift D Common Stock 500 0.00 55,247
2023-05-16 FRATES JAMES M Officer S-Sale D Common Stock 32,000 26.93 861.7K 56,176
2023-05-15 Yeramian Patrick D Officer M-Exempt A Common Stock 9,764 6.88 67.2K 220,382
2023-04-17 Yeramian Patrick D Officer M-Exempt A Common Stock 44,861 0.37 16.6K 253,278
2023-03-29 Morningside Venture Investments Ltd 10% Owner S-Sale D Common Stock 29,048 30.45 884.5K 6,997,302
2023-03-28 Morningside Venture Investments Ltd 10% Owner S-Sale D Common Stock 100,000 30.37 3.04M 7,026,350
2023-03-27 Morningside Venture Investments Ltd 10% Owner S-Sale D Common Stock 32,964 30.25 997.2K 7,154,350
2023-03-21 Morningside Venture Investments Ltd 10% Owner S-Sale D Common Stock 28,807 32.17 926.7K 7,187,314
2023-03-16 Yeramian Patrick D Officer A-Award A Common Stock 9,167 0.00 158,839
2023-03-16 Olinger Margaret Officer A-Award A Stock Option (right to buy) 82,500 32.08 2.65M 82,500
2023-03-16 Morningside Venture Investments Ltd 10% Owner S-Sale D Common Stock 9,122 32.55 296.9K 7,250,762
2023-03-16 Mazzariello Gina Officer A-Award A Common Stock 18,333 0.00 55,747
2023-03-16 MILNE GEORGE M JR Director S-Sale D Common Stock 33,084 31.86 1.05M 863,937
2023-03-16 Klee Justin B. Director / Officer A-Award A Stock Option (right to buy) 225,000 32.08 7.22M 225,000
2023-03-16 Firestone Karen Director P-Purchase A Common Stock 1,000 31.99 32.0K 1,000
2023-03-16 FRATES JAMES M Officer A-Award A Common Stock 21,667 0.00 23,176 D
2023-03-16 Cohen Joshua B Director / Officer A-Award A Common Stock 50,000 0.00 2,842,617
2023-03-15 Morningside Venture Investments Ltd 10% Owner S-Sale D Common Stock 41,066 33.68 1.38M 7,259,884
2023-03-14 Morningside Venture Investments Ltd 10% Owner S-Sale D Common Stock 70,714 34.54 2.44M 7,409,884
2023-03-02 Morningside Venture Investments Ltd 10% Owner S-Sale D Common Stock 50,000 33.75 1.69M 7,480,598
2023-02-24 Mazzariello Gina Officer S-Sale D Common Stock 3,586 34.49 123.7K 37,414
2023-02-23 Morningside Venture Investments Ltd 10% Owner S-Sale D Common Stock 48,889 35.55 1.74M 7,581,709
2023-02-22 Morningside Venture Investments Ltd 10% Owner S-Sale D Common Stock 47,888 34.70 1.66M 7,532,710
2023-01-06 Yeramian Patrick D Officer S-Sale A Common Stock 1,405 36.08 50.7K 204,928
2023-01-06 Olinger Margaret Officer S-Sale A Common Stock 743 36.79 27.3K 214,355
2023-01-06 Klee Justin B. Officer S-Sale A Common Stock 1,846 36.79 67.9K 2,892,617
2023-01-06 FRATES JAMES M Officer S-Sale A Common Stock 822 36.79 30.2K 34,009
2023-01-06 Cohen Joshua B Officer S-Sale A Common Stock 1,846 36.79 67.9K 2,892,617
2022-12-31 Morningside Venture Investments Ltd 10% Owner 0 0.00 0
2022-12-30 FRATES JAMES M Officer M-Exempt D Stock Option (Right to Buy) 5,000 0.00 447,000
2022-11-11 VIKING GLOBAL INVESTORS LP C-Conversion D Series C-1 Preferred Stock 4,870,536 0.00 0
2022-07-06 ALS Invest 1 B.V. Director S-Sale D Common Stock 18,312 19.54 357.8K 5,937,577
2022-06-09 Quimi Daphne Director A-Award A Stock Option (Right to Buy) 19,000 0.00 19,000
2022-06-09 MILNE GEORGE M JR Director A-Award A Stock Option (Right to Buy) 19,000 0.00 19,000
2022-06-09 FONTEYNE PAUL R. Director A-Award A Stock Option (Right to Buy) 19,000 0.00 19,000
2022-06-09 Cheng Isaac Director A-Award A Stock Option (Right to Buy) 19,000 0.00 19,000
2022-05-05 Klee Justin B. Officer M-Exempt D Stock Option (right to buy) 334,520 0.00 0
2022-05-05 Cohen Joshua B Officer M-Exempt D Stock Option (right to buy) 334,520 0.00 0
2022-02-22 Mazzariello Gina Officer A-Award A Common Stock 41,000 0.00 41,000
2022-02-11 FRATES JAMES M Officer A-Award A Stock Option (right to buy) 25,000 19.63 490.6K 25,000
2022-01-11 VIKING GLOBAL INVESTORS LP P-Purchase A Common Stock 2,300,000 19.00 43.70M 2,300,000
2022-01-11 Morningside Venture Investments Ltd 10% Owner C-Conversion D Series A Preferred Stock 1,409,035 0.00 0
2022-01-11 DRAGSA 96 LLC 10% Owner D Common Stock 0 0.00 2,300,000
2022-01-11 ALS Invest 1 B.V. 10% Owner C-Conversion A Common Stock 4,826,503 0.00 5,955,889
2022-01-06 Yeramian Patrick D Officer D Stock Option (Right to Buy) 2,789 0.33 920.37 0
2022-01-06 VIKING GLOBAL INVESTORS LP I Series C-1 Preferred Stock 4,870,536 0.00 0
2022-01-06 Quimi Daphne Director D Stock Option (Right to Buy) 81,100 7.09 575.0K 0
2022-01-06 Olinger Margaret Officer A-Award A Stock Option (right to buy) 127,500 19.00 2.42M 127,500
2022-01-06 Morningside Venture Investments Ltd 10% Owner D Series A Preferred Stock 1,409,035 0.00 0
2022-01-06 MILNE GEORGE M JR Director D Common Stock 0 0.00 195,081
2022-01-06 Klee Justin B. Director / Officer A-Award A Stock Option (right to buy) 337,500 19.00 6.41M 337,500
2022-01-06 FRATES JAMES M Officer D Stock Option (Right to Buy) 452,000 6.88 3.11M 0
2022-01-06 FONTEYNE PAUL R. Director D Stock Option (Right to Buy) 81,100 6.88 558.0K 0
2022-01-06 Cohen Joshua B Director / Officer D Series C-1 Preferred Stock 4,870 0.00 0
2022-01-06 Cheng Isaac Director I Series B Preferred Stock 6,410,964 0.00 0
2022-01-06 ALS Invest 1 B.V. 10% Owner D Series B Preferred Stock 4,826,503 0.00 0

Executive team

Top executives
Shares Outstanding
83.13M

Executive compensation

Executive compensation (annual)
# Year Executive Salary Bonus Stock award Option award Incentive Other Total % Stock-
based
Filing
1 2025 Justin Klee Co-Chief Executive Officer and Director 686.2K 650.2K 817.8K 548.1K 17.5K 2.72M 53.97%
2 2025 Joshua Cohen Co-Chief Executive Officer and Director 686.2K 650.2K 817.8K 548.1K 17.5K 2.72M 53.97%
3 2025 Camille L. Bedrosian, M.D. Chief Medical Officer 575.0K 247.0K 312.9K 275.6K 157.2K 1.57M 35.71%
4 2025 James Frates Chief Financial Officer 540.6K 247.0K 311.1K 259.1K 17.5K 1.38M 40.58%
5 2024 Joshua Cohen Co-Chief Executive Officer and Director 686.2K 2.59M 2.69M 521.9K 17.3K 6.50M 81.14%
6 2024 Justin Klee Co-Chief Executive Officer and Director 686.2K 2.59M 2.69M 521.9K 17.3K 6.50M 81.14%
7 2024 James Frates Chief Financial Officer 540.6K 885.7K 848.4K 248.4K 17.3K 2.54M 68.26%
8 2024 Gina M. Mazzariello Chief Legal Officer and General Counsel 478.4K 805.8K 777.7K 219.8K 17.3K 2.30M 68.88%
9 2023 Joshua Cohen Co-Chief Executive Officer and Director 621.0K 1.60M 4.73M 447.7K 11.5K 7.42M 85.44%
10 2023 Justin Klee Co-Chief Executive Officer and Director 621.0K 1.60M 4.73M 447.7K 11.5K 7.42M 85.44%
11 2023 James Frates Chief Financial Officer 510.0K 695.1K 2.05M 241.7K 11.5K 3.51M 78.26%
12 2023 Margaret Olinger Former Chief Commercial Officer 488.8K 618.2K 1.74M 225.2K 378.1K 3.45M 68.32%
13 2023 Gina M. Mazzariello Chief Legal Officer and General Counsel 460.0K 588.1K 1.74M 217.8K 11.5K 3.01M 77.13%
14 2023 Camille L. Bedrosian, M.D. Chief Medical Officer 56.8K 173.0K 754.2K 1.39M 2.8K 2.37M 90.20%
15 2022 Joshua Cohen Co-Chief Executive Officer and Director 539.3K 1.43M 4.75M 453.0K 9.2K 7.18M 86.05%
16 2022 Justin Klee Co-Chief Executive Officer and Director 539.3K 1.43M 4.75M 453.0K 9.2K 7.18M 86.05%
17 2022 Gina M. Mazzariello Chief Legal Officer and General Counsel 342.6K 250.0K 1.23M 4.09M 193.1K 9.2K 6.11M 87.00%
18 2022 James Frates Chief Financial Officer 439.5K 601.7K 2.36M 246.5K 9.2K 3.66M 81.00%
19 2022 Margaret Olinger Former Chief Commercial Officer 424.3K 538.3K 1.80M 228.8K 9.2K 3.00M 77.89%
20 2021 James Frates Chief Financial Officer 375.0K 615.0K 2.05M 205.1K 8.7K 3.26M 63.03%
21 2021 Justin Klee Co-Chief Executive Officer and Director 417.8K 698.0K 300.0K 8.7K 1.42M 49.00%
22 2021 Joshua Cohen Co-Chief Executive officer and Director 417.8K 698.0K 300.0K 8.7K 1.42M 49.00%
23 2021 Joshua Cohen Co-Chief Executive Officer and Director 417.8K 698.0K 300.0K 8.7K 1.42M 49.00%
24 2021 Margaret Olinger Chief Commercial Officer 372.0K 296.4K 186.3K 8.7K 863.4K 34.33%
25 2021 Margaret Olinger Former Chief Commercial Officer 372.0K 296.4K 186.3K 8.7K 863.4K 34.33%
26 2020 Justin Klee Co-Chief Executive Officer and Director 370.0K 97.0K 203.5K 670.5K 14.47%
27 2020 Joshua Cohen Co-Chief Executive officer and Director 370.0K 97.0K 203.5K 670.5K 14.47%
28 2020 Margaret Olinger Chief Commercial Officer 360.2K 154.8K 515.0K 0.00%
CEO compensation breakdown

Proxy statements

Proxy statements (DEF 14A)
Filing date Form type Filing
2026-04-23 DEFA14A
2026-04-23 DEF 14A
2025-04-24 DEFA14A
2025-04-24 DEF 14A

Recent SEC filings

Recent SEC filings
Filing date Form type Filing
2026-05-07 8-K
2026-05-07 10-Q
2026-04-23 DEFA14A
2026-04-23 DEF 14A
2026-04-23 ARS
2026-03-26 SC 13G/A
2026-03-24 8-K
2026-03-09 4
2026-03-09 4
2026-03-09 4

Executive team

NameTitleCompensationGender
Joshua Cohen Co-Founder, Co-CEO & Director 1M male
Justin Klee Co-Founder, Co-CEO & Director 1M male
Camille L. Bedrosian Chief Medical Officer 1M
James Frates Chief Financial Officer 817.2K male
Gina Mazzariello Chief Legal Officer & General Counsel 715.5K female
Dan Monahan Chief Commercial Officer male
Linda A. Arsenault Chief Human Resources Officer female
Lindsey Allen Head of Investor Relations & Communications female
Machelle Manuel Vice President & Head of Global Medical Affairs
Tammy Sarnelli Global Head of Regulatory Affairs female
Tom Holmes Chief Technical Operations Officer male
Jamie Timmons Head of Global Medical Strategy & Communications
ESG Rating
C+
BIOTECHNOLOGY
2026
E (Environmental)
40.8 / 56.3
Company / Sector avg.
S (Social)
39.4 / 62.4
Company / Sector avg.
G (Governance)
45.7 / 60.9
Company / Sector avg.
ESG Total
41.9 / 59.9
Company / Sector avg.
ESG Score History BIOTECHNOLOGY
Benchmark vs Sector
Senate Trading Activity

No Senate trading activity found for this company.

House Trading Activity
Transaction Date Disclosed Representative District Owner Type Amount Link
2022-10-12 2022-11-16 Christopher L. Jacobs NY27 Purchase $1,001 - $15,000
Market share among peers
Peer comparison — filtered group (TTM)
Your opinion

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Dividend yield history

Dividend history

Earnings history

Earnings reports

Stock splits